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The map label for this gene is 120610838

Identifier: 120610838

GI number: 120610838

Start: 2378332

End: 2379288

Strand: Direct

Name: 120610838

Synonym: Aave_2164

Alternate gene names: NA

Gene position: 2378332-2379288 (Clockwise)

Preceding gene: 120610832

Following gene: 120610839

Centisome position: 44.43

GC content: 69.59

Gene sequence:

>957_bases
ATGGTGGGCGGCACAGGCTATTTCACGCACCGCGAATGCTGGAAGCACGAGATGGGACCGGGACACCCGGAATGCCCGGG
GCGGCTGGACGCCATCGAGGACCGGCTGCTGGCCACCGGCGTGGCCGACGCGCTCGAGCGCTTCGAGGCGCCCGAGGCCT
CGCTGGCCGACGTCGAACTGGCACACGACCGCATGCACGTGGCCGCGCTGCGCGGCCTGTCCGACCGGCTCGCGGAAGAG
ATCCTGGCCGGCGGCCCCGCCCATGCGCAGGTCGATCCGGACACCTCCATCAACCCCCACACCTGGCCGGCCGCGCTGCG
GGCCGCGGGCGCGGCCCTGGCCGCCACCGATGCCGTCATCGCGGGCGAGCTGGAAAACGCCTTCTGCTGCGTGCGACCGC
CCGGGCACCACGCCACGCGCAGCAAGGCCATGGGCTTCTGCTTCTTCAACAATGTCGCGATCGCGGCCCGGTATGCGCTC
CAGCGCCACAAGCTGCAGCGTGTCGCGGTGGTGGATTTCGACGTGCACCACGGCAACGGCACCGAGGACATCCTCGCGAA
CGACCCGCGCGCGCTGATGGTCGGCATCTTCCAGCATCCGTTCTACCCGTTCAGCGGCGACAAGGACCCGGCGCCCAACA
TGCTCAACGTGCCCGTGGCCGCCTACACGCGCGGCATGGACATCCGCGAGCTGATCGAGATGCTCTGGATCCCGCGGCTG
GAGGCCTTCAAGCCCGAGATGATCTTCGTCTCGGCCGGCTTCGACGGCCACCGCGACGACGACATGGGCCAGCTCGGCCT
CACCGAGCAGGACTACGCCTGGATCACGCAGCGCATCAAGGACATCGCCCGCCGTTATTCCAAGGGCCGCATCGTCTCCT
GCCTGGAGGGCGGCTACGTGATGGATGCCCTCGCGCGCAGCGTGGAAGCCCACGTGCGCGTGCTGGCCGACCTCTGA

Upstream 100 bases:

>100_bases
CCACGATCACCGTGTTAAGCTGATCCAGAAGCGACCGGATCTTGTGCTGTGTATTCATGAGACCCGAAGTTATCCGAAAA
AAACCAGAGACAAGGGATTC

Downstream 100 bases:

>100_bases
GGCGAACCGCCCGCCATACAGCCCAAGCTTCTTCGCCGCCATGACCGAACCCGCCGCTTCCACGTCCGCCTCCGCCGTCG
GCGCCCCGTTGCTCCACACC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MVGGTGYFTHRECWKHEMGPGHPECPGRLDAIEDRLLATGVADALERFEAPEASLADVELAHDRMHVAALRGLSDRLAEE
ILAGGPAHAQVDPDTSINPHTWPAALRAAGAALAATDAVIAGELENAFCCVRPPGHHATRSKAMGFCFFNNVAIAARYAL
QRHKLQRVAVVDFDVHHGNGTEDILANDPRALMVGIFQHPFYPFSGDKDPAPNMLNVPVAAYTRGMDIRELIEMLWIPRL
EAFKPEMIFVSAGFDGHRDDDMGQLGLTEQDYAWITQRIKDIARRYSKGRIVSCLEGGYVMDALARSVEAHVRVLADL

Sequences:

>Translated_318_residues
MVGGTGYFTHRECWKHEMGPGHPECPGRLDAIEDRLLATGVADALERFEAPEASLADVELAHDRMHVAALRGLSDRLAEE
ILAGGPAHAQVDPDTSINPHTWPAALRAAGAALAATDAVIAGELENAFCCVRPPGHHATRSKAMGFCFFNNVAIAARYAL
QRHKLQRVAVVDFDVHHGNGTEDILANDPRALMVGIFQHPFYPFSGDKDPAPNMLNVPVAAYTRGMDIRELIEMLWIPRL
EAFKPEMIFVSAGFDGHRDDDMGQLGLTEQDYAWITQRIKDIARRYSKGRIVSCLEGGYVMDALARSVEAHVRVLADL
>Mature_318_residues
MVGGTGYFTHRECWKHEMGPGHPECPGRLDAIEDRLLATGVADALERFEAPEASLADVELAHDRMHVAALRGLSDRLAEE
ILAGGPAHAQVDPDTSINPHTWPAALRAAGAALAATDAVIAGELENAFCCVRPPGHHATRSKAMGFCFFNNVAIAARYAL
QRHKLQRVAVVDFDVHHGNGTEDILANDPRALMVGIFQHPFYPFSGDKDPAPNMLNVPVAAYTRGMDIRELIEMLWIPRL
EAFKPEMIFVSAGFDGHRDDDMGQLGLTEQDYAWITQRIKDIARRYSKGRIVSCLEGGYVMDALARSVEAHVRVLADL

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=328, Percent_Identity=35.9756097560976, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI17158039, Length=329, Percent_Identity=34.9544072948328, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI30795204, Length=329, Percent_Identity=34.9544072948328, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI30795202, Length=329, Percent_Identity=34.9544072948328, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI13128864, Length=307, Percent_Identity=31.9218241042345, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI62750347, Length=328, Percent_Identity=33.5365853658537, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI62750349, Length=328, Percent_Identity=33.5365853658537, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI148539870, Length=349, Percent_Identity=33.810888252149, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI169234807, Length=349, Percent_Identity=33.810888252149, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI153085395, Length=325, Percent_Identity=33.8461538461538, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI226529806, Length=326, Percent_Identity=33.4355828220859, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI13128860, Length=286, Percent_Identity=24.1258741258741, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI13128862, Length=329, Percent_Identity=23.1003039513678, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI293336691, Length=283, Percent_Identity=22.6148409893993, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=315, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206283, Length=313, Percent_Identity=32.9073482428115, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17540332, Length=313, Percent_Identity=32.9073482428115, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI193209491, Length=319, Percent_Identity=32.6018808777429, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25154020, Length=305, Percent_Identity=32.4590163934426, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25154022, Length=305, Percent_Identity=32.7868852459016, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17537347, Length=322, Percent_Identity=31.055900621118, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17534739, Length=311, Percent_Identity=25.4019292604502, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508561, Length=270, Percent_Identity=25.9259259259259, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17561978, Length=270, Percent_Identity=25.1851851851852, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=320, Percent_Identity=29.0625, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321244, Length=285, Percent_Identity=22.4561403508772, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323999, Length=314, Percent_Identity=22.9299363057325, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325325, Length=169, Percent_Identity=27.810650887574, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325141, Length=96, Percent_Identity=37.5, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360899, Length=307, Percent_Identity=34.8534201954397, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642146, Length=307, Percent_Identity=34.8534201954397, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642144, Length=307, Percent_Identity=34.8534201954397, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642142, Length=307, Percent_Identity=34.8534201954397, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281360799, Length=326, Percent_Identity=31.9018404907975, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24641720, Length=326, Percent_Identity=31.9018404907975, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360801, Length=326, Percent_Identity=31.9018404907975, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657891, Length=287, Percent_Identity=25.4355400696864, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24644244, Length=326, Percent_Identity=20.8588957055215, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34898; Mature: 34898

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGGTGYFTHRECWKHEMGPGHPECPGRLDAIEDRLLATGVADALERFEAPEASLADVEL
CCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AHDRMHVAALRGLSDRLAEEILAGGPAHAQVDPDTSINPHTWPAALRAAGAALAATDAVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGELENAFCCVRPPGHHATRSKAMGFCFFNNVAIAARYALQRHKLQRVAVVDFDVHHGNG
CCCCCCCEEEECCCCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEEECCCC
TEDILANDPRALMVGIFQHPFYPFSGDKDPAPNMLNVPVAAYTRGMDIRELIEMLWIPRL
CCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHCCCCHHHHHHHHCCCCH
EAFKPEMIFVSAGFDGHRDDDMGQLGLTEQDYAWITQRIKDIARRYSKGRIVSCLEGGYV
HHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
MDALARSVEAHVRVLADL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVGGTGYFTHRECWKHEMGPGHPECPGRLDAIEDRLLATGVADALERFEAPEASLADVEL
CCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AHDRMHVAALRGLSDRLAEEILAGGPAHAQVDPDTSINPHTWPAALRAAGAALAATDAVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGELENAFCCVRPPGHHATRSKAMGFCFFNNVAIAARYALQRHKLQRVAVVDFDVHHGNG
CCCCCCCEEEECCCCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEEECCCC
TEDILANDPRALMVGIFQHPFYPFSGDKDPAPNMLNVPVAAYTRGMDIRELIEMLWIPRL
CCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHCCCCHHHHHHHHCCCCH
EAFKPEMIFVSAGFDGHRDDDMGQLGLTEQDYAWITQRIKDIARRYSKGRIVSCLEGGYV
HHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
MDALARSVEAHVRVLADL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]