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The map label for this gene is gcp

Identifier: 120610825

GI number: 120610825

Start: 2362171

End: 2363217

Strand: Direct

Name: gcp

Synonym: Aave_2151

Alternate gene names: 120610825

Gene position: 2362171-2363217 (Clockwise)

Preceding gene: 120610823

Following gene: 120610827

Centisome position: 44.13

GC content: 72.97

Gene sequence:

>1047_bases
ATGGTCAAGAGTCAGCTCATCCTCGGAATCGAATCCTCCTGCGACGAAACCGGCGTGGCCCTCGTGCGTGCGCCGGCGGA
CGGCAGCGTGCCCACGCTGCTCGCCCATGCCCTGCACAGCCAGATCGACATGCACCAGGCCTATGGCGGCGTGGTGCCCG
AACTGGCGAGCCGCGACCACATCCGGCGCGTGCTGCCACTGACCGGGACCGTGCTGGCCGAGGCGGACTGCCGCCTCGCG
GAGGTGGACGTGGTGGCCTACACGCGCGGGCCGGGCCTGGCCGGCGCGCTGCTCGTGGGGGCGGGCGTGGCCTGTGCCCT
GGGTGCGTCGCTGGACCGGCCGGTGCTGGGCGTGCACCATCTGGAGGGGCATTTGCTGTCGCCCTTCCTGAGCGCCGACC
CGCCGGAATTCCCCTTCGTCGCGCTGCTGGTGTCGGGCGGCCACACCCAGTTGATGCGCGTGGACGGCGTGGGCCGCTAC
GAACTGCTGGGCGAGACCATCGACGACGCGGCCGGCGAGGCCTTCGACAAGTCCGCCAAGCTGCTGGGCCTGGGGTACCC
GGGCGGGCCCGCGCTGTCCCGGCTGGCGGAGCAGGGCGACGCCGCGGCCTTCAAGCTGCCGCGGCCGCTGCTGCACAGCG
GCAACCTGGATTTCTCGTTCGCCGGCCTCAAGACGGCCGTGCTCACGCAGGCGAAGAAGCTGGGCGACGAGCTGCCCGCG
CGCAAGGCCGACCTGGCCGCCAGCACCCAGGCCGCCATCGTCGATGTGCTCGTGAAGAAGACGCTGGCGGCACTGCAGGC
GTCCGGCCTGCGCCGCGTGGTGGTGGCCGGCGGCGTGGGGGCCAACCGGCTGCTGCGCGCGCAGCTGGACGCCGCCTGCG
CCCGCATGGGCGTGCGCGTGCACTATCCCGAACTCCACCTGTGCACCGACAACGGCGCCATGATCGCCATGGCCGCCGCC
ATGCGCCTGCAGGCGGGGCGCGAGGCCCCCAACCGCGAGTACGCGTTCGACGTCAAGCCGCGCTGGCCGCTGGACGCGCT
GGCGTAG

Upstream 100 bases:

>100_bases
TCGGCGTGTACGGCATGCGCGCGGGCCAGTGGGACCTGCGCATGCGCTCCGACCGCTGGTGAGGGCGGGCGGCGGCCGGG
GCGCCTACACTTGCGCGCTT

Downstream 100 bases:

>100_bases
CGGGCTCCGGCTGCCGAGCTGGCAGGCGGGCACAAAAAAGCGCCCGGCCACCGAAGGCACGGGCGCAAGGGCGACAACCG
AGGGCGGAGCCGGATGCGCC

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVKSQLILGIESSCDETGVALVRAPADGSVPTLLAHALHSQIDMHQAYGGVVPELASRDHIRRVLPLTGTVLAEADCRLA
EVDVVAYTRGPGLAGALLVGAGVACALGASLDRPVLGVHHLEGHLLSPFLSADPPEFPFVALLVSGGHTQLMRVDGVGRY
ELLGETIDDAAGEAFDKSAKLLGLGYPGGPALSRLAEQGDAAAFKLPRPLLHSGNLDFSFAGLKTAVLTQAKKLGDELPA
RKADLAASTQAAIVDVLVKKTLAALQASGLRRVVVAGGVGANRLLRAQLDAACARMGVRVHYPELHLCTDNGAMIAMAAA
MRLQAGREAPNREYAFDVKPRWPLDALA

Sequences:

>Translated_348_residues
MVKSQLILGIESSCDETGVALVRAPADGSVPTLLAHALHSQIDMHQAYGGVVPELASRDHIRRVLPLTGTVLAEADCRLA
EVDVVAYTRGPGLAGALLVGAGVACALGASLDRPVLGVHHLEGHLLSPFLSADPPEFPFVALLVSGGHTQLMRVDGVGRY
ELLGETIDDAAGEAFDKSAKLLGLGYPGGPALSRLAEQGDAAAFKLPRPLLHSGNLDFSFAGLKTAVLTQAKKLGDELPA
RKADLAASTQAAIVDVLVKKTLAALQASGLRRVVVAGGVGANRLLRAQLDAACARMGVRVHYPELHLCTDNGAMIAMAAA
MRLQAGREAPNREYAFDVKPRWPLDALA
>Mature_348_residues
MVKSQLILGIESSCDETGVALVRAPADGSVPTLLAHALHSQIDMHQAYGGVVPELASRDHIRRVLPLTGTVLAEADCRLA
EVDVVAYTRGPGLAGALLVGAGVACALGASLDRPVLGVHHLEGHLLSPFLSADPPEFPFVALLVSGGHTQLMRVDGVGRY
ELLGETIDDAAGEAFDKSAKLLGLGYPGGPALSRLAEQGDAAAFKLPRPLLHSGNLDFSFAGLKTAVLTQAKKLGDELPA
RKADLAASTQAAIVDVLVKKTLAALQASGLRRVVVAGGVGANRLLRAQLDAACARMGVRVHYPELHLCTDNGAMIAMAAA
MRLQAGREAPNREYAFDVKPRWPLDALA

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=362, Percent_Identity=33.1491712707182, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI8923380, Length=328, Percent_Identity=30.4878048780488, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789445, Length=341, Percent_Identity=53.6656891495601, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71995670, Length=347, Percent_Identity=30.2593659942363, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17557464, Length=337, Percent_Identity=29.3768545994065, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=376, Percent_Identity=32.7127659574468, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322891, Length=352, Percent_Identity=28.4090909090909, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129063, Length=359, Percent_Identity=33.7047353760446, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357207, Length=339, Percent_Identity=31.858407079646, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_ACIAC (A1TP41)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970503.1
- ProteinModelPortal:   A1TP41
- SMR:   A1TP41
- STRING:   A1TP41
- MEROPS:   M22.001
- GeneID:   4668989
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2151
- NMPDR:   fig|397945.5.peg.1857
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   A1TP41
- ProtClustDB:   PRK09604
- BioCyc:   AAVE397945:AAVE_2151-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36320; Mature: 36320

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSQLILGIESSCDETGVALVRAPADGSVPTLLAHALHSQIDMHQAYGGVVPELASRDH
CCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHH
IRRVLPLTGTVLAEADCRLAEVDVVAYTRGPGLAGALLVGAGVACALGASLDRPVLGVHH
HHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHH
LEGHLLSPFLSADPPEFPFVALLVSGGHTQLMRVDGVGRYELLGETIDDAAGEAFDKSAK
HCCHHHCHHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCHHHCCCCC
LLGLGYPGGPALSRLAEQGDAAAFKLPRPLLHSGNLDFSFAGLKTAVLTQAKKLGDELPA
EEEECCCCCHHHHHHHHCCCCCEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCC
RKADLAASTQAAIVDVLVKKTLAALQASGLRRVVVAGGVGANRLLRAQLDAACARMGVRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEE
HYPELHLCTDNGAMIAMAAAMRLQAGREAPNREYAFDVKPRWPLDALA
ECCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHCC
>Mature Secondary Structure
MVKSQLILGIESSCDETGVALVRAPADGSVPTLLAHALHSQIDMHQAYGGVVPELASRDH
CCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHH
IRRVLPLTGTVLAEADCRLAEVDVVAYTRGPGLAGALLVGAGVACALGASLDRPVLGVHH
HHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHH
LEGHLLSPFLSADPPEFPFVALLVSGGHTQLMRVDGVGRYELLGETIDDAAGEAFDKSAK
HCCHHHCHHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCHHHCCCCC
LLGLGYPGGPALSRLAEQGDAAAFKLPRPLLHSGNLDFSFAGLKTAVLTQAKKLGDELPA
EEEECCCCCHHHHHHHHCCCCCEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCC
RKADLAASTQAAIVDVLVKKTLAALQASGLRRVVVAGGVGANRLLRAQLDAACARMGVRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEE
HYPELHLCTDNGAMIAMAAAMRLQAGREAPNREYAFDVKPRWPLDALA
ECCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA