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The map label for this gene is treF [H]

Identifier: 120610794

GI number: 120610794

Start: 2327412

End: 2329178

Strand: Direct

Name: treF [H]

Synonym: Aave_2117

Alternate gene names: 120610794

Gene position: 2327412-2329178 (Clockwise)

Preceding gene: 120610791

Following gene: 120610795

Centisome position: 43.48

GC content: 72.16

Gene sequence:

>1767_bases
ATGCGAGAACTCGGCCGTAGCCCATCCGTTGTCCCGAAGGCTCCCTTCCTGACCCTGACCCGCCGCATGTCCGCATTGCC
CACACATACTTCCAGCGCAGAGCCCCGGGCGCACCATGCGGTGCCGCCCATCGAGGGCACCGGTCCCATCGACGCCACCC
CGGCCGCCCGCGCCGCCGCGGCCCGCAGCGTTCCGCCACCGGACACGCGCTCCCCGGCCGACCGCTACGAGGAGCTGTTC
GTGGAGGTGCAGCGCCAGCGCGTGTTCGAGGATTCCAAGACCTTCGTGGACTGTGCGCCCCGCATGCCGCCCGAAGACAT
CCTGGCCGCCTACCGCGCCGAACGCGGCGGTCCCGGCTTCGACCTGGCCGGCTTCGTGCATCGCCACTTCACCCCGCCGC
GCAGCGCCTGCGAGCGTTCCACCGCGCCGCCGGGCCTGCCGCTGGCGGCGCACATCGACGCGCTCTGGGACGAACTGGCG
CGGCACCCGGCCCACCACCCCCGGCGCGGTTCCCTGCTGGAACTGCCGCATCCCTACGTCGTGCCCGGCGGCCGCTTCGT
GGAGATGTACTACTGGGATTCGTACTTCACCATGCTGGGCCTGGTGCCCAGCGGGCGCCCGCGGCTGCTGCATGCGATGA
CGGACAACTTCGCCTACCTCATCGACACCTACGGCCACGTGCCCAACGGCACGCGCACCTATTACCTGAGCCGCTCGCAG
CCGCCGGTGTTCGCGCTGATGGCGGGCCTGTGCGAATCCACGCGGGGGCAGGGCGCGGGCCGCTACCTGCCGCAGATGCT
GCGCGAATACGCTTTCTGGATGGACGGCGCCGACGGGCTGGAGCCCGGCGGCACCCACCGGCGCGTGGTGGCCCTGCCCG
ACGGCAGCGTGCTCAACCGTTACTGGGACGACCGCGACACCCCGCGGGAGGAATCCTGGCGCGAGGACATGGAAACCGCC
GCCGCCTGCACCCGCCCGGCGCACGAGGTGTTCCGCGACCTGCGGGCCGCCGCCGAATCGGGCTGGGATTTCAGTTCGCG
CTGGCTGGACGACCTGGACGCCGCCGCCACGCGCACCGCCTGCCTGGCCGGCATCTGCACCACGCGCATCCTGCCCGTGG
ACCTGAACGCGCTGCTGCACGCGAGCGAGACGATGATCGCCCGCCTGAGCCGCGAGGCCGGCGACACCGCCACTGCGGAG
GATTTCGACGGCCGCGCCGCGCGCCGGGCCGGGGCGATCACCCGTTTTCTCTGGAACGACGAGGCCGGGGCCTTCCTGGA
CTACGACTGGCAGAACCGCGTGCCGCGGCCCGCCCTCACGGCCGCGACGGTGGCGCCGCTGTTCACCGGTACCGCCACGC
TGGACCAGGCGCGCGCGCTCGCGGCGACGGTGCGGCGGCGCCTGCTGGTGCGCGGCGGCCTCGCCACCACCGAGATCGCG
AGCGGCGAACAGTGGGACCGGCCCAACGGCTGGGCGCCGATGCAATGGATGGGCTCGCAAGGCTTCGCGCGCTATGGCGA
CCGGGACGAGGGCTGCCGCCAGCTGGCCAGCGACATCCGCGAGCGCTGGCTCGCCACCGTGCGCCACGTGTACGACAAGG
AAGGCCGGCTGGTGGAGAAATACGCGCTGTGCGAGAGCGACTGCGATGCCTCCGCGGGTGGCGACGGTGGCGAATATCCG
CTGCAGGATGGTTTCGGCTGGACGAACGGCGTGGTGCGGGGCTGGCTGGATGATCCGGCGTGGAACGGAACGACCGCCAG
GACCTGA

Upstream 100 bases:

>100_bases
GGCGATTAACTAATTTGTATGTGGATGGGAGGGCACGGCGCTGCGTCCGACGCGCTGCCCGGGCATTTCCGACAGGATAT
GGCCAGGTCGCGGTGGTCCA

Downstream 100 bases:

>100_bases
GCCCCCGGTTGAAGATACCCATCTTCGGGGAGATGCCAAGACGTCGGGATGGCCCAGCTTTCCGAGTCCCCCGGCCACGG
GAGGCATTTCCATTCGGCGC

Product: Alpha,alpha-trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MRELGRSPSVVPKAPFLTLTRRMSALPTHTSSAEPRAHHAVPPIEGTGPIDATPAARAAAARSVPPPDTRSPADRYEELF
VEVQRQRVFEDSKTFVDCAPRMPPEDILAAYRAERGGPGFDLAGFVHRHFTPPRSACERSTAPPGLPLAAHIDALWDELA
RHPAHHPRRGSLLELPHPYVVPGGRFVEMYYWDSYFTMLGLVPSGRPRLLHAMTDNFAYLIDTYGHVPNGTRTYYLSRSQ
PPVFALMAGLCESTRGQGAGRYLPQMLREYAFWMDGADGLEPGGTHRRVVALPDGSVLNRYWDDRDTPREESWREDMETA
AACTRPAHEVFRDLRAAAESGWDFSSRWLDDLDAAATRTACLAGICTTRILPVDLNALLHASETMIARLSREAGDTATAE
DFDGRAARRAGAITRFLWNDEAGAFLDYDWQNRVPRPALTAATVAPLFTGTATLDQARALAATVRRRLLVRGGLATTEIA
SGEQWDRPNGWAPMQWMGSQGFARYGDRDEGCRQLASDIRERWLATVRHVYDKEGRLVEKYALCESDCDASAGGDGGEYP
LQDGFGWTNGVVRGWLDDPAWNGTTART

Sequences:

>Translated_588_residues
MRELGRSPSVVPKAPFLTLTRRMSALPTHTSSAEPRAHHAVPPIEGTGPIDATPAARAAAARSVPPPDTRSPADRYEELF
VEVQRQRVFEDSKTFVDCAPRMPPEDILAAYRAERGGPGFDLAGFVHRHFTPPRSACERSTAPPGLPLAAHIDALWDELA
RHPAHHPRRGSLLELPHPYVVPGGRFVEMYYWDSYFTMLGLVPSGRPRLLHAMTDNFAYLIDTYGHVPNGTRTYYLSRSQ
PPVFALMAGLCESTRGQGAGRYLPQMLREYAFWMDGADGLEPGGTHRRVVALPDGSVLNRYWDDRDTPREESWREDMETA
AACTRPAHEVFRDLRAAAESGWDFSSRWLDDLDAAATRTACLAGICTTRILPVDLNALLHASETMIARLSREAGDTATAE
DFDGRAARRAGAITRFLWNDEAGAFLDYDWQNRVPRPALTAATVAPLFTGTATLDQARALAATVRRRLLVRGGLATTEIA
SGEQWDRPNGWAPMQWMGSQGFARYGDRDEGCRQLASDIRERWLATVRHVYDKEGRLVEKYALCESDCDASAGGDGGEYP
LQDGFGWTNGVVRGWLDDPAWNGTTART
>Mature_588_residues
MRELGRSPSVVPKAPFLTLTRRMSALPTHTSSAEPRAHHAVPPIEGTGPIDATPAARAAAARSVPPPDTRSPADRYEELF
VEVQRQRVFEDSKTFVDCAPRMPPEDILAAYRAERGGPGFDLAGFVHRHFTPPRSACERSTAPPGLPLAAHIDALWDELA
RHPAHHPRRGSLLELPHPYVVPGGRFVEMYYWDSYFTMLGLVPSGRPRLLHAMTDNFAYLIDTYGHVPNGTRTYYLSRSQ
PPVFALMAGLCESTRGQGAGRYLPQMLREYAFWMDGADGLEPGGTHRRVVALPDGSVLNRYWDDRDTPREESWREDMETA
AACTRPAHEVFRDLRAAAESGWDFSSRWLDDLDAAATRTACLAGICTTRILPVDLNALLHASETMIARLSREAGDTATAE
DFDGRAARRAGAITRFLWNDEAGAFLDYDWQNRVPRPALTAATVAPLFTGTATLDQARALAATVRRRLLVRGGLATTEIA
SGEQWDRPNGWAPMQWMGSQGFARYGDRDEGCRQLASDIRERWLATVRHVYDKEGRLVEKYALCESDCDASAGGDGGEYP
LQDGFGWTNGVVRGWLDDPAWNGTTART

Specific function: Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=549, Percent_Identity=33.1511839708561, Blast_Score=272, Evalue=7e-73,
Organism=Escherichia coli, GI1789936, Length=510, Percent_Identity=53.5294117647059, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1787447, Length=501, Percent_Identity=49.9001996007984, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17565078, Length=527, Percent_Identity=31.3092979127135, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17542196, Length=526, Percent_Identity=32.1292775665399, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI25141398, Length=532, Percent_Identity=30.2631578947368, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI25148109, Length=554, Percent_Identity=29.7833935018051, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71987755, Length=439, Percent_Identity=29.6127562642369, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319473, Length=458, Percent_Identity=29.0393013100437, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320204, Length=463, Percent_Identity=28.2937365010799, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656661, Length=525, Percent_Identity=33.3333333333333, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI17933716, Length=525, Percent_Identity=33.3333333333333, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24656670, Length=525, Percent_Identity=33.3333333333333, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24656680, Length=525, Percent_Identity=33.9047619047619, Blast_Score=265, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24656675, Length=525, Percent_Identity=33.9047619047619, Blast_Score=265, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24656685, Length=512, Percent_Identity=32.6171875, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI22024178, Length=534, Percent_Identity=30.5243445692884, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI45551104, Length=375, Percent_Identity=31.7333333333333, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28573474, Length=292, Percent_Identity=29.7945205479452, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 65075; Mature: 65075

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2 ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELGRSPSVVPKAPFLTLTRRMSALPTHTSSAEPRAHHAVPPIEGTGPIDATPAARAAA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARSVPPPDTRSPADRYEELFVEVQRQRVFEDSKTFVDCAPRMPPEDILAAYRAERGGPGF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCCC
DLAGFVHRHFTPPRSACERSTAPPGLPLAAHIDALWDELARHPAHHPRRGSLLELPHPYV
CHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
VPGGRFVEMYYWDSYFTMLGLVPSGRPRLLHAMTDNFAYLIDTYGHVPNGTRTYYLSRSQ
CCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCC
PPVFALMAGLCESTRGQGAGRYLPQMLREYAFWMDGADGLEPGGTHRRVVALPDGSVLNR
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHH
YWDDRDTPREESWREDMETAAACTRPAHEVFRDLRAAAESGWDFSSRWLDDLDAAATRTA
HCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
CLAGICTTRILPVDLNALLHASETMIARLSREAGDTATAEDFDGRAARRAGAITRFLWND
HHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECC
EAGAFLDYDWQNRVPRPALTAATVAPLFTGTATLDQARALAATVRRRLLVRGGLATTEIA
CCCCEECCCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SGEQWDRPNGWAPMQWMGSQGFARYGDRDEGCRQLASDIRERWLATVRHVYDKEGRLVEK
CCCCCCCCCCCCCHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
YALCESDCDASAGGDGGEYPLQDGFGWTNGVVRGWLDDPAWNGTTART
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRELGRSPSVVPKAPFLTLTRRMSALPTHTSSAEPRAHHAVPPIEGTGPIDATPAARAAA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARSVPPPDTRSPADRYEELFVEVQRQRVFEDSKTFVDCAPRMPPEDILAAYRAERGGPGF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCCC
DLAGFVHRHFTPPRSACERSTAPPGLPLAAHIDALWDELARHPAHHPRRGSLLELPHPYV
CHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
VPGGRFVEMYYWDSYFTMLGLVPSGRPRLLHAMTDNFAYLIDTYGHVPNGTRTYYLSRSQ
CCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCC
PPVFALMAGLCESTRGQGAGRYLPQMLREYAFWMDGADGLEPGGTHRRVVALPDGSVLNR
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHH
YWDDRDTPREESWREDMETAAACTRPAHEVFRDLRAAAESGWDFSSRWLDDLDAAATRTA
HCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
CLAGICTTRILPVDLNALLHASETMIARLSREAGDTATAEDFDGRAARRAGAITRFLWND
HHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECC
EAGAFLDYDWQNRVPRPALTAATVAPLFTGTATLDQARALAATVRRRLLVRGGLATTEIA
CCCCEECCCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SGEQWDRPNGWAPMQWMGSQGFARYGDRDEGCRQLASDIRERWLATVRHVYDKEGRLVEK
CCCCCCCCCCCCCHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
YALCESDCDASAGGDGGEYPLQDGFGWTNGVVRGWLDDPAWNGTTART
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA