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The map label for this gene is guaB [H]

Identifier: 120610791

GI number: 120610791

Start: 2324260

End: 2324709

Strand: Direct

Name: guaB [H]

Synonym: Aave_2114

Alternate gene names: 120610791

Gene position: 2324260-2324709 (Clockwise)

Preceding gene: 120610790

Following gene: 120610794

Centisome position: 43.42

GC content: 68.22

Gene sequence:

>450_bases
ATGACCGCAGTCGCAGACATCCTCAGATCCAAGGCCCACCAGGAGGTCTTCACCATCGCGCCGTCCGACTCCATGCTCGA
CGCGCTGCGCCTGATGGCCGACAAGGGCATCGGTGCGCTGCTCGTGATGGACGGGGAGCGCATCGCCGGCATCGTCACCG
AGCGGGATTACGCGCGCAAGGTGGCGCTGCTGGGGCGCACATCGGGCGACACCCGCGTGGCGGACGTGATGACGCGCGCC
GTGCGCTTCGTGCGGCCCGCGCAGACCAGCGGCCAGTGCCTGGCGCTCATGAGCGAGAACCGGCTGCGGCACCTGCCCGT
CGTGGAGGAGGACGGCACGCTCGTGGGCCTCATCTCCATCGGCGACCTCGTGAAGGACGTGATCTCCGAGCAGCAGTTCA
TCATCGAGCAGATGGAGCAGTACATCACCGGGGGCGGACGGCCCGCATAG

Upstream 100 bases:

>100_bases
CCGGCCATGGCCGGGCCACGCCCCGTTGCGGTCCGCGCGGCTTGCATGGACACTGGCGCCAGGCCAGATGCCGTTCACCA
TCCAGCACCGGGAGGCTTCC

Downstream 100 bases:

>100_bases
GCGGCTCGCCGGCGCCGCTCCGGAACACGGCGCTCCCCGTCAAAGCGCAAGCGAGGTCTGCTGCTGGCCGAAGTGCCTCC
CGAGTGCGGGGATGACCTGC

Product: CBS domain-containing protein

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MTAVADILRSKAHQEVFTIAPSDSMLDALRLMADKGIGALLVMDGERIAGIVTERDYARKVALLGRTSGDTRVADVMTRA
VRFVRPAQTSGQCLALMSENRLRHLPVVEEDGTLVGLISIGDLVKDVISEQQFIIEQMEQYITGGGRPA

Sequences:

>Translated_149_residues
MTAVADILRSKAHQEVFTIAPSDSMLDALRLMADKGIGALLVMDGERIAGIVTERDYARKVALLGRTSGDTRVADVMTRA
VRFVRPAQTSGQCLALMSENRLRHLPVVEEDGTLVGLISIGDLVKDVISEQQFIIEQMEQYITGGGRPA
>Mature_148_residues
TAVADILRSKAHQEVFTIAPSDSMLDALRLMADKGIGALLVMDGERIAGIVTERDYARKVALLGRTSGDTRVADVMTRAV
RFVRPAQTSGQCLALMSENRLRHLPVVEEDGTLVGLISIGDLVKDVISEQQFIIEQMEQYITGGGRPA

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 16197; Mature: 16066

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVADILRSKAHQEVFTIAPSDSMLDALRLMADKGIGALLVMDGERIAGIVTERDYARK
CCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHEEEECCHHHHHH
VALLGRTSGDTRVADVMTRAVRFVRPAQTSGQCLALMSENRLRHLPVVEEDGTLVGLISI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEECCCCCEEEHHHH
GDLVKDVISEQQFIIEQMEQYITGGGRPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAVADILRSKAHQEVFTIAPSDSMLDALRLMADKGIGALLVMDGERIAGIVTERDYARK
CHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHEEEECCHHHHHH
VALLGRTSGDTRVADVMTRAVRFVRPAQTSGQCLALMSENRLRHLPVVEEDGTLVGLISI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEECCCCCEEEHHHH
GDLVKDVISEQQFIIEQMEQYITGGGRPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]