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The map label for this gene is iciA [C]

Identifier: 120610258

GI number: 120610258

Start: 1736377

End: 1737333

Strand: Reverse

Name: iciA [C]

Synonym: Aave_1573

Alternate gene names: 120610258

Gene position: 1737333-1736377 (Counterclockwise)

Preceding gene: 120610260

Following gene: 120610256

Centisome position: 32.46

GC content: 72.31

Gene sequence:

>957_bases
ATGCTGGACTACGCCGGACTCGAGGCCCTCGCGGCCGTGGTGCGCGAGGGCAGTTTCGAACGTGCGGCGCGGCGCCTGCA
CGTCACGCCTTCGGCGGTCTCGCAGCGCGTCAAGCAACTGGAAGAGCGTGCGGGACAGGTGCTGGTACAGCGCGGTACCC
CCTGCACGGGCACCGAGGCCGGACGCCGGCTGTGCCTGCACCTGGAGCAGGTGGCCCTCCTGGAAAACGAACTGCGGCGG
GTCCACCCCGCGCTGGTGCCCGATGCCCACGCGCCTGCGCCCACGGTCAAGCTGGCGGTGAACGACGATTCGCTGTCCAC
CTGGTTCATGGACGCGATGGCGGCCTTCGCCGAAGGCGGCAACGAATTGCTGGACGTGCGCATCGACGACCAGGAGCACA
CCGCGCAGCGGCTGCGCGAAGGCGAGGTGATCGCCGCCGTGACGGCCACCGCCGGCGCCATCGCGGGCTGCAACACCTGG
CCGCTGGGCTCCATGCACTACGTGGCGGCGGCCAGCCCGGCCTTCGTGCGCCGCCATTTCGGGCCGGACACGGGCGGGGT
GACCCAGGACACCATCGCGCAGGCGCCGATGATGGTGTACAGCCGCAACGACCGCCTGCAGGACCAGTGGCTGCAGCGCC
AGGGCCTCGGCTCGCGCCGCCATCCGCCCCGCCACTTCCTGCCGTCCAACCAGGGCTTCCTGCGCAGCTGCGAGATGGGC
ATCGGCTGGGGCATGCACCCCACGGTGCTGATCGAGCGGCAGCTCGCGGACGGCACGCTGGTGGAGATGCTGCCGGGCAC
CGGCATGGACGTGGCGCTCTACTGGGCCCACCCGCGTTCGGCCCAGGCGGGGCTGGAGCGGCTCACGCAGTGCGTCATGG
CGGCGGCGCAGGCCTGGCTGGGCGCGGATGCCGGCAGGCGGCGGGCGGGGACGCCGCGCAAGCCGCCGAAGAAATAG

Upstream 100 bases:

>100_bases
CAGGGAAGAGGAAGGAAGAAGTGCCCACATGCGACCGATTCTGGGCGGGTGTATAAATTATGTAAACTTAAAAACTCTAA
CCTTCATTAAGTATTGCTTC

Downstream 100 bases:

>100_bases
CCCGCCCGGGTCAATTCCCCCCGACTTCCACGCGCACGGGCAGCCCTGGAACCGGCACCTGCGCCAGCGCGCGGCGCCGC
GCGGGCGACACGGCCCCTGC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MLDYAGLEALAAVVREGSFERAARRLHVTPSAVSQRVKQLEERAGQVLVQRGTPCTGTEAGRRLCLHLEQVALLENELRR
VHPALVPDAHAPAPTVKLAVNDDSLSTWFMDAMAAFAEGGNELLDVRIDDQEHTAQRLREGEVIAAVTATAGAIAGCNTW
PLGSMHYVAAASPAFVRRHFGPDTGGVTQDTIAQAPMMVYSRNDRLQDQWLQRQGLGSRRHPPRHFLPSNQGFLRSCEMG
IGWGMHPTVLIERQLADGTLVEMLPGTGMDVALYWAHPRSAQAGLERLTQCVMAAAQAWLGADAGRRRAGTPRKPPKK

Sequences:

>Translated_318_residues
MLDYAGLEALAAVVREGSFERAARRLHVTPSAVSQRVKQLEERAGQVLVQRGTPCTGTEAGRRLCLHLEQVALLENELRR
VHPALVPDAHAPAPTVKLAVNDDSLSTWFMDAMAAFAEGGNELLDVRIDDQEHTAQRLREGEVIAAVTATAGAIAGCNTW
PLGSMHYVAAASPAFVRRHFGPDTGGVTQDTIAQAPMMVYSRNDRLQDQWLQRQGLGSRRHPPRHFLPSNQGFLRSCEMG
IGWGMHPTVLIERQLADGTLVEMLPGTGMDVALYWAHPRSAQAGLERLTQCVMAAAQAWLGADAGRRRAGTPRKPPKK
>Mature_318_residues
MLDYAGLEALAAVVREGSFERAARRLHVTPSAVSQRVKQLEERAGQVLVQRGTPCTGTEAGRRLCLHLEQVALLENELRR
VHPALVPDAHAPAPTVKLAVNDDSLSTWFMDAMAAFAEGGNELLDVRIDDQEHTAQRLREGEVIAAVTATAGAIAGCNTW
PLGSMHYVAAASPAFVRRHFGPDTGGVTQDTIAQAPMMVYSRNDRLQDQWLQRQGLGSRRHPPRHFLPSNQGFLRSCEMG
IGWGMHPTVLIERQLADGTLVEMLPGTGMDVALYWAHPRSAQAGLERLTQCVMAAAQAWLGADAGRRRAGTPRKPPKK

Specific function: Specific Inhibitor Of Chromosomal Initiation Of Replication In VItro. Binds The Three 13-Mers In The Origin (Oric) To Block Initiation Of Replication. [C]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=274, Percent_Identity=36.4963503649635, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34669; Mature: 34669

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYAGLEALAAVVREGSFERAARRLHVTPSAVSQRVKQLEERAGQVLVQRGTPCTGTEA
CCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCHH
GRRLCLHLEQVALLENELRRVHPALVPDAHAPAPTVKLAVNDDSLSTWFMDAMAAFAEGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
NELLDVRIDDQEHTAQRLREGEVIAAVTATAGAIAGCNTWPLGSMHYVAAASPAFVRRHF
CEEEEEEECCHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHC
GPDTGGVTQDTIAQAPMMVYSRNDRLQDQWLQRQGLGSRRHPPRHFLPSNQGFLRSCEMG
CCCCCCCCHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHC
IGWGMHPTVLIERQLADGTLVEMLPGTGMDVALYWAHPRSAQAGLERLTQCVMAAAQAWL
CCCCCCCCEEEEEHHCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
GADAGRRRAGTPRKPPKK
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDYAGLEALAAVVREGSFERAARRLHVTPSAVSQRVKQLEERAGQVLVQRGTPCTGTEA
CCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCHH
GRRLCLHLEQVALLENELRRVHPALVPDAHAPAPTVKLAVNDDSLSTWFMDAMAAFAEGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
NELLDVRIDDQEHTAQRLREGEVIAAVTATAGAIAGCNTWPLGSMHYVAAASPAFVRRHF
CEEEEEEECCHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHC
GPDTGGVTQDTIAQAPMMVYSRNDRLQDQWLQRQGLGSRRHPPRHFLPSNQGFLRSCEMG
CCCCCCCCHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHC
IGWGMHPTVLIERQLADGTLVEMLPGTGMDVALYWAHPRSAQAGLERLTQCVMAAAQAWL
CCCCCCCCEEEEEHHCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
GADAGRRRAGTPRKPPKK
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]