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The map label for this gene is clpX

Identifier: 120610145

GI number: 120610145

Start: 1607287

End: 1608552

Strand: Reverse

Name: clpX

Synonym: Aave_1458

Alternate gene names: 120610145

Gene position: 1608552-1607287 (Counterclockwise)

Preceding gene: 120610146

Following gene: 120610144

Centisome position: 30.05

GC content: 63.67

Gene sequence:

>1266_bases
ATGGCCGAGAAAAAAGGCTCTTCCAGCGAAAAAACCCTTTACTGCTCCTTCTGCGGCAAGAGCCAGCACGAGGTGAAGAA
ACTCATCGCTGGCCCGTCGGTTTTCATTTGCGACGAGTGCATCGACCTGTGCAATGAGATCATCCGCGACGAGCTGCCTT
CAACCGAAGGTGCGCGGGATTCGCGCGGCGACCTGCCGACCCCGTCGGAGATCAAGGCCAACCTCGACAACTACGTGATC
GGCCAGGAAATCGCCAAGCGCACCCTGGCCGTGGCCGTGTACAACCACTACAAGCGCCTGCGCCACAAGGACAAGGCCGG
CAAGGACGAGGTCGAGCTCGCGAAAAGCAACATCCTGCTGATCGGCCCCACCGGCTCGGGCAAGACCCTGCTGGCCCAGA
CCCTCGCGCGCATGCTCGACGTGCCCTTCGTGATGGCCGACGCCACCACCCTCACCGAGGCCGGCTACGTCGGCGAGGAC
GTCGAGAACATCGTCCAGAAGCTGCTGCAGAGCTGCAACTACGAGGTGGAACGGGCCCAGCGCGGCATCGTCTACATCGA
CGAGATCGACAAGATCTCCCGCAAGTCCGACAACCCTTCCATCACGCGCGATGTCTCCGGCGAAGGCGTGCAGCAGGCGC
TGCTCAAGCTGATCGAGGGCACCATGGCCAGCGTCCCCCCCCAGGGCGGCCGCAAGCATCCCAACCAGGATTTCCTGCAG
ATCGACACGACCAACATCCTGTTCATCTGCGGCGGCGCCTTCGCCGGCCTGGAAAAGGTCATCGAGAACCGCACGGAGGC
CTCGGGCATCGGCTTCGGCGCCGCCGTCAAGAGCAAGAAGCAGCGCTCGCTCACCGAGGTGTTCACCGAGATCGAGCCTG
AAGACCTCATCAAGTTCGGCCTCATCCCCGAACTGGTCGGCCGCATGCCCGTGGTCACGGCGCTGGCGGAACTCAGCGAG
GACGCCCTGGTGCAGATCCTCACGGAGCCCAAGAACGCCCTGGTCAAGCAGTACAGCAAGCTGCTGGCCATGGAGGGCGT
GGAGCTGGAGATCCGCCCCGCCGCCCTCAAGGCCATCGCCCGCAAGGCCCTGGCCCGCAAGACCGGCGCCCGCGGCCTGC
GCTCCATCCTCGAGCAGTCCCTGATCGGTACCATGTTCGATCTTCCCAATACCAGCAACGTGGAGAAGGTCGTGGTGGAC
GAATCCACCATCGAAGAGAACAAGGCCCCGTTGCTCGTCTACCGGGAAGCGGCCAAGAAGGCCTGA

Upstream 100 bases:

>100_bases
AGCGGCGTTGCCTCCGGCGGCGTTTTCTGCCAGGGAAGGCGTCCGCCGCCATTTCGTTATCATCCCGCCCACAGTTCCCG
CAACACGAGGCAATGCCCCC

Downstream 100 bases:

>100_bases
GCCGCCCTCCCCTGCCGGGGAGGCACTCGCCTGCGGCCGGACGCCCTGCCGCGGCCCCGGTCATCCAGGATGGTGCCGCG
GGTTGAAAATACCGGCTGGT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MAEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDELPSTEGARDSRGDLPTPSEIKANLDNYVI
GQEIAKRTLAVAVYNHYKRLRHKDKAGKDEVELAKSNILLIGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGED
VENIVQKLLQSCNYEVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTMASVPPQGGRKHPNQDFLQ
IDTTNILFICGGAFAGLEKVIENRTEASGIGFGAAVKSKKQRSLTEVFTEIEPEDLIKFGLIPELVGRMPVVTALAELSE
DALVQILTEPKNALVKQYSKLLAMEGVELEIRPAALKAIARKALARKTGARGLRSILEQSLIGTMFDLPNTSNVEKVVVD
ESTIEENKAPLLVYREAAKKA

Sequences:

>Translated_421_residues
MAEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDELPSTEGARDSRGDLPTPSEIKANLDNYVI
GQEIAKRTLAVAVYNHYKRLRHKDKAGKDEVELAKSNILLIGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGED
VENIVQKLLQSCNYEVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTMASVPPQGGRKHPNQDFLQ
IDTTNILFICGGAFAGLEKVIENRTEASGIGFGAAVKSKKQRSLTEVFTEIEPEDLIKFGLIPELVGRMPVVTALAELSE
DALVQILTEPKNALVKQYSKLLAMEGVELEIRPAALKAIARKALARKTGARGLRSILEQSLIGTMFDLPNTSNVEKVVVD
ESTIEENKAPLLVYREAAKKA
>Mature_420_residues
AEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDELPSTEGARDSRGDLPTPSEIKANLDNYVIG
QEIAKRTLAVAVYNHYKRLRHKDKAGKDEVELAKSNILLIGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGEDV
ENIVQKLLQSCNYEVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTMASVPPQGGRKHPNQDFLQI
DTTNILFICGGAFAGLEKVIENRTEASGIGFGAAVKSKKQRSLTEVFTEIEPEDLIKFGLIPELVGRMPVVTALAELSED
ALVQILTEPKNALVKQYSKLLAMEGVELEIRPAALKAIARKALARKTGARGLRSILEQSLIGTMFDLPNTSNVEKVVVDE
STIEENKAPLLVYREAAKKA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=329, Percent_Identity=51.063829787234, Blast_Score=312, Evalue=4e-85,
Organism=Escherichia coli, GI1786642, Length=416, Percent_Identity=72.1153846153846, Blast_Score=616, Evalue=1e-178,
Organism=Escherichia coli, GI1790366, Length=102, Percent_Identity=43.1372549019608, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=307, Percent_Identity=46.5798045602606, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71982905, Length=307, Percent_Identity=46.5798045602606, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71988663, Length=419, Percent_Identity=37.9474940334129, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71988660, Length=260, Percent_Identity=40.7692307692308, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319704, Length=432, Percent_Identity=38.1944444444444, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24648289, Length=318, Percent_Identity=46.5408805031447, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24648291, Length=318, Percent_Identity=46.5408805031447, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_ACIAC (A1TM61)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969823.1
- ProteinModelPortal:   A1TM61
- STRING:   A1TM61
- GeneID:   4666614
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1458
- NMPDR:   fig|397945.5.peg.1280
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   A1TM61
- ProtClustDB:   PRK05342
- BioCyc:   AAVE397945:AAVE_1458-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45985; Mature: 45854

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDELPSTEGARD
CCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
SRGDLPTPSEIKANLDNYVIGQEIAKRTLAVAVYNHYKRLRHKDKAGKDEVELAKSNILL
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEE
IGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGEDVENIVQKLLQSCNYEVERAQ
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHC
RGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTMASVPPQGGRKHPNQDFLQ
CCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IDTTNILFICGGAFAGLEKVIENRTEASGIGFGAAVKSKKQRSLTEVFTEIEPEDLIKFG
EECCEEEEEECCHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
LIPELVGRMPVVTALAELSEDALVQILTEPKNALVKQYSKLLAMEGVELEIRPAALKAIA
CHHHHHCCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHH
RKALARKTGARGLRSILEQSLIGTMFDLPNTSNVEKVVVDESTIEENKAPLLVYREAAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCCCCEEEECCHHCC
A
C
>Mature Secondary Structure 
AEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDELPSTEGARD
CCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
SRGDLPTPSEIKANLDNYVIGQEIAKRTLAVAVYNHYKRLRHKDKAGKDEVELAKSNILL
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEE
IGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGEDVENIVQKLLQSCNYEVERAQ
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHC
RGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTMASVPPQGGRKHPNQDFLQ
CCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IDTTNILFICGGAFAGLEKVIENRTEASGIGFGAAVKSKKQRSLTEVFTEIEPEDLIKFG
EECCEEEEEECCHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
LIPELVGRMPVVTALAELSEDALVQILTEPKNALVKQYSKLLAMEGVELEIRPAALKAIA
CHHHHHCCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHH
RKALARKTGARGLRSILEQSLIGTMFDLPNTSNVEKVVVDESTIEENKAPLLVYREAAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCCCCEEEECCHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA