Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 120610146

GI number: 120610146

Start: 1608655

End: 1609263

Strand: Reverse

Name: clpP

Synonym: Aave_1459

Alternate gene names: 120610146

Gene position: 1609263-1608655 (Counterclockwise)

Preceding gene: 120610147

Following gene: 120610145

Centisome position: 30.06

GC content: 63.05

Gene sequence:

>609_bases
ATGAGCGCACTGGAAACACAGGCCCTGGGCATGATTCCCATGGTGATCGAGCAGTCGGGACGCGGCGAGCGGTCCTACGA
CATCTATTCGCGCCTGCTCAAGGAGCGGATCGTCTTCCTGATCGGCGAGGTGAACGACCAGACCGCCAACCTGGTCGTGG
CGCAGCTGCTGTTCCTGGAGAGCGAGAACCCCGACAAGGATATTTCCTTCTACATCAACTCCCCCGGCGGCAGCGTGACG
GCCGGCATGGCCATCTACGACACGATGCAGTTCATCAAGCCGGACGTGTCCACCATGTGCCTGGGCTTCGCGGCCAGCAT
GGGCGCCTTCCTGCTGGCGGCCGGCGCCAAGGGCAAGCGCTTCTCGCTGCCCAATTCGAAGATCATGATCCACCAGGTGC
TCGGCGGCGCACGCGGCCAGGCCACGGACATCGAGATCCATGCACGGGACATCCTGCGTACCAAGGACCAGATGAACCGC
ATCCTGGCGGAACGCACCGGACAGCCCCTGGAAAAGGTCAAGGCCGACACCGAACGCGACTATTTCCTCACTGCCGACGA
GGCCAAGGAATACGGCCTGGTCGACCAGGTGGTGACCCAGCGTCCCTGA

Upstream 100 bases:

>100_bases
TCCGCAGCGCGCCGGCTCCTGCCCGCCATCCGGGGCTTGTGCTGGCGAGCACAGGCCCCAATTCATTTCTCGGTACAGTA
TCTGCATGACTGGAGAAAAC

Downstream 100 bases:

>100_bases
CCAGCGGCGTTGCCTCCGGCGGCGTTTTCTGCCAGGGAAGGCGTCCGCCGCCATTTCGTTATCATCCCGCCCACAGTTCC
CGCAACACGAGGCAATGCCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERIVFLIGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVT
AGMAIYDTMQFIKPDVSTMCLGFAASMGAFLLAAGAKGKRFSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNR
ILAERTGQPLEKVKADTERDYFLTADEAKEYGLVDQVVTQRP

Sequences:

>Translated_202_residues
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERIVFLIGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVT
AGMAIYDTMQFIKPDVSTMCLGFAASMGAFLLAAGAKGKRFSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNR
ILAERTGQPLEKVKADTERDYFLTADEAKEYGLVDQVVTQRP
>Mature_201_residues
SALETQALGMIPMVIEQSGRGERSYDIYSRLLKERIVFLIGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVTA
GMAIYDTMQFIKPDVSTMCLGFAASMGAFLLAAGAKGKRFSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRI
LAERTGQPLEKVKADTERDYFLTADEAKEYGLVDQVVTQRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=202, Percent_Identity=56.9306930693069, Blast_Score=244, Evalue=4e-65,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=70.9844559585492, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=200, Percent_Identity=53, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=57.2164948453608, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_ACIAC (A1TM62)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969824.1
- ProteinModelPortal:   A1TM62
- SMR:   A1TM62
- STRING:   A1TM62
- MEROPS:   S14.001
- GeneID:   4665682
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1459
- NMPDR:   fig|397945.5.peg.1281
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   A1TM62
- ProtClustDB:   PRK00277
- BioCyc:   AAVE397945:AAVE_1459-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22295; Mature: 22164

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERIVFLIGEVNDQTANLVVAQLLFLE
CCCCHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTMCLGFAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
FSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRILAERTGQPLEKVKADTERD
EECCCCCEEHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
YFLTADEAKEYGLVDQVVTQRP
EEEECCHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
SALETQALGMIPMVIEQSGRGERSYDIYSRLLKERIVFLIGEVNDQTANLVVAQLLFLE
CCCHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTMCLGFAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
FSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRILAERTGQPLEKVKADTERD
EECCCCCEEHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
YFLTADEAKEYGLVDQVVTQRP
EEEECCHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA