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The map label for this gene is lon [H]

Identifier: 120610144

GI number: 120610144

Start: 1604726

End: 1607152

Strand: Reverse

Name: lon [H]

Synonym: Aave_1457

Alternate gene names: 120610144

Gene position: 1607152-1604726 (Counterclockwise)

Preceding gene: 120610145

Following gene: 120610143

Centisome position: 30.02

GC content: 65.35

Gene sequence:

>2427_bases
ATGTCCGGACATACCCCCCTGCCAGCCACCCCCATCGACCTCCCACTGCTTCCCTTGCGCGACGTGGTGGTGTTCCCCCA
CATGGTGATTCCGCTGTTCGTGGGCCGGCCCAAGAGCATCAAGGCCCTGGAACTGGCCATGGACGCCGACCGGCGCATCA
TGCTGGTCGCCCAGAAGACCGCGGCCAAGGACGAGCCGCTGGTGTCCGACATGTTCGACGTCGGCTGCGTCTCCACGATC
CTGCAGATGCTCAAGCTGCCCGACGGCACCGTCAAGGTGCTGGTGGAAGGCCAGCAGCGGGCCCAGGTCACCTCCATCGA
GGACCATGAAAGCCACTTCACCTCCACCGTGACGCCCGTGCCCGCCAGCGACGGCGACCACAAGCCCAGCGAGATCGAAG
CGCTGCGCCGCGCGGTGATGCAGCAGTTCGACCAGTACGTCAAGCTGAACAAGAAGATCCCGCCCGAGATCCTCACCTCC
ATCGCGAGCATCGACGATCCGGGCCGCCTTGCCGACACCATCGCCGCCCACCTGCCCCTCAAGCTGGAGAACAAGCAGGC
CGTGCTGGACCTGGCCGATGTCAAGGAACGCCTCGAGAACCTGTTCGAGCAGCTCGACCGCGAGGTGGACATCCTCAACG
TGGACAAGCGCATCCGCGGCCGCGTCAAGCGCCAGATGGAGAAGAACCAGCGCGACTTCTACCTGAACGAGCAGGTGAAG
GCCATCCAGAAGGAACTGGGCGAAGGCGAGGAAGGCGCGGACATCGAGGAGATCGAGAAGAAGATCAAGGCCGCGAAGAT
GCCCGCGGACGCGCGCAAGAAGGCCGAGAGCGAACTCAAGAAGCTCAAGCTGATGTCGCCCATGTCGGCGGAAGCCACGG
TCGTGCGCAACTACATCGAGGTCCTGACCGGCCTGCCCTGGAGCAAGCGCACGAAGATCAAGCACGACCTCGCCAACGCG
GAGGAAGTGCTCAACGAGGACCACTACGGCCTGGACAAGGTCAAGGACCGCATCCTCGAATACCTCGCGGTGCAGCAGCG
CGTGGACAAGGTCAAGGCCCCCATCCTCTGCCTGGTGGGCCCGCCCGGGGTCGGCAAGACCTCGCTCGGCCAGTCCATCG
CCAAGGCGACGGGCCGCAAGTACGTGCGCATGGCGCTCGGCGGCATGCGCGACGAGGCGGAAATCCGCGGCCACCGCCGC
ACCTACATCGGCGCCATGCCCGGCAAGGTGCTGCAGAGCCTGAACAAGGTCGGCACACGCAACCCGCTCTTCCTGCTCGA
CGAGATCGACAAGCTGGGCACGGACTTCCGCGGCGACCCGTCCAGCGCGCTGCTGGAAGTGCTCGACCCGGAGCAGAACC
ACAAGTTCGGCGACCACTACGTGGAGGTCGATTTCGACCTGAGCGACGTGATGTTCGTGGCCACGTCGAACTCCATGAAC
ATCCCGCCCGCCCTGCTGGACCGGATGGAAGTCATCCGCCTCTCGGGCTACACGGAAGACGAGAAGGCGAACATCGCCAT
CAAGTACCTGCTGCCCAAGCAGATGGTCAACAACGGCGTCAAGGACGAGGAGTTGCGGGTCGAGGAAAGCGCGGTGCGCG
ACGTCATCCGCTACTACACCCGCGAGGCAGGCGTGCGCTCGCTCGAGCGCGAACTCTCCAAGATCTGCCGAAAGGTGGTC
AAGGGCCTGCAGCTCAAGAAGCTCGAGCCCCAGGTGGTGGTCACCGCGGACAACCTGGCCGAATACCTGGGCGTGCGCAA
GCACACCTATGGCCGGGCGGAACAGCAGAACCAGGTGGGCCAGGTGGTCGGCCTCGCGTGGACCGAGGTCGGCGGCGACC
TGCTCACCATCGAAGCCGCGACCATGCCCGGCAAGGGAACCATCACGCGCACGGGCTCGCTCGGCGACGTCATGAAGGAA
TCCGTGGAAGCCGCGCGCACCGTGGTGCGCAGCCGCGCCCACCGCCTGGGCATCAAGGACGAGGTGTTCGAGAAGCGCGA
CATGCACATCCACGTGCCGGACGGTGCCACGCCCAAGGATGGCCCGAGCGCCGGCGCGGCCATGACCACGGCCTTCGTAT
CCGCCCTCACGGGCATCCCCGTGCGCAGCGATGTCGCGATGACCGGCGAGATCACCCTGCGGGGCGAGGTCACGGCCATC
GGCGGCCTGAAGGAAAAGCTGCTCGCGGCACTGCGCGGCGGCATCAAGACGGTGCTGATTCCCGAGGAAAACGTCAAGGA
CCTGCAGGAGATCCCGGACAACGTGAAGAGCGGCCTGGAGATCATTCCGGTCAAGTGGATCGACAAGGTGCTGGAAGTCG
CCCTGGAGCGCAAGCCGATCGCGCTGACGGAAGAAGAGATCGCCGCGTCCATCACCGCCCGGGAAAACCGCCAGGCACAG
GGCTCCACGGATTCCGTGAAGCATTGA

Upstream 100 bases:

>100_bases
GGCCGGACGCCCTGCCGCGGCCCCGGTCATCCAGGATGGTGCCGCGGGTTGAAAATACCGGCTGGTGGACCATATTCCAC
TCAGTTTCACAAGGATTCCC

Downstream 100 bases:

>100_bases
ACGCGAAATTTTTCCGGAACCACCCAAAAAGTGCGCTACAATTCACTCCATCGATGCCAAACGTTGTAGAATGCAAGGCT
TCGGTAAATGCGGGAATAGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MSGHTPLPATPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALELAMDADRRIMLVAQKTAAKDEPLVSDMFDVGCVSTI
LQMLKLPDGTVKVLVEGQQRAQVTSIEDHESHFTSTVTPVPASDGDHKPSEIEALRRAVMQQFDQYVKLNKKIPPEILTS
IASIDDPGRLADTIAAHLPLKLENKQAVLDLADVKERLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
AIQKELGEGEEGADIEEIEKKIKAAKMPADARKKAESELKKLKLMSPMSAEATVVRNYIEVLTGLPWSKRTKIKHDLANA
EEVLNEDHYGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRR
TYIGAMPGKVLQSLNKVGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
IPPALLDRMEVIRLSGYTEDEKANIAIKYLLPKQMVNNGVKDEELRVEESAVRDVIRYYTREAGVRSLERELSKICRKVV
KGLQLKKLEPQVVVTADNLAEYLGVRKHTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAATMPGKGTITRTGSLGDVMKE
SVEAARTVVRSRAHRLGIKDEVFEKRDMHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRSDVAMTGEITLRGEVTAI
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPDNVKSGLEIIPVKWIDKVLEVALERKPIALTEEEIAASITARENRQAQ
GSTDSVKH

Sequences:

>Translated_808_residues
MSGHTPLPATPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALELAMDADRRIMLVAQKTAAKDEPLVSDMFDVGCVSTI
LQMLKLPDGTVKVLVEGQQRAQVTSIEDHESHFTSTVTPVPASDGDHKPSEIEALRRAVMQQFDQYVKLNKKIPPEILTS
IASIDDPGRLADTIAAHLPLKLENKQAVLDLADVKERLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
AIQKELGEGEEGADIEEIEKKIKAAKMPADARKKAESELKKLKLMSPMSAEATVVRNYIEVLTGLPWSKRTKIKHDLANA
EEVLNEDHYGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRR
TYIGAMPGKVLQSLNKVGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
IPPALLDRMEVIRLSGYTEDEKANIAIKYLLPKQMVNNGVKDEELRVEESAVRDVIRYYTREAGVRSLERELSKICRKVV
KGLQLKKLEPQVVVTADNLAEYLGVRKHTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAATMPGKGTITRTGSLGDVMKE
SVEAARTVVRSRAHRLGIKDEVFEKRDMHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRSDVAMTGEITLRGEVTAI
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPDNVKSGLEIIPVKWIDKVLEVALERKPIALTEEEIAASITARENRQAQ
GSTDSVKH
>Mature_807_residues
SGHTPLPATPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALELAMDADRRIMLVAQKTAAKDEPLVSDMFDVGCVSTIL
QMLKLPDGTVKVLVEGQQRAQVTSIEDHESHFTSTVTPVPASDGDHKPSEIEALRRAVMQQFDQYVKLNKKIPPEILTSI
ASIDDPGRLADTIAAHLPLKLENKQAVLDLADVKERLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVKA
IQKELGEGEEGADIEEIEKKIKAAKMPADARKKAESELKKLKLMSPMSAEATVVRNYIEVLTGLPWSKRTKIKHDLANAE
EVLNEDHYGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRT
YIGAMPGKVLQSLNKVGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMNI
PPALLDRMEVIRLSGYTEDEKANIAIKYLLPKQMVNNGVKDEELRVEESAVRDVIRYYTREAGVRSLERELSKICRKVVK
GLQLKKLEPQVVVTADNLAEYLGVRKHTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAATMPGKGTITRTGSLGDVMKES
VEAARTVVRSRAHRLGIKDEVFEKRDMHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRSDVAMTGEITLRGEVTAIG
GLKEKLLAALRGGIKTVLIPEENVKDLQEIPDNVKSGLEIIPVKWIDKVLEVALERKPIALTEEEIAASITARENRQAQG
STDSVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.3900709219858, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI21396489, Length=661, Percent_Identity=39.4856278366112, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=68.2704811443433, Blast_Score=1067, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=40, Blast_Score=483, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=541, Percent_Identity=39.9260628465804, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=717, Percent_Identity=40.4463040446304, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=43.2432432432432, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24666867, Length=629, Percent_Identity=43.2432432432432, Blast_Score=500, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89416; Mature: 89285

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGHTPLPATPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALELAMDADRRIMLVAQKT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECC
AAKDEPLVSDMFDVGCVSTILQMLKLPDGTVKVLVEGQQRAQVTSIEDHESHFTSTVTPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCHHHHHHCCCCCCC
PASDGDHKPSEIEALRRAVMQQFDQYVKLNKKIPPEILTSIASIDDPGRLADTIAAHLPL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCE
KLENKQAVLDLADVKERLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
EECCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
AIQKELGEGEEGADIEEIEKKIKAAKMPADARKKAESELKKLKLMSPMSAEATVVRNYIE
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLTGLPWSKRTKIKHDLANAEEVLNEDHYGLDKVKDRILEYLAVQQRVDKVKAPILCLVG
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGAMPGKVLQSLNKVGTR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
CCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKANIAIKYLLPKQMVNNGVKDEELRVEESAVRDVIRYYT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGVRSLERELSKICRKVVKGLQLKKLEPQVVVTADNLAEYLGVRKHTYGRAEQQNQVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHH
QVVGLAWTEVGGDLLTIEAATMPGKGTITRTGSLGDVMKESVEAARTVVRSRAHRLGIKD
HHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVFEKRDMHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRSDVAMTGEITLRGEVTAI
HHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEC
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPDNVKSGLEIIPVKWIDKVLEVALERKPI
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHCCCCC
ALTEEEIAASITARENRQAQGSTDSVKH
EECHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGHTPLPATPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALELAMDADRRIMLVAQKT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECC
AAKDEPLVSDMFDVGCVSTILQMLKLPDGTVKVLVEGQQRAQVTSIEDHESHFTSTVTPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCHHHHHHCCCCCCC
PASDGDHKPSEIEALRRAVMQQFDQYVKLNKKIPPEILTSIASIDDPGRLADTIAAHLPL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCE
KLENKQAVLDLADVKERLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
EECCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
AIQKELGEGEEGADIEEIEKKIKAAKMPADARKKAESELKKLKLMSPMSAEATVVRNYIE
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLTGLPWSKRTKIKHDLANAEEVLNEDHYGLDKVKDRILEYLAVQQRVDKVKAPILCLVG
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGAMPGKVLQSLNKVGTR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
CCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKANIAIKYLLPKQMVNNGVKDEELRVEESAVRDVIRYYT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGVRSLERELSKICRKVVKGLQLKKLEPQVVVTADNLAEYLGVRKHTYGRAEQQNQVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHH
QVVGLAWTEVGGDLLTIEAATMPGKGTITRTGSLGDVMKESVEAARTVVRSRAHRLGIKD
HHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVFEKRDMHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRSDVAMTGEITLRGEVTAI
HHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEC
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPDNVKSGLEIIPVKWIDKVLEVALERKPI
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHCCCCC
ALTEEEIAASITARENRQAQGSTDSVKH
EECHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]