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The map label for this gene is hflK [H]

Identifier: 120610118

GI number: 120610118

Start: 1571849

End: 1573264

Strand: Direct

Name: hflK [H]

Synonym: Aave_1431

Alternate gene names: 120610118

Gene position: 1571849-1573264 (Clockwise)

Preceding gene: 120610117

Following gene: 120610119

Centisome position: 29.37

GC content: 66.67

Gene sequence:

>1416_bases
TTGGGCACAATGCCGCGAGACCCATCTTCTCGAAAACTAGAGATCTATCGCATGAATCATCCTTTCAGAGCCTGGCGTCT
GGCATCGCTGCCCGGGCGGATCCGGGGCATGTTCAATCTGAATGATCCCCGCTGGGGCCGCGGCGATGACAAGGCTGATG
GTGCGAACCGCCCGGATTCCGATCGTCCGAACCCGCCTCCCGGGGGTAACCGCGGCCGCGATCCCCAGGGCCAGCCGCCC
GACCTGGACGAACTGTGGCGCGACCTCAACCGCAAGCTCGGGGGCCTCTTCGGCGGACGCAACGGCGGCGGGCGCGGTCC
CGGCAACGGATCGGGCGGTGGATTCCAGCCCGACATGAAGAACACCGGCGTGGGCGTCGGCCTGATCGCCGCGGTGGCCG
TGCTGATCTGGCTGGGCTCCGGCTTCTTCATCGTCCAGGAAGGGCAGCAGGCCGTCATCACCCAGTTCGGCAAGTACAAG
ACCACGGTCAACGCCGGCTTCAACTGGCGCCTGCCGTACCCCATCCAGCGGCACGAACTCGTGTTCGTCACCCAGATCCG
TTCCGCCGACGTCGGCCGGGACAGCATCATCAAGAGCACCGGCCTGCGCGAGTCGGCCATGCTCACCGAGGACGAGAACA
TCGTCGAGATCAAGTTCGCCGTCCAGTACCGCCTGAACGATGCCCGGGCCTGGCTGTTCGAGAGCCGCAACCCCGGTGAA
GCCGTGATCCAGGTGGCCGAGACGGCCGTGCGCGAGATCGTCGGCAAGATGCGCATGGATACCGCCCTGGCCGAGGAACG
CGACCAGATCGCGCCCCGCGTCCGCACCCTCATGCAGACCATCCTGGACCGCTACAAGATCGGTGTCGAGGTGGTGGGCA
TCAACCTGCAGCAGGGCGGCGTGCGTCCGCCCGAGCAGGTGCAGGCCGCGTTCGACGATGTCCTGAAGGCCGGTCAGGAG
CGCGAGCGCGCGAAGAACGAAGCCCAGGCCTACGCCAACGACGTGATTCCCCGCGCGGTCGGTTCCGCTTCCAGGCTCAC
CGAGGAAGCCGCCGCCTACAAGGCCCGGATCGTCGCCCAGGCGCAGGGGGATGCCCAGCGCTTCAGCTCCGTGCTCACCG
AGTATCAGAAGGCGCCGCAGGTCACCCGCGACCGCATGTACCTCGAAGCCATGCAGCAGATCTACTCGAACGTCACCAAG
GTGCTGGTGGACTCGCGCCAGGGTTCGAACCTGCTGTATCTCCCGCTGGACAAGATCATGCAGAACGTTTCCCAGGGCGG
AGCCGCCGCGGCGCCCACCCCGGAAGCGCCCCCGGCATCGTCGTCCTCATCCATACCTTCCAGTACCACCCAGGCATTCC
CCATCGATTCCCGCGCGCGCGACACCAGCCGCACCCGGGACCGTGAAGCCCGCTAG

Upstream 100 bases:

>100_bases
GCCTGAACTGCGCAGCCAGTTGACCGCTGCGGCACTGGCCGCCCGCGAAAACCCCATGACCCCAGGCGCCGATGCTGAAT
TTCCAGCGCCTTGAGGCCAG

Downstream 100 bases:

>100_bases
CCCGAGGGAGAGACAGTCGTGAACAGAGTCGGATTCATCGTTTCCTCCCTGCTGGTAGTGCTCGCCCTGCTCAGCTCCGC
GCTATTCGTCGTGGACCAGC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MGTMPRDPSSRKLEIYRMNHPFRAWRLASLPGRIRGMFNLNDPRWGRGDDKADGANRPDSDRPNPPPGGNRGRDPQGQPP
DLDELWRDLNRKLGGLFGGRNGGGRGPGNGSGGGFQPDMKNTGVGVGLIAAVAVLIWLGSGFFIVQEGQQAVITQFGKYK
TTVNAGFNWRLPYPIQRHELVFVTQIRSADVGRDSIIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPGE
AVIQVAETAVREIVGKMRMDTALAEERDQIAPRVRTLMQTILDRYKIGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQE
RERAKNEAQAYANDVIPRAVGSASRLTEEAAAYKARIVAQAQGDAQRFSSVLTEYQKAPQVTRDRMYLEAMQQIYSNVTK
VLVDSRQGSNLLYLPLDKIMQNVSQGGAAAAPTPEAPPASSSSSIPSSTTQAFPIDSRARDTSRTRDREAR

Sequences:

>Translated_471_residues
MGTMPRDPSSRKLEIYRMNHPFRAWRLASLPGRIRGMFNLNDPRWGRGDDKADGANRPDSDRPNPPPGGNRGRDPQGQPP
DLDELWRDLNRKLGGLFGGRNGGGRGPGNGSGGGFQPDMKNTGVGVGLIAAVAVLIWLGSGFFIVQEGQQAVITQFGKYK
TTVNAGFNWRLPYPIQRHELVFVTQIRSADVGRDSIIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPGE
AVIQVAETAVREIVGKMRMDTALAEERDQIAPRVRTLMQTILDRYKIGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQE
RERAKNEAQAYANDVIPRAVGSASRLTEEAAAYKARIVAQAQGDAQRFSSVLTEYQKAPQVTRDRMYLEAMQQIYSNVTK
VLVDSRQGSNLLYLPLDKIMQNVSQGGAAAAPTPEAPPASSSSSIPSSTTQAFPIDSRARDTSRTRDREAR
>Mature_470_residues
GTMPRDPSSRKLEIYRMNHPFRAWRLASLPGRIRGMFNLNDPRWGRGDDKADGANRPDSDRPNPPPGGNRGRDPQGQPPD
LDELWRDLNRKLGGLFGGRNGGGRGPGNGSGGGFQPDMKNTGVGVGLIAAVAVLIWLGSGFFIVQEGQQAVITQFGKYKT
TVNAGFNWRLPYPIQRHELVFVTQIRSADVGRDSIIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPGEA
VIQVAETAVREIVGKMRMDTALAEERDQIAPRVRTLMQTILDRYKIGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQER
ERAKNEAQAYANDVIPRAVGSASRLTEEAAAYKARIVAQAQGDAQRFSSVLTEYQKAPQVTRDRMYLEAMQQIYSNVTKV
LVDSRQGSNLLYLPLDKIMQNVSQGGAAAAPTPEAPPASSSSSIPSSTTQAFPIDSRARDTSRTRDREAR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=292, Percent_Identity=36.3013698630137, Blast_Score=208, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 51816; Mature: 51685

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTMPRDPSSRKLEIYRMNHPFRAWRLASLPGRIRGMFNLNDPRWGRGDDKADGANRPDS
CCCCCCCCCCCEEEEEEECCCHHHHEECCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCC
DRPNPPPGGNRGRDPQGQPPDLDELWRDLNRKLGGLFGGRNGGGRGPGNGSGGGFQPDMK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
NTGVGVGLIAAVAVLIWLGSGFFIVQEGQQAVITQFGKYKTTVNAGFNWRLPYPIQRHEL
CCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCEEEEEECCEEECCCCCCCCCCE
VFVTQIRSADVGRDSIIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPGE
EEEEEECCCCCCHHHHHHHCCCCHHHEECCCCCEEEEEEEEEEEECCHHEEEECCCCCHH
AVIQVAETAVREIVGKMRMDTALAEERDQIAPRVRTLMQTILDRYKIGVEVVGINLQQGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
VRPPEQVQAAFDDVLKAGQERERAKNEAQAYANDVIPRAVGSASRLTEEAAAYKARIVAQ
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AQGDAQRFSSVLTEYQKAPQVTRDRMYLEAMQQIYSNVTKVLVDSRQGSNLLYLPLDKIM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
QNVSQGGAAAAPTPEAPPASSSSSIPSSTTQAFPIDSRARDTSRTRDREAR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
GTMPRDPSSRKLEIYRMNHPFRAWRLASLPGRIRGMFNLNDPRWGRGDDKADGANRPDS
CCCCCCCCCCEEEEEEECCCHHHHEECCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCC
DRPNPPPGGNRGRDPQGQPPDLDELWRDLNRKLGGLFGGRNGGGRGPGNGSGGGFQPDMK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
NTGVGVGLIAAVAVLIWLGSGFFIVQEGQQAVITQFGKYKTTVNAGFNWRLPYPIQRHEL
CCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCEEEEEECCEEECCCCCCCCCCE
VFVTQIRSADVGRDSIIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPGE
EEEEEECCCCCCHHHHHHHCCCCHHHEECCCCCEEEEEEEEEEEECCHHEEEECCCCCHH
AVIQVAETAVREIVGKMRMDTALAEERDQIAPRVRTLMQTILDRYKIGVEVVGINLQQGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
VRPPEQVQAAFDDVLKAGQERERAKNEAQAYANDVIPRAVGSASRLTEEAAAYKARIVAQ
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AQGDAQRFSSVLTEYQKAPQVTRDRMYLEAMQQIYSNVTKVLVDSRQGSNLLYLPLDKIM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
QNVSQGGAAAAPTPEAPPASSSSSIPSSTTQAFPIDSRARDTSRTRDREAR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]