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The map label for this gene is ggt [H]

Identifier: 120610097

GI number: 120610097

Start: 1548442

End: 1550328

Strand: Reverse

Name: ggt [H]

Synonym: Aave_1410

Alternate gene names: 120610097

Gene position: 1550328-1548442 (Counterclockwise)

Preceding gene: 120610098

Following gene: 120610096

Centisome position: 28.96

GC content: 71.65

Gene sequence:

>1887_bases
ATGCGCGGCGTTACCCCGAGATCATTCCACTGCACGACGCGAAGGAGGCGTACCCGCATGAAGTTCCCGTCCACCCGCCG
CACCGCCCTGGCCCTGGCCGCCGCCACGGCCCTGCTGGCCGCCTGCTCCACCGCCCCGCAACTCGCCTACTCGGTGCCGG
ACCAGCCCGAAGGGTCTTCGGGATACATGGAGAAGCCCGGCTGGGCCACGCGCCAGTTCGCGGTCGCCGCGGCCAATCCG
CTGGCCACCGATGCGGGCTACCAGGTGCTCAAGGCCGGAGGTTCGGCCATCGACGCGGCCATCGCGGTGCAGATGGTGCT
CGCGCTGGTCGAACCCCAGTCCAGCGGCATCGGCGGCGGCGCCTTCCTGCTGCATGCCGCGGGCAGCAAGGTGGAAGCGT
ACGACGGGCGCGAAACCGCCCCCGCCGCCGCCAACGAGAACCTGTTCCTCGGCCGGGACGGCAAGCCTGTGCCGTTCTAC
GACGGCGTGGTCGGCGGCCGCTCGGTCGGCGTGCCCGGCGCGGTGCGCATGCTGGAGATGGCGCACCGCGAGCATGGGGT
GCTGCCCTGGGCACAACTGTTCGAGCCCGCCATCCGGCTGGCCGAAGGCGGCTTCAAGGTGAGCGCCCGGCTCCACAGCC
TGCTCGCCAACGAGAAATACCTGGCGCAGGACCCGGCCGCGCGGGCCTACTTCTTCGATCCCGCGGGCAAGCCCTGGCCC
GTGGGGCACGTACTGCGCAATCCCGAGCTCGCGGCCGTCCTGCGGGCCATCGCGCAGAACGGCTCCAGGGCGCTGCTGGA
GGGCGAGGTCGCCCAGGCCATCGTGGCCAAGGTGCAGGGCCATCCGACGAATCCCGGCCAACTGAGCCTGGCGGACCTGG
CGGGCTACCAGCCGAAGAAGCGCGAAGCGCTGTGCAGCGACTACGCCGTGGCGGCCCACGCCTACCGCATGTGCGGCTTT
CCGCCGCCCGGCTCGGGAGCGATCGCCGTGGCGCAGATCCTCGGCATCCTGCAGCAGACGCCCGCGGCCGGCATGCCGCT
GCAGGCCGGCCCGAACGGGCCCCAGGACCTGCAGCCCGGCGCCGACTGGCTCTACTACTACAACGAGGCCGCGCGCCTGG
CCTTCGCCGACCGCGGGCTCTACGTGGCCGATCCGGACTTCGTGCAGCCGCCGGCGGGCAGCTGGTCGAGCCTGGTGGAC
CCCGCCTATCTGGCGCAGCGCGCGCGCCTCATCGGCCCGCAGAGCCTGAAGGTGGCCCAGCCCGGCACGCCGGGGGCCGC
GAGGACGGCCCTGGCGCCGATGCCCGACCAGATCGAGCACGGCACCAGCCACATCAGCGTGGTGGACGCCCGTGGCAATG
CCGTGGCGATGACGACGACCATCGAGGACCAGTTCGGTTCCCGCCAGATGGTCAAGGGCTTCCTGCTGAACAACGAGCTG
ACCGACTTCAGCTTCGCGCCCCGCGACGCGGCCGGCCGGCCCATCGCGAACCGCGTGGAACCCGGCAAGCGCCCCCGCTC
CTCCATGGCCCCGACCCTGGTCTTCGACAAGGCCACCGGCCAGCTCGCGATGAGCGGCGGCAGCCCGGGCGGCGCGCTCA
TCATCCACTACACCGCCAAGACGCTGTACGGCATCTTCAACTGGGGGCTGACTCCGCAGCAGGCCATCAACCTGCCGAAC
TTCGGCAACCTCAACGGCCCCACCATGCTGGAGGAAAAGCGCTTCCTGCCCTCCACCGTGGAGCAGCTGCGCACGCGCGG
CGCCGAGGTGCGCGAGATGAACATGACCAGCGGGCTGCAGGCCATCACCCGCGCCAACGTGCACGGCCAGCCGATGTGGC
TGGGCGGCGCCGATCCGCGCCGCGAGGGCATCGTGATGGGCGACTGA

Upstream 100 bases:

>100_bases
CCTGGCACGCTTCGTGGTGGAAGACCGCCGTCCGGGCCCGGTACGGGACTGACGTACCCGCTTGTAACAAAGCCGCCACG
GGCCGGGGCGGGCCGATAGG

Downstream 100 bases:

>100_bases
GCGGCCATGCGGCCCATCGGGCACGGCCGGACTAGCACATTGCGTGCGCAGCGCCAAGCCCCCGCGCGGCGGGGCTGTGG
TTTCGGCGGTGCATGCCCGC

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MRGVTPRSFHCTTRRRRTRMKFPSTRRTALALAAATALLAACSTAPQLAYSVPDQPEGSSGYMEKPGWATRQFAVAAANP
LATDAGYQVLKAGGSAIDAAIAVQMVLALVEPQSSGIGGGAFLLHAAGSKVEAYDGRETAPAAANENLFLGRDGKPVPFY
DGVVGGRSVGVPGAVRMLEMAHREHGVLPWAQLFEPAIRLAEGGFKVSARLHSLLANEKYLAQDPAARAYFFDPAGKPWP
VGHVLRNPELAAVLRAIAQNGSRALLEGEVAQAIVAKVQGHPTNPGQLSLADLAGYQPKKREALCSDYAVAAHAYRMCGF
PPPGSGAIAVAQILGILQQTPAAGMPLQAGPNGPQDLQPGADWLYYYNEAARLAFADRGLYVADPDFVQPPAGSWSSLVD
PAYLAQRARLIGPQSLKVAQPGTPGAARTALAPMPDQIEHGTSHISVVDARGNAVAMTTTIEDQFGSRQMVKGFLLNNEL
TDFSFAPRDAAGRPIANRVEPGKRPRSSMAPTLVFDKATGQLAMSGGSPGGALIIHYTAKTLYGIFNWGLTPQQAINLPN
FGNLNGPTMLEEKRFLPSTVEQLRTRGAEVREMNMTSGLQAITRANVHGQPMWLGGADPRREGIVMGD

Sequences:

>Translated_628_residues
MRGVTPRSFHCTTRRRRTRMKFPSTRRTALALAAATALLAACSTAPQLAYSVPDQPEGSSGYMEKPGWATRQFAVAAANP
LATDAGYQVLKAGGSAIDAAIAVQMVLALVEPQSSGIGGGAFLLHAAGSKVEAYDGRETAPAAANENLFLGRDGKPVPFY
DGVVGGRSVGVPGAVRMLEMAHREHGVLPWAQLFEPAIRLAEGGFKVSARLHSLLANEKYLAQDPAARAYFFDPAGKPWP
VGHVLRNPELAAVLRAIAQNGSRALLEGEVAQAIVAKVQGHPTNPGQLSLADLAGYQPKKREALCSDYAVAAHAYRMCGF
PPPGSGAIAVAQILGILQQTPAAGMPLQAGPNGPQDLQPGADWLYYYNEAARLAFADRGLYVADPDFVQPPAGSWSSLVD
PAYLAQRARLIGPQSLKVAQPGTPGAARTALAPMPDQIEHGTSHISVVDARGNAVAMTTTIEDQFGSRQMVKGFLLNNEL
TDFSFAPRDAAGRPIANRVEPGKRPRSSMAPTLVFDKATGQLAMSGGSPGGALIIHYTAKTLYGIFNWGLTPQQAINLPN
FGNLNGPTMLEEKRFLPSTVEQLRTRGAEVREMNMTSGLQAITRANVHGQPMWLGGADPRREGIVMGD
>Mature_628_residues
MRGVTPRSFHCTTRRRRTRMKFPSTRRTALALAAATALLAACSTAPQLAYSVPDQPEGSSGYMEKPGWATRQFAVAAANP
LATDAGYQVLKAGGSAIDAAIAVQMVLALVEPQSSGIGGGAFLLHAAGSKVEAYDGRETAPAAANENLFLGRDGKPVPFY
DGVVGGRSVGVPGAVRMLEMAHREHGVLPWAQLFEPAIRLAEGGFKVSARLHSLLANEKYLAQDPAARAYFFDPAGKPWP
VGHVLRNPELAAVLRAIAQNGSRALLEGEVAQAIVAKVQGHPTNPGQLSLADLAGYQPKKREALCSDYAVAAHAYRMCGF
PPPGSGAIAVAQILGILQQTPAAGMPLQAGPNGPQDLQPGADWLYYYNEAARLAFADRGLYVADPDFVQPPAGSWSSLVD
PAYLAQRARLIGPQSLKVAQPGTPGAARTALAPMPDQIEHGTSHISVVDARGNAVAMTTTIEDQFGSRQMVKGFLLNNEL
TDFSFAPRDAAGRPIANRVEPGKRPRSSMAPTLVFDKATGQLAMSGGSPGGALIIHYTAKTLYGIFNWGLTPQQAINLPN
FGNLNGPTMLEEKRFLPSTVEQLRTRGAEVREMNMTSGLQAITRANVHGQPMWLGGADPRREGIVMGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=582, Percent_Identity=30.7560137457045, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915090, Length=582, Percent_Identity=30.7560137457045, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915096, Length=582, Percent_Identity=30.7560137457045, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915094, Length=582, Percent_Identity=30.7560137457045, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI113429324, Length=561, Percent_Identity=29.9465240641711, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI153266885, Length=541, Percent_Identity=31.0536044362292, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266901, Length=542, Percent_Identity=30.9963099630996, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI113429326, Length=566, Percent_Identity=29.5053003533569, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI153266907, Length=539, Percent_Identity=29.3135435992579, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI109148539, Length=554, Percent_Identity=28.5198555956679, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI30581157, Length=197, Percent_Identity=35.5329949238579, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI30581155, Length=197, Percent_Identity=35.5329949238579, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI218505805, Length=194, Percent_Identity=30.4123711340206, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1789856, Length=564, Percent_Identity=33.5106382978723, Blast_Score=245, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17542894, Length=569, Percent_Identity=30.0527240773286, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193208245, Length=657, Percent_Identity=28.158295281583, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI212646519, Length=580, Percent_Identity=29.4827586206897, Blast_Score=196, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI193208247, Length=582, Percent_Identity=29.3814432989691, Blast_Score=196, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI72000294, Length=580, Percent_Identity=29.4827586206897, Blast_Score=195, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17506189, Length=550, Percent_Identity=26.3636363636364, Blast_Score=155, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI72001497, Length=232, Percent_Identity=26.2931034482759, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=26.2931034482759, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=194, Percent_Identity=32.4742268041237, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859893, Length=551, Percent_Identity=30.8529945553539, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI45551474, Length=572, Percent_Identity=29.7202797202797, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24642670, Length=572, Percent_Identity=29.7202797202797, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24642666, Length=572, Percent_Identity=29.7202797202797, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI161077878, Length=572, Percent_Identity=29.7202797202797, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI161077880, Length=572, Percent_Identity=29.7202797202797, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI161077496, Length=551, Percent_Identity=27.5862068965517, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI18859741, Length=568, Percent_Identity=27.4647887323944, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 66545; Mature: 66545

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVTPRSFHCTTRRRRTRMKFPSTRRTALALAAATALLAACSTAPQLAYSVPDQPEGSS
CCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCC
GYMEKPGWATRQFAVAAANPLATDAGYQVLKAGGSAIDAAIAVQMVLALVEPQSSGIGGG
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
AFLLHAAGSKVEAYDGRETAPAAANENLFLGRDGKPVPFYDGVVGGRSVGVPGAVRMLEM
EEEEEECCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AHREHGVLPWAQLFEPAIRLAEGGFKVSARLHSLLANEKYLAQDPAARAYFFDPAGKPWP
HHHHCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCCC
VGHVLRNPELAAVLRAIAQNGSRALLEGEVAQAIVAKVQGHPTNPGQLSLADLAGYQPKK
CHHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCHH
REALCSDYAVAAHAYRMCGFPPPGSGAIAVAQILGILQQTPAAGMPLQAGPNGPQDLQPG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
ADWLYYYNEAARLAFADRGLYVADPDFVQPPAGSWSSLVDPAYLAQRARLIGPQSLKVAQ
CCEEEEECCHHEEEEECCCEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCEEEEC
PGTPGAARTALAPMPDQIEHGTSHISVVDARGNAVAMTTTIEDQFGSRQMVKGFLLNNEL
CCCCCHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEEEEEHHHHHCCHHHHHHHHHCCCC
TDFSFAPRDAAGRPIANRVEPGKRPRSSMAPTLVFDKATGQLAMSGGSPGGALIIHYTAK
CCCCCCCCCCCCCCCHHCCCCCCCCCHHCCCEEEEECCCCEEEECCCCCCCEEEEEEHHH
TLYGIFNWGLTPQQAINLPNFGNLNGPTMLEEKRFLPSTVEQLRTRGAEVREMNMTSGLQ
HHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEHHHHHHHH
AITRANVHGQPMWLGGADPRREGIVMGD
HHHHCCCCCCEEEECCCCCCCCCCEECC
>Mature Secondary Structure
MRGVTPRSFHCTTRRRRTRMKFPSTRRTALALAAATALLAACSTAPQLAYSVPDQPEGSS
CCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCC
GYMEKPGWATRQFAVAAANPLATDAGYQVLKAGGSAIDAAIAVQMVLALVEPQSSGIGGG
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
AFLLHAAGSKVEAYDGRETAPAAANENLFLGRDGKPVPFYDGVVGGRSVGVPGAVRMLEM
EEEEEECCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AHREHGVLPWAQLFEPAIRLAEGGFKVSARLHSLLANEKYLAQDPAARAYFFDPAGKPWP
HHHHCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCCC
VGHVLRNPELAAVLRAIAQNGSRALLEGEVAQAIVAKVQGHPTNPGQLSLADLAGYQPKK
CHHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCHH
REALCSDYAVAAHAYRMCGFPPPGSGAIAVAQILGILQQTPAAGMPLQAGPNGPQDLQPG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
ADWLYYYNEAARLAFADRGLYVADPDFVQPPAGSWSSLVDPAYLAQRARLIGPQSLKVAQ
CCEEEEECCHHEEEEECCCEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCEEEEC
PGTPGAARTALAPMPDQIEHGTSHISVVDARGNAVAMTTTIEDQFGSRQMVKGFLLNNEL
CCCCCHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEEEEEHHHHHCCHHHHHHHHHCCCC
TDFSFAPRDAAGRPIANRVEPGKRPRSSMAPTLVFDKATGQLAMSGGSPGGALIIHYTAK
CCCCCCCCCCCCCCCHHCCCCCCCCCHHCCCEEEEECCCCEEEECCCCCCCEEEEEEHHH
TLYGIFNWGLTPQQAINLPNFGNLNGPTMLEEKRFLPSTVEQLRTRGAEVREMNMTSGLQ
HHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEHHHHHHHH
AITRANVHGQPMWLGGADPRREGIVMGD
HHHHCCCCCCEEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]