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The map label for this gene is mlhB [H]

Identifier: 120610048

GI number: 120610048

Start: 1488445

End: 1489290

Strand: Direct

Name: mlhB [H]

Synonym: Aave_1361

Alternate gene names: 120610048

Gene position: 1488445-1489290 (Clockwise)

Preceding gene: 120610045

Following gene: 120610049

Centisome position: 27.81

GC content: 74.59

Gene sequence:

>846_bases
ATGCCTACCACCTCCGCTTCCCGCTCCACGCCCGCCGGCGCCCGCTCCGAGTCCACCATTGCGGTGGCGCCGGGGCAGGA
CGTCGCCGTGCGCATGTACGGCCGCAGGAAAACCGGCGAGACGTCGCCGCTGGTCGTGCATTTCCATGGCGGCGCCTTCG
TGTCCGGCGACCTGGACAGCGGCTGCACCATCGCCGGGCTGCTGCAGGAAGCCGGGGCGCTGGTGGTGTCGGTGGCCTAC
CCGCTGGCCCCCGAGCATCCGTTCCCGCAGCCGCTGGAGACGGGCTATGCCGTGCTGCAGTGGGCCTACCGCTACCGCAC
GCGGCTGGCCGGCACGGGCGCGCCGGTCTATGTGGCCGGGGAGGAGGCCGGCGGCAACCTGGCGGCGGGCGTGTGCCTCA
TGGCGCGCGACCAGTCCCACCCGCCGCTGGCGGGGCAGATCCTCGTGTCGCCCATGCTCGACCCCTGCGTCGGCACGCCG
TCGCTGCGGGCCGCCACCGAGGGCGCGGAGGCCTGCCGCTGGGCGCTGGGGTGGGAAAAGTTCCTGCGCTGCGCGCGCGA
CGCGGAGCACCCGTATGCGGTGCCCGGCACCGCGCAGCGGCTGGCGGGCCTGCCGCCCACGCTGCTGCTGGTCGGCGACA
CCGACCCCATGCACGACGAGACGCTGGCCTATGCGGCACGGCTGAAGGCCGCCGGCCTGCCGGTGGAACTGCACGTGCTG
CGCAAGGCCGAGCGATGGCCCGATGCGCTGCTGGAGCCCGGCACACAGGCCTGTCCGTGCGCGGACGAGGCGCGCGAGCG
GTTCCGGAGCTTCCTGGATGCCGGGCGATGTCCGGCACCGCGCTGA

Upstream 100 bases:

>100_bases
GTTCGGACTTTGGAAACAGTGCGGCCCGCATCGGCTGGTTTATCGTCGCGGTCCGGCCCCCTACATTTGCAGCACCGGAT
CGTTTCCGGCCACACCGCCC

Downstream 100 bases:

>100_bases
AACCCCTCTTTCGAAGAACGCTCCTTCCGTCACCACGGAAGGTATTGACCTCAACAATGGTTGAGGTTTGAGAATCCGGC
TCCGTTGCCGTATCCGTGCA

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MPTTSASRSTPAGARSESTIAVAPGQDVAVRMYGRRKTGETSPLVVHFHGGAFVSGDLDSGCTIAGLLQEAGALVVSVAY
PLAPEHPFPQPLETGYAVLQWAYRYRTRLAGTGAPVYVAGEEAGGNLAAGVCLMARDQSHPPLAGQILVSPMLDPCVGTP
SLRAATEGAEACRWALGWEKFLRCARDAEHPYAVPGTAQRLAGLPPTLLLVGDTDPMHDETLAYAARLKAAGLPVELHVL
RKAERWPDALLEPGTQACPCADEARERFRSFLDAGRCPAPR

Sequences:

>Translated_281_residues
MPTTSASRSTPAGARSESTIAVAPGQDVAVRMYGRRKTGETSPLVVHFHGGAFVSGDLDSGCTIAGLLQEAGALVVSVAY
PLAPEHPFPQPLETGYAVLQWAYRYRTRLAGTGAPVYVAGEEAGGNLAAGVCLMARDQSHPPLAGQILVSPMLDPCVGTP
SLRAATEGAEACRWALGWEKFLRCARDAEHPYAVPGTAQRLAGLPPTLLLVGDTDPMHDETLAYAARLKAAGLPVELHVL
RKAERWPDALLEPGTQACPCADEARERFRSFLDAGRCPAPR
>Mature_280_residues
PTTSASRSTPAGARSESTIAVAPGQDVAVRMYGRRKTGETSPLVVHFHGGAFVSGDLDSGCTIAGLLQEAGALVVSVAYP
LAPEHPFPQPLETGYAVLQWAYRYRTRLAGTGAPVYVAGEEAGGNLAAGVCLMARDQSHPPLAGQILVSPMLDPCVGTPS
LRAATEGAEACRWALGWEKFLRCARDAEHPYAVPGTAQRLAGLPPTLLLVGDTDPMHDETLAYAARLKAAGLPVELHVLR
KAERWPDALLEPGTQACPCADEARERFRSFLDAGRCPAPR

Specific function: Lactone hydrolase that is required for the degradation of monocyclic monoterpenes such as menthol and carvone. Catalyzes the ring opening of lactones formed during degradation of monocyclic monoterpenes. Can hydrolyze epsilon-caprolactone, the lactone der

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=93, Percent_Identity=43.010752688172, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.83 [H]

Molecular weight: Translated: 29718; Mature: 29587

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTSASRSTPAGARSESTIAVAPGQDVAVRMYGRRKTGETSPLVVHFHGGAFVSGDLDS
CCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCEEEECCCCC
GCTIAGLLQEAGALVVSVAYPLAPEHPFPQPLETGYAVLQWAYRYRTRLAGTGAPVYVAG
CCHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
EEAGGNLAAGVCLMARDQSHPPLAGQILVSPMLDPCVGTPSLRAATEGAEACRWALGWEK
CCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHH
FLRCARDAEHPYAVPGTAQRLAGLPPTLLLVGDTDPMHDETLAYAARLKAAGLPVELHVL
HHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHHH
RKAERWPDALLEPGTQACPCADEARERFRSFLDAGRCPAPR
HHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PTTSASRSTPAGARSESTIAVAPGQDVAVRMYGRRKTGETSPLVVHFHGGAFVSGDLDS
CCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCEEEECCCCC
GCTIAGLLQEAGALVVSVAYPLAPEHPFPQPLETGYAVLQWAYRYRTRLAGTGAPVYVAG
CCHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
EEAGGNLAAGVCLMARDQSHPPLAGQILVSPMLDPCVGTPSLRAATEGAEACRWALGWEK
CCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHH
FLRCARDAEHPYAVPGTAQRLAGLPPTLLLVGDTDPMHDETLAYAARLKAAGLPVELHVL
HHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHHH
RKAERWPDALLEPGTQACPCADEARERFRSFLDAGRCPAPR
HHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA