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The map label for this gene is parE [H]

Identifier: 120610027

GI number: 120610027

Start: 1464961

End: 1466943

Strand: Direct

Name: parE [H]

Synonym: Aave_1340

Alternate gene names: 120610027

Gene position: 1464961-1466943 (Clockwise)

Preceding gene: 120610020

Following gene: 120610028

Centisome position: 27.37

GC content: 68.58

Gene sequence:

>1983_bases
ATGGCAGCCAAACCCTCTTCCGTTTCGCCCAGCGACTATTCCGAAGGTTCGATCCGCGTGCTCAAGGGCCTGGAGCCCGT
GAAGCAGCGGCCGGGCATGTACACGCGCACCGACAACCCGCTGCACATCATCCAGGAAGTGCTCGACAATGCCGCCGACG
AGGCCCTGGCCGGGCACGGCAAGCGCATCAAGGTCACCCTGTTCGCCGACGGCTCCGTCGGCATCGAGGACGACGGGCGC
GGCATTCCGTTCGGCCTGCACCCCGAGGAAAAGGCCCCGGTGATCGAGCTGGTCTTCACGCGGCTGCACGCGGGCGGCAA
GTTCGACAAGGGCAAGGGCGGCGCCTACAGCTTCTCGGGCGGCCTGCACGGCGTGGGTGTCTCGGTCACCAACGCCCTGG
CATTGCGCCTGGAGGCCACGACCCACCGCGACGGACAGATCGCGCGCCTCGTGTTCGAGGGCGGCGACGTCACCGAGCCG
CTCACGGCCCGGCCCCTGGCCGCGGGCGAGCGCCGCCAGGGCACCACGGTGCGTGTCTGGCCGGACGGCAGGTATTTCGA
ATCCACCGCGCTGCCGATGGGCGAGCTGGTCCACCTGCTGCGCAGCAAGGCCGTGCTGATGCCGGGCGTGACGGTGTCGC
TGGTCAACGAGAAGACGAAGGAGACGCAGACCTGGCAATACAAGGGCGGCCTGCGCGACTACCTGGGCCAGAGCCTGCCG
GCCGACCCGGTGATCCCGCTCTTCGAGGGCGAGGGCTATGCCGACCGGCACAACGAGAGCTTCGCCGAAGGCGAGGGCGC
CGCATGGTGCGTGGGCTTCACCGACGAGGGCGCGCCCGTGCGCGAGAGCTACGTCAACCTGATTCCCACCAGCGCGGGCG
GCACGCACGACGCGGGCCTGCGCGACGGCCTGTTCCAGGCTGTGAAGAGCTTCATCGAGCTGCACTCGCTGCTGCCCAAG
GGCGTGAAGCTGCTGCCCGAGGACGTGTTCGCCCGCGCCTCGTACGTGCTCTCGGCCAAGGTGCTGGATCCGCAGTTCCA
GGGCCAGGTGAAGGAAAAACTCAATTCGCGCGATGCCGTCCGGCTGGTGTCGAGCTACGTGCGGCCCGCGCTCGAGCTGT
GGCTGCACCAGCACGTGGACTACGGGCGCAAGCTCGCCGAACTCGCCATCAAGGCCGCGCAGACCCGCCAGAAGGCCGGG
CAGAAGGTCGAGAAGAAGAAGGGCTCCGGCGTGGCCGTGCTGCCGGGCAAGCTCACCGACTGCGAAAGCCGCGACCTGTC
GCACAACGAGGTATTCCTGGTGGAGGGCGACTCCGCCGGCGGCAGCGCCAAGATGGGCCGCGACAAGGAATGCCAGGCCG
TGCTGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAGGTGGACCGCGACCGGTTGTTCGCCAACACCGAGATCCACGAC
ATCTCCGTGGCGCTGGGCGTGGACCCGCACGGCCCGAACGACACGCCGGACCTCTCCGGCCTGCGCTATGGCAAGGTCTG
CATCCTGTCGGACGCCGACGTGGACGGCTCGCACATCCAGGTGCTGCTGCTCACGCTGTTCTTCCGCCACTTCCCCAAGC
TGATCGAGGCGGGCCACATCTACGTGGCGCGCCCGCCGCTCTACCGCGTGGACGTGCCGGCGCGCGGCAAGAAGCCGGCC
TCGAAGGTCTATGCGCTGGACGACGGCGAGCTGGAGGCCATCCTCGACAAATGCGCCAAGGATGGCGTGGCGCGCGAGAA
GTGCCAGATCAGCCGCTTCAAGGGGCTGGGCGAGATGAACGCCGAGCAGCTCTGGGAGACCACGCTCAACCCCGACACCC
GCCGCCTGCTGCCCGTGCAGCTGGGCGACCTGGGCTTCGCCGAAACCGAGGGCCTCATCACCAAGCTCATGGGCAAGGGA
GAGGCGGCCGCGCGGCGCGAGCTGATGGAACTGCACGGCGACGCCGTGGAAGTGGATATCTGA

Upstream 100 bases:

>100_bases
CGCCGGCGCTTGCCGGGAAATGCGGGTTAACCCGCGTGGCAGGCGGGTGGCTGTCTTTCCATCCAGTACCGCCGGGCACA
CCGCACTACAATCCGCGCCC

Downstream 100 bases:

>100_bases
GCCATGGCGGCGTGGCGCGTGGCGGATGGCACGGCGGTGGTCCGGCTGCGGCAGCAGCTGGCGGCGGGAGCGCGGATGGC
CGCGCTGGGGCTCGCCCTGT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MAAKPSSVSPSDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGHGKRIKVTLFADGSVGIEDDGR
GIPFGLHPEEKAPVIELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALALRLEATTHRDGQIARLVFEGGDVTEP
LTARPLAAGERRQGTTVRVWPDGRYFESTALPMGELVHLLRSKAVLMPGVTVSLVNEKTKETQTWQYKGGLRDYLGQSLP
ADPVIPLFEGEGYADRHNESFAEGEGAAWCVGFTDEGAPVRESYVNLIPTSAGGTHDAGLRDGLFQAVKSFIELHSLLPK
GVKLLPEDVFARASYVLSAKVLDPQFQGQVKEKLNSRDAVRLVSSYVRPALELWLHQHVDYGRKLAELAIKAAQTRQKAG
QKVEKKKGSGVAVLPGKLTDCESRDLSHNEVFLVEGDSAGGSAKMGRDKECQAVLPLRGKVLNTWEVDRDRLFANTEIHD
ISVALGVDPHGPNDTPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIYVARPPLYRVDVPARGKKPA
SKVYALDDGELEAILDKCAKDGVAREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGDLGFAETEGLITKLMGKG
EAAARRELMELHGDAVEVDI

Sequences:

>Translated_660_residues
MAAKPSSVSPSDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGHGKRIKVTLFADGSVGIEDDGR
GIPFGLHPEEKAPVIELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALALRLEATTHRDGQIARLVFEGGDVTEP
LTARPLAAGERRQGTTVRVWPDGRYFESTALPMGELVHLLRSKAVLMPGVTVSLVNEKTKETQTWQYKGGLRDYLGQSLP
ADPVIPLFEGEGYADRHNESFAEGEGAAWCVGFTDEGAPVRESYVNLIPTSAGGTHDAGLRDGLFQAVKSFIELHSLLPK
GVKLLPEDVFARASYVLSAKVLDPQFQGQVKEKLNSRDAVRLVSSYVRPALELWLHQHVDYGRKLAELAIKAAQTRQKAG
QKVEKKKGSGVAVLPGKLTDCESRDLSHNEVFLVEGDSAGGSAKMGRDKECQAVLPLRGKVLNTWEVDRDRLFANTEIHD
ISVALGVDPHGPNDTPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIYVARPPLYRVDVPARGKKPA
SKVYALDDGELEAILDKCAKDGVAREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGDLGFAETEGLITKLMGKG
EAAARRELMELHGDAVEVDI
>Mature_659_residues
AAKPSSVSPSDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGHGKRIKVTLFADGSVGIEDDGRG
IPFGLHPEEKAPVIELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALALRLEATTHRDGQIARLVFEGGDVTEPL
TARPLAAGERRQGTTVRVWPDGRYFESTALPMGELVHLLRSKAVLMPGVTVSLVNEKTKETQTWQYKGGLRDYLGQSLPA
DPVIPLFEGEGYADRHNESFAEGEGAAWCVGFTDEGAPVRESYVNLIPTSAGGTHDAGLRDGLFQAVKSFIELHSLLPKG
VKLLPEDVFARASYVLSAKVLDPQFQGQVKEKLNSRDAVRLVSSYVRPALELWLHQHVDYGRKLAELAIKAAQTRQKAGQ
KVEKKKGSGVAVLPGKLTDCESRDLSHNEVFLVEGDSAGGSAKMGRDKECQAVLPLRGKVLNTWEVDRDRLFANTEIHDI
SVALGVDPHGPNDTPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIYVARPPLYRVDVPARGKKPAS
KVYALDDGELEAILDKCAKDGVAREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGDLGFAETEGLITKLMGKGE
AAARRELMELHGDAVEVDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=649, Percent_Identity=23.8828967642527, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913406, Length=603, Percent_Identity=23.5489220563847, Blast_Score=109, Evalue=9e-24,
Organism=Escherichia coli, GI1789408, Length=655, Percent_Identity=48.0916030534351, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI48994957, Length=585, Percent_Identity=38.1196581196581, Blast_Score=354, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=563, Percent_Identity=24.1563055062167, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI212645845, Length=559, Percent_Identity=25.0447227191413, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=150, Percent_Identity=32.6666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=601, Percent_Identity=24.2928452579035, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136538, Length=350, Percent_Identity=27.4285714285714, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71741; Mature: 71610

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKPSSVSPSDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGHG
CCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
KRIKVTLFADGSVGIEDDGRGIPFGLHPEEKAPVIELVFTRLHAGGKFDKGKGGAYSFSG
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECC
GLHGVGVSVTNALALRLEATTHRDGQIARLVFEGGDVTEPLTARPLAAGERRQGTTVRVW
CCCCCCHHHHCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEC
PDGRYFESTALPMGELVHLLRSKAVLMPGVTVSLVNEKTKETQTWQYKGGLRDYLGQSLP
CCCCEECCCCCCHHHHHHHHHHCEEECCCCEEEECCCCCCCCCCEEECCCHHHHHCCCCC
ADPVIPLFEGEGYADRHNESFAEGEGAAWCVGFTDEGAPVRESYVNLIPTSAGGTHDAGL
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHEEECCCCCCCCCHH
RDGLFQAVKSFIELHSLLPKGVKLLPEDVFARASYVLSAKVLDPQFQGQVKEKLNSRDAV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHH
RLVSSYVRPALELWLHQHVDYGRKLAELAIKAAQTRQKAGQKVEKKKGSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESRDLSHNEVFLVEGDSAGGSAKMGRDKECQAVLPLRGKVLNTWEVDRDRLFANTEIHD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCHHEEECCCEEE
ISVALGVDPHGPNDTPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHI
EEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
YVARPPLYRVDVPARGKKPASKVYALDDGELEAILDKCAKDGVAREKCQISRFKGLGEMN
EEECCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
AEQLWETTLNPDTRRLLPVQLGDLGFAETEGLITKLMGKGEAAARRELMELHGDAVEVDI
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
AAKPSSVSPSDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGHG
CCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
KRIKVTLFADGSVGIEDDGRGIPFGLHPEEKAPVIELVFTRLHAGGKFDKGKGGAYSFSG
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECC
GLHGVGVSVTNALALRLEATTHRDGQIARLVFEGGDVTEPLTARPLAAGERRQGTTVRVW
CCCCCCHHHHCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEC
PDGRYFESTALPMGELVHLLRSKAVLMPGVTVSLVNEKTKETQTWQYKGGLRDYLGQSLP
CCCCEECCCCCCHHHHHHHHHHCEEECCCCEEEECCCCCCCCCCEEECCCHHHHHCCCCC
ADPVIPLFEGEGYADRHNESFAEGEGAAWCVGFTDEGAPVRESYVNLIPTSAGGTHDAGL
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHEEECCCCCCCCCHH
RDGLFQAVKSFIELHSLLPKGVKLLPEDVFARASYVLSAKVLDPQFQGQVKEKLNSRDAV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHH
RLVSSYVRPALELWLHQHVDYGRKLAELAIKAAQTRQKAGQKVEKKKGSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESRDLSHNEVFLVEGDSAGGSAKMGRDKECQAVLPLRGKVLNTWEVDRDRLFANTEIHD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCHHEEECCCEEE
ISVALGVDPHGPNDTPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHI
EEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
YVARPPLYRVDVPARGKKPASKVYALDDGELEAILDKCAKDGVAREKCQISRFKGLGEMN
EEECCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
AEQLWETTLNPDTRRLLPVQLGDLGFAETEGLITKLMGKGEAAARRELMELHGDAVEVDI
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]