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The map label for this gene is mutL [H]

Identifier: 120609987

GI number: 120609987

Start: 1426960

End: 1429056

Strand: Reverse

Name: mutL [H]

Synonym: Aave_1300

Alternate gene names: 120609987

Gene position: 1429056-1426960 (Counterclockwise)

Preceding gene: 120609989

Following gene: 120609986

Centisome position: 26.7

GC content: 73.3

Gene sequence:

>2097_bases
ATGACCCCAGAGCCAGCCCTCCCGCGCCGCCCGATCCGCGATCTTCCGGACGAACTGATCAGCCAGATCGCCGCGGGCGA
AGTGGTGGAGCGGCCCGCGTCGGCCGTGCGCGAACTCGTGGACAACGCGCTGGATGCAGGCGCCCGGCAGATCACCGTGC
GGCTGCTGGCCGGCGGCGTCCGCCTGATCGCGGTGGAGGACGACGGCTGCGGCATCCCGCCCGAGGAACTGCCGGTGGCG
CTGCGCCGCCACGCGACCAGCAAGATCACCAATCTGCACGACCTGGAGTCGGTGGCGACCATGGGCTTTCGCGGCGAGGC
GCTGGCCGCCATCGCGTCGGTCTCGGAGATGGCCCTGCTGTCGCGGACCGAGGAGCAGCCCACGGCCTTCCTGCTCGACG
CGCGCAGCGGCGAGCTGCGCCCCGCGGCGCGCGCACGCGGCACCACGGTGGAAGTGAAGGAGCTGTTCTTCTCCACACCC
GCGCGGCGCAAGTTCCTGAAGACCGATGCGACGGAACTGGCGCATTGCATCGAGGCCGTGCGCCGCCACGCGCTGGCGCG
GCCGGACGTCGGGTTCGCGATCTGGCACGAAGGCAAGCTGGTCGAGCAATGGCGCGCGGCGCTCGTCCCCCCCGCGGCCT
CGGCGGACGGCACCGTGGACGATGCGGCGCTGGAGGAGGCGCTGGCGCGCCGTCTGTCCGACGTGCTGGGCGAGGACTTC
CTGGCCGAATCGATCGCCGTGCGGCACCGCTCCGGGCCGGTGACGGTCACCGGGAGGGCCGGGCTGCCGGACGCCGCGCG
CTCGCGCGCCGATCAGCAGTTCTGCTACGTCAACGGCCGGTTCGTGCGCGACAAGGTGCTCACGCATGCGGCCCGCAGCG
CCTACGAGGACGTGCTGCACGGGCAGAAGCAGCCGGTGTATGCGCTCTATGTGGCGATCGATCCCATGCGGGTGGACGTG
AACGTGCACCCCACCAAGATCGAGGTGCGCTTCCGCGACAGCCGCGAAGTCCACCAGGCCGTGCGGCATGCGGTGGAGAA
CGCCCTGGCGGCCCCCCGCGCGCAAGCGCTGGCGGCCGCCGCGCAAGGCGCTGCCGAAGCGGGCGCGCCCGCCACGGATT
CGCCGGCGCCTCCCACTGCCCGCGTGGCGCCGCCCGCCGCCCTGCCCCGGCAGGCCGCGATGCATTTCGATGCCCGCCCC
GGGCACCGCGTCACCGACCTGGAAGCGCTCTGGGGCCGCAAGGACACCGCGCCCTCCACACGGCCTGACGGCACCACGGA
CTTCGCGCCGCCCCCTGCACCGCATGCGCCGCTGTCTTCCGCCGCTGCACCGGGGGGGGCCGCCACCGTGCAGGAGGCTT
CCCCGGCCTATGCCCCGGCCGGCGGTGCCCTGCCGGCCGTGGATACGCCCGCGGCCCCGCAGGGAGGCGCGCCGGACGGC
CCTGGCGCCTTCGCGGCAGTGCCCGACGCCCCTGCGCAGGCCGCGGCACCTTCCAGTGCCGAGCCGGCAGTCTGGCCGCT
GGGGCGCGCGGTGGCCCAGATCCACGGCGTATACATCCTGGCCGAGAATGCCCAGGGCATGGTGATCGTGGACATGCACG
CGGCGCACGAGCGCATCGTGTACGAGCGCCTCAAGGCCCAGGTGGACGCCAGCGAGCGCATCGCGAGCCAGCCGCTGCTG
ATTCCCGCGACATTCGCCGCCACGCCCGAGGAAGTGGCCACGGCGGAAGCCCATGCCGACACGCTCGACATGCTCGGCCT
CGAAGTCTCGCCCTTCTCGCCCCGCACGCTGGCGGTGCGCGCCGTGCCCACCTCGCTCGCGCAGGGCGATGCGGTGGAAC
TGGCGCGCAGCGTGCTCGCGGAGCTGGCGGCGCACGATGCCACCACCGTGGTGCAGCGGGCCCGCAACGAGATCCTGGGC
ACCATGGCCTGCCACGGCGCGGTGCGCGCGCACCGGCGGCTGACGCTGGACGAGATGAACGCGCTGCTGCGACAGATGGA
AGTGACGGAACGCTCCGACCAATGCAACCATGGCCGGCCCACGTGGCGGCAACTGTCGATGCGCGAACTGGACGCGCTGT
TCCTGCGCGGACGCTGA

Upstream 100 bases:

>100_bases
AGGGGTCGGAGGCACGGGCAGGTGCTTTCGCCCCGCGAAGGGGGCGGGCACCCGGCGGCGCGGCGCGTAACTCTAACCGC
ACTGCCTACAATGCCGCCCG

Downstream 100 bases:

>100_bases
CACCCCTTCGAAGGACCTCTCCATGCCGCTCCACCGCGTTCCGCTCCGCCACCGCTTCTACCGGACATCCACGGTGCGCG
GCCTCATGGCCCTGGCCGCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MTPEPALPRRPIRDLPDELISQIAAGEVVERPASAVRELVDNALDAGARQITVRLLAGGVRLIAVEDDGCGIPPEELPVA
LRRHATSKITNLHDLESVATMGFRGEALAAIASVSEMALLSRTEEQPTAFLLDARSGELRPAARARGTTVEVKELFFSTP
ARRKFLKTDATELAHCIEAVRRHALARPDVGFAIWHEGKLVEQWRAALVPPAASADGTVDDAALEEALARRLSDVLGEDF
LAESIAVRHRSGPVTVTGRAGLPDAARSRADQQFCYVNGRFVRDKVLTHAARSAYEDVLHGQKQPVYALYVAIDPMRVDV
NVHPTKIEVRFRDSREVHQAVRHAVENALAAPRAQALAAAAQGAAEAGAPATDSPAPPTARVAPPAALPRQAAMHFDARP
GHRVTDLEALWGRKDTAPSTRPDGTTDFAPPPAPHAPLSSAAAPGGAATVQEASPAYAPAGGALPAVDTPAAPQGGAPDG
PGAFAAVPDAPAQAAAPSSAEPAVWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQVDASERIASQPLL
IPATFAATPEEVATAEAHADTLDMLGLEVSPFSPRTLAVRAVPTSLAQGDAVELARSVLAELAAHDATTVVQRARNEILG
TMACHGAVRAHRRLTLDEMNALLRQMEVTERSDQCNHGRPTWRQLSMRELDALFLRGR

Sequences:

>Translated_698_residues
MTPEPALPRRPIRDLPDELISQIAAGEVVERPASAVRELVDNALDAGARQITVRLLAGGVRLIAVEDDGCGIPPEELPVA
LRRHATSKITNLHDLESVATMGFRGEALAAIASVSEMALLSRTEEQPTAFLLDARSGELRPAARARGTTVEVKELFFSTP
ARRKFLKTDATELAHCIEAVRRHALARPDVGFAIWHEGKLVEQWRAALVPPAASADGTVDDAALEEALARRLSDVLGEDF
LAESIAVRHRSGPVTVTGRAGLPDAARSRADQQFCYVNGRFVRDKVLTHAARSAYEDVLHGQKQPVYALYVAIDPMRVDV
NVHPTKIEVRFRDSREVHQAVRHAVENALAAPRAQALAAAAQGAAEAGAPATDSPAPPTARVAPPAALPRQAAMHFDARP
GHRVTDLEALWGRKDTAPSTRPDGTTDFAPPPAPHAPLSSAAAPGGAATVQEASPAYAPAGGALPAVDTPAAPQGGAPDG
PGAFAAVPDAPAQAAAPSSAEPAVWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQVDASERIASQPLL
IPATFAATPEEVATAEAHADTLDMLGLEVSPFSPRTLAVRAVPTSLAQGDAVELARSVLAELAAHDATTVVQRARNEILG
TMACHGAVRAHRRLTLDEMNALLRQMEVTERSDQCNHGRPTWRQLSMRELDALFLRGR
>Mature_697_residues
TPEPALPRRPIRDLPDELISQIAAGEVVERPASAVRELVDNALDAGARQITVRLLAGGVRLIAVEDDGCGIPPEELPVAL
RRHATSKITNLHDLESVATMGFRGEALAAIASVSEMALLSRTEEQPTAFLLDARSGELRPAARARGTTVEVKELFFSTPA
RRKFLKTDATELAHCIEAVRRHALARPDVGFAIWHEGKLVEQWRAALVPPAASADGTVDDAALEEALARRLSDVLGEDFL
AESIAVRHRSGPVTVTGRAGLPDAARSRADQQFCYVNGRFVRDKVLTHAARSAYEDVLHGQKQPVYALYVAIDPMRVDVN
VHPTKIEVRFRDSREVHQAVRHAVENALAAPRAQALAAAAQGAAEAGAPATDSPAPPTARVAPPAALPRQAAMHFDARPG
HRVTDLEALWGRKDTAPSTRPDGTTDFAPPPAPHAPLSSAAAPGGAATVQEASPAYAPAGGALPAVDTPAAPQGGAPDGP
GAFAAVPDAPAQAAAPSSAEPAVWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQVDASERIASQPLLI
PATFAATPEEVATAEAHADTLDMLGLEVSPFSPRTLAVRAVPTSLAQGDAVELARSVLAELAAHDATTVVQRARNEILGT
MACHGAVRAHRRLTLDEMNALLRQMEVTERSDQCNHGRPTWRQLSMRELDALFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=343, Percent_Identity=32.0699708454811, Blast_Score=186, Evalue=9e-47,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=28.0701754385965, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=28.9017341040462, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4505911, Length=360, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI189458898, Length=360, Percent_Identity=27.2222222222222, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=193, Percent_Identity=32.1243523316062, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI263191589, Length=254, Percent_Identity=27.9527559055118, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=27.1186440677966, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=376, Percent_Identity=23.4042553191489, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI91992162, Length=376, Percent_Identity=23.4042553191489, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1790612, Length=626, Percent_Identity=37.0607028753994, Blast_Score=323, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71991825, Length=342, Percent_Identity=33.6257309941521, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=26.1838440111421, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=373, Percent_Identity=28.686327077748, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=347, Percent_Identity=27.6657060518732, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=316, Percent_Identity=24.6835443037975, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323063, Length=365, Percent_Identity=23.5616438356164, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136968, Length=380, Percent_Identity=30.5263157894737, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17136970, Length=373, Percent_Identity=26.8096514745308, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 74124; Mature: 73992

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEPALPRRPIRDLPDELISQIAAGEVVERPASAVRELVDNALDAGARQITVRLLAGGV
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHEEEECCE
RLIAVEDDGCGIPPEELPVALRRHATSKITNLHDLESVATMGFRGEALAAIASVSEMALL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SRTEEQPTAFLLDARSGELRPAARARGTTVEVKELFFSTPARRKFLKTDATELAHCIEAV
HCCCCCCCEEEEECCCCCCCCHHHHCCCEEHHHHHHHCCHHHHHHHHCCHHHHHHHHHHH
RRHALARPDVGFAIWHEGKLVEQWRAALVPPAASADGTVDDAALEEALARRLSDVLGEDF
HHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAESIAVRHRSGPVTVTGRAGLPDAARSRADQQFCYVNGRFVRDKVLTHAARSAYEDVLH
HHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHC
GQKQPVYALYVAIDPMRVDVNVHPTKIEVRFRDSREVHQAVRHAVENALAAPRAQALAAA
CCCCCEEEEEEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AQGAAEAGAPATDSPAPPTARVAPPAALPRQAAMHFDARPGHRVTDLEALWGRKDTAPST
HHCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCC
RPDGTTDFAPPPAPHAPLSSAAAPGGAATVQEASPAYAPAGGALPAVDTPAAPQGGAPDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGAFAAVPDAPAQAAAPSSAEPAVWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIV
CCCEEECCCCCCHHCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHH
YERLKAQVDASERIASQPLLIPATFAATPEEVATAEAHADTLDMLGLEVSPFSPRTLAVR
HHHHHHHCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
AVPTSLAQGDAVELARSVLAELAAHDATTVVQRARNEILGTMACHGAVRAHRRLTLDEMN
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALLRQMEVTERSDQCNHGRPTWRQLSMRELDALFLRGR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPEPALPRRPIRDLPDELISQIAAGEVVERPASAVRELVDNALDAGARQITVRLLAGGV
CCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHEEEECCE
RLIAVEDDGCGIPPEELPVALRRHATSKITNLHDLESVATMGFRGEALAAIASVSEMALL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SRTEEQPTAFLLDARSGELRPAARARGTTVEVKELFFSTPARRKFLKTDATELAHCIEAV
HCCCCCCCEEEEECCCCCCCCHHHHCCCEEHHHHHHHCCHHHHHHHHCCHHHHHHHHHHH
RRHALARPDVGFAIWHEGKLVEQWRAALVPPAASADGTVDDAALEEALARRLSDVLGEDF
HHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAESIAVRHRSGPVTVTGRAGLPDAARSRADQQFCYVNGRFVRDKVLTHAARSAYEDVLH
HHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHC
GQKQPVYALYVAIDPMRVDVNVHPTKIEVRFRDSREVHQAVRHAVENALAAPRAQALAAA
CCCCCEEEEEEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AQGAAEAGAPATDSPAPPTARVAPPAALPRQAAMHFDARPGHRVTDLEALWGRKDTAPST
HHCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCC
RPDGTTDFAPPPAPHAPLSSAAAPGGAATVQEASPAYAPAGGALPAVDTPAAPQGGAPDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGAFAAVPDAPAQAAAPSSAEPAVWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIV
CCCEEECCCCCCHHCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHH
YERLKAQVDASERIASQPLLIPATFAATPEEVATAEAHADTLDMLGLEVSPFSPRTLAVR
HHHHHHHCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
AVPTSLAQGDAVELARSVLAELAAHDATTVVQRARNEILGTMACHGAVRAHRRLTLDEMN
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALLRQMEVTERSDQCNHGRPTWRQLSMRELDALFLRGR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]