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The map label for this gene is nhaA [H]

Identifier: 120609865

GI number: 120609865

Start: 1299340

End: 1300392

Strand: Direct

Name: nhaA [H]

Synonym: Aave_1177

Alternate gene names: 120609865

Gene position: 1299340-1300392 (Clockwise)

Preceding gene: 120609864

Following gene: 120609868

Centisome position: 24.27

GC content: 66.19

Gene sequence:

>1053_bases
ATGACCGATCCGACCCGGAAAGAACCCTCCGGCCTGGAAGCTGATCCGTCGTCCACACCTGACCTGTGGGCCCAGAGTGC
TCCTGAAAAAATAGCAAAAGACACCCCCGCCGCCGCCGGCAAGCCCCCGGGCTGGGAGCGCGACGTGCTGGAAAAACTCG
TCTTCGCCACACTCTCCGAACAGCGCTCCGCGCGCCGCTGGCGTGTTTTCACCCGCATGGCATGGCTGGTTTTCCTGGTC
GCCGTGGCCTGGGTGTTGCTTGCGCGCGACGTTGCGGCGCCCAGCAAAAGCACGCCCCACACCGCCGTGGTGGACATCAA
GGGCGAGATCGCGTCCGGTGCCGAGGCGAGCGCGGAATTCGTGGTCGCGGCCATGCGCAGTGCCTTCGAGGACTCCGGCT
CCCAGGCCGTGGTGCTGCTCATCAACTCCCCCGGCGGCAGCCCGGTGCAGGCAGGCATCATCAACGACGAGATCCTGAGG
CTCAAGGCCAAGTACAACAAGCCGGTCTATGCGGTGGTCGAGGAAACCTGCGCCTCCGCCGCCTACTACATCGCGGCCGG
AGCCGACCAGATCTTCGTGGACAAGGCCAGCATCGTCGGCAGCATCGGCGTGTTGATGGACGGATTCGGCTTCACCGGCA
CGATGGAAAAGCTCGGCGTGGAGCGCCGCCTGCTCACGGCGGGCGAGAACAAGGGCTTCCTCGATCCGTTCAGCCCGATG
TCGGAGAAGCAGCGTACGTATGCGCAGGCCATGCTCGACCAGATCCACCAGCAGTTCATCCAGGTGGTGCAGAAAGGGCG
GGGCGATCGCCTCAAGCCCACGGCGGACACGTTCAGCGGCCTGTTCTGGACGGGCCAGCAGGCCGTCGACATGGGCCTGG
CCGACCACCTGGGCAACCTCGATTACGTGGCCCGCGAGGTCGTCAAGGCCGAGGACATCATCGACTACACGCGCCGGGAC
AACGTGGCCGAGCGCCTGGTGAAGAAGTTCGGCGCTGCCATGGGCGAAACGGCCATCCGCGCCCTGGGCGCCAGCCTGCC
GGCGGTGCGCTGA

Upstream 100 bases:

>100_bases
GCCGTGGCGGACTGGTGAAGATCGCAATTTCGGAAGAGTCCGGAGTGGTGCGCTGGCATACTGGCTCCCAATTGCAACCC
GTGGAATTCTGAGACATCCC

Downstream 100 bases:

>100_bases
ACAGGCGGGTTCACTTCCAGCAAAAAAAGAGGCGCCGCGGCGCCTCTTTTTCGTTCCTGCCCGGGATCAGCGTCCAATGG
CGAACACGACGGGCGTGCGA

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTDPTRKEPSGLEADPSSTPDLWAQSAPEKIAKDTPAAAGKPPGWERDVLEKLVFATLSEQRSARRWRVFTRMAWLVFLV
AVAWVLLARDVAAPSKSTPHTAVVDIKGEIASGAEASAEFVVAAMRSAFEDSGSQAVVLLINSPGGSPVQAGIINDEILR
LKAKYNKPVYAVVEETCASAAYYIAAGADQIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLLTAGENKGFLDPFSPM
SEKQRTYAQAMLDQIHQQFIQVVQKGRGDRLKPTADTFSGLFWTGQQAVDMGLADHLGNLDYVAREVVKAEDIIDYTRRD
NVAERLVKKFGAAMGETAIRALGASLPAVR

Sequences:

>Translated_350_residues
MTDPTRKEPSGLEADPSSTPDLWAQSAPEKIAKDTPAAAGKPPGWERDVLEKLVFATLSEQRSARRWRVFTRMAWLVFLV
AVAWVLLARDVAAPSKSTPHTAVVDIKGEIASGAEASAEFVVAAMRSAFEDSGSQAVVLLINSPGGSPVQAGIINDEILR
LKAKYNKPVYAVVEETCASAAYYIAAGADQIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLLTAGENKGFLDPFSPM
SEKQRTYAQAMLDQIHQQFIQVVQKGRGDRLKPTADTFSGLFWTGQQAVDMGLADHLGNLDYVAREVVKAEDIIDYTRRD
NVAERLVKKFGAAMGETAIRALGASLPAVR
>Mature_349_residues
TDPTRKEPSGLEADPSSTPDLWAQSAPEKIAKDTPAAAGKPPGWERDVLEKLVFATLSEQRSARRWRVFTRMAWLVFLVA
VAWVLLARDVAAPSKSTPHTAVVDIKGEIASGAEASAEFVVAAMRSAFEDSGSQAVVLLINSPGGSPVQAGIINDEILRL
KAKYNKPVYAVVEETCASAAYYIAAGADQIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLLTAGENKGFLDPFSPMS
EKQRTYAQAMLDQIHQQFIQVVQKGRGDRLKPTADTFSGLFWTGQQAVDMGLADHLGNLDYVAREVVKAEDIIDYTRRDN
VAERLVKKFGAAMGETAIRALGASLPAVR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=258, Percent_Identity=30.6201550387597, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788064, Length=221, Percent_Identity=28.5067873303167, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37819; Mature: 37688

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPTRKEPSGLEADPSSTPDLWAQSAPEKIAKDTPAAAGKPPGWERDVLEKLVFATLSE
CCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QRSARRWRVFTRMAWLVFLVAVAWVLLARDVAAPSKSTPHTAVVDIKGEIASGAEASAEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHH
VVAAMRSAFEDSGSQAVVLLINSPGGSPVQAGIINDEILRLKAKYNKPVYAVVEETCASA
HHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AYYIAAGADQIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLLTAGENKGFLDPFSPM
HHHEECCCCHHEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
SEKQRTYAQAMLDQIHQQFIQVVQKGRGDRLKPTADTFSGLFWTGQQAVDMGLADHLGNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHCCCH
DYVAREVVKAEDIIDYTRRDNVAERLVKKFGAAMGETAIRALGASLPAVR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDPTRKEPSGLEADPSSTPDLWAQSAPEKIAKDTPAAAGKPPGWERDVLEKLVFATLSE
CCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QRSARRWRVFTRMAWLVFLVAVAWVLLARDVAAPSKSTPHTAVVDIKGEIASGAEASAEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHH
VVAAMRSAFEDSGSQAVVLLINSPGGSPVQAGIINDEILRLKAKYNKPVYAVVEETCASA
HHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AYYIAAGADQIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLLTAGENKGFLDPFSPM
HHHEECCCCHHEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
SEKQRTYAQAMLDQIHQQFIQVVQKGRGDRLKPTADTFSGLFWTGQQAVDMGLADHLGNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHCCCH
DYVAREVVKAEDIIDYTRRDNVAERLVKKFGAAMGETAIRALGASLPAVR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA