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The map label for this gene is kynA [H]

Identifier: 120609843

GI number: 120609843

Start: 1275564

End: 1276469

Strand: Reverse

Name: kynA [H]

Synonym: Aave_1155

Alternate gene names: 120609843

Gene position: 1276469-1275564 (Counterclockwise)

Preceding gene: 120609844

Following gene: 120609837

Centisome position: 23.85

GC content: 67.99

Gene sequence:

>906_bases
ATGTGCCCCCACGCCACGCAAGCATCCAGCGCGCCTTCGTCCGCGGCCGCGGCCTCTTCCGCGCACGCGTCCCGGCCCGA
AGCCATCGTGCACGACGAGCGCGCGCAGCTCGATTTCAGCCGCGACATGAGCTATGGCGACTACCTGCAGCTCGACGCGA
TCCTGAACGCGCAGAAGCCGCTGTCGCCCAACCACAACGAGATGCTGTTCATCGTGCAGCACCAGACCAGCGAGCTGTGG
ATGAAGCTCATGCTGCACGAGCTGCGCGCCGCGATCGACCATGTGGCGCGGGACGACCTGCCGCCGGCCTTCAAGATGCT
GGCCCGGGTGTCCAAGATCATGGAACAGCTGGTCCATGCCTGGGATGTGCTGGCCACGATGACGCCGCCCGAGTACAGCG
CCATCCGGCCCTATCTCGCGCAGTCGAGCGGCTTCCAGAGCTACCAGTACCGCTGCATCGAGTTCTCGCTGGGCAACAAG
AACGCGGCGATGCTCAAGCCGCATGCGCACCGGCCGGACCTGCTCGCGCAGGTGCAGGCCGCCTACGAGGCGCCCTCGCT
CTACGACGAGGCACTGCGCCTGCTGGCCCGCCGGGGCATTCCCGTGCCCGCGAGCCACACGGACCGCGACTGGACGCAGC
CCTATGCCGGGAGCGATGCGGTGGAGGGCGCCTGGCTCGCCGTCTATCGCGATACGCAGCGCTACTGGGACCTGTACCAG
CTGGGCGAGAAGCTCACGGACCTGGAGGATGCCTTCCGCCTCTGGCGATTCCGCCACGTGACCACGGTGGAGCGCGTGAT
CGGGTTCAAGCGCGGCACCGGCGGCACGGGCGGCGTGAGCTACCTGCGGCGCATGCTGGACGTGGTGCTGTTTCCGGAGA
TCTGGCGGCTCCGCACCAGCCTTTGA

Upstream 100 bases:

>100_bases
TGGAGCACCTGCGCGCCGTCCTGGACAGCAGCGAATGGCGCCGCCCCGAGTTCAACCAGCAACACGCCGTGACCTGAAGG
CCGGCAGGAGACATCGCACC

Downstream 100 bases:

>100_bases
ATCCTCCTGCGTCGCGTTCGGCGCATTGCCAGGGCGGGTAATCGGGGTACGCTGGCACCTATACGGCGGTGCTGTGCACC
ATCGCCGGGCTGCTCGCCGC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MCPHATQASSAPSSAAAASSAHASRPEAIVHDERAQLDFSRDMSYGDYLQLDAILNAQKPLSPNHNEMLFIVQHQTSELW
MKLMLHELRAAIDHVARDDLPPAFKMLARVSKIMEQLVHAWDVLATMTPPEYSAIRPYLAQSSGFQSYQYRCIEFSLGNK
NAAMLKPHAHRPDLLAQVQAAYEAPSLYDEALRLLARRGIPVPASHTDRDWTQPYAGSDAVEGAWLAVYRDTQRYWDLYQ
LGEKLTDLEDAFRLWRFRHVTTVERVIGFKRGTGGTGGVSYLRRMLDVVLFPEIWRLRTSL

Sequences:

>Translated_301_residues
MCPHATQASSAPSSAAAASSAHASRPEAIVHDERAQLDFSRDMSYGDYLQLDAILNAQKPLSPNHNEMLFIVQHQTSELW
MKLMLHELRAAIDHVARDDLPPAFKMLARVSKIMEQLVHAWDVLATMTPPEYSAIRPYLAQSSGFQSYQYRCIEFSLGNK
NAAMLKPHAHRPDLLAQVQAAYEAPSLYDEALRLLARRGIPVPASHTDRDWTQPYAGSDAVEGAWLAVYRDTQRYWDLYQ
LGEKLTDLEDAFRLWRFRHVTTVERVIGFKRGTGGTGGVSYLRRMLDVVLFPEIWRLRTSL
>Mature_301_residues
MCPHATQASSAPSSAAAASSAHASRPEAIVHDERAQLDFSRDMSYGDYLQLDAILNAQKPLSPNHNEMLFIVQHQTSELW
MKLMLHELRAAIDHVARDDLPPAFKMLARVSKIMEQLVHAWDVLATMTPPEYSAIRPYLAQSSGFQSYQYRCIEFSLGNK
NAAMLKPHAHRPDLLAQVQAAYEAPSLYDEALRLLARRGIPVPASHTDRDWTQPYAGSDAVEGAWLAVYRDTQRYWDLYQ
LGEKLTDLEDAFRLWRFRHVTTVERVIGFKRGTGGTGGVSYLRRMLDVVLFPEIWRLRTSL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=334, Percent_Identity=28.4431137724551, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32564651, Length=138, Percent_Identity=36.231884057971, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=138, Percent_Identity=36.231884057971, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17530891, Length=169, Percent_Identity=36.6863905325444, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 34139; Mature: 34139

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPHATQASSAPSSAAAASSAHASRPEAIVHDERAQLDFSRDMSYGDYLQLDAILNAQKP
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHHCCHHHCCCCCCHHHHHHHHCCCCC
LSPNHNEMLFIVQHQTSELWMKLMLHELRAAIDHVARDDLPPAFKMLARVSKIMEQLVHA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
WDVLATMTPPEYSAIRPYLAQSSGFQSYQYRCIEFSLGNKNAAMLKPHAHRPDLLAQVQA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHH
AYEAPSLYDEALRLLARRGIPVPASHTDRDWTQPYAGSDAVEGAWLAVYRDTQRYWDLYQ
HHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
LGEKLTDLEDAFRLWRFRHVTTVERVIGFKRGTGGTGGVSYLRRMLDVVLFPEIWRLRTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure
MCPHATQASSAPSSAAAASSAHASRPEAIVHDERAQLDFSRDMSYGDYLQLDAILNAQKP
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHHCCHHHCCCCCCHHHHHHHHCCCCC
LSPNHNEMLFIVQHQTSELWMKLMLHELRAAIDHVARDDLPPAFKMLARVSKIMEQLVHA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
WDVLATMTPPEYSAIRPYLAQSSGFQSYQYRCIEFSLGNKNAAMLKPHAHRPDLLAQVQA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHH
AYEAPSLYDEALRLLARRGIPVPASHTDRDWTQPYAGSDAVEGAWLAVYRDTQRYWDLYQ
HHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
LGEKLTDLEDAFRLWRFRHVTTVERVIGFKRGTGGTGGVSYLRRMLDVVLFPEIWRLRTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA