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The map label for this gene is dctA [H]

Identifier: 120609738

GI number: 120609738

Start: 1149754

End: 1151073

Strand: Reverse

Name: dctA [H]

Synonym: Aave_1045

Alternate gene names: 120609738

Gene position: 1151073-1149754 (Counterclockwise)

Preceding gene: 120609750

Following gene: 120609736

Centisome position: 21.5

GC content: 66.89

Gene sequence:

>1320_bases
ATGCCAGAGAACAAAAGAAAGCTTCCCCCTACGGTCAGCATCCTGATCGCGATGCTCATCGGCATCCTCACCGGATACCT
GATCAACACGCACGTCGCGGACAAGGCGGCGGTCGCGGGTTACGTATCGATCCTCTCGGACATCTTCCTGCGGCTCATCA
AGATGCTGATCGCGCCGCTGGTCTTCTCCACCCTGGTGGTGGGCATCGCCCACATGGGTGACGCCGCCGCCGTGGGCCGC
GTGTTCCTCAAGGCCATGGCGTGGTTCCTGACGGCCTCGCTGGTCTCGCTGGCCCTGGGCCTGGTCCTGGCCAACGTGCT
CCAGCCCGGCGCCAACCTGGGCCTGCCGCTGCCGGACACCCACCAGGCGACGCAGCTGGCCACGGGCAAGTTCACGCTCA
AGGAGTTCGTGAACCATCTCGTGCCCAAGTCGTTCGCGGAGGCGATGGCCAACAACGAGATCCTGCAGATCGTGGTGTTC
TCGATGTTCTTCGGCGTCGCGCTCGCCGGCCTCGGCGACAAGGCCCGCACGCTGGTGCGCTGCGTGGAGGAGCTGTCCCA
CGCCATGCTCAAGATCACCGGCTACGTGATGCGCTTCGCACCCGTGGCGGTGTTCGCCGCCATGGCCGCCACGGTGGCGG
TGAACGGCCTGGGCATCCTGCTCAAGTTCGCGGTGTTCATGGGCCAGTTCTACCTGGGCCTGCTGCTGCTGTGGGCCCTG
CTGATCACCGCGGGCTTCATCGCGCTGCGCGGCCGCGTGTTCAAGCTGCTGCGCAACATCCGCGAGGCGTTCCTGCTGTC
CTTCGCCACGGCCAGCTCCGAAGCCGCCTACCCCAAGCTGCTGGACGCGCTCGACCGCTTCGGCGTGAAGCGCCGGGTGT
CCAGCTTCGTGATGCCGCTGGGCTACTCGTTCAACCTCGATGGCTCGATGATCTACTGCACGTTCGCCACGCTGTTCATC
GCGCAGGCCTACGGCATCCACCTGCCGATCGAGACGCAGATCACCATGCTGCTGATCCTGATGCTCACCTCCAAGGGCAT
GGCCGGCGTGCCGCGCGCCTCCCTGGTGGTGATCGCCGCCACGCTGAACCAGTTCCACATCCCCGAGGCCGGCCTGCTGC
TGATCCTGGGCGTGGACACCTTCCTGGACATGGGCCGCTCGGCGACGAATGCCGTGGGCAACTCCATCGCCGCCGCGGTC
GTGGCGAAGTGGGAAGACGCCCTGCTGTCGGAAGAGGATGCGGCCGTGCACGCCGCCACGCTGGACACCCAGCCCGACGA
CGCCCCCGCAGGCGCTCCGGGCACCGCCACGGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGGCCCGGGTACGCACACGTATTGAACGACAATGCGCCACCCCCGCCAACGGCGCAAGGAGAGCGCCAGGGGACCCATC
GCTCATTTCTGCCTAGCACC

Downstream 100 bases:

>100_bases
CCGCCACGCCCGCCGCAAGGGGCCCTGCGCCAGCGCGCCGGGCCCCTTGCTTTTTTTCAGCCCGCCTGCAGGCCGCGGGC
CACGCCGTCCTGCCAGCGCC

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MPENKRKLPPTVSILIAMLIGILTGYLINTHVADKAAVAGYVSILSDIFLRLIKMLIAPLVFSTLVVGIAHMGDAAAVGR
VFLKAMAWFLTASLVSLALGLVLANVLQPGANLGLPLPDTHQATQLATGKFTLKEFVNHLVPKSFAEAMANNEILQIVVF
SMFFGVALAGLGDKARTLVRCVEELSHAMLKITGYVMRFAPVAVFAAMAATVAVNGLGILLKFAVFMGQFYLGLLLLWAL
LITAGFIALRGRVFKLLRNIREAFLLSFATASSEAAYPKLLDALDRFGVKRRVSSFVMPLGYSFNLDGSMIYCTFATLFI
AQAYGIHLPIETQITMLLILMLTSKGMAGVPRASLVVIAATLNQFHIPEAGLLLILGVDTFLDMGRSATNAVGNSIAAAV
VAKWEDALLSEEDAAVHAATLDTQPDDAPAGAPGTATAA

Sequences:

>Translated_439_residues
MPENKRKLPPTVSILIAMLIGILTGYLINTHVADKAAVAGYVSILSDIFLRLIKMLIAPLVFSTLVVGIAHMGDAAAVGR
VFLKAMAWFLTASLVSLALGLVLANVLQPGANLGLPLPDTHQATQLATGKFTLKEFVNHLVPKSFAEAMANNEILQIVVF
SMFFGVALAGLGDKARTLVRCVEELSHAMLKITGYVMRFAPVAVFAAMAATVAVNGLGILLKFAVFMGQFYLGLLLLWAL
LITAGFIALRGRVFKLLRNIREAFLLSFATASSEAAYPKLLDALDRFGVKRRVSSFVMPLGYSFNLDGSMIYCTFATLFI
AQAYGIHLPIETQITMLLILMLTSKGMAGVPRASLVVIAATLNQFHIPEAGLLLILGVDTFLDMGRSATNAVGNSIAAAV
VAKWEDALLSEEDAAVHAATLDTQPDDAPAGAPGTATAA
>Mature_438_residues
PENKRKLPPTVSILIAMLIGILTGYLINTHVADKAAVAGYVSILSDIFLRLIKMLIAPLVFSTLVVGIAHMGDAAAVGRV
FLKAMAWFLTASLVSLALGLVLANVLQPGANLGLPLPDTHQATQLATGKFTLKEFVNHLVPKSFAEAMANNEILQIVVFS
MFFGVALAGLGDKARTLVRCVEELSHAMLKITGYVMRFAPVAVFAAMAATVAVNGLGILLKFAVFMGQFYLGLLLLWALL
ITAGFIALRGRVFKLLRNIREAFLLSFATASSEAAYPKLLDALDRFGVKRRVSSFVMPLGYSFNLDGSMIYCTFATLFIA
QAYGIHLPIETQITMLLILMLTSKGMAGVPRASLVVIAATLNQFHIPEAGLLLILGVDTFLDMGRSATNAVGNSIAAAVV
AKWEDALLSEEDAAVHAATLDTQPDDAPAGAPGTATAA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=471, Percent_Identity=23.5668789808917, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI66773030, Length=478, Percent_Identity=24.2677824267782, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI40254478, Length=435, Percent_Identity=24.8275862068966, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI21314632, Length=407, Percent_Identity=27.5184275184275, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4827012, Length=453, Percent_Identity=26.7108167770419, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI5032093, Length=390, Percent_Identity=27.1794871794872, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223468564, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI223468566, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI194239697, Length=281, Percent_Identity=28.1138790035587, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI262359914, Length=378, Percent_Identity=22.2222222222222, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI301601644, Length=170, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789947, Length=425, Percent_Identity=38.8235294117647, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1790514, Length=404, Percent_Identity=42.0792079207921, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1788024, Length=400, Percent_Identity=24.25, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789473, Length=273, Percent_Identity=25.6410256410256, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983099, Length=430, Percent_Identity=25.5813953488372, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=422, Percent_Identity=25.5924170616114, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=443, Percent_Identity=25.9593679458239, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17537407, Length=425, Percent_Identity=24.4705882352941, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=470, Percent_Identity=24.0425531914894, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=412, Percent_Identity=26.4563106796117, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=410, Percent_Identity=23.9024390243902, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583025, Length=459, Percent_Identity=24.6187363834423, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17137668, Length=459, Percent_Identity=24.6187363834423, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24583023, Length=459, Percent_Identity=24.6187363834423, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281360483, Length=453, Percent_Identity=26.7108167770419, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137666, Length=453, Percent_Identity=26.7108167770419, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281360481, Length=449, Percent_Identity=26.7260579064588, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46679; Mature: 46548

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PENKRKLPPTVSILIAMLIGILTGYLINTHVADKAAVAGYVSILSDIFLRLIKMLIAPL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSTLVVGIAHMGDAAAVGRVFLKAMAWFLTASLVSLALGLVLANVLQPGANLGLPLPDT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HQATQLATGKFTLKEFVNHLVPKSFAEAMANNEILQIVVFSMFFGVALAGLGDKARTLVR
CHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
CVEELSHAMLKITGYVMRFAPVAVFAAMAATVAVNGLGILLKFAVFMGQFYLGLLLLWAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITAGFIALRGRVFKLLRNIREAFLLSFATASSEAAYPKLLDALDRFGVKRRVSSFVMPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GYSFNLDGSMIYCTFATLFIAQAYGIHLPIETQITMLLILMLTSKGMAGVPRASLVVIAA
CCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TLNQFHIPEAGLLLILGVDTFLDMGRSATNAVGNSIAAAVVAKWEDALLSEEDAAVHAAT
HHHHHCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LDTQPDDAPAGAPGTATAA
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA