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The map label for this gene is galE [H]

Identifier: 120609737

GI number: 120609737

Start: 1148681

End: 1149697

Strand: Direct

Name: galE [H]

Synonym: Aave_1044

Alternate gene names: 120609737

Gene position: 1148681-1149697 (Clockwise)

Preceding gene: 120609727

Following gene: 120609739

Centisome position: 21.46

GC content: 72.07

Gene sequence:

>1017_bases
GTGATACTTGTAACGGGCGGGGCCGGATTCATCGGCTCGCATACCTGCGTGGCACTGGCCGAGGCCGGGCTGCCATTTCT
CATCCTGGACAACTTCTGCAACAGCCGCCGCTCGGTACTGGAGCGCGTGGGCCGCATCACCGGCCGCGTGCCCGACCTGG
TCGAGGGCGACGTGCGGGACGAGGGCCTGCTGGCGCGGATCTTCGCGGAGCATTCCATCGATGCGGTGATCCATTTCGCC
GCGCTCAAGGCGGTGGGCGAATCGGTGCGGGAGCCGCTGTCGTACTACGACAACAACGTGGCCGGCACGGTGGCGCTGCT
GCGCGCGATGCGCAAGGCGGACGTCCGCACCCTGGTGTTCTCCTCGTCCGCGACGGTGTACGGCGAGCCGGCCTCCCTGC
CCATCCGCGAGGATTTCCCCCTCTCGGCCACCAACCCGTACGGCCAGAGCAAGCTCATGATGGAGCAGGTGCTGGCCGAC
GTGGACGCCTCCGAGCCCGGCCGCTGGCGCATCGCCCGGCTGCGCTACTTCAACCCCGTGGGCGCGCACGAAAGCGGCCT
CATCGGCGAAGACCCGCAGGACGTTCCCAACAACCTGCTGCCCTACGTGGCCCAGGTGGCCGTGGGGCTGCGCGAGCGCC
TGAGCGTGTATGGCGGCGACTACCCCACGCCGGACGGCACGGGCGTGCGCGACTACATCCACGTGTGCGACCTGGCCGAT
GGCCACGTGGCGGCGCTGCGCTACCTGCGCGCGCACCCCGGCCTGCTCACGGTGAACCTGGGCACGGGGCGGCCCGTGTC
GGTGCTGGAGATGGTGCGCGGCTTCGAGGCCGCGAGCGGCCGGCCGGTGCCCTACCAGGTGGTGGCGCGGCGGCCCGGGG
ACGTGGCCGCCTGCTGGGCCGACCCGGGGCTGGCCGAACGGCTGCTGGGCTGGAAGGCCCGCCACGGCCTCGACCGGATG
TGCGCCGACGCCTGGCGCTGGCAGGACGGCGTGGCCCGCGGCCTGCAGGCGGGCTGA

Upstream 100 bases:

>100_bases
TTCCGCCAGGGGCCCGGGCTGGTGCGCGGACCGCATCCCGGGGTTGGCCTGCCGGTATTACGCAGGCCAGAATAGGGTGG
ATTCAACGGGAGCAGATCGC

Downstream 100 bases:

>100_bases
AAAAAAGCAAGGGGCCCGGCGCGCTGGCGCAGGGCCCCTTGCGGCGGGCGTGGCGGTCAGGCCGCCGTGGCGGTGCCCGG
AGCGCCTGCGGGGGCGTCGT

Product: UDP-galactose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MILVTGGAGFIGSHTCVALAEAGLPFLILDNFCNSRRSVLERVGRITGRVPDLVEGDVRDEGLLARIFAEHSIDAVIHFA
ALKAVGESVREPLSYYDNNVAGTVALLRAMRKADVRTLVFSSSATVYGEPASLPIREDFPLSATNPYGQSKLMMEQVLAD
VDASEPGRWRIARLRYFNPVGAHESGLIGEDPQDVPNNLLPYVAQVAVGLRERLSVYGGDYPTPDGTGVRDYIHVCDLAD
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEAASGRPVPYQVVARRPGDVAACWADPGLAERLLGWKARHGLDRM
CADAWRWQDGVARGLQAG

Sequences:

>Translated_338_residues
MILVTGGAGFIGSHTCVALAEAGLPFLILDNFCNSRRSVLERVGRITGRVPDLVEGDVRDEGLLARIFAEHSIDAVIHFA
ALKAVGESVREPLSYYDNNVAGTVALLRAMRKADVRTLVFSSSATVYGEPASLPIREDFPLSATNPYGQSKLMMEQVLAD
VDASEPGRWRIARLRYFNPVGAHESGLIGEDPQDVPNNLLPYVAQVAVGLRERLSVYGGDYPTPDGTGVRDYIHVCDLAD
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEAASGRPVPYQVVARRPGDVAACWADPGLAERLLGWKARHGLDRM
CADAWRWQDGVARGLQAG
>Mature_338_residues
MILVTGGAGFIGSHTCVALAEAGLPFLILDNFCNSRRSVLERVGRITGRVPDLVEGDVRDEGLLARIFAEHSIDAVIHFA
ALKAVGESVREPLSYYDNNVAGTVALLRAMRKADVRTLVFSSSATVYGEPASLPIREDFPLSATNPYGQSKLMMEQVLAD
VDASEPGRWRIARLRYFNPVGAHESGLIGEDPQDVPNNLLPYVAQVAVGLRERLSVYGGDYPTPDGTGVRDYIHVCDLAD
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEAASGRPVPYQVVARRPGDVAACWADPGLAERLLGWKARHGLDRM
CADAWRWQDGVARGLQAG

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=334, Percent_Identity=56.8862275449102, Blast_Score=380, Evalue=1e-106,
Organism=Homo sapiens, GI56118217, Length=334, Percent_Identity=56.8862275449102, Blast_Score=380, Evalue=1e-106,
Organism=Homo sapiens, GI189083684, Length=334, Percent_Identity=56.8862275449102, Blast_Score=380, Evalue=1e-106,
Organism=Homo sapiens, GI7657641, Length=276, Percent_Identity=26.8115942028986, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI42516563, Length=316, Percent_Identity=26.8987341772152, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786974, Length=328, Percent_Identity=57.3170731707317, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI48994969, Length=386, Percent_Identity=25.9067357512953, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788353, Length=380, Percent_Identity=25.2631578947368, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=50.5747126436782, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=50.8670520231214, Blast_Score=346, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI17539532, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=49.7093023255814, Blast_Score=332, Evalue=6e-92,
Organism=Drosophila melanogaster, GI19923002, Length=336, Percent_Identity=55.6547619047619, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI21356223, Length=324, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36566; Mature: 36566

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGSHTCVALAEAGLPFLILDNFCNSRRSVLERVGRITGRVPDLVEGDVRD
CEEEECCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCC
EGLLARIFAEHSIDAVIHFAALKAVGESVREPLSYYDNNVAGTVALLRAMRKADVRTLVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEE
SSSATVYGEPASLPIREDFPLSATNPYGQSKLMMEQVLADVDASEPGRWRIARLRYFNPV
ECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
GAHESGLIGEDPQDVPNNLLPYVAQVAVGLRERLSVYGGDYPTPDGTGVRDYIHVCDLAD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEAASGRPVPYQVVARRPGDVAACWA
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHEEECCCCCEEEEEC
DPGLAERLLGWKARHGLDRMCADAWRWQDGVARGLQAG
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILVTGGAGFIGSHTCVALAEAGLPFLILDNFCNSRRSVLERVGRITGRVPDLVEGDVRD
CEEEECCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCC
EGLLARIFAEHSIDAVIHFAALKAVGESVREPLSYYDNNVAGTVALLRAMRKADVRTLVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEE
SSSATVYGEPASLPIREDFPLSATNPYGQSKLMMEQVLADVDASEPGRWRIARLRYFNPV
ECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
GAHESGLIGEDPQDVPNNLLPYVAQVAVGLRERLSVYGGDYPTPDGTGVRDYIHVCDLAD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEAASGRPVPYQVVARRPGDVAACWA
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHEEECCCCCEEEEEC
DPGLAERLLGWKARHGLDRMCADAWRWQDGVARGLQAG
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]