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The map label for this gene is lysA [H]

Identifier: 120609686

GI number: 120609686

Start: 1088433

End: 1089716

Strand: Reverse

Name: lysA [H]

Synonym: Aave_0992

Alternate gene names: 120609686

Gene position: 1089716-1088433 (Counterclockwise)

Preceding gene: 120609687

Following gene: 120609685

Centisome position: 20.36

GC content: 69.7

Gene sequence:

>1284_bases
ATGACGCTGACCGCATTGCCCGGCCATCCTCACATCGCCTACCGGGGCGACGACCTCTTCATCGAATCCGTGCGGGCCGC
CGACCTGGCGCAGGAGCACGGCACGCCGCTCTACGTCTATTCCAAGGCGTCCATGCTGTCGGCCCTGGAGGCCTACCAGC
GGGGCTTCGCGGGCCGCAAGGTGCAGATCTGCTACGCCATGAAGGCCAATTCCTCCCTGGGCGTGCTGCAGCTGTTCGCG
CGGGCGGGCTGCGGCTTCGACATCGTTTCCGCCGGCGAACTCCGGCGCGTGCTGGCGGCGGGGGGCGAGGCAGCCAAGGT
GATCTTCTCCGGCGTGGGCAAGACGCGCCAGGAGATGCGCGAGGCCCTCGAAGCCGGCATCGGCTGCTTCAACGTGGAGA
GCGAGCCCGAACTCGAGGTGCTGAACGAGGTCGCGATGGCCTGCGGCCGGCGCGCGCCCGTGAGCATCCGCGTGAATCCC
AACGTGGATCCGAAGACCCATCCCTATATCTCGACCGGCCTCAAGGGCAACAAGTTCGGCGTGGCCCACGAGCGCACGGT
CGCCACCTACCAGCGCGCCGCGGCCCTGCCGGGCCTGCAGGTGGTGGGCATCGACTGCCACATCGGCTCGCAGATCACCG
AGGCCACGCCCTACCTCGACGCCGTGGACCGCATGCTCGACCTGGTCGCGCAGATCGAGTCGGCCGGCATTCCCATCCAC
CACATCGATTTCGGCGGCGGCCTGGGCATCGACTACAACGGCGACACGCCGCCCGCGGCGGATGCGCTGTGGAAGCAGCT
GCTCGCGCGCCTGGACGCGCGCGGCTACGGCGACCGGCAGTTCATGATCGAGCCCGGACGCTCCCTCGTGGGCAATGCGG
GCGTCTGCCTGACCGAGGTGCTCTACGTGAAGCCGGGCGAGCAGAAGAACTTCTGCATCGTCGATGCCGCGATGAACGAC
CTGCCCCGCCCCGCCATGTACCAGGCGTTCCACGGCATCGTGCCGGTGGCCGCGCCTGCCCGGGATGCGGCCACCGCCGT
GTACGACGTGGTCGGCCCGGTGTGCGAGAGCGGCGACTGGATCGGCCGGGACCGCACGCTGGCCGTGCGTGCGGGCGACC
GGCTGGCCGTGCTGTCCGCGGGGGCCTATTGCAGTTCCATGGGCAGCACCTACAACACCCGCGCGCGGCCCGCCGAAGTG
CTGGTGGACGGCACCCACGCCCACCTGATCCGCACGCGCGAGCCGTTGGAAGACACGTTCCGCCACGAGAAACTGCCCGG
CTGA

Upstream 100 bases:

>100_bases
CGTCCCTGACGCCGCCCGAGCCCGCCGTGCCGGCCGCCGCGCCCGCGTCCTCTCCCGCGTCCTCCCCCGCGTCCTCCCCC
GCTTCCGCCACCACCACGCC

Downstream 100 bases:

>100_bases
ACGTTCGCTTGATGCGCATCAAGCTCCCGCCGGGCCGGTGTCCGTACATTGGCCGTTTCACGACGGACGGGACGCCATGG
CATCGGAACCTCTGGAACTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTLTALPGHPHIAYRGDDLFIESVRAADLAQEHGTPLYVYSKASMLSALEAYQRGFAGRKVQICYAMKANSSLGVLQLFA
RAGCGFDIVSAGELRRVLAAGGEAAKVIFSGVGKTRQEMREALEAGIGCFNVESEPELEVLNEVAMACGRRAPVSIRVNP
NVDPKTHPYISTGLKGNKFGVAHERTVATYQRAAALPGLQVVGIDCHIGSQITEATPYLDAVDRMLDLVAQIESAGIPIH
HIDFGGGLGIDYNGDTPPAADALWKQLLARLDARGYGDRQFMIEPGRSLVGNAGVCLTEVLYVKPGEQKNFCIVDAAMND
LPRPAMYQAFHGIVPVAAPARDAATAVYDVVGPVCESGDWIGRDRTLAVRAGDRLAVLSAGAYCSSMGSTYNTRARPAEV
LVDGTHAHLIRTREPLEDTFRHEKLPG

Sequences:

>Translated_427_residues
MTLTALPGHPHIAYRGDDLFIESVRAADLAQEHGTPLYVYSKASMLSALEAYQRGFAGRKVQICYAMKANSSLGVLQLFA
RAGCGFDIVSAGELRRVLAAGGEAAKVIFSGVGKTRQEMREALEAGIGCFNVESEPELEVLNEVAMACGRRAPVSIRVNP
NVDPKTHPYISTGLKGNKFGVAHERTVATYQRAAALPGLQVVGIDCHIGSQITEATPYLDAVDRMLDLVAQIESAGIPIH
HIDFGGGLGIDYNGDTPPAADALWKQLLARLDARGYGDRQFMIEPGRSLVGNAGVCLTEVLYVKPGEQKNFCIVDAAMND
LPRPAMYQAFHGIVPVAAPARDAATAVYDVVGPVCESGDWIGRDRTLAVRAGDRLAVLSAGAYCSSMGSTYNTRARPAEV
LVDGTHAHLIRTREPLEDTFRHEKLPG
>Mature_426_residues
TLTALPGHPHIAYRGDDLFIESVRAADLAQEHGTPLYVYSKASMLSALEAYQRGFAGRKVQICYAMKANSSLGVLQLFAR
AGCGFDIVSAGELRRVLAAGGEAAKVIFSGVGKTRQEMREALEAGIGCFNVESEPELEVLNEVAMACGRRAPVSIRVNPN
VDPKTHPYISTGLKGNKFGVAHERTVATYQRAAALPGLQVVGIDCHIGSQITEATPYLDAVDRMLDLVAQIESAGIPIHH
IDFGGGLGIDYNGDTPPAADALWKQLLARLDARGYGDRQFMIEPGRSLVGNAGVCLTEVLYVKPGEQKNFCIVDAAMNDL
PRPAMYQAFHGIVPVAAPARDAATAVYDVVGPVCESGDWIGRDRTLAVRAGDRLAVLSAGAYCSSMGSTYNTRARPAEVL
VDGTHAHLIRTREPLEDTFRHEKLPG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=359, Percent_Identity=23.6768802228412, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789203, Length=432, Percent_Identity=34.0277777777778, Blast_Score=147, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17562780, Length=399, Percent_Identity=23.3082706766917, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45772; Mature: 45641

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTALPGHPHIAYRGDDLFIESVRAADLAQEHGTPLYVYSKASMLSALEAYQRGFAGRK
CEEECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCE
VQICYAMKANSSLGVLQLFARAGCGFDIVSAGELRRVLAAGGEAAKVIFSGVGKTRQEMR
EEEEEEEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCHHHHHHH
EALEAGIGCFNVESEPELEVLNEVAMACGRRAPVSIRVNPNVDPKTHPYISTGLKGNKFG
HHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCC
VAHERTVATYQRAAALPGLQVVGIDCHIGSQITEATPYLDAVDRMLDLVAQIESAGIPIH
CCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEE
HIDFGGGLGIDYNGDTPPAADALWKQLLARLDARGYGDRQFMIEPGRSLVGNAGVCLTEV
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCHHHHEE
LYVKPGEQKNFCIVDAAMNDLPRPAMYQAFHGIVPVAAPARDAATAVYDVVGPVCESGDW
EEECCCCCCCEEEEECHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
IGRDRTLAVRAGDRLAVLSAGAYCSSMGSTYNTRARPAEVLVDGTHAHLIRTREPLEDTF
CCCCCEEEEECCCEEEEEECCHHHHHCCCCCCCCCCCCEEEEECCHHEEEECCCCHHHHH
RHEKLPG
HHCCCCC
>Mature Secondary Structure 
TLTALPGHPHIAYRGDDLFIESVRAADLAQEHGTPLYVYSKASMLSALEAYQRGFAGRK
EEECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCE
VQICYAMKANSSLGVLQLFARAGCGFDIVSAGELRRVLAAGGEAAKVIFSGVGKTRQEMR
EEEEEEEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCHHHHHHH
EALEAGIGCFNVESEPELEVLNEVAMACGRRAPVSIRVNPNVDPKTHPYISTGLKGNKFG
HHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCC
VAHERTVATYQRAAALPGLQVVGIDCHIGSQITEATPYLDAVDRMLDLVAQIESAGIPIH
CCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEE
HIDFGGGLGIDYNGDTPPAADALWKQLLARLDARGYGDRQFMIEPGRSLVGNAGVCLTEV
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCHHHHEE
LYVKPGEQKNFCIVDAAMNDLPRPAMYQAFHGIVPVAAPARDAATAVYDVVGPVCESGDW
EEECCCCCCCEEEEECHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
IGRDRTLAVRAGDRLAVLSAGAYCSSMGSTYNTRARPAEVLVDGTHAHLIRTREPLEDTF
CCCCCEEEEECCCEEEEEECCHHHHHCCCCCCCCCCCCEEEEECCHHEEEECCCCHHHHH
RHEKLPG
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]