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The map label for this gene is dht [H]

Identifier: 120609663

GI number: 120609663

Start: 1063612

End: 1065072

Strand: Direct

Name: dht [H]

Synonym: Aave_0969

Alternate gene names: 120609663

Gene position: 1063612-1065072 (Clockwise)

Preceding gene: 120609662

Following gene: 120609664

Centisome position: 19.87

GC content: 69.4

Gene sequence:

>1461_bases
ATGACCCCCAGCCTTCTGATCCGCGGCGGCACCGTGGTGAACGCCGACCGCGAGGAGCGTGCCGACGTGCTGTGCGTGGA
CGGCCGCATCGAGGCCGTGGGCGGTGACGCCGCCCGGCTCGCACCCTCAGGCACGCAGACGCTCGATGCCGGCGGCCAGT
ACGTGCTGCCCGGCGGCATCGATCCACACACGCACATGCAGTTGCCCTTCATGGGCACCGTGACGATGGACGACTTCTAC
ACCGGCACGGCAGCGGGGCTGGCCGGCGGGACGACCACCATCATCGATTTCGTGATCCCCGATCCGAAGGAGCCGCTGAT
GGATGCCTACCGCAAGTGGCGCGGATGGGCCGAGAAATCCGCCGCGGACTATTCCTTCCACGTGGCCGTGACCTGGTGGA
GCGACCAGGTGCATGCGGACATGGGCACCCTGGTGCGCGAGGAAGGCGTGAACAGCTTCAAGCACTTCATGGCCTACAAG
AACGCGATCATGTGCGACGACGAGACGCTGGTGAACAGTTTCAAGCGCGCGCTGGAATTGGGCGCCATGCCCACCGTGCA
TGCGGAGAACGGGGAGCTGGTCTACCTGCTGCAGCAGGAGGTGGCCAAGATGGGCATCACCGGCCCCGAGGGCCATCCGC
TGGCCCGCCCACCCATGGTGGAGGCCGAGGCCGCCAACCGCGCCATCGCCATCGCCGACGTGCTGGGCGTGCCGATCTAC
GTGGTGCACGTGAGCTGCGCCGAGGCGGCCGAGGCGATCGCCCGGGCCCGCGCGCGTGGCCAGCGCGTGTTCGGGGAAGT
GCTGGCGGGCCACCTGCTGGTGGACGACAGCGTGTATCGCGATCCGGACTTCGCCACTGCCGCGGCCCACGTGATGAGCC
CGCCCTTCCGGCCACGCGCGGGCGGCCACCAGGAGGCGCTGTGGCGCGGCCTGCAGTCGGGCCAGCTGCACACCACGGCC
ACCGACCACTGCACCTTCTGCGCCGCCCAGAAGGCCATGGGGCGCGACAATTTCGCGAAGATTCCGAACGGCACGGGCGG
CGTGGAGGAGCGCATGGCCGCGATCTGGGACGGCGGAGTGAACACCGGCCGCCTGACACCCAGCGAATTCGTGGCGATCA
CGTCCGCCAACGCTGCGAAGCTGTTCAACATCTATCCGCGCAAGGGCTTCGTGGGCCCGGGCGCGGACGCCGACCTCGTG
CTGTGGGACCCGGAAGGTACCAAGACCTTCTCGGCCAAGACCCAGCACAGCAAGGGCGATTTCAATATCTTCGAGGGCCG
CACCGTGCGCGGCATTCCCAGCCACACCGTCAGCCAGGGGCGCGTGGTGTTCGCGCGGGGCGACCTGCGCGCCGAGCAGG
GCGCGGGCCGCTATGTGCACCGCCCGGCCTTCGGCGCGAACTTCCAGGCCGTGCACAAGCGTGCGCAGGACCTGGCCCCC
AGCGCCGTCGCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CGCGACCGCCCGGAGGCCGCGGTAGCGGCCCCGCCGGCCCGCCGCGGCGCAGCGCTCTGCCCGCGGCCGGGCACTTTCCT
TCCAGAGACAAGGAGAACCC

Downstream 100 bases:

>100_bases
GAACGGACAAGGAAAACCCATGGACACGACCACCACCGACAAGACCGACATCCGCCAGCTGCGCGTGAATGGCGAGCGCC
TCTGGGATTCGCTCATGGAA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTPSLLIRGGTVVNADREERADVLCVDGRIEAVGGDAARLAPSGTQTLDAGGQYVLPGGIDPHTHMQLPFMGTVTMDDFY
TGTAAGLAGGTTTIIDFVIPDPKEPLMDAYRKWRGWAEKSAADYSFHVAVTWWSDQVHADMGTLVREEGVNSFKHFMAYK
NAIMCDDETLVNSFKRALELGAMPTVHAENGELVYLLQQEVAKMGITGPEGHPLARPPMVEAEAANRAIAIADVLGVPIY
VVHVSCAEAAEAIARARARGQRVFGEVLAGHLLVDDSVYRDPDFATAAAHVMSPPFRPRAGGHQEALWRGLQSGQLHTTA
TDHCTFCAAQKAMGRDNFAKIPNGTGGVEERMAAIWDGGVNTGRLTPSEFVAITSANAAKLFNIYPRKGFVGPGADADLV
LWDPEGTKTFSAKTQHSKGDFNIFEGRTVRGIPSHTVSQGRVVFARGDLRAEQGAGRYVHRPAFGANFQAVHKRAQDLAP
SAVARA

Sequences:

>Translated_486_residues
MTPSLLIRGGTVVNADREERADVLCVDGRIEAVGGDAARLAPSGTQTLDAGGQYVLPGGIDPHTHMQLPFMGTVTMDDFY
TGTAAGLAGGTTTIIDFVIPDPKEPLMDAYRKWRGWAEKSAADYSFHVAVTWWSDQVHADMGTLVREEGVNSFKHFMAYK
NAIMCDDETLVNSFKRALELGAMPTVHAENGELVYLLQQEVAKMGITGPEGHPLARPPMVEAEAANRAIAIADVLGVPIY
VVHVSCAEAAEAIARARARGQRVFGEVLAGHLLVDDSVYRDPDFATAAAHVMSPPFRPRAGGHQEALWRGLQSGQLHTTA
TDHCTFCAAQKAMGRDNFAKIPNGTGGVEERMAAIWDGGVNTGRLTPSEFVAITSANAAKLFNIYPRKGFVGPGADADLV
LWDPEGTKTFSAKTQHSKGDFNIFEGRTVRGIPSHTVSQGRVVFARGDLRAEQGAGRYVHRPAFGANFQAVHKRAQDLAP
SAVARA
>Mature_485_residues
TPSLLIRGGTVVNADREERADVLCVDGRIEAVGGDAARLAPSGTQTLDAGGQYVLPGGIDPHTHMQLPFMGTVTMDDFYT
GTAAGLAGGTTTIIDFVIPDPKEPLMDAYRKWRGWAEKSAADYSFHVAVTWWSDQVHADMGTLVREEGVNSFKHFMAYKN
AIMCDDETLVNSFKRALELGAMPTVHAENGELVYLLQQEVAKMGITGPEGHPLARPPMVEAEAANRAIAIADVLGVPIYV
VHVSCAEAAEAIARARARGQRVFGEVLAGHLLVDDSVYRDPDFATAAAHVMSPPFRPRAGGHQEALWRGLQSGQLHTTAT
DHCTFCAAQKAMGRDNFAKIPNGTGGVEERMAAIWDGGVNTGRLTPSEFVAITSANAAKLFNIYPRKGFVGPGADADLVL
WDPEGTKTFSAKTQHSKGDFNIFEGRTVRGIPSHTVSQGRVVFARGDLRAEQGAGRYVHRPAFGANFQAVHKRAQDLAPS
AVARA

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=486, Percent_Identity=50.4115226337449, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI4503379, Length=473, Percent_Identity=46.5116279069767, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI4503377, Length=461, Percent_Identity=46.6377440347072, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=48.3801295896328, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4503051, Length=483, Percent_Identity=44.5134575569358, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI62422571, Length=483, Percent_Identity=44.5134575569358, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI19923821, Length=483, Percent_Identity=44.7204968944099, Blast_Score=408, Evalue=1e-114,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=36.6379310344828, Blast_Score=298, Evalue=8e-82,
Organism=Escherichia coli, GI1786722, Length=470, Percent_Identity=26.5957446808511, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17539558, Length=486, Percent_Identity=46.7078189300411, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71989490, Length=490, Percent_Identity=45.1020408163265, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI86575075, Length=457, Percent_Identity=33.4792122538293, Blast_Score=258, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6322218, Length=402, Percent_Identity=24.6268656716418, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221377917, Length=461, Percent_Identity=47.7223427331887, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17137462, Length=459, Percent_Identity=46.4052287581699, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24644287, Length=297, Percent_Identity=48.4848484848485, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24644289, Length=229, Percent_Identity=50.2183406113537, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI18859883, Length=423, Percent_Identity=24.822695035461, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52172; Mature: 52041

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSLLIRGGTVVNADREERADVLCVDGRIEAVGGDAARLAPSGTQTLDAGGQYVLPGGI
CCCCEEEECCEEECCCHHHCCCEEEECCEEEECCCCHHCCCCCCCCEECCCCCEEECCCC
DPHTHMQLPFMGTVTMDDFYTGTAAGLAGGTTTIIDFVIPDPKEPLMDAYRKWRGWAEKS
CCCCEEECCEEEEEEECCCCCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHCC
AADYSFHVAVTWWSDQVHADMGTLVREEGVNSFKHFMAYKNAIMCDDETLVNSFKRALEL
CCCEEEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
GAMPTVHAENGELVYLLQQEVAKMGITGPEGHPLARPPMVEAEAANRAIAIADVLGVPIY
CCCCEEECCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCEE
VVHVSCAEAAEAIARARARGQRVFGEVLAGHLLVDDSVYRDPDFATAAAHVMSPPFRPRA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCC
GGHQEALWRGLQSGQLHTTATDHCTFCAAQKAMGRDNFAKIPNGTGGVEERMAAIWDGGV
CCCHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCC
NTGRLTPSEFVAITSANAAKLFNIYPRKGFVGPGADADLVLWDPEGTKTFSAKTQHSKGD
CCCCCCHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCC
FNIFEGRTVRGIPSHTVSQGRVVFARGDLRAEQGAGRYVHRPAFGANFQAVHKRAQDLAP
EEEECCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCC
SAVARA
HHHHCC
>Mature Secondary Structure 
TPSLLIRGGTVVNADREERADVLCVDGRIEAVGGDAARLAPSGTQTLDAGGQYVLPGGI
CCCEEEECCEEECCCHHHCCCEEEECCEEEECCCCHHCCCCCCCCEECCCCCEEECCCC
DPHTHMQLPFMGTVTMDDFYTGTAAGLAGGTTTIIDFVIPDPKEPLMDAYRKWRGWAEKS
CCCCEEECCEEEEEEECCCCCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHCC
AADYSFHVAVTWWSDQVHADMGTLVREEGVNSFKHFMAYKNAIMCDDETLVNSFKRALEL
CCCEEEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
GAMPTVHAENGELVYLLQQEVAKMGITGPEGHPLARPPMVEAEAANRAIAIADVLGVPIY
CCCCEEECCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCEE
VVHVSCAEAAEAIARARARGQRVFGEVLAGHLLVDDSVYRDPDFATAAAHVMSPPFRPRA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCC
GGHQEALWRGLQSGQLHTTATDHCTFCAAQKAMGRDNFAKIPNGTGGVEERMAAIWDGGV
CCCHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCC
NTGRLTPSEFVAITSANAAKLFNIYPRKGFVGPGADADLVLWDPEGTKTFSAKTQHSKGD
CCCCCCHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCC
FNIFEGRTVRGIPSHTVSQGRVVFARGDLRAEQGAGRYVHRPAFGANFQAVHKRAQDLAP
EEEECCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCC
SAVARA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]