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The map label for this gene is vipA [H]

Identifier: 120609643

GI number: 120609643

Start: 1034943

End: 1036241

Strand: Direct

Name: vipA [H]

Synonym: Aave_0949

Alternate gene names: 120609643

Gene position: 1034943-1036241 (Clockwise)

Preceding gene: 120609642

Following gene: 120609644

Centisome position: 19.33

GC content: 62.2

Gene sequence:

>1299_bases
ATGATGAACCTGGAAAATGCAACCATTGCCGTGATCGGCCTGGGCTACGTGGGCTTGCCACTGGCCGTTGAATTCGGAAA
GCAACGCCCTGTGCTGGGGTTTGACATCAACGCGGAACGCATCGCGGAACTGCAGTCCGGCAAAGACGGCACTCTTGAGG
TAACGTCCGAGGATCTGAGGGCGGCAACCCATCTGCGCTACAGCGCGGACCCGGAAGACCTCAAGGATTGCGGAATCTTC
ATCGTGACCGTGCCGACCCCGGTGGACACTGCCAATCGGCCCGACATGACGCCGCTGGTCAAGGCCAGCGAGACGGTAGG
CCGCGCCATGCCACAGGGGGCTGTGGTGATCTACGAGTCCACCGTGTATCCCGGTGCAACGGAGGAGGTGTGCGTCCCCG
TGCTGGAACGTTGCAGCGGCAAGACATTCAACACCGGTTTCTTCTGTGGCTACAGCCCCGAGCGCATCAATCCGGGCGAC
AAGGTCAACACGCTTACCAAGATCCGGAAAATCACCAGCGGCAGCACCCCTGAAGTGGCGGATGCCGTGGACGCTCTCTA
CGCCGAGATCATCACCGCAGGCACCCACAAGGCGAGCAGCCTGAAGGTGGCCGAAGCCGCGAAGGTCATCGAAAACACGC
AGCGCGACCTCAATATCGCCCTGGTAAACGAACTGTCGGTCATCTTCGAGCGATTGGGGATCGATACGCTCGACGTGCTG
GAAGCCGCCGGCAGCAAGTGGAACTTCCTGCCTTTCCGGCCGGGGCTCGTGGGCGGCCACTGCATTGGGGTGGACCCGTA
CTATCTGACCCATAAGGCCGAGGAAGTGGGCTACCACCCTCAGGTCATCCTGGCCGGACGGCGCATCAACGACAACATGG
CGCGCTACGTGGCGCGAAACACCATCCGGCTGATGCTGCGCAACGGCATGGACGTTCCCCGGTGCCGCATCGGTGTCCTG
GGCATCACGTTCAAGGAGAACTGCCCGGACATCCGCAACAGCAAGGTTGTGGACATGGTGCGGGAGTTCGAATCCTGGGG
CGCCAATGTGGTCGTCTGTGATCCATGGGCCAATGCGCAGGACGTGCAGCACGAATATGGCATCTCCCTGGGAAGCGTGT
CCGCGCAGGAACCCGTCGATGCGCTGGTCGTTGCGGTGGGTCACCACCAGTTCCGTGAAGCCAGCCTTTCCGAACTGCGC
GCCTTCTGTCGCGGCGACCGCCCCGTGCTGGCTGACGTCAAGAGCCTCCATGACCGCCACCAGGCCGTGGCATCCGGCTT
CACCGTGTTCCGTCTGTGA

Upstream 100 bases:

>100_bases
CGAGGATGACATCGTGCGACTCGATGACATCTATGGCCGCTCGTCCTCTGGAGGCGGCAACTGAACGCTGGCGCAGCCTG
TTGAATTCTTGCTGAAGTAG

Downstream 100 bases:

>100_bases
CTTCCCCGACTTCTGATCGTCCATGAAAAATTTTGCCCTCATCGGCGCTGCCGGCTACATCGCCCCCCGGCACATGCGCG
CCATCAAGGACACAGGCCAC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MMNLENATIAVIGLGYVGLPLAVEFGKQRPVLGFDINAERIAELQSGKDGTLEVTSEDLRAATHLRYSADPEDLKDCGIF
IVTVPTPVDTANRPDMTPLVKASETVGRAMPQGAVVIYESTVYPGATEEVCVPVLERCSGKTFNTGFFCGYSPERINPGD
KVNTLTKIRKITSGSTPEVADAVDALYAEIITAGTHKASSLKVAEAAKVIENTQRDLNIALVNELSVIFERLGIDTLDVL
EAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAEEVGYHPQVILAGRRINDNMARYVARNTIRLMLRNGMDVPRCRIGVL
GITFKENCPDIRNSKVVDMVREFESWGANVVVCDPWANAQDVQHEYGISLGSVSAQEPVDALVVAVGHHQFREASLSELR
AFCRGDRPVLADVKSLHDRHQAVASGFTVFRL

Sequences:

>Translated_432_residues
MMNLENATIAVIGLGYVGLPLAVEFGKQRPVLGFDINAERIAELQSGKDGTLEVTSEDLRAATHLRYSADPEDLKDCGIF
IVTVPTPVDTANRPDMTPLVKASETVGRAMPQGAVVIYESTVYPGATEEVCVPVLERCSGKTFNTGFFCGYSPERINPGD
KVNTLTKIRKITSGSTPEVADAVDALYAEIITAGTHKASSLKVAEAAKVIENTQRDLNIALVNELSVIFERLGIDTLDVL
EAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAEEVGYHPQVILAGRRINDNMARYVARNTIRLMLRNGMDVPRCRIGVL
GITFKENCPDIRNSKVVDMVREFESWGANVVVCDPWANAQDVQHEYGISLGSVSAQEPVDALVVAVGHHQFREASLSELR
AFCRGDRPVLADVKSLHDRHQAVASGFTVFRL
>Mature_432_residues
MMNLENATIAVIGLGYVGLPLAVEFGKQRPVLGFDINAERIAELQSGKDGTLEVTSEDLRAATHLRYSADPEDLKDCGIF
IVTVPTPVDTANRPDMTPLVKASETVGRAMPQGAVVIYESTVYPGATEEVCVPVLERCSGKTFNTGFFCGYSPERINPGD
KVNTLTKIRKITSGSTPEVADAVDALYAEIITAGTHKASSLKVAEAAKVIENTQRDLNIALVNELSVIFERLGIDTLDVL
EAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAEEVGYHPQVILAGRRINDNMARYVARNTIRLMLRNGMDVPRCRIGVL
GITFKENCPDIRNSKVVDMVREFESWGANVVVCDPWANAQDVQHEYGISLGSVSAQEPVDALVVAVGHHQFREASLSELR
AFCRGDRPVLADVKSLHDRHQAVASGFTVFRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=412, Percent_Identity=29.8543689320388, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47122; Mature: 47122

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLENATIAVIGLGYVGLPLAVEFGKQRPVLGFDINAERIAELQSGKDGTLEVTSEDLR
CCCCCCCEEEEEECCHHCCHHHEECCCCCCEEEECCCHHHHHHHHCCCCCEEEECHHHHH
AATHLRYSADPEDLKDCGIFIVTVPTPVDTANRPDMTPLVKASETVGRAMPQGAVVIYES
HHHHCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEC
TVYPGATEEVCVPVLERCSGKTFNTGFFCGYSPERINPGDKVNTLTKIRKITSGSTPEVA
CCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
DAVDALYAEIITAGTHKASSLKVAEAAKVIENTQRDLNIALVNELSVIFERLGIDTLDVL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHH
EAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAEEVGYHPQVILAGRRINDNMARYVARN
HHCCCCCCCCCCCCCCCCCEEECCCCCEEECCHHHCCCCCEEEEECCCCCHHHHHHHHHH
TIRLMLRNGMDVPRCRIGVLGITFKENCPDIRNSKVVDMVREFESWGANVVVCDPWANAQ
HHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHH
DVQHEYGISLGSVSAQEPVDALVVAVGHHQFREASLSELRAFCRGDRPVLADVKSLHDRH
HHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QAVASGFTVFRL
HHHHCCEEEEEC
>Mature Secondary Structure
MMNLENATIAVIGLGYVGLPLAVEFGKQRPVLGFDINAERIAELQSGKDGTLEVTSEDLR
CCCCCCCEEEEEECCHHCCHHHEECCCCCCEEEECCCHHHHHHHHCCCCCEEEECHHHHH
AATHLRYSADPEDLKDCGIFIVTVPTPVDTANRPDMTPLVKASETVGRAMPQGAVVIYES
HHHHCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEC
TVYPGATEEVCVPVLERCSGKTFNTGFFCGYSPERINPGDKVNTLTKIRKITSGSTPEVA
CCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
DAVDALYAEIITAGTHKASSLKVAEAAKVIENTQRDLNIALVNELSVIFERLGIDTLDVL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHH
EAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAEEVGYHPQVILAGRRINDNMARYVARN
HHCCCCCCCCCCCCCCCCCEEECCCCCEEECCHHHCCCCCEEEEECCCCCHHHHHHHHHH
TIRLMLRNGMDVPRCRIGVLGITFKENCPDIRNSKVVDMVREFESWGANVVVCDPWANAQ
HHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHH
DVQHEYGISLGSVSAQEPVDALVVAVGHHQFREASLSELRAFCRGDRPVLADVKSLHDRH
HHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QAVASGFTVFRL
HHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]