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The map label for this gene is glk [H]

Identifier: 120609635

GI number: 120609635

Start: 1024915

End: 1025760

Strand: Reverse

Name: glk [H]

Synonym: Aave_0941

Alternate gene names: 120609635

Gene position: 1025760-1024915 (Counterclockwise)

Preceding gene: 120609636

Following gene: 120609634

Centisome position: 19.16

GC content: 69.86

Gene sequence:

>846_bases
ATGCTCGAGCGCATCACCGCCTCACTGCCTTCGCTGGCCCCCGCCGAACAGCGGGTGGGCCAGCTGGTGCTGCAGGACGC
GCGTGCGTTCGCGCGGCTGCCGGTGCGGGAGCTGGCGGCGCGGGCGGGGGTGAGCAAGCCCACGGTGGTGCGCTTTTGCC
GCAGCATGGGGTACGACGGGCTGGCCGACTTCAAGCTCAAGCTCGCGGGCAGCGTGAGCGAGGGCGTGCCGTTCATCCAC
CGCAGCGTGGACGCCGACGACAAGACCGGCGACGTGCTCGTGAAGGTCGTGGACAACGCCGTCGCCGCATTCCTGCAGTA
CCGCAACGCGGCGAGCACCAAGGCCATCGAGCAGGCCGCGCAGGCGATCGCAGCCACCTGGCAGACAGGCCGGCGCATCG
AGTTCTACGGCGCCGGCAACTCGGGCATCGTGGCGCAGGACGCGCAGCACAAGTTCTTCCGGCTGGGCGTGACCAGCCTC
GCGACCAGCGATGGACACATGCAGGTCATGAGCGCGACCCTGCTGGGACCGGGCGACTGCGTGGTGATCGTCTCCAACTC
CGGGCGCACGCGCGACCTCATGGACGCGACCGACATCGCCCGCAGGAACGGCGCCACCACCATCGCCATCACCGCCAGCG
GCTCGCCCCTGGCCAGCGCCTGCCACATCCATCTGGCGGCGGACCATCCAGAGGGATACGACCGCTACAGCCCGATGGTC
TCCCGCCTGCTGCACCTGCTCATCATCGACGTGCTCGCCACCTGCGTGGCGCTGCGCATCGGCGAGCCGCTGCAGCCCCG
CCTGCAGCAGATGAAGGACAACCTGCGGGCCAAGCGCTACACCTGA

Upstream 100 bases:

>100_bases
TGCTCCGCGGCCATTCGACGGGTGAGGCCGCGCCAGTTTCACGGGCTATGGGCAGTGGCACTCATCCAGTGCCCTCCAGC
CTTCGCACGGGACTGCTGAC

Downstream 100 bases:

>100_bases
ACGAAGCGCCACCGCGCGGTCCCTCGACCACGCGGCTCCATCCCGCCCGCCACGGGCAATCCACCTGCCGATCGCAGGCA
ATGAACCGGCCCCATGTGGA

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLERITASLPSLAPAEQRVGQLVLQDARAFARLPVRELAARAGVSKPTVVRFCRSMGYDGLADFKLKLAGSVSEGVPFIH
RSVDADDKTGDVLVKVVDNAVAAFLQYRNAASTKAIEQAAQAIAATWQTGRRIEFYGAGNSGIVAQDAQHKFFRLGVTSL
ATSDGHMQVMSATLLGPGDCVVIVSNSGRTRDLMDATDIARRNGATTIAITASGSPLASACHIHLAADHPEGYDRYSPMV
SRLLHLLIIDVLATCVALRIGEPLQPRLQQMKDNLRAKRYT

Sequences:

>Translated_281_residues
MLERITASLPSLAPAEQRVGQLVLQDARAFARLPVRELAARAGVSKPTVVRFCRSMGYDGLADFKLKLAGSVSEGVPFIH
RSVDADDKTGDVLVKVVDNAVAAFLQYRNAASTKAIEQAAQAIAATWQTGRRIEFYGAGNSGIVAQDAQHKFFRLGVTSL
ATSDGHMQVMSATLLGPGDCVVIVSNSGRTRDLMDATDIARRNGATTIAITASGSPLASACHIHLAADHPEGYDRYSPMV
SRLLHLLIIDVLATCVALRIGEPLQPRLQQMKDNLRAKRYT
>Mature_281_residues
MLERITASLPSLAPAEQRVGQLVLQDARAFARLPVRELAARAGVSKPTVVRFCRSMGYDGLADFKLKLAGSVSEGVPFIH
RSVDADDKTGDVLVKVVDNAVAAFLQYRNAASTKAIEQAAQAIAATWQTGRRIEFYGAGNSGIVAQDAQHKFFRLGVTSL
ATSDGHMQVMSATLLGPGDCVVIVSNSGRTRDLMDATDIARRNGATTIAITASGSPLASACHIHLAADHPEGYDRYSPMV
SRLLHLLIIDVLATCVALRIGEPLQPRLQQMKDNLRAKRYT

Specific function: Represses The Expression Of The Hex Regulon (Zwf, Eda, Glp And Gap) (By Similarity). [C]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=37.8571428571429, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87082369, Length=248, Percent_Identity=28.6290322580645, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082130, Length=215, Percent_Identity=29.3023255813954, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788767, Length=266, Percent_Identity=24.812030075188, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 30210; Mature: 30210

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERITASLPSLAPAEQRVGQLVLQDARAFARLPVRELAARAGVSKPTVVRFCRSMGYDG
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCC
LADFKLKLAGSVSEGVPFIHRSVDADDKTGDVLVKVVDNAVAAFLQYRNAASTKAIEQAA
CCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QAIAATWQTGRRIEFYGAGNSGIVAQDAQHKFFRLGVTSLATSDGHMQVMSATLLGPGDC
HHHHHHHCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCE
VVIVSNSGRTRDLMDATDIARRNGATTIAITASGSPLASACHIHLAADHPEGYDRYSPMV
EEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
SRLLHLLIIDVLATCVALRIGEPLQPRLQQMKDNLRAKRYT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLERITASLPSLAPAEQRVGQLVLQDARAFARLPVRELAARAGVSKPTVVRFCRSMGYDG
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCC
LADFKLKLAGSVSEGVPFIHRSVDADDKTGDVLVKVVDNAVAAFLQYRNAASTKAIEQAA
CCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QAIAATWQTGRRIEFYGAGNSGIVAQDAQHKFFRLGVTSLATSDGHMQVMSATLLGPGDC
HHHHHHHCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCE
VVIVSNSGRTRDLMDATDIARRNGATTIAITASGSPLASACHIHLAADHPEGYDRYSPMV
EEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
SRLLHLLIIDVLATCVALRIGEPLQPRLQQMKDNLRAKRYT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA