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The map label for this gene is flbD [H]

Identifier: 120609575

GI number: 120609575

Start: 956995

End: 958116

Strand: Direct

Name: flbD [H]

Synonym: Aave_0881

Alternate gene names: 120609575

Gene position: 956995-958116 (Clockwise)

Preceding gene: 120609574

Following gene: 120609580

Centisome position: 17.88

GC content: 71.75

Gene sequence:

>1122_bases
ATGCCACCCGTCCATTTCCTGAAGGCCTTTCCCGAAGACGGCGATGCGCCGGCCCGGCACCGGTACGCGGCACCGCTGCT
CACGCTGCCGGGCGCCCGGGCCATGCCCACGTCGATCCGCGCCACCGCGCAGGTGTTCGAGGACCCGCGCTCGCTGGCGC
TGCTCGAGCGCATCCGCCTCGTCGCGCCCAGCGATGCGAACGTGCTCATCCTGGGCGAGACGGGCACCGGCAAGGAACTG
ATCGCGCGCCACGTGCACGCGCTGAGCGCGCGGCGCTCAGGGCCGTTCGTGGCCGTGAACTGCGGTGCGCTGTCGGAGAC
GCTGGTGGAGAGCGAACTGTTCGGCCACGAGAAGGGCGCCTTCACCGGCGCCTTCACCGCCAAGGCCGGCTGGTTCGAGG
CCGCCCACGGCGGCACGCTGTTCCTCGACGAGGTGGGCGACCTGCCGCTGTCCATCCAGGTCAAGCTGCTGCGGGTGCTG
CAGGAGCGCGAGGTGGTGCGGCTGGGTGCGCGAAGGAGCCTGCCGGTGGACGTGCGCGTGGTGGCGGCCACCAATGTGCG
CCTGCAGGACGCGGTGGCCGCGGGGAATTTCCGCCAGGACCTGTTCTACCGGCTGCATGTGGTGAACCTCGCGCTGCCCA
CGCTGCGCGAGCGGCCGGGCGACATCCTGCCGCTCGCGCGCCATTTCATCGACGAGTACCGGCACCGCCTGGGCTACGGT
CCGGTGCGGCTCGATGCGGGTGCGGAGCGCAAGCTGCTCGCCCACGACTGGCCCGGCAACATCCGCGAGCTGGAGAACGT
GATCCACCACGGCCTGCTGGTCTGCCGCCGCGGCGTGCTCCTGGCCGAGGACCTGCAGCTGTCGTCGCTGGGCCTGCGGC
GCCGCTCCGGGAGCGACGCGCCGGCGGATGCGACGCCGCTGCAGGCGCTGGAAACGGCGCTGTCGGGCCTGTTCCAGCAG
CAGGGCGACCAGTTGTACGAGCGCATCGAGGAAACCGTCGTGCGCGCCGCCTTCGAGTTCTGCCACCGCAACCAGGTGCA
GGCCGCGCGCCTGCTGGGCATCAGCCGCAACGTGCTGCGCGCGCGCCTGATCCGGCACGGGGACATCACGGCGTTGAGGT
GA

Upstream 100 bases:

>100_bases
TTGGAATCCTTATTTGCCGCCAGGGGGATGCCGTCCCAACAATGGGCTCATGCGGCAGTGCAGCGCCTTTGCCGGCCGCG
GACCTTTCCTTTGACTGCCC

Downstream 100 bases:

>100_bases
CGCCCCGTGAGCGGCTGCGCCGCTTCCGTGCAGCCGCCAGAGTCGGCAGCCCTTCGGACACGTCCAAGCCTGCGCAGGCA
GGCGCGGAGCCGCGGCCCTC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPPVHFLKAFPEDGDAPARHRYAAPLLTLPGARAMPTSIRATAQVFEDPRSLALLERIRLVAPSDANVLILGETGTGKEL
IARHVHALSARRSGPFVAVNCGALSETLVESELFGHEKGAFTGAFTAKAGWFEAAHGGTLFLDEVGDLPLSIQVKLLRVL
QEREVVRLGARRSLPVDVRVVAATNVRLQDAVAAGNFRQDLFYRLHVVNLALPTLRERPGDILPLARHFIDEYRHRLGYG
PVRLDAGAERKLLAHDWPGNIRELENVIHHGLLVCRRGVLLAEDLQLSSLGLRRRSGSDAPADATPLQALETALSGLFQQ
QGDQLYERIEETVVRAAFEFCHRNQVQAARLLGISRNVLRARLIRHGDITALR

Sequences:

>Translated_373_residues
MPPVHFLKAFPEDGDAPARHRYAAPLLTLPGARAMPTSIRATAQVFEDPRSLALLERIRLVAPSDANVLILGETGTGKEL
IARHVHALSARRSGPFVAVNCGALSETLVESELFGHEKGAFTGAFTAKAGWFEAAHGGTLFLDEVGDLPLSIQVKLLRVL
QEREVVRLGARRSLPVDVRVVAATNVRLQDAVAAGNFRQDLFYRLHVVNLALPTLRERPGDILPLARHFIDEYRHRLGYG
PVRLDAGAERKLLAHDWPGNIRELENVIHHGLLVCRRGVLLAEDLQLSSLGLRRRSGSDAPADATPLQALETALSGLFQQ
QGDQLYERIEETVVRAAFEFCHRNQVQAARLLGISRNVLRARLIRHGDITALR
>Mature_372_residues
PPVHFLKAFPEDGDAPARHRYAAPLLTLPGARAMPTSIRATAQVFEDPRSLALLERIRLVAPSDANVLILGETGTGKELI
ARHVHALSARRSGPFVAVNCGALSETLVESELFGHEKGAFTGAFTAKAGWFEAAHGGTLFLDEVGDLPLSIQVKLLRVLQ
EREVVRLGARRSLPVDVRVVAATNVRLQDAVAAGNFRQDLFYRLHVVNLALPTLRERPGDILPLARHFIDEYRHRLGYGP
VRLDAGAERKLLAHDWPGNIRELENVIHHGLLVCRRGVLLAEDLQLSSLGLRRRSGSDAPADATPLQALETALSGLFQQQ
GDQLYERIEETVVRAAFEFCHRNQVQAARLLGISRNVLRARLIRHGDITALR

Specific function: Activation of sigma-54-dependent flagellar gene promoters and strong negative autoregulatory effects on its own promoter. The synthesis and function of flbD in C.crescentus is controlled by an internal cell-cycle clock [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI87082117, Length=234, Percent_Identity=55.5555555555556, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1788550, Length=336, Percent_Identity=42.2619047619048, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1790437, Length=326, Percent_Identity=45.398773006135, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788905, Length=327, Percent_Identity=42.8134556574924, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI87082152, Length=331, Percent_Identity=42.5981873111783, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789087, Length=322, Percent_Identity=46.2732919254658, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1789233, Length=325, Percent_Identity=39.6923076923077, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1786524, Length=283, Percent_Identity=48.4098939929329, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1790299, Length=308, Percent_Identity=42.2077922077922, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=43.167701863354, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=34.7962382445141, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=31.4641744548287, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789828, Length=227, Percent_Identity=38.3259911894273, Blast_Score=138, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 41104; Mature: 40973

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVHFLKAFPEDGDAPARHRYAAPLLTLPGARAMPTSIRATAQVFEDPRSLALLERIRL
CCCHHHHHCCCCCCCCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
VAPSDANVLILGETGTGKELIARHVHALSARRSGPFVAVNCGALSETLVESELFGHEKGA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCC
FTGAFTAKAGWFEAAHGGTLFLDEVGDLPLSIQVKLLRVLQEREVVRLGARRSLPVDVRV
EEEEEECCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
VAATNVRLQDAVAAGNFRQDLFYRLHVVNLALPTLRERPGDILPLARHFIDEYRHRLGYG
EEECCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PVRLDAGAERKLLAHDWPGNIRELENVIHHGLLVCRRGVLLAEDLQLSSLGLRRRSGSDA
CEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHCCCCCC
PADATPLQALETALSGLFQQQGDQLYERIEETVVRAAFEFCHRNQVQAARLLGISRNVLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ARLIRHGDITALR
HHHHHCCCCEECC
>Mature Secondary Structure 
PPVHFLKAFPEDGDAPARHRYAAPLLTLPGARAMPTSIRATAQVFEDPRSLALLERIRL
CCHHHHHCCCCCCCCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
VAPSDANVLILGETGTGKELIARHVHALSARRSGPFVAVNCGALSETLVESELFGHEKGA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCC
FTGAFTAKAGWFEAAHGGTLFLDEVGDLPLSIQVKLLRVLQEREVVRLGARRSLPVDVRV
EEEEEECCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
VAATNVRLQDAVAAGNFRQDLFYRLHVVNLALPTLRERPGDILPLARHFIDEYRHRLGYG
EEECCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PVRLDAGAERKLLAHDWPGNIRELENVIHHGLLVCRRGVLLAEDLQLSSLGLRRRSGSDA
CEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHCCCCCC
PADATPLQALETALSGLFQQQGDQLYERIEETVVRAAFEFCHRNQVQAARLLGISRNVLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ARLIRHGDITALR
HHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2315326; 11259647 [H]