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The map label for this gene is ffh [H]

Identifier: 120609564

GI number: 120609564

Start: 943753

End: 945132

Strand: Direct

Name: ffh [H]

Synonym: Aave_0870

Alternate gene names: 120609564

Gene position: 943753-945132 (Clockwise)

Preceding gene: 120609555

Following gene: 120609574

Centisome position: 17.63

GC content: 66.74

Gene sequence:

>1380_bases
ATGGCATCCGCCCTCACCGAAAAACTCTCCCGGCTCGTCAAGGAGATGCGAGGCCAGGCCCGCATCACCGAATCCAACGT
GCAGGACATGCTGCGCGAGGTGCGCATGGCGCTGCTGGAGGCCGACGTGGCCCTGCCGGTGGTGCGCGACTTCATCGCGC
GCGTGAAGGAAAAGGCCCTGGGCCAGGAGGTGCTGGGCTCGCTCAAGCCGGGGCAGACCCTGGTCTCCATCGTGAACCGC
GAACTGGCCGCGACCATGGGCGAGGGCGTCTCGGACATCAACCTCGCCGCCCAGCCCCCGGCCGTGATCCTGATGGCGGG
CCTGCAGGGCGCCGGCAAGACGACGACCACGGCCAAGCTGGCCAAGCACCTGATCGAGAAGCGCAAGAAGAAGGTGCTCA
CCGTCTCCGGCGACGTGTACCGCCCGGCCGCCATCGAGCAGCTCAAGACGGTGACGAAGCAGGCGGGTGCCGAATGGTTT
CCCAGCACGCCCGAGCAGAAGCCCCTGGACATCGCGCGCGCCGCGATCGACCACGCCCGCCGCCACTATTTCGACGTGCT
GCTGGTCGATACGGCCGGCCGCCTCGCGATCGACGAGGCGCTCATGAACGAGATCAAGGAGCTGCACGCGGCGCTGAACC
CGGTCGAGACGCTGTTCGTGGTCGATGCCATGCAGGGCCAGGACGCGGTCAACACGGCCAAGGCCTTCAAGGAGGCGCTG
CCGCTCACCGGCATCGTGCTGACCAAGCTCGACGGCGATTCCCGCGGCGGCGCGGCCCTGTCGGTGCGGCAGGTGACGGG
CGCTCCGATCAAGTTCGCCGGTGTGTCCGAGAAGATCGACGGCCTGGAAGTGTTCGACGCCGAACGCCATGCAGGCCGCG
TGCTGGGCATGGGCGACATCGTGGCCCTGGTGGAGCAGGTGAGCGCGGGCGTCGACCTGGAGGCCGCGCAGAAGCTGGCC
GCCAAGGTCAAGAGCGGCGACGGCTTCGACCTGAACGACTTCCTCGGCCAGCTGCAGCAGATGAAGCAGATGGGCGGCAT
CTCCAGCCTCATGGACAAGCTGCCCTCCGAATTGATGGCCAAGGCCGGCCAGGTGGACATGAACAAGGCCGAGAAGGACA
TCCGCCGCAAGGAAGGCATCATCCAGAGCATGACGCCCCAGGAGCGCCGCAAGCCCGAGATCATCAAGGCCACGCGAAAG
AAGCGCATCGCGGCCGGGGCGGGCGTGCAGGTGCAGGAGGTGAACCGCCTGCTCAACGAGTTCGACCAGATGCAGGGCAT
GATGAAGAAGATGAAGGGCGGCGGCCTCATGAAGATGATGAAGAAGATGGGCGGCATGAAGGGCTTCGGCGGGGGCGGCA
TGCCCAAGCTGCCGTTCTGA

Upstream 100 bases:

>100_bases
GAGACGCTGGGTAAAATCATGGGCCCACAGTTTAGCCCGCCGCTGCCCAGGCGGCCCGGCCCGGATGCAGCGTCCGGCCC
GCCCAACCGGAATACGTCCC

Downstream 100 bases:

>100_bases
TCCTTTACCCGCCGTCTTTCTTCTTCACTTTCGATCCAGGCCCTGCCCCGCAGGGCCTTTTCTTTGGGTGCAGCCCTGCC
GGCCGCCCATGAAAAAAGCC

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MASALTEKLSRLVKEMRGQARITESNVQDMLREVRMALLEADVALPVVRDFIARVKEKALGQEVLGSLKPGQTLVSIVNR
ELAATMGEGVSDINLAAQPPAVILMAGLQGAGKTTTTAKLAKHLIEKRKKKVLTVSGDVYRPAAIEQLKTVTKQAGAEWF
PSTPEQKPLDIARAAIDHARRHYFDVLLVDTAGRLAIDEALMNEIKELHAALNPVETLFVVDAMQGQDAVNTAKAFKEAL
PLTGIVLTKLDGDSRGGAALSVRQVTGAPIKFAGVSEKIDGLEVFDAERHAGRVLGMGDIVALVEQVSAGVDLEAAQKLA
AKVKSGDGFDLNDFLGQLQQMKQMGGISSLMDKLPSELMAKAGQVDMNKAEKDIRRKEGIIQSMTPQERRKPEIIKATRK
KRIAAGAGVQVQEVNRLLNEFDQMQGMMKKMKGGGLMKMMKKMGGMKGFGGGGMPKLPF

Sequences:

>Translated_459_residues
MASALTEKLSRLVKEMRGQARITESNVQDMLREVRMALLEADVALPVVRDFIARVKEKALGQEVLGSLKPGQTLVSIVNR
ELAATMGEGVSDINLAAQPPAVILMAGLQGAGKTTTTAKLAKHLIEKRKKKVLTVSGDVYRPAAIEQLKTVTKQAGAEWF
PSTPEQKPLDIARAAIDHARRHYFDVLLVDTAGRLAIDEALMNEIKELHAALNPVETLFVVDAMQGQDAVNTAKAFKEAL
PLTGIVLTKLDGDSRGGAALSVRQVTGAPIKFAGVSEKIDGLEVFDAERHAGRVLGMGDIVALVEQVSAGVDLEAAQKLA
AKVKSGDGFDLNDFLGQLQQMKQMGGISSLMDKLPSELMAKAGQVDMNKAEKDIRRKEGIIQSMTPQERRKPEIIKATRK
KRIAAGAGVQVQEVNRLLNEFDQMQGMMKKMKGGGLMKMMKKMGGMKGFGGGGMPKLPF
>Mature_458_residues
ASALTEKLSRLVKEMRGQARITESNVQDMLREVRMALLEADVALPVVRDFIARVKEKALGQEVLGSLKPGQTLVSIVNRE
LAATMGEGVSDINLAAQPPAVILMAGLQGAGKTTTTAKLAKHLIEKRKKKVLTVSGDVYRPAAIEQLKTVTKQAGAEWFP
STPEQKPLDIARAAIDHARRHYFDVLLVDTAGRLAIDEALMNEIKELHAALNPVETLFVVDAMQGQDAVNTAKAFKEALP
LTGIVLTKLDGDSRGGAALSVRQVTGAPIKFAGVSEKIDGLEVFDAERHAGRVLGMGDIVALVEQVSAGVDLEAAQKLAA
KVKSGDGFDLNDFLGQLQQMKQMGGISSLMDKLPSELMAKAGQVDMNKAEKDIRRKEGIIQSMTPQERRKPEIIKATRKK
RIAAGAGVQVQEVNRLLNEFDQMQGMMKKMKGGGLMKMMKKMGGMKGFGGGGMPKLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=463, Percent_Identity=31.9654427645788, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI226371618, Length=406, Percent_Identity=32.0197044334975, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.1515151515151, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI23308697, Length=309, Percent_Identity=29.126213592233, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI295424842, Length=309, Percent_Identity=29.126213592233, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788963, Length=457, Percent_Identity=63.6761487964989, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1789874, Length=257, Percent_Identity=36.1867704280156, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=418, Percent_Identity=30.622009569378, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193206261, Length=201, Percent_Identity=38.8059701492537, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=466, Percent_Identity=31.7596566523605, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17647949, Length=443, Percent_Identity=32.9571106094808, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24641198, Length=202, Percent_Identity=34.6534653465347, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49527; Mature: 49396

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASALTEKLSRLVKEMRGQARITESNVQDMLREVRMALLEADVALPVVRDFIARVKEKAL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLGSLKPGQTLVSIVNRELAATMGEGVSDINLAAQPPAVILMAGLQGAGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AKHLIEKRKKKVLTVSGDVYRPAAIEQLKTVTKQAGAEWFPSTPEQKPLDIARAAIDHAR
HHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RHYFDVLLVDTAGRLAIDEALMNEIKELHAALNPVETLFVVDAMQGQDAVNTAKAFKEAL
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGIVLTKLDGDSRGGAALSVRQVTGAPIKFAGVSEKIDGLEVFDAERHAGRVLGMGDI
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCCCCCCHHCCCHHHCCCCCCHHHH
VALVEQVSAGVDLEAAQKLAAKVKSGDGFDLNDFLGQLQQMKQMGGISSLMDKLPSELMA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KAGQVDMNKAEKDIRRKEGIIQSMTPQERRKPEIIKATRKKRIAAGAGVQVQEVNRLLNE
HCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FDQMQGMMKKMKGGGLMKMMKKMGGMKGFGGGGMPKLPF
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASALTEKLSRLVKEMRGQARITESNVQDMLREVRMALLEADVALPVVRDFIARVKEKAL
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLGSLKPGQTLVSIVNRELAATMGEGVSDINLAAQPPAVILMAGLQGAGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AKHLIEKRKKKVLTVSGDVYRPAAIEQLKTVTKQAGAEWFPSTPEQKPLDIARAAIDHAR
HHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RHYFDVLLVDTAGRLAIDEALMNEIKELHAALNPVETLFVVDAMQGQDAVNTAKAFKEAL
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGIVLTKLDGDSRGGAALSVRQVTGAPIKFAGVSEKIDGLEVFDAERHAGRVLGMGDI
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCCCCCCHHCCCHHHCCCCCCHHHH
VALVEQVSAGVDLEAAQKLAAKVKSGDGFDLNDFLGQLQQMKQMGGISSLMDKLPSELMA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KAGQVDMNKAEKDIRRKEGIIQSMTPQERRKPEIIKATRKKRIAAGAGVQVQEVNRLLNE
HCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FDQMQGMMKKMKGGGLMKMMKKMGGMKGFGGGGMPKLPF
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]