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The map label for this gene is mrdB [H]

Identifier: 120609540

GI number: 120609540

Start: 917304

End: 918464

Strand: Direct

Name: mrdB [H]

Synonym: Aave_0846

Alternate gene names: 120609540

Gene position: 917304-918464 (Clockwise)

Preceding gene: 120609538

Following gene: 120609544

Centisome position: 17.14

GC content: 68.3

Gene sequence:

>1161_bases
ATGTCCGCCGTTTTCGACAAGCCTTCCCTGCCGCAGCGCATCCTGCCCCTGTTCCGCGGCTTCGACTGGCCGCTCATCGC
GGTGCTGCTGCTGCTGTCGTCGATCGGCCTGGTGGCGATGTACTCCTCGGGCTACGACCACGGCACCCGGTTCTACGACC
ACGGCCGCAACATGCTGCTGGCCGCGGGCATCCTGTTCGCCGTCGCGCAGATCCCGCCGCAGCGGCTCATGATGCTGGCG
GTGCCGCTCTACACCGCCGGCGTGGCGCTGCTGGTGGCGGTGGCGCTCTTCGGCATCATCAAGAAGGGCGCGCAGCGCTG
GATCAACGTGGGCATCGTGATCCAGCCGAGCGAGATCCTCAAGATCGCGATGCCGCTCATGCTGGCCTGGTGGTTCCAGA
AGCGCGAAGGGCAGTTGCGCCCGCTGGACTTCGTGGTGGCCGGCGTGCTGCTCGCCGTGCCCGTGGGCCTCATCATGAAG
CAGCCCGACCTGGGCACCTCGCTGCTGGTGCTCGCGGCCGGGCTGTCGGTGATCTTCTTCGCCGGATTGCCCTGGAAGCT
CGTGCTGCCCCCGGTGATCCTGGGCGGCATCGGCATCGCGCTCATCGTGTGGTTCGAGCCGCAGCTCTGCGCGGACGGCG
TGCGCTGGCCGGTGCTGCACGACTACCAGCAGCAGCGCATCTGCACGCTGCTCGACCCCACGCGCGACCCGCTGGGCAAG
GGGTTCCACATCATCCAGGGCATGATCGCCATCGGCTCGGGCGGTGTCTGGGGCAAGGGCTTCATGGCCGGCACGCAGAC
CCACCTGGAATTCATCCCCGAGCGCACCACCGACTTCATCTTCGCGGCCTATTCCGAGGAGTTCGGCCTGGTGGGCAACC
TGTTCCTGATCGTCAGCCTGCTGCTGCTCGTCTGGCGCGGGCTGGCGATCGCGCTGGGCGCGACGACGCTGTTCTCGCGC
CTCATGGCCGGTGCCGTGTCGATGATCTTCTTCACCTACGCCTTCGTGAACATGGGCATGGTGAGCGGCATCCTGCCCGT
GGTGGGCGTGCCGCTGCCCTTCGTGAGCTACGGCGGCACCGCGATGGTCACGCTGGGGCTGGCGCTGGGGGTGCTGATGT
CCATCGCCCGCGCGCAGCGGCAGCCGCTGGCCCCGGCCTGA

Upstream 100 bases:

>100_bases
GAGCGGTGGCGAAGTGCGTGGGACGGGCGGGAGGCGTCGTGGGTGGACCGGCATTGTGCCGGGGGCCGGCCCGGCGGGGC
GGCGCCGATAATGGCGCCCC

Downstream 100 bases:

>100_bases
GGCCGGCAGCCCGTTCTTAGAGCGGCTAACACCACCGATCCACGAAGCGCGCGCAGATGATCGCTGCAGCCAGTTTCAAC
AGCGCTTCGTGGATGTCCAG

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSAVFDKPSLPQRILPLFRGFDWPLIAVLLLLSSIGLVAMYSSGYDHGTRFYDHGRNMLLAAGILFAVAQIPPQRLMMLA
VPLYTAGVALLVAVALFGIIKKGAQRWINVGIVIQPSEILKIAMPLMLAWWFQKREGQLRPLDFVVAGVLLAVPVGLIMK
QPDLGTSLLVLAAGLSVIFFAGLPWKLVLPPVILGGIGIALIVWFEPQLCADGVRWPVLHDYQQQRICTLLDPTRDPLGK
GFHIIQGMIAIGSGGVWGKGFMAGTQTHLEFIPERTTDFIFAAYSEEFGLVGNLFLIVSLLLLVWRGLAIALGATTLFSR
LMAGAVSMIFFTYAFVNMGMVSGILPVVGVPLPFVSYGGTAMVTLGLALGVLMSIARAQRQPLAPA

Sequences:

>Translated_386_residues
MSAVFDKPSLPQRILPLFRGFDWPLIAVLLLLSSIGLVAMYSSGYDHGTRFYDHGRNMLLAAGILFAVAQIPPQRLMMLA
VPLYTAGVALLVAVALFGIIKKGAQRWINVGIVIQPSEILKIAMPLMLAWWFQKREGQLRPLDFVVAGVLLAVPVGLIMK
QPDLGTSLLVLAAGLSVIFFAGLPWKLVLPPVILGGIGIALIVWFEPQLCADGVRWPVLHDYQQQRICTLLDPTRDPLGK
GFHIIQGMIAIGSGGVWGKGFMAGTQTHLEFIPERTTDFIFAAYSEEFGLVGNLFLIVSLLLLVWRGLAIALGATTLFSR
LMAGAVSMIFFTYAFVNMGMVSGILPVVGVPLPFVSYGGTAMVTLGLALGVLMSIARAQRQPLAPA
>Mature_385_residues
SAVFDKPSLPQRILPLFRGFDWPLIAVLLLLSSIGLVAMYSSGYDHGTRFYDHGRNMLLAAGILFAVAQIPPQRLMMLAV
PLYTAGVALLVAVALFGIIKKGAQRWINVGIVIQPSEILKIAMPLMLAWWFQKREGQLRPLDFVVAGVLLAVPVGLIMKQ
PDLGTSLLVLAAGLSVIFFAGLPWKLVLPPVILGGIGIALIVWFEPQLCADGVRWPVLHDYQQQRICTLLDPTRDPLGKG
FHIIQGMIAIGSGGVWGKGFMAGTQTHLEFIPERTTDFIFAAYSEEFGLVGNLFLIVSLLLLVWRGLAIALGATTLFSRL
MAGAVSMIFFTYAFVNMGMVSGILPVVGVPLPFVSYGGTAMVTLGLALGVLMSIARAQRQPLAPA

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=346, Percent_Identity=49.1329479768786, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1786277, Length=385, Percent_Identity=27.7922077922078, Blast_Score=141, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41723; Mature: 41592

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVFDKPSLPQRILPLFRGFDWPLIAVLLLLSSIGLVAMYSSGYDHGTRFYDHGRNMLL
CCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
AAGILFAVAQIPPQRLMMLAVPLYTAGVALLVAVALFGIIKKGAQRWINVGIVIQPSEIL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEECHHHHH
KIAMPLMLAWWFQKREGQLRPLDFVVAGVLLAVPVGLIMKQPDLGTSLLVLAAGLSVIFF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGLPWKLVLPPVILGGIGIALIVWFEPQLCADGVRWPVLHDYQQQRICTLLDPTRDPLGK
CCCCHHHHHHHHHHHHHHHHHHEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFHIIQGMIAIGSGGVWGKGFMAGTQTHLEFIPERTTDFIFAAYSEEFGLVGNLFLIVSL
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHHHH
LLLVWRGLAIALGATTLFSRLMAGAVSMIFFTYAFVNMGMVSGILPVVGVPLPFVSYGGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCH
AMVTLGLALGVLMSIARAQRQPLAPA
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAVFDKPSLPQRILPLFRGFDWPLIAVLLLLSSIGLVAMYSSGYDHGTRFYDHGRNMLL
CCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
AAGILFAVAQIPPQRLMMLAVPLYTAGVALLVAVALFGIIKKGAQRWINVGIVIQPSEIL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEECHHHHH
KIAMPLMLAWWFQKREGQLRPLDFVVAGVLLAVPVGLIMKQPDLGTSLLVLAAGLSVIFF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGLPWKLVLPPVILGGIGIALIVWFEPQLCADGVRWPVLHDYQQQRICTLLDPTRDPLGK
CCCCHHHHHHHHHHHHHHHHHHEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GFHIIQGMIAIGSGGVWGKGFMAGTQTHLEFIPERTTDFIFAAYSEEFGLVGNLFLIVSL
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHHHH
LLLVWRGLAIALGATTLFSRLMAGAVSMIFFTYAFVNMGMVSGILPVVGVPLPFVSYGGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCH
AMVTLGLALGVLMSIARAQRQPLAPA
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]