Click here to switch to the map view.

The map label for this gene is penA [H]

Identifier: 120609509

GI number: 120609509

Start: 880043

End: 881788

Strand: Direct

Name: penA [H]

Synonym: Aave_0815

Alternate gene names: 120609509

Gene position: 880043-881788 (Clockwise)

Preceding gene: 120609508

Following gene: 120609510

Centisome position: 16.44

GC content: 67.81

Gene sequence:

>1746_bases
ATGAGCCGCAGCGTCCTCTACACCTCCAGCCCGCTGCTCGCGAGCAAGACGCCCGTCTGGCGCAGCAAGTTCATCGTCGC
CATGGTGGCGCTGGGCTTCCTCGCGCTGGCCGGGCGCGCGGCGTACGTGCAGGTGTTCGGCAACGACTTCTTCCAGCGGC
AGGGCGAAGTGCGCTTCGCGCGCACGCTGGAGCTGCCCGCCAACCGCGGCCGCATCCTGGACCGCAACGGGCTCATCCTG
GCCTCCAGCGTGCCGGCCGCCAGCATCTGGGCCATTCCGGAAGACGTGGAGCAGGACAAGCCCGAGGTGCAGGCCAAGCT
GCCCCAGTTGGCCAAACTGCTGGAGATGCCGCTGCCGGCCCTGAAGGCGAAGCTGGCCGACGAGGACAAGACCTTCGTCT
GGATCAAGCGCCAGCTCGACTGGGAGGTGGGCCAGAAGATCGCCGCCCTCGACATCAAGGGCATCTACCAGCGCAAGGAA
TACAAGCGCCAGTACCCCGAGGGCGAAGCCGCCGCTCACGTGGTGGGCTTCACCAACGTGGAAGACCACGGCCAGGAGGG
CGTGGAACTCGCCTTCGACAAGGACCTGGCGGGCAAGCCCGGGTCGCGCCGCGTCATCAAGGACCGCATGGGTCGTGTCG
TGGAGGGCGTGGGCGCCGAAGTGCCGCCCGTGGACGGCAAGGACATGCAGCTGTCGATCGACAGCAAGGTGCAGTTCTTC
GCCTACCAGAAGCTGCGCGACCAGGTGGCGCTGCACAAGGCCAAGGCGGGCAGCGTGGTCGTGATCGATGCGCACACGGG
CGAGCTGCTGGCGCTGGCCAACTACCCGAGCTACGTGCCCGACAAGCGGCAGAACCTGACCGGTGAGCAGTTGCGCAACC
GCGCGATCACCGACGTGTTCGAGCCCGGCTCGACCATGAAGCCCTTCACCATCGGCCTCGCGCTCGAGACCGGCCGCGTG
CGGCCCGACACCATCATCGACACCAATCCCGGACGCGTCACGATCACGGGCTCCACCATCTCCGACACGAGCAACCACGG
CGTGCTCACGGTGGAGGGCGTGATCCAGAAGTCCAGCAACGTGGGCACGACCAAGATCGCCATGCAGATGCCCGCCAAGG
AGATGTGGGAGACCTTCTCCGCCGCGGGTTTCGGCCAGAAGCCGCAGATCCACTTTCCCGGCGTGGTGACGGGGCGCCTG
CGCCCCTACAAGACCTGGCGCCCGGTGGAGCAGGCCACCATGTCCTACGGCTACGGCCTCTCGGCCAGCCTGCTGCAGAT
GGCGCGCTCCTATACCGTGTTCGCCAACGACGGCAAGATCATTCCCGCCACCATGCTCAAGACCCACGAGCCCGCGGTGG
GCGTGCCGGTGTTCTCCCCGCGCACGGCCGCGCAGATCCGCAAGATGCTGCAGATGGCCGCGGGCCCCGGGGGCACGGGC
CAGCAGGCGCAGACCGTGGGCTACTCCGTGGGCGGCAAGTCGGGCACGGCGCGCAAGCAGATCGGCAAGACCTACGCCTC
CGGCAAGTACCGTGCATGGTTCACGGGCCTCGCGCCCATCGAGAAGCCGCGCATCATCGTCGCGGTGATGATCGACGAGC
CCAGCAACGGCGTGTTCTACGGCGGGGCCGTGGCCGCGCCGGTGTTCAGTGAGGTCGTGCAGCAGACGCTGCGCATGATG
GGCGTGCCGCCGGACATGGCCGTCAAGCCCCGGATCGTCTCCAACGGCGTGGAGGAGTCGCTATGA

Upstream 100 bases:

>100_bases
CCACGCCCGCGATCACCCAGTACGTGACGGACGACGGCACGCCCGTGCCGACCCCCACCGCGCCGGCCTCCGCCGCCACG
GCGCCCGCGGGAGTTCGCCG

Downstream 100 bases:

>100_bases
CCGAGCCCCAATCCCCATCAGGGCATCCCACGCCCCCGCTGCTCGGCTCCGTGCCGGAGGCGCTGGAGTGGCTGCGCGCC
CATGCCCCGCAGGGTGCGCT

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MSRSVLYTSSPLLASKTPVWRSKFIVAMVALGFLALAGRAAYVQVFGNDFFQRQGEVRFARTLELPANRGRILDRNGLIL
ASSVPAASIWAIPEDVEQDKPEVQAKLPQLAKLLEMPLPALKAKLADEDKTFVWIKRQLDWEVGQKIAALDIKGIYQRKE
YKRQYPEGEAAAHVVGFTNVEDHGQEGVELAFDKDLAGKPGSRRVIKDRMGRVVEGVGAEVPPVDGKDMQLSIDSKVQFF
AYQKLRDQVALHKAKAGSVVVIDAHTGELLALANYPSYVPDKRQNLTGEQLRNRAITDVFEPGSTMKPFTIGLALETGRV
RPDTIIDTNPGRVTITGSTISDTSNHGVLTVEGVIQKSSNVGTTKIAMQMPAKEMWETFSAAGFGQKPQIHFPGVVTGRL
RPYKTWRPVEQATMSYGYGLSASLLQMARSYTVFANDGKIIPATMLKTHEPAVGVPVFSPRTAAQIRKMLQMAAGPGGTG
QQAQTVGYSVGGKSGTARKQIGKTYASGKYRAWFTGLAPIEKPRIIVAVMIDEPSNGVFYGGAVAAPVFSEVVQQTLRMM
GVPPDMAVKPRIVSNGVEESL

Sequences:

>Translated_581_residues
MSRSVLYTSSPLLASKTPVWRSKFIVAMVALGFLALAGRAAYVQVFGNDFFQRQGEVRFARTLELPANRGRILDRNGLIL
ASSVPAASIWAIPEDVEQDKPEVQAKLPQLAKLLEMPLPALKAKLADEDKTFVWIKRQLDWEVGQKIAALDIKGIYQRKE
YKRQYPEGEAAAHVVGFTNVEDHGQEGVELAFDKDLAGKPGSRRVIKDRMGRVVEGVGAEVPPVDGKDMQLSIDSKVQFF
AYQKLRDQVALHKAKAGSVVVIDAHTGELLALANYPSYVPDKRQNLTGEQLRNRAITDVFEPGSTMKPFTIGLALETGRV
RPDTIIDTNPGRVTITGSTISDTSNHGVLTVEGVIQKSSNVGTTKIAMQMPAKEMWETFSAAGFGQKPQIHFPGVVTGRL
RPYKTWRPVEQATMSYGYGLSASLLQMARSYTVFANDGKIIPATMLKTHEPAVGVPVFSPRTAAQIRKMLQMAAGPGGTG
QQAQTVGYSVGGKSGTARKQIGKTYASGKYRAWFTGLAPIEKPRIIVAVMIDEPSNGVFYGGAVAAPVFSEVVQQTLRMM
GVPPDMAVKPRIVSNGVEESL
>Mature_580_residues
SRSVLYTSSPLLASKTPVWRSKFIVAMVALGFLALAGRAAYVQVFGNDFFQRQGEVRFARTLELPANRGRILDRNGLILA
SSVPAASIWAIPEDVEQDKPEVQAKLPQLAKLLEMPLPALKAKLADEDKTFVWIKRQLDWEVGQKIAALDIKGIYQRKEY
KRQYPEGEAAAHVVGFTNVEDHGQEGVELAFDKDLAGKPGSRRVIKDRMGRVVEGVGAEVPPVDGKDMQLSIDSKVQFFA
YQKLRDQVALHKAKAGSVVVIDAHTGELLALANYPSYVPDKRQNLTGEQLRNRAITDVFEPGSTMKPFTIGLALETGRVR
PDTIIDTNPGRVTITGSTISDTSNHGVLTVEGVIQKSSNVGTTKIAMQMPAKEMWETFSAAGFGQKPQIHFPGVVTGRLR
PYKTWRPVEQATMSYGYGLSASLLQMARSYTVFANDGKIIPATMLKTHEPAVGVPVFSPRTAAQIRKMLQMAAGPGGTGQ
QAQTVGYSVGGKSGTARKQIGKTYASGKYRAWFTGLAPIEKPRIIVAVMIDEPSNGVFYGGAVAAPVFSEVVQQTLRMMG
VPPDMAVKPRIVSNGVEESL

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=548, Percent_Identity=39.4160583941606, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1786854, Length=587, Percent_Identity=26.2350936967632, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63229; Mature: 63097

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVLYTSSPLLASKTPVWRSKFIVAMVALGFLALAGRAAYVQVFGNDFFQRQGEVRFA
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCEEEE
RTLELPANRGRILDRNGLILASSVPAASIWAIPEDVEQDKPEVQAKLPQLAKLLEMPLPA
EEEECCCCCCEEEECCCEEEEECCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHCCCHH
LKAKLADEDKTFVWIKRQLDWEVGQKIAALDIKGIYQRKEYKRQYPEGEAAAHVVGFTNV
HHHHHCCCCCEEEEEEEECCHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCC
EDHGQEGVELAFDKDLAGKPGSRRVIKDRMGRVVEGVGAEVPPVDGKDMQLSIDSKVQFF
HHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
AYQKLRDQVALHKAKAGSVVVIDAHTGELLALANYPSYVPDKRQNLTGEQLRNRAITDVF
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHC
EPGSTMKPFTIGLALETGRVRPDTIIDTNPGRVTITGSTISDTSNHGVLTVEGVIQKSSN
CCCCCCCCEEEEEEEECCCCCCCCEEECCCCEEEEECCEECCCCCCCEEEEEEEEECCCC
VGTTKIAMQMPAKEMWETFSAAGFGQKPQIHFPGVVTGRLRPYKTWRPVEQATMSYGYGL
CCCEEEEEECCHHHHHHHHHHCCCCCCCCEECCCEEECCCCCCCCCCCHHHHHHHCCCCC
SASLLQMARSYTVFANDGKIIPATMLKTHEPAVGVPVFSPRTAAQIRKMLQMAAGPGGTG
HHHHHHHHHCEEEEECCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
QQAQTVGYSVGGKSGTARKQIGKTYASGKYRAWFTGLAPIEKPRIIVAVMIDEPSNGVFY
CCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCEEE
GGAVAAPVFSEVVQQTLRMMGVPPDMAVKPRIVSNGVEESL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHCC
>Mature Secondary Structure 
SRSVLYTSSPLLASKTPVWRSKFIVAMVALGFLALAGRAAYVQVFGNDFFQRQGEVRFA
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCEEEE
RTLELPANRGRILDRNGLILASSVPAASIWAIPEDVEQDKPEVQAKLPQLAKLLEMPLPA
EEEECCCCCCEEEECCCEEEEECCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHCCCHH
LKAKLADEDKTFVWIKRQLDWEVGQKIAALDIKGIYQRKEYKRQYPEGEAAAHVVGFTNV
HHHHHCCCCCEEEEEEEECCHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCC
EDHGQEGVELAFDKDLAGKPGSRRVIKDRMGRVVEGVGAEVPPVDGKDMQLSIDSKVQFF
HHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
AYQKLRDQVALHKAKAGSVVVIDAHTGELLALANYPSYVPDKRQNLTGEQLRNRAITDVF
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHC
EPGSTMKPFTIGLALETGRVRPDTIIDTNPGRVTITGSTISDTSNHGVLTVEGVIQKSSN
CCCCCCCCEEEEEEEECCCCCCCCEEECCCCEEEEECCEECCCCCCCEEEEEEEEECCCC
VGTTKIAMQMPAKEMWETFSAAGFGQKPQIHFPGVVTGRLRPYKTWRPVEQATMSYGYGL
CCCEEEEEECCHHHHHHHHHHCCCCCCCCEECCCEEECCCCCCCCCCCHHHHHHHCCCCC
SASLLQMARSYTVFANDGKIIPATMLKTHEPAVGVPVFSPRTAAQIRKMLQMAAGPGGTG
HHHHHHHHHCEEEEECCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
QQAQTVGYSVGGKSGTARKQIGKTYASGKYRAWFTGLAPIEKPRIIVAVMIDEPSNGVFY
CCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCEEE
GGAVAAPVFSEVVQQTLRMMGVPPDMAVKPRIVSNGVEESL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]