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The map label for this gene is yegD [H]

Identifier: 120609328

GI number: 120609328

Start: 678729

End: 679979

Strand: Direct

Name: yegD [H]

Synonym: Aave_0628

Alternate gene names: 120609328

Gene position: 678729-679979 (Clockwise)

Preceding gene: 120609327

Following gene: 120609330

Centisome position: 12.68

GC content: 69.94

Gene sequence:

>1251_bases
ATGCGCCCGCTGACCCTTGGCATCGACTTCGGCACTTCCAATTCCGCGATGGCGGTCCGGCGCGACGGGGAAACGGCGCA
GATGGTGCCCGTGGAGCAGTCGTTCCACACGCTGCCGACGGCGATGTTCTTCAATACCGAAGAATCCCGGACGCACGTGG
GCCGGGATGCGATCGCCCAGTACCTGGCGGGTACCGAGGGGCGGCTGATGCGTTCGCTCAAGAGCCTGCTGGGCAGCGCG
CTGCTGGAAGAGAAGACGGCGGTGCAGGGAACGCTGATGAGCTACCAGGACATCATCGCGCTCTTCCTGCGCACGATGGC
GCAGCGCGCGCAGGCCGTCGTGGGCGATGTGCCCGCGCACGTCGTGCTGGGGCGTCCGGTGCATTTCGTGGATGGGGATC
CGGCGCGGGATGCGCTGGCGGAGGGGGCGCTGCGGCGGGCGGCGGAAATGGCCGGCTTCGCGGACATTTCCTTCCAGCTC
GAACCCATCGCGGCGGCGCTCGACTACGAGCAGCGCGTGGACCGGGAAACGCGCGTACTGGTGGTGGACATCGGTGGGGG
GACATCCGACTTCACGGTGGTCCTGCTCGGGCCGGAGCGCTCTCGCCGCGCCGACCGCAGCGGCGACGTGCTCGCCACCG
CTGGCGTGCACCTGGGCGGCACGGACTTCGACCAGCGTCTCAGCCGCTCGCACGTGATGCCCCTGCTCGGCCTCGGGCAC
CACGGCCCATCGGGGCGGGAAGTGCCCAGCCGCATCTTCTTCGACCTTTCGACATGGCACCTGATCCAGTGGCTCTACAG
CCCCAAGGCCCTCGCGGAAGCGAAGGGGCTGCGGTCGGACTATCGTGACGCCCGCCTGCATGACCGGCTGATGGTGGTGC
TGTCGGAGCGGTGGGGGCATCGCCTCGCACAGGCGGTGGAGCAGGCGAAGATCGATGTATCGAGCACCGGGGCGCCGGCA
GCGCTGCCGCTCGGATGGCTGGAGCGGGATCTCGAGGCGACCGTTACCCCGGTTTCGATGGCGGGCACGCTGCAGCAGCC
ATTGCAGGAGGTGGTGCGGTGTGCCGCGGAATGCCTCGTCGCGGCCGACCTCGGAGCCCGGGGCGTGGACGCGCTCTACC
TCACGGGCGGTTCCTCGGCCCTCAAGCCCTTGCGCGAAGCGCTGGCCGTGGCGTTTCCCGGCGTGCCCCAGGTCGAGGGG
GACCTGTTCGGCGGCGTGGCCTCCGGGCTGGCGTACACCGTCCGCGCCTGA

Upstream 100 bases:

>100_bases
CTTCCCGCTGGCTCTGCTGGCCTTCCGGCTGGCGTTCTGTCCGGGCACGGCCCCCGCGAACCGGAGCCTGCCCCTGTTCC
CACCCTGCTTTTCGTATCCC

Downstream 100 bases:

>100_bases
GGCGGGGGCTGGCGCGTGGCCCCCTGCCGGCCCCACGCAGCTGCTGTCTCCGCCCAGGCCTGCCGTCCGGTGGGCGCTGG
AGGTCTCAGCTGTCCTCGGC

Product: molecular chaperone, HSP70 class

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRPLTLGIDFGTSNSAMAVRRDGETAQMVPVEQSFHTLPTAMFFNTEESRTHVGRDAIAQYLAGTEGRLMRSLKSLLGSA
LLEEKTAVQGTLMSYQDIIALFLRTMAQRAQAVVGDVPAHVVLGRPVHFVDGDPARDALAEGALRRAAEMAGFADISFQL
EPIAAALDYEQRVDRETRVLVVDIGGGTSDFTVVLLGPERSRRADRSGDVLATAGVHLGGTDFDQRLSRSHVMPLLGLGH
HGPSGREVPSRIFFDLSTWHLIQWLYSPKALAEAKGLRSDYRDARLHDRLMVVLSERWGHRLAQAVEQAKIDVSSTGAPA
ALPLGWLERDLEATVTPVSMAGTLQQPLQEVVRCAAECLVAADLGARGVDALYLTGGSSALKPLREALAVAFPGVPQVEG
DLFGGVASGLAYTVRA

Sequences:

>Translated_416_residues
MRPLTLGIDFGTSNSAMAVRRDGETAQMVPVEQSFHTLPTAMFFNTEESRTHVGRDAIAQYLAGTEGRLMRSLKSLLGSA
LLEEKTAVQGTLMSYQDIIALFLRTMAQRAQAVVGDVPAHVVLGRPVHFVDGDPARDALAEGALRRAAEMAGFADISFQL
EPIAAALDYEQRVDRETRVLVVDIGGGTSDFTVVLLGPERSRRADRSGDVLATAGVHLGGTDFDQRLSRSHVMPLLGLGH
HGPSGREVPSRIFFDLSTWHLIQWLYSPKALAEAKGLRSDYRDARLHDRLMVVLSERWGHRLAQAVEQAKIDVSSTGAPA
ALPLGWLERDLEATVTPVSMAGTLQQPLQEVVRCAAECLVAADLGARGVDALYLTGGSSALKPLREALAVAFPGVPQVEG
DLFGGVASGLAYTVRA
>Mature_416_residues
MRPLTLGIDFGTSNSAMAVRRDGETAQMVPVEQSFHTLPTAMFFNTEESRTHVGRDAIAQYLAGTEGRLMRSLKSLLGSA
LLEEKTAVQGTLMSYQDIIALFLRTMAQRAQAVVGDVPAHVVLGRPVHFVDGDPARDALAEGALRRAAEMAGFADISFQL
EPIAAALDYEQRVDRETRVLVVDIGGGTSDFTVVLLGPERSRRADRSGDVLATAGVHLGGTDFDQRLSRSHVMPLLGLGH
HGPSGREVPSRIFFDLSTWHLIQWLYSPKALAEAKGLRSDYRDARLHDRLMVVLSERWGHRLAQAVEQAKIDVSSTGAPA
ALPLGWLERDLEATVTPVSMAGTLQQPLQEVVRCAAECLVAADLGARGVDALYLTGGSSALKPLREALAVAFPGVPQVEG
DLFGGVASGLAYTVRA

Specific function: Unknown

COG id: COG0443

COG function: function code O; Molecular chaperone

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 70 family [H]

Homologues:

Organism=Homo sapiens, GI16507237, Length=417, Percent_Identity=23.5011990407674, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI34419635, Length=270, Percent_Identity=28.1481481481481, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87082035, Length=455, Percent_Identity=31.6483516483516, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786196, Length=247, Percent_Identity=28.7449392712551, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786870, Length=235, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534015, Length=246, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534013, Length=246, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507981, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17568549, Length=248, Percent_Identity=25.4032258064516, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322426, Length=421, Percent_Identity=24.2280285035629, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323401, Length=428, Percent_Identity=21.4953271028037, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647034, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24647038, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24647036, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737967, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571721, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571719, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018181
- InterPro:   IPR001023
- InterPro:   IPR013126 [H]

Pfam domain/function: PF00012 HSP70 [H]

EC number: NA

Molecular weight: Translated: 44726; Mature: 44726

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00329 HSP70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLTLGIDFGTSNSAMAVRRDGETAQMVPVEQSFHTLPTAMFFNTEESRTHVGRDAIAQ
CCCEEEEEECCCCCCEEEEEECCCCEEEEEHHHHHHHCCHHEEECCCHHHHHCCHHHHHH
YLAGTEGRLMRSLKSLLGSALLEEKTAVQGTLMSYQDIIALFLRTMAQRAQAVVGDVPAH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVLGRPVHFVDGDPARDALAEGALRRAAEMAGFADISFQLEPIAAALDYEQRVDRETRVL
EEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHCHHHHCCCCCEEE
VVDIGGGTSDFTVVLLGPERSRRADRSGDVLATAGVHLGGTDFDQRLSRSHVMPLLGLGH
EEECCCCCCCEEEEEECCCHHCCCCCCCCEEEECCEECCCCCHHHHHHHHHCCHHHCCCC
HGPSGREVPSRIFFDLSTWHLIQWLYSPKALAEAKGLRSDYRDARLHDRLMVVLSERWGH
CCCCCCCCCHHHHEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAQAVEQAKIDVSSTGAPAALPLGWLERDLEATVTPVSMAGTLQQPLQEVVRCAAECLV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AADLGARGVDALYLTGGSSALKPLREALAVAFPGVPQVEGDLFGGVASGLAYTVRA
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEECC
>Mature Secondary Structure
MRPLTLGIDFGTSNSAMAVRRDGETAQMVPVEQSFHTLPTAMFFNTEESRTHVGRDAIAQ
CCCEEEEEECCCCCCEEEEEECCCCEEEEEHHHHHHHCCHHEEECCCHHHHHCCHHHHHH
YLAGTEGRLMRSLKSLLGSALLEEKTAVQGTLMSYQDIIALFLRTMAQRAQAVVGDVPAH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVLGRPVHFVDGDPARDALAEGALRRAAEMAGFADISFQLEPIAAALDYEQRVDRETRVL
EEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHCHHHHCCCCCEEE
VVDIGGGTSDFTVVLLGPERSRRADRSGDVLATAGVHLGGTDFDQRLSRSHVMPLLGLGH
EEECCCCCCCEEEEEECCCHHCCCCCCCCEEEECCEECCCCCHHHHHHHHHCCHHHCCCC
HGPSGREVPSRIFFDLSTWHLIQWLYSPKALAEAKGLRSDYRDARLHDRLMVVLSERWGH
CCCCCCCCCHHHHEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAQAVEQAKIDVSSTGAPAALPLGWLERDLEATVTPVSMAGTLQQPLQEVVRCAAECLV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AADLGARGVDALYLTGGSSALKPLREALAVAFPGVPQVEGDLFGGVASGLAYTVRA
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7940673; 7984428 [H]