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The map label for this gene is pyrE [H]

Identifier: 120608992

GI number: 120608992

Start: 320917

End: 321636

Strand: Direct

Name: pyrE [H]

Synonym: Aave_0289

Alternate gene names: 120608992

Gene position: 320917-321636 (Clockwise)

Preceding gene: 120608990

Following gene: 120608993

Centisome position: 6.0

GC content: 67.92

Gene sequence:

>720_bases
ATGGTGGCAGACGGCGCGCGGCGGCGGACGGGAGAGGAAACGGCGGGAGACGGCGCGTCGGCGGACCGCCTCGCCCAGGA
ATTCGTGCATTTCGCCGTGGAGGCGGGCGTGCTCAGGTTCGGCGAATTCAAGACCAAGGCGGGCCGCATGAGCCCGTACT
TCTTCAATGCCGGGCTTTTCGACGATGGCGCCAAGATGGGCCGGCTCGCGGAATTCTATGCAAAAGCCCTGTTGGCCAGC
GGCATCGAATTCGACATGGTCTTCGGGCCCGCCTACAAGGGCATCCCGCTGGCCGCCACGGTGGCGGTGGAGCTGGCCCG
CCATGGCCGCAATGTCCCCTTCGCCTACAACCGCAAGGAAGCCAAGGACCACGGCGAAGGCGGCACGCTGGTCGGCGCGC
CGCTGCAGGGCCGCGTGCTCATCGTGGACGACGTGATGTCCGCCGGCACCGCCGCGCGCGAGTCCATCGCGCTCATCCGG
GCCGCCGGAGCCATTCCCCATGCGATGGCCATCGCCCTCGACCGCCAGGAAAAGGCCACCGAGAACGGCCAGGACGTGGA
CCACAGCGCCGTGCAGTACGTGCGCAGCCAGTTGGGCATGCAGGTGTGCACCATCGCCAAGCTGGCCGATTTATTGCAAT
ATCTGCAGGACCGGGGCGGCTCCGACATGGGAGCCCACCACGAGCGCGTGCTGGCCTACCGCCAGCGCTACGGCGTCTGA

Upstream 100 bases:

>100_bases
ATCCGGCCGCGTCTCGGCGATCCAGGCCTCCACGCCCTTCGAGGCGGCGGAGCGGATGCCGTTGAGGTTCAGGCTGGTCA
ATTTGAAAAGGGAAGCATCC

Downstream 100 bases:

>100_bases
ACCGCGCCCGACCTTTCTTCGCACGCTGCCGCCCCCGGACCTTTTCGGGGCGGCGGGAGAGCACGGACATCTGCACAGCA
TGGAAGCCCTTCCGGTGAAG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MVADGARRRTGEETAGDGASADRLAQEFVHFAVEAGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKMGRLAEFYAKALLAS
GIEFDMVFGPAYKGIPLAATVAVELARHGRNVPFAYNRKEAKDHGEGGTLVGAPLQGRVLIVDDVMSAGTAARESIALIR
AAGAIPHAMAIALDRQEKATENGQDVDHSAVQYVRSQLGMQVCTIAKLADLLQYLQDRGGSDMGAHHERVLAYRQRYGV

Sequences:

>Translated_239_residues
MVADGARRRTGEETAGDGASADRLAQEFVHFAVEAGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKMGRLAEFYAKALLAS
GIEFDMVFGPAYKGIPLAATVAVELARHGRNVPFAYNRKEAKDHGEGGTLVGAPLQGRVLIVDDVMSAGTAARESIALIR
AAGAIPHAMAIALDRQEKATENGQDVDHSAVQYVRSQLGMQVCTIAKLADLLQYLQDRGGSDMGAHHERVLAYRQRYGV
>Mature_239_residues
MVADGARRRTGEETAGDGASADRLAQEFVHFAVEAGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKMGRLAEFYAKALLAS
GIEFDMVFGPAYKGIPLAATVAVELARHGRNVPFAYNRKEAKDHGEGGTLVGAPLQGRVLIVDDVMSAGTAARESIALIR
AAGAIPHAMAIALDRQEKATENGQDVDHSAVQYVRSQLGMQVCTIAKLADLLQYLQDRGGSDMGAHHERVLAYRQRYGV

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=177, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790073, Length=215, Percent_Identity=52.093023255814, Blast_Score=220, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17508631, Length=158, Percent_Identity=32.2784810126582, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323530, Length=218, Percent_Identity=46.3302752293578, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323927, Length=230, Percent_Identity=41.7391304347826, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25688; Mature: 25688

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADGARRRTGEETAGDGASADRLAQEFVHFAVEAGVLRFGEFKTKAGRMSPYFFNAGLF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
DDGAKMGRLAEFYAKALLASGIEFDMVFGPAYKGIPLAATVAVELARHGRNVPFAYNRKE
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AKDHGEGGTLVGAPLQGRVLIVDDVMSAGTAARESIALIRAAGAIPHAMAIALDRQEKAT
HHCCCCCCCEECCCCCCCEEEEECHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHC
ENGQDVDHSAVQYVRSQLGMQVCTIAKLADLLQYLQDRGGSDMGAHHERVLAYRQRYGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVADGARRRTGEETAGDGASADRLAQEFVHFAVEAGVLRFGEFKTKAGRMSPYFFNAGLF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
DDGAKMGRLAEFYAKALLASGIEFDMVFGPAYKGIPLAATVAVELARHGRNVPFAYNRKE
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AKDHGEGGTLVGAPLQGRVLIVDDVMSAGTAARESIALIRAAGAIPHAMAIALDRQEKAT
HHCCCCCCCEECCCCCCCEEEEECHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHC
ENGQDVDHSAVQYVRSQLGMQVCTIAKLADLLQYLQDRGGSDMGAHHERVLAYRQRYGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA