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The map label for this gene is polC [H]

Identifier: 120608729

GI number: 120608729

Start: 16085

End: 16750

Strand: Direct

Name: polC [H]

Synonym: Aave_0016

Alternate gene names: 120608729

Gene position: 16085-16750 (Clockwise)

Preceding gene: 120608728

Following gene: 120608732

Centisome position: 0.3

GC content: 71.77

Gene sequence:

>666_bases
ATGCCGTCCCGTATCGCCGTCATCGATTTTGAAACCACCGGCATGACGCCCTCGCAGGGCGCCCGTGCCACCGAAGTGGC
CATCGTGCTCATGGAAGAGGGCCGGCCCGTGGACCGGTTCCAGAGCCTCATGAGGACCGGGGCCTGGCTGCCCCCCTTCA
TCATCCAGCTCACGGGCATCACGCCGGCCATGCTGGACACCGCGCCGCCCGCCGAGTCGGTGATGCGCGAGGCCGCCCGC
TTCGTCGGCGATGCGCCCATGGTGGCGCACAACGCTTCGTTCGACAGCCGCTTCTGGGCCGCGGAGCTGGCCCGCGCGGA
TCTGCCCGCGCCCCACGCCTTCGCCTGCACGGTGCTGCTGTCCCGCCGCCTGTATCCCGAAGCAGCGAGCCACCAGTTGG
GCCGCATCGTGGCGCACCTCGGCCTGCCGCCCGCTGCGCGCGCCCACCGGGCGCTGGCGGATGCGGAGATGGCCGCGGCA
TTGCTGGGGCGCATGCAGCACGACCTGCGCACCCGCTACGGCATCGCCGATCCCGGCCATGCGCTGCTCGCGTCGCTGCA
GCGCTGCGCACGCAAGGGAATGGACAAGCTGCTCGCACGGCATGCCATGGGCGAAGACCTGTGGCGGGACGCTGCCCACT
GCGAGCCGGCAGCCCCGCTGCCCTGA

Upstream 100 bases:

>100_bases
CGCGCCAGGGTGGCGGCGGCCCCTCCACCGGGGGCGGTGGCCGCGGGGCGGGCTGACAGCGCCGGCCTGGTCCGGAAGCG
GGAAGGGCGACAATCGCCCC

Downstream 100 bases:

>100_bases
AAGCCCGAGCCAGCTCCCGCACGGCACCGTCCAGTCAGAACACCGCCCTGGCCGCGGCGGGCGCGAGGGCATCGGCCAGA
TCGCGTGCCAGGGGCCCGAC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPSRIAVIDFETTGMTPSQGARATEVAIVLMEEGRPVDRFQSLMRTGAWLPPFIIQLTGITPAMLDTAPPAESVMREAAR
FVGDAPMVAHNASFDSRFWAAELARADLPAPHAFACTVLLSRRLYPEAASHQLGRIVAHLGLPPAARAHRALADAEMAAA
LLGRMQHDLRTRYGIADPGHALLASLQRCARKGMDKLLARHAMGEDLWRDAAHCEPAAPLP

Sequences:

>Translated_221_residues
MPSRIAVIDFETTGMTPSQGARATEVAIVLMEEGRPVDRFQSLMRTGAWLPPFIIQLTGITPAMLDTAPPAESVMREAAR
FVGDAPMVAHNASFDSRFWAAELARADLPAPHAFACTVLLSRRLYPEAASHQLGRIVAHLGLPPAARAHRALADAEMAAA
LLGRMQHDLRTRYGIADPGHALLASLQRCARKGMDKLLARHAMGEDLWRDAAHCEPAAPLP
>Mature_220_residues
PSRIAVIDFETTGMTPSQGARATEVAIVLMEEGRPVDRFQSLMRTGAWLPPFIIQLTGITPAMLDTAPPAESVMREAARF
VGDAPMVAHNASFDSRFWAAELARADLPAPHAFACTVLLSRRLYPEAASHQLGRIVAHLGLPPAARAHRALADAEMAAAL
LGRMQHDLRTRYGIADPGHALLASLQRCARKGMDKLLARHAMGEDLWRDAAHCEPAAPLP

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 23924; Mature: 23793

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRIAVIDFETTGMTPSQGARATEVAIVLMEEGRPVDRFQSLMRTGAWLPPFIIQLTGI
CCCCEEEEEEECCCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHCCCC
TPAMLDTAPPAESVMREAARFVGDAPMVAHNASFDSRFWAAELARADLPAPHAFACTVLL
CHHHHCCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
SRRLYPEAASHQLGRIVAHLGLPPAARAHRALADAEMAAALLGRMQHDLRTRYGIADPGH
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLASLQRCARKGMDKLLARHAMGEDLWRDAAHCEPAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PSRIAVIDFETTGMTPSQGARATEVAIVLMEEGRPVDRFQSLMRTGAWLPPFIIQLTGI
CCCEEEEEEECCCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHCCCC
TPAMLDTAPPAESVMREAARFVGDAPMVAHNASFDSRFWAAELARADLPAPHAFACTVLL
CHHHHCCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
SRRLYPEAASHQLGRIVAHLGLPPAARAHRALADAEMAAALLGRMQHDLRTRYGIADPGH
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLASLQRCARKGMDKLLARHAMGEDLWRDAAHCEPAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]