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The map label for this gene is hom [H]

Identifier: 120608724

GI number: 120608724

Start: 11029

End: 12429

Strand: Direct

Name: hom [H]

Synonym: Aave_0011

Alternate gene names: 120608724

Gene position: 11029-12429 (Clockwise)

Preceding gene: 120608723

Following gene: 120608726

Centisome position: 0.21

GC content: 73.66

Gene sequence:

>1401_bases
ATGTTCAATGATCCCCAATGGCGTCCCCTTCCTGCCGCCGCCCCCGCCAGCGGTGCGGGCCTGCGTCCCCTGCGCGTGGG
CATGATCGGCATCGGCACGGTGGGCCTGGGCACCTGGCAGGTGCTGGCACGCAATCAGGCGCAGATCGCGGCGCGCGCGG
GCCGGGGCATCGAAATCGTGGCGGTGGCGGCCCGCGACCTGGCGCGCGCCAGGCGCGTGCTCGGCGACGGGGCCGCTGGC
GTGGAGCTCACCGGCGATCCGCTGGCGCTGGCCACGCACCCTGGCATCGACGTGCTGCTGGAGGTGGCCGGGGGCACGGA
TGCCCCGCGCGAATGGGTGACGGCGGCCATGGGCCTCGGCAAGCCCGTGGTCACGGCCAACAAGGCGCTGCTGGCGGTGC
ATGGCAACGCGCTGTTCGCCCAGGCGGAGTCGCGCGGCGTGCCGCTCGCCTATGAAGCGGCCGTGGCCGGCGGCATCCCG
ATCGTGAAGGCACTGCGCGAAGGTGCCGCGGCGAACCGCGTGGAATGGCTGGCCGGCATCGTGAACGGCACCAGCAACTA
CATCCTGAGCCGCATGCGCCAGGCGGGCCTGGCGTTCGGCGACGCGCTGGCGGAAGCCCAGGCCCTGGGCTACGCGGAGG
CCGATCCCACCTTCGATGTGGACGGCATCGATGCCGCGCACAAGACCGCCCTGCTGGCGGCCAACGCTTTCGGCATGCCC
GTCCGCTTCGACCGTGCCCATGTGGAGGGCATCCGTGGCGTGGATGCGCTGGATGTGGCCGCGGCGCGGGAGTGGGGCCA
TGCCGTGAAACTGCTGGGCATCGCGCGGGGGCAGGGGGAATCGGTGGAGCTGCGGGTGCACCCTGCGCTGGTGCCCGCCA
CGCACCTGCTCGCGCAGGTGGAGGGGGCGATGAACGCCGTCATGCTGCGAGGGGATGCGCAGGGCATCGCGCTGCACTAC
GGCGCCGGGGCGGGAGCGGAGCCGACCGCCTCCGCCGTGGTCGCCGATCTGGTGGACCTGGCCCGCCAGACGGTGGCGCA
GGCCGGCGGCCCCGTCCGCTGCACGGTGCCGCCGCTGGGCGTGCCGGTCGCGGCATGGGTGGATCGCCCCGTGCTGTGCA
TGGACGACGTGGTGACCCGGCATTACCTGCGCGTTCCCTTGCGCGAGGATGCCGAGGGCATCGCGCCGGCCGCACTGGCG
CAGTGGCTGGCGCAGGCCGGTGTCGTCGTGGAACGGCTGGATGCCTGGCGTCCCCGGGGCCACGGCAGCGACCAGGCCCA
GTTGCTGGCGCTCACCCGGCCTGCGCGGGACGGCGCCGTTCGCGACGTCCTGCAGCGCGCCGCCCAGGCGGACTGGTGCC
TTGGGGCACCGGCGCACCTGCGCGTCGAAAACCTGGAATGA

Upstream 100 bases:

>100_bases
CGCCTGGTGTCATTCCCTCCTCGAACGAACCCGGCCCGACCGCCGGGTTTTTCGTTTCCGGGCCTGAGCGCCCTTCGTTC
GAGAGAAAGAGAGTGACCCG

Downstream 100 bases:

>100_bases
CGGCCGGCAGGCCGCGGGGCGAACGGTGATTCAGCGCTTCTGCTTCTGGTAGGCCTCGTGGGCCGGGACGCCGCGGTCGG
TGTCCTTGAGGCCCCGCTCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MFNDPQWRPLPAAAPASGAGLRPLRVGMIGIGTVGLGTWQVLARNQAQIAARAGRGIEIVAVAARDLARARRVLGDGAAG
VELTGDPLALATHPGIDVLLEVAGGTDAPREWVTAAMGLGKPVVTANKALLAVHGNALFAQAESRGVPLAYEAAVAGGIP
IVKALREGAAANRVEWLAGIVNGTSNYILSRMRQAGLAFGDALAEAQALGYAEADPTFDVDGIDAAHKTALLAANAFGMP
VRFDRAHVEGIRGVDALDVAAAREWGHAVKLLGIARGQGESVELRVHPALVPATHLLAQVEGAMNAVMLRGDAQGIALHY
GAGAGAEPTASAVVADLVDLARQTVAQAGGPVRCTVPPLGVPVAAWVDRPVLCMDDVVTRHYLRVPLREDAEGIAPAALA
QWLAQAGVVVERLDAWRPRGHGSDQAQLLALTRPARDGAVRDVLQRAAQADWCLGAPAHLRVENLE

Sequences:

>Translated_466_residues
MFNDPQWRPLPAAAPASGAGLRPLRVGMIGIGTVGLGTWQVLARNQAQIAARAGRGIEIVAVAARDLARARRVLGDGAAG
VELTGDPLALATHPGIDVLLEVAGGTDAPREWVTAAMGLGKPVVTANKALLAVHGNALFAQAESRGVPLAYEAAVAGGIP
IVKALREGAAANRVEWLAGIVNGTSNYILSRMRQAGLAFGDALAEAQALGYAEADPTFDVDGIDAAHKTALLAANAFGMP
VRFDRAHVEGIRGVDALDVAAAREWGHAVKLLGIARGQGESVELRVHPALVPATHLLAQVEGAMNAVMLRGDAQGIALHY
GAGAGAEPTASAVVADLVDLARQTVAQAGGPVRCTVPPLGVPVAAWVDRPVLCMDDVVTRHYLRVPLREDAEGIAPAALA
QWLAQAGVVVERLDAWRPRGHGSDQAQLLALTRPARDGAVRDVLQRAAQADWCLGAPAHLRVENLE
>Mature_466_residues
MFNDPQWRPLPAAAPASGAGLRPLRVGMIGIGTVGLGTWQVLARNQAQIAARAGRGIEIVAVAARDLARARRVLGDGAAG
VELTGDPLALATHPGIDVLLEVAGGTDAPREWVTAAMGLGKPVVTANKALLAVHGNALFAQAESRGVPLAYEAAVAGGIP
IVKALREGAAANRVEWLAGIVNGTSNYILSRMRQAGLAFGDALAEAQALGYAEADPTFDVDGIDAAHKTALLAANAFGMP
VRFDRAHVEGIRGVDALDVAAAREWGHAVKLLGIARGQGESVELRVHPALVPATHLLAQVEGAMNAVMLRGDAQGIALHY
GAGAGAEPTASAVVADLVDLARQTVAQAGGPVRCTVPPLGVPVAAWVDRPVLCMDDVVTRHYLRVPLREDAEGIAPAALA
QWLAQAGVVVERLDAWRPRGHGSDQAQLLALTRPARDGAVRDVLQRAAQADWCLGAPAHLRVENLE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=247, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48289; Mature: 48289

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNDPQWRPLPAAAPASGAGLRPLRVGMIGIGTVGLGTWQVLARNQAQIAARAGRGIEIV
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEE
AVAARDLARARRVLGDGAAGVELTGDPLALATHPGIDVLLEVAGGTDAPREWVTAAMGLG
EEHHHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCC
KPVVTANKALLAVHGNALFAQAESRGVPLAYEAAVAGGIPIVKALREGAAANRVEWLAGI
CCEEECCCEEEEEECCEEEEECCCCCCCEEEHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
VNGTSNYILSRMRQAGLAFGDALAEAQALGYAEADPTFDVDGIDAAHKTALLAANAFGMP
HCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCC
VRFDRAHVEGIRGVDALDVAAAREWGHAVKLLGIARGQGESVELRVHPALVPATHLLAQV
EEECHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EGAMNAVMLRGDAQGIALHYGAGAGAEPTASAVVADLVDLARQTVAQAGGPVRCTVPPLG
HHHHEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
VPVAAWVDRPVLCMDDVVTRHYLRVPLREDAEGIAPAALAQWLAQAGVVVERLDAWRPRG
CCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
HGSDQAQLLALTRPARDGAVRDVLQRAAQADWCLGAPAHLRVENLE
CCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MFNDPQWRPLPAAAPASGAGLRPLRVGMIGIGTVGLGTWQVLARNQAQIAARAGRGIEIV
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEE
AVAARDLARARRVLGDGAAGVELTGDPLALATHPGIDVLLEVAGGTDAPREWVTAAMGLG
EEHHHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCC
KPVVTANKALLAVHGNALFAQAESRGVPLAYEAAVAGGIPIVKALREGAAANRVEWLAGI
CCEEECCCEEEEEECCEEEEECCCCCCCEEEHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
VNGTSNYILSRMRQAGLAFGDALAEAQALGYAEADPTFDVDGIDAAHKTALLAANAFGMP
HCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCC
VRFDRAHVEGIRGVDALDVAAAREWGHAVKLLGIARGQGESVELRVHPALVPATHLLAQV
EEECHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EGAMNAVMLRGDAQGIALHYGAGAGAEPTASAVVADLVDLARQTVAQAGGPVRCTVPPLG
HHHHEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
VPVAAWVDRPVLCMDDVVTRHYLRVPLREDAEGIAPAALAQWLAQAGVVVERLDAWRPRG
CCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
HGSDQAQLLALTRPARDGAVRDVLQRAAQADWCLGAPAHLRVENLE
CCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]