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The map label for this gene is garR [H]

Identifier: 119946961

GI number: 119946961

Start: 4148234

End: 4149094

Strand: Reverse

Name: garR [H]

Synonym: Ping_3356

Alternate gene names: 119946961

Gene position: 4149094-4148234 (Counterclockwise)

Preceding gene: 119946962

Following gene: 119946960

Centisome position: 91.0

GC content: 38.1

Gene sequence:

>861_bases
ATGAAAAAATTTGGGTTTATAGGCTTAGGAATTATGGGTAATGCAATGGCATTAAACTTGGTTAAAGCAGGGCTAGATGT
AACAGTTTGGAATCGAAATGTTGATAAATGTACTGAACTGGTTGCACTGGGCGCTCATCAAGGAAAAACACCAAGAGAAG
TAGCAGAAACATGCGATATCACTTTTACTATTGTTTCTGATCCTGCAGCTGCTTTAGCTATTTCTGAAGGGCCTGATGGC
GTAGTGGCAGGCATTGGTGAAGGTCGTAGTTATATTGATATGTCTACTGTTGATGATGCGACTTCACAAACTATTTCAGC
AGCAATAATAAAAGCAGGCGGGCGCTTTTTAGAAGCTCCTGTTTCTGGGACAAAAAAACCAGCGGAAGATGGCACTTTAA
TTATTTTAGCAGCAGGAGATAAGTCCCTTTATGATGATGCCTTACCCGCCTTTGAAATAATGGGGAAAATGTCTCCATAC
TTGGGTGAGGTTGGTCAGGGCGCTAAAATGAAACTTGTAGTCAATATGATTATGGGTGGAATGTTAAGTATTTTCAGTGA
AGGAATATCACTCGGCCTTAAAGCAAACCTTGATGGTAAACAGTTACTAGATATTATTGATGCAGGTGCAATGGCAAACC
CTATGTTTAAAGTTAAAGGGCCAATGCTATTAGATGAAAATTACACTACAAGCTTTCCTCTTAAACATATGCAAAAAGAC
ATGAGATTAGCTGTAGATTTAGGTGATAAATTAAATTTAACGTTACCGACTGCCGCTATTACAAATGAATCTTTCAAACA
AGCACGTAAAGCTGGTTTTTCAGATGAAGACATAGCTGCAATTTATAAAACAGTGAAATAA

Upstream 100 bases:

>100_bases
CGCAGTCTCTCTACTTATTCGAAAGATAGCTGATTAATCAATAAGATCTTTCGTCTGCTGTGAATAAAGAAACTAGTTAA
AAAATAAGGTAATGATATTT

Downstream 100 bases:

>100_bases
AGTCTATAAGATATAGTGCTAATTTTTCTACCTTAAATAATCGTAGTAATAGCAGCTATTACTGCGATTATTTTTATTGA
ACTATATAAAATAATGATCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKKFGFIGLGIMGNAMALNLVKAGLDVTVWNRNVDKCTELVALGAHQGKTPREVAETCDITFTIVSDPAAALAISEGPDG
VVAGIGEGRSYIDMSTVDDATSQTISAAIIKAGGRFLEAPVSGTKKPAEDGTLIILAAGDKSLYDDALPAFEIMGKMSPY
LGEVGQGAKMKLVVNMIMGGMLSIFSEGISLGLKANLDGKQLLDIIDAGAMANPMFKVKGPMLLDENYTTSFPLKHMQKD
MRLAVDLGDKLNLTLPTAAITNESFKQARKAGFSDEDIAAIYKTVK

Sequences:

>Translated_286_residues
MKKFGFIGLGIMGNAMALNLVKAGLDVTVWNRNVDKCTELVALGAHQGKTPREVAETCDITFTIVSDPAAALAISEGPDG
VVAGIGEGRSYIDMSTVDDATSQTISAAIIKAGGRFLEAPVSGTKKPAEDGTLIILAAGDKSLYDDALPAFEIMGKMSPY
LGEVGQGAKMKLVVNMIMGGMLSIFSEGISLGLKANLDGKQLLDIIDAGAMANPMFKVKGPMLLDENYTTSFPLKHMQKD
MRLAVDLGDKLNLTLPTAAITNESFKQARKAGFSDEDIAAIYKTVK
>Mature_286_residues
MKKFGFIGLGIMGNAMALNLVKAGLDVTVWNRNVDKCTELVALGAHQGKTPREVAETCDITFTIVSDPAAALAISEGPDG
VVAGIGEGRSYIDMSTVDDATSQTISAAIIKAGGRFLEAPVSGTKKPAEDGTLIILAAGDKSLYDDALPAFEIMGKMSPY
LGEVGQGAKMKLVVNMIMGGMLSIFSEGISLGLKANLDGKQLLDIIDAGAMANPMFKVKGPMLLDENYTTSFPLKHMQKD
MRLAVDLGDKLNLTLPTAAITNESFKQARKAGFSDEDIAAIYKTVK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=47.5177304964539, Blast_Score=270, Evalue=9e-73,
Organism=Homo sapiens, GI23308751, Length=289, Percent_Identity=28.3737024221453, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=31.8996415770609, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=31.4685314685315, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.5261324041812, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789092, Length=281, Percent_Identity=27.4021352313167, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=27.9461279461279, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=35.1063829787234, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=27.7397260273973, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=27.7397260273973, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30211; Mature: 30211

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFGFIGLGIMGNAMALNLVKAGLDVTVWNRNVDKCTELVALGAHQGKTPREVAETCDI
CCCCCEEEECHHCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCCE
TFTIVSDPAAALAISEGPDGVVAGIGEGRSYIDMSTVDDATSQTISAAIIKAGGRFLEAP
EEEEECCCCEEEEECCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEECC
VSGTKKPAEDGTLIILAAGDKSLYDDALPAFEIMGKMSPYLGEVGQGAKMKLVVNMIMGG
CCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHH
MLSIFSEGISLGLKANLDGKQLLDIIDAGAMANPMFKVKGPMLLDENYTTSFPLKHMQKD
HHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCHHHHHHH
MRLAVDLGDKLNLTLPTAAITNESFKQARKAGFSDEDIAAIYKTVK
HEEEEECCCCEEEEECHHHHCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKKFGFIGLGIMGNAMALNLVKAGLDVTVWNRNVDKCTELVALGAHQGKTPREVAETCDI
CCCCCEEEECHHCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCCE
TFTIVSDPAAALAISEGPDGVVAGIGEGRSYIDMSTVDDATSQTISAAIIKAGGRFLEAP
EEEEECCCCEEEEECCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEECC
VSGTKKPAEDGTLIILAAGDKSLYDDALPAFEIMGKMSPYLGEVGQGAKMKLVVNMIMGG
CCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHH
MLSIFSEGISLGLKANLDGKQLLDIIDAGAMANPMFKVKGPMLLDENYTTSFPLKHMQKD
HHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCHHHHHHH
MRLAVDLGDKLNLTLPTAAITNESFKQARKAGFSDEDIAAIYKTVK
HEEEEECCCCEEEEECHHHHCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]