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The map label for this gene is parE [H]

Identifier: 119946960

GI number: 119946960

Start: 4144889

End: 4146778

Strand: Reverse

Name: parE [H]

Synonym: Ping_3354

Alternate gene names: 119946960

Gene position: 4146778-4144889 (Counterclockwise)

Preceding gene: 119946961

Following gene: 119946958

Centisome position: 90.95

GC content: 44.71

Gene sequence:

>1890_bases
ATGAGCGACCAATACAATTCAGACTCGATCGAGGTATTAAACGGTCTTGATCCCGTTCGCCACCGTCCGGGAATGTACAC
CGACACATCACGTCCGAATCATCTTGGTCAGGAAGTTATCGACAATAGTGTGGATGAAGCGCTAGCGGGGCATGCGGCGA
CTATCCAAGTGATTTTACACGAGGATCAATCATTAGAAGTTATTGATGATGGACGTGGTATGCCGGTTGATATTCACCCT
GAAGAGCGTATTTCAGGTGTTGAGCTTATTTTCTGTAAATTACATGCAGGGGGTAAATTTTCAGGTAAAAATTACGAAAT
ATCTGGTGGTCTTCACGGTGTTGGGATCTCCGTCGTTAATGCATTATCAAAACGTGTTGATGTGAGTATTCGTCGTGATG
GTCAAGTGTATGAAATTGCCTTTGAAAATGGTGAAAAGGTTGAGGAGTTACACGTAACGGGAGTCTGTGGAAAACGCAAT
ACAGGTACGACAGTACATTTTCATCCCGATCCCGCTTACTTTGACAGCGCCCGCTTTTCAGTGTCCCGTTTACTGCATCT
GTTAAAAGCCAAAGCCGTCTTATGTGCGGGTCTTACCATCAAATTTAAAGACAAAGTAAATAAAAATGACTATCAGTGGT
GCTATCAAGATGGTTTAAATGATTACCTGCTGGAAGCTGTTGCAGACAACGAGTTATTACCACCGCAGCCCTTTACTGGC
AAGTTTTCAGCAAAAAGTGAAACAGCAGAGTGGTCGGTAGTGTGGTTACCCGATGGCGGGCCTTCACTATCAGAAAGTTA
CGTAAATTTAATACCGACAGTGCAGGGCGGCACACACGTTAATGGTTTTAGGCAGGGACTGCTGGATGCAATGCGTGAGT
TCTGTGATATTCGTAACCTTCTACCGCGCGGTCTAAAATTAAGCCCGGAAGATATTTGGGATAGATGTGCCTATATCCTT
TCGGTTAAAATCAAAGAGCCGCAGTTTGCCGGACAAACTAAAGAACGACTCTCATCAAGGCAGTGCGTCGCTTTTGTTTC
CGGTATAGTAAAAGATGCCTTTAGTTTATGGCTCAATGCGCATGTTAATGAGGCTGAGTTACTGGCTGACTTCTGCATTA
ATAATGCCCAGACCCGGACGCGTAAAACTAAAAAAATTGCCCGTAAAAAAATAACTCAAGGCCCCGCTCTTCCAGGTAAA
TTAACTGATTGTTCGACTCAGGAAACCATGCGTGGGGAGATTTTTTTAGTTGAAGGTGATTCGGCTGGTGGCTCTGCAAA
ACAGGCGCGGGATCGCGAGTTTCAGGCTATTATGCCGTTACGGGGAAAAATCAAAAATACCTGGGAAGACGACTCTGATA
TTATTTTAAATTCCGAAGAAATACATAATATATCCGTGGCGATAGGAATCGATCCTGCTTCCTCGGACTTATCCGGTTTA
CGTTATGGAAAAATCTGTATCCTTGCCGATGCCGATTCCGATGGTCTGCATATCGCGACGCTTATCTGCGCCTTGTTCGT
TCGTCATTTTAGAGCCGTGGTTGATGCCGGACACCTGTTTGTCGCGATGCCGCCATTATACCGAATCGACATAGGTAAAG
AGGTTTATTATGCCTTGGATGAAGCAGAAAAAGACGGGGTGTTAGACCGTATCGAAGCGGAGAAAAAACGCGGTAAAGTC
AATGTTCAGCGCTTTAAAGGTTTGGGTGAAATGAACCCGTTGCAGTTACGTGAAACGACTATGGATCCTAATACTCGCCG
TTTAGTTCAGCTGACGACCGAAGGCGCTGAGGAAATGTTAGAAATGATGGATATGTTACTGGCGAAAAAACGCGCAGGAG
ATCGTAAAGTCTGGCTTGAAGATAAAGGTGATATGGCATCGGTTGATTAA

Upstream 100 bases:

>100_bases
GCATGAGCGACCAATACAATTCAGACTTTATTTTGCTGATGAATTTTAAGTGATAATTGGGTAAAATGAATCCCCCCGTT
TTTTCAATATAGGTACAAGC

Downstream 100 bases:

>100_bases
TTACCCGCGCTCATTGCACATTAATACTATAAAAAGAGCGTGCTTATCACCTGCTTATCTTGGTAGATAAGTGGTTGATG
AGCACCATATTTGAGCTTTA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSDQYNSDSIEVLNGLDPVRHRPGMYTDTSRPNHLGQEVIDNSVDEALAGHAATIQVILHEDQSLEVIDDGRGMPVDIHP
EERISGVELIFCKLHAGGKFSGKNYEISGGLHGVGISVVNALSKRVDVSIRRDGQVYEIAFENGEKVEELHVTGVCGKRN
TGTTVHFHPDPAYFDSARFSVSRLLHLLKAKAVLCAGLTIKFKDKVNKNDYQWCYQDGLNDYLLEAVADNELLPPQPFTG
KFSAKSETAEWSVVWLPDGGPSLSESYVNLIPTVQGGTHVNGFRQGLLDAMREFCDIRNLLPRGLKLSPEDIWDRCAYIL
SVKIKEPQFAGQTKERLSSRQCVAFVSGIVKDAFSLWLNAHVNEAELLADFCINNAQTRTRKTKKIARKKITQGPALPGK
LTDCSTQETMRGEIFLVEGDSAGGSAKQARDREFQAIMPLRGKIKNTWEDDSDIILNSEEIHNISVAIGIDPASSDLSGL
RYGKICILADADSDGLHIATLICALFVRHFRAVVDAGHLFVAMPPLYRIDIGKEVYYALDEAEKDGVLDRIEAEKKRGKV
NVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTTEGAEEMLEMMDMLLAKKRAGDRKVWLEDKGDMASVD

Sequences:

>Translated_629_residues
MSDQYNSDSIEVLNGLDPVRHRPGMYTDTSRPNHLGQEVIDNSVDEALAGHAATIQVILHEDQSLEVIDDGRGMPVDIHP
EERISGVELIFCKLHAGGKFSGKNYEISGGLHGVGISVVNALSKRVDVSIRRDGQVYEIAFENGEKVEELHVTGVCGKRN
TGTTVHFHPDPAYFDSARFSVSRLLHLLKAKAVLCAGLTIKFKDKVNKNDYQWCYQDGLNDYLLEAVADNELLPPQPFTG
KFSAKSETAEWSVVWLPDGGPSLSESYVNLIPTVQGGTHVNGFRQGLLDAMREFCDIRNLLPRGLKLSPEDIWDRCAYIL
SVKIKEPQFAGQTKERLSSRQCVAFVSGIVKDAFSLWLNAHVNEAELLADFCINNAQTRTRKTKKIARKKITQGPALPGK
LTDCSTQETMRGEIFLVEGDSAGGSAKQARDREFQAIMPLRGKIKNTWEDDSDIILNSEEIHNISVAIGIDPASSDLSGL
RYGKICILADADSDGLHIATLICALFVRHFRAVVDAGHLFVAMPPLYRIDIGKEVYYALDEAEKDGVLDRIEAEKKRGKV
NVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTTEGAEEMLEMMDMLLAKKRAGDRKVWLEDKGDMASVD
>Mature_628_residues
SDQYNSDSIEVLNGLDPVRHRPGMYTDTSRPNHLGQEVIDNSVDEALAGHAATIQVILHEDQSLEVIDDGRGMPVDIHPE
ERISGVELIFCKLHAGGKFSGKNYEISGGLHGVGISVVNALSKRVDVSIRRDGQVYEIAFENGEKVEELHVTGVCGKRNT
GTTVHFHPDPAYFDSARFSVSRLLHLLKAKAVLCAGLTIKFKDKVNKNDYQWCYQDGLNDYLLEAVADNELLPPQPFTGK
FSAKSETAEWSVVWLPDGGPSLSESYVNLIPTVQGGTHVNGFRQGLLDAMREFCDIRNLLPRGLKLSPEDIWDRCAYILS
VKIKEPQFAGQTKERLSSRQCVAFVSGIVKDAFSLWLNAHVNEAELLADFCINNAQTRTRKTKKIARKKITQGPALPGKL
TDCSTQETMRGEIFLVEGDSAGGSAKQARDREFQAIMPLRGKIKNTWEDDSDIILNSEEIHNISVAIGIDPASSDLSGLR
YGKICILADADSDGLHIATLICALFVRHFRAVVDAGHLFVAMPPLYRIDIGKEVYYALDEAEKDGVLDRIEAEKKRGKVN
VQRFKGLGEMNPLQLRETTMDPNTRRLVQLTTEGAEEMLEMMDMLLAKKRAGDRKVWLEDKGDMASVD

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=624, Percent_Identity=25, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI19913406, Length=622, Percent_Identity=22.9903536977492, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1789408, Length=631, Percent_Identity=72.9001584786054, Blast_Score=983, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=558, Percent_Identity=37.4551971326165, Blast_Score=349, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17535065, Length=633, Percent_Identity=23.8546603475513, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=596, Percent_Identity=24.8322147651007, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324241, Length=627, Percent_Identity=24.4019138755981, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17136538, Length=633, Percent_Identity=23.8546603475513, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.- [C]

Molecular weight: Translated: 69810; Mature: 69679

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQYNSDSIEVLNGLDPVRHRPGMYTDTSRPNHLGQEVIDNSVDEALAGHAATIQVILH
CCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCEEEEEEEE
EDQSLEVIDDGRGMPVDIHPEERISGVELIFCKLHAGGKFSGKNYEISGGLHGVGISVVN
CCCCEEEEECCCCCCEECCHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVDVSIRRDGQVYEIAFENGEKVEELHVTGVCGKRNTGTTVHFHPDPAYFDSARFS
HHHHHCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCCCCCCEEEECCCCCHHCHHHHH
VSRLLHLLKAKAVLCAGLTIKFKDKVNKNDYQWCYQDGLNDYLLEAVADNELLPPQPFTG
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
KFSAKSETAEWSVVWLPDGGPSLSESYVNLIPTVQGGTHVNGFRQGLLDAMREFCDIRNL
CCCCCCCCCEEEEEEECCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGLKLSPEDIWDRCAYILSVKIKEPQFAGQTKERLSSRQCVAFVSGIVKDAFSLWLNA
CCCCCCCCHHHHHHHHEEHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HVNEAELLADFCINNAQTRTRKTKKIARKKITQGPALPGKLTDCSTQETMRGEIFLVEGD
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKIKNTWEDDSDIILNSEEIHNISVAIGIDPASSDLSGL
CCCCCHHHHHCCCHHEECCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCC
RYGKICILADADSDGLHIATLICALFVRHFRAVVDAGHLFVAMPPLYRIDIGKEVYYALD
EECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHH
EAEKDGVLDRIEAEKKRGKVNVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTTEGAEEML
HHCCCCCHHHHHHHHHCCCEEHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEHHHHHHHH
EMMDMLLAKKRAGDRKVWLEDKGDMASVD
HHHHHHHHHHCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SDQYNSDSIEVLNGLDPVRHRPGMYTDTSRPNHLGQEVIDNSVDEALAGHAATIQVILH
CCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCEEEEEEEE
EDQSLEVIDDGRGMPVDIHPEERISGVELIFCKLHAGGKFSGKNYEISGGLHGVGISVVN
CCCCEEEEECCCCCCEECCHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVDVSIRRDGQVYEIAFENGEKVEELHVTGVCGKRNTGTTVHFHPDPAYFDSARFS
HHHHHCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCCCCCCEEEECCCCCHHCHHHHH
VSRLLHLLKAKAVLCAGLTIKFKDKVNKNDYQWCYQDGLNDYLLEAVADNELLPPQPFTG
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
KFSAKSETAEWSVVWLPDGGPSLSESYVNLIPTVQGGTHVNGFRQGLLDAMREFCDIRNL
CCCCCCCCCEEEEEEECCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGLKLSPEDIWDRCAYILSVKIKEPQFAGQTKERLSSRQCVAFVSGIVKDAFSLWLNA
CCCCCCCCHHHHHHHHEEHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HVNEAELLADFCINNAQTRTRKTKKIARKKITQGPALPGKLTDCSTQETMRGEIFLVEGD
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKIKNTWEDDSDIILNSEEIHNISVAIGIDPASSDLSGL
CCCCCHHHHHCCCHHEECCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCC
RYGKICILADADSDGLHIATLICALFVRHFRAVVDAGHLFVAMPPLYRIDIGKEVYYALD
EECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHH
EAEKDGVLDRIEAEKKRGKVNVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTTEGAEEML
HHCCCCCHHHHHHHHHCCCEEHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEHHHHHHHH
EMMDMLLAKKRAGDRKVWLEDKGDMASVD
HHHHHHHHHHCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]