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The map label for this gene is ndk

Identifier: 119946932

GI number: 119946932

Start: 4107597

End: 4108031

Strand: Reverse

Name: ndk

Synonym: Ping_3326

Alternate gene names: 119946932

Gene position: 4108031-4107597 (Counterclockwise)

Preceding gene: 119946934

Following gene: 119946931

Centisome position: 90.1

GC content: 44.83

Gene sequence:

>435_bases
ATGCCATTAGAAAGAACACTTTCAATCATTAAACCCGACGCCGTAGGTAAACACCTTACTGGTAGAATTTTAGCGCGTTT
TGAACGTGCTGGCTTACAGCCTGTTGCTATAAAAATGGTTCGCCTAACCAGTGAGCAAGCTGAGGCTTTTTATGCAGAGC
ATAAAGGCCGAGAGTTTTACCAACCATTAATTGATTTTATGACTTCCGGGCCGATGGTCGTGCAGGTTTTACAAGCTGAA
AATGCAATCAATCTGTATCGTGAAATGATCGGAAAAACCGATCCTACGCAAGCGGCTGCCGGTACTATTCGTGCTGATTT
TGCTGAATCTACCCGCTGTAATGCAGTGCATGGATCCGATAGCCCCGCTTCTGCGGCAAAAGAAATCGCCTTCTTTTTTA
GCGATGATGAAATATGCCCACCAGCAGCAGATTAA

Upstream 100 bases:

>100_bases
GAAGTGTGAGATTGCGTTTCATCTATTCATCTTCTTATTGATGGCGAGGGATTATACGGTTATATTAGGCATTCTGTTCA
TTAATATTTAAGTCATCATT

Downstream 100 bases:

>100_bases
AATGAGTGAAAGCTGGGTAATTTTATGAATGATATTGTCATCTTGTTAGAGTATTCCCCTCCATACCTTTACGGGATAGT
CACTATTCTGGGCTTGTTGA

Product: nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MPLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFYQPLIDFMTSGPMVVQVLQAE
NAINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSDSPASAAKEIAFFFSDDEICPPAAD

Sequences:

>Translated_144_residues
MPLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFYQPLIDFMTSGPMVVQVLQAE
NAINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSDSPASAAKEIAFFFSDDEICPPAAD
>Mature_143_residues
PLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFYQPLIDFMTSGPMVVQVLQAEN
AINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSDSPASAAKEIAFFFSDDEICPPAAD

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=44.4444444444444, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=41.9117647058824, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=41.9117647058824, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=41.9117647058824, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=41.9117647058824, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.9117647058824, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=39.2592592592593, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=39.2592592592593, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=39.568345323741, Blast_Score=109, Evalue=7e-25,
Organism=Homo sapiens, GI7019465, Length=142, Percent_Identity=36.6197183098592, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI37574614, Length=142, Percent_Identity=36.6197183098592, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=40, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=34.5323741007194, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=35.2941176470588, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.1111111111111, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=140, Percent_Identity=56.4285714285714, Blast_Score=174, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=40.4411764705882, Blast_Score=116, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45549037, Length=144, Percent_Identity=40.2777777777778, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=38.0597014925373, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PSYIN (A1SZU8)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944612.1
- ProteinModelPortal:   A1SZU8
- SMR:   A1SZU8
- STRING:   A1SZU8
- GeneID:   4625740
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3326
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   HEMPIFF
- PhylomeDB:   A1SZU8
- BioCyc:   PING357804:PING_3326-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15758; Mature: 15627

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFY
CCHHHHHHHHCCCHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
QPLIDFMTSGPMVVQVLQAENAINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSD
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
SPASAAKEIAFFFSDDEICPPAAD
CHHHHHHHHHHEECCCCCCCCCCC
>Mature Secondary Structure 
PLERTLSIIKPDAVGKHLTGRILARFERAGLQPVAIKMVRLTSEQAEAFYAEHKGREFY
CHHHHHHHHCCCHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
QPLIDFMTSGPMVVQVLQAENAINLYREMIGKTDPTQAAAGTIRADFAESTRCNAVHGSD
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
SPASAAKEIAFFFSDDEICPPAAD
CHHHHHHHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA