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The map label for this gene is treR [H]

Identifier: 119946839

GI number: 119946839

Start: 3989171

End: 3990127

Strand: Reverse

Name: treR [H]

Synonym: Ping_3233

Alternate gene names: 119946839

Gene position: 3990127-3989171 (Counterclockwise)

Preceding gene: 119946840

Following gene: 119946838

Centisome position: 87.51

GC content: 41.69

Gene sequence:

>957_bases
ATGACAAAAAAATTAACTATTCTTGATATCGCAAAGTTAGCCGGGGTTGGAAAATCGACCGTTTCCCGTGTCTTAACTAA
CGACCCTAAAGTAAAGGCGAGTACCCGAGAAAAAGTGCAGCGACTTATTCAGGAATCTGGTTTTGTGCCATCGAAATCAG
CCCAAATTATGGGTGGCGGGCGTACCAACGTTATCGGTATTATTTTATCTCGTTTGGATTCTGCCTCCGAAAATAAAGTG
GTGAGTGCTATTCTGGAAGTGATCTATGCAGCGGGTTACGATGCGCTGATTATGGAAGGGCAATTTAGTGCAGCAAAAAC
CGATGAGCATTTAGCCGTTTTACAAAAAAAAGATGTTGATGGTGTTATTTTATTTGGTTTTACCGGCTGTGATTTATCAA
GCGTTGAAAAGTTAGCCCATAAAGCCGTGGTTATTGCCGTTGATAGTAAGCGTGTTTCATCTGTTGGTTATGATAATGAT
GGCATTATTAAACAGGCAATGAACTATATGCAGGCACAGGGAAAGCAGCATATTAGTTTTATCGGTGTCGATATTAAGGA
TAAAACAACGGGCTTAATGCGTCTTAATGCTTATTTGGATTATTGTCAGTCTGCCAATATAAAACCGCACTATCAAACAG
GGTTACTGAATTATCACAGTGCTTATGAACTCACTGATTTGGTGCTGATGCCTGAAACAGAGGCAATTGTTTGTGCCAGT
GATACCTTAGCGATGGGGGTTGCTAAACGTCTTCAGGAACTTGGCCGCAGCGAAATACTGGTATCAGGTGTGGGGGCAAC
AGATTTATTAGCCTTTATTTTTCCAAATACATTCAGTATCGATCCCGGTTATTACGCGGTAGGCAAAACTTCTGCAGATT
TACTTATCAAACAGTTAGAGGGCGGACGCGAAGTGATGCACATTACCCAACAGGCCTTCCTAGCTAACCCATCTTAA

Upstream 100 bases:

>100_bases
GCTTTTTTTAATTATTGATATTCACGCCACTCTGTAAAATCATTAAAATCCCTCCCATCACAGAGATAATAAACAAGTCT
TTTTCAACTCGAATAAACTT

Downstream 100 bases:

>100_bases
TAAGCACTCATAAAAAAAGCACTAAAAAGGTGATAATGCTTGCAGGTTAAAATTATTCCTAACTGGGTTGTGAGTTTTAT
TTGGAATGTTCTGTTCGTCA

Product: trehalose repressor

Products: NA

Alternate protein names: Trehalose operon repressor [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTKKLTILDIAKLAGVGKSTVSRVLTNDPKVKASTREKVQRLIQESGFVPSKSAQIMGGGRTNVIGIILSRLDSASENKV
VSAILEVIYAAGYDALIMEGQFSAAKTDEHLAVLQKKDVDGVILFGFTGCDLSSVEKLAHKAVVIAVDSKRVSSVGYDND
GIIKQAMNYMQAQGKQHISFIGVDIKDKTTGLMRLNAYLDYCQSANIKPHYQTGLLNYHSAYELTDLVLMPETEAIVCAS
DTLAMGVAKRLQELGRSEILVSGVGATDLLAFIFPNTFSIDPGYYAVGKTSADLLIKQLEGGREVMHITQQAFLANPS

Sequences:

>Translated_318_residues
MTKKLTILDIAKLAGVGKSTVSRVLTNDPKVKASTREKVQRLIQESGFVPSKSAQIMGGGRTNVIGIILSRLDSASENKV
VSAILEVIYAAGYDALIMEGQFSAAKTDEHLAVLQKKDVDGVILFGFTGCDLSSVEKLAHKAVVIAVDSKRVSSVGYDND
GIIKQAMNYMQAQGKQHISFIGVDIKDKTTGLMRLNAYLDYCQSANIKPHYQTGLLNYHSAYELTDLVLMPETEAIVCAS
DTLAMGVAKRLQELGRSEILVSGVGATDLLAFIFPNTFSIDPGYYAVGKTSADLLIKQLEGGREVMHITQQAFLANPS
>Mature_317_residues
TKKLTILDIAKLAGVGKSTVSRVLTNDPKVKASTREKVQRLIQESGFVPSKSAQIMGGGRTNVIGIILSRLDSASENKVV
SAILEVIYAAGYDALIMEGQFSAAKTDEHLAVLQKKDVDGVILFGFTGCDLSSVEKLAHKAVVIAVDSKRVSSVGYDNDG
IIKQAMNYMQAQGKQHISFIGVDIKDKTTGLMRLNAYLDYCQSANIKPHYQTGLLNYHSAYELTDLVLMPETEAIVCASD
TLAMGVAKRLQELGRSEILVSGVGATDLLAFIFPNTFSIDPGYYAVGKTSADLLIKQLEGGREVMHITQQAFLANPS

Specific function: Repressor of the treBC operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=43.7106918238994, Blast_Score=254, Evalue=4e-69,
Organism=Escherichia coli, GI48994940, Length=316, Percent_Identity=26.5822784810127, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787906, Length=269, Percent_Identity=27.5092936802974, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786540, Length=318, Percent_Identity=23.8993710691824, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790194, Length=311, Percent_Identity=25.08038585209, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790369, Length=308, Percent_Identity=24.025974025974, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790715, Length=312, Percent_Identity=21.1538461538462, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787580, Length=330, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787948, Length=316, Percent_Identity=24.0506329113924, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789068, Length=271, Percent_Identity=24.7232472324723, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- InterPro:   IPR012771 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34324; Mature: 34193

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKLTILDIAKLAGVGKSTVSRVLTNDPKVKASTREKVQRLIQESGFVPSKSAQIMGGG
CCCEEEHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCC
RTNVIGIILSRLDSASENKVVSAILEVIYAAGYDALIMEGQFSAAKTDEHLAVLQKKDVD
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GVILFGFTGCDLSSVEKLAHKAVVIAVDSKRVSSVGYDNDGIIKQAMNYMQAQGKQHISF
EEEEEEECCCCHHHHHHHHHCEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEE
IGVDIKDKTTGLMRLNAYLDYCQSANIKPHYQTGLLNYHSAYELTDLVLMPETEAIVCAS
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHEEEEEECCCCEEEEEC
DTLAMGVAKRLQELGRSEILVSGVGATDLLAFIFPNTFSIDPGYYAVGKTSADLLIKQLE
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEECCCCEEEECCCHHHHHHHHHC
GGREVMHITQQAFLANPS
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKKLTILDIAKLAGVGKSTVSRVLTNDPKVKASTREKVQRLIQESGFVPSKSAQIMGGG
CCEEEHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCC
RTNVIGIILSRLDSASENKVVSAILEVIYAAGYDALIMEGQFSAAKTDEHLAVLQKKDVD
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GVILFGFTGCDLSSVEKLAHKAVVIAVDSKRVSSVGYDNDGIIKQAMNYMQAQGKQHISF
EEEEEEECCCCHHHHHHHHHCEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEE
IGVDIKDKTTGLMRLNAYLDYCQSANIKPHYQTGLLNYHSAYELTDLVLMPETEAIVCAS
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHEEEEEECCCCEEEEEC
DTLAMGVAKRLQELGRSEILVSGVGATDLLAFIFPNTFSIDPGYYAVGKTSADLLIKQLE
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEECCCCEEEECCCHHHHHHHHHC
GGREVMHITQQAFLANPS
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7751273; 11677609 [H]