Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 119946797

GI number: 119946797

Start: 3939600

End: 3939926

Strand: Reverse

Name: trxA [H]

Synonym: Ping_3190

Alternate gene names: 119946797

Gene position: 3939926-3939600 (Counterclockwise)

Preceding gene: 119946802

Following gene: 119946796

Centisome position: 86.41

GC content: 39.76

Gene sequence:

>327_bases
ATGAGCGAAAATATCGTAACGTTAAGTGATGCAAGTTTTGAAGATGATGTAGTTAATGCCGAAGGTCCTGTTTTAGTTGA
TTTTTGGGCTGAATGGTGTGGACCTTGTAAAATGATCGCTCCTATTCTTCAGGAAGTTGCGGCTGAATACGCAGGTAAAG
TCACTATTGGTAAATTAAATATAGACGAAAACAGTGCGACCCCGCCTAAATTTGGTATTCGTGGCATTCCAACGCTGTTG
TTATTTAAAGACGGTAAAGTTGCTGCAACGAAAGTTGGGGCGCTTTCCAAAACCCAACTTGTAGAATTTTTGGATGCAAA
TATCTAA

Upstream 100 bases:

>100_bases
CAATAAGTATTGTGTTCAATTCACATGTCAAAAATCAAAAATCAAAAATTAATTTACATAATAGTAATTAATTATTAGTA
ATACCTTTCTGGAGATAAAA

Downstream 100 bases:

>100_bases
AAGATTCAATACAGATTGGACAAGTTGTGATCTGCAGCGTGTTCAATCTGGACTAACGCAAAATTTAGTGCTACCCTTGT
GCTCAAAATACAAACAAACA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSENIVTLSDASFEDDVVNAEGPVLVDFWAEWCGPCKMIAPILQEVAAEYAGKVTIGKLNIDENSATPPKFGIRGIPTLL
LFKDGKVAATKVGALSKTQLVEFLDANI

Sequences:

>Translated_108_residues
MSENIVTLSDASFEDDVVNAEGPVLVDFWAEWCGPCKMIAPILQEVAAEYAGKVTIGKLNIDENSATPPKFGIRGIPTLL
LFKDGKVAATKVGALSKTQLVEFLDANI
>Mature_107_residues
SENIVTLSDASFEDDVVNAEGPVLVDFWAEWCGPCKMIAPILQEVAAEYAGKVTIGKLNIDENSATPPKFGIRGIPTLLL
FKDGKVAATKVGALSKTQLVEFLDANI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=42.3913043478261, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI21361657, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI5031973, Length=103, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI38505222, Length=82, Percent_Identity=40.2439024390244, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=72.2222222222222, Blast_Score=168, Evalue=6e-44,
Organism=Escherichia coli, GI1788936, Length=107, Percent_Identity=39.2523364485981, Blast_Score=89, Evalue=7e-20,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=36.5591397849462, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=107, Percent_Identity=32.7102803738318, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=43.2098765432099, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=106, Percent_Identity=36.7924528301887, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=91, Percent_Identity=39.5604395604396, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=39.0804597701149, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=39.0804597701149, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=87, Percent_Identity=39.0804597701149, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=84, Percent_Identity=35.7142857142857, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=110, Percent_Identity=33.6363636363636, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=41.1111111111111, Blast_Score=73, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=36.9565217391304, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=42.4657534246575, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664269, Length=111, Percent_Identity=28.8288288288288, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17648013, Length=99, Percent_Identity=35.3535353535354, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=99, Percent_Identity=35.3535353535354, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=89, Percent_Identity=32.5842696629214, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639068, Length=105, Percent_Identity=25.7142857142857, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11567; Mature: 11436

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENIVTLSDASFEDDVVNAEGPVLVDFWAEWCGPCKMIAPILQEVAAEYAGKVTIGKLN
CCCCEEEECCCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
IDENSATPPKFGIRGIPTLLLFKDGKVAATKVGALSKTQLVEFLDANI
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SENIVTLSDASFEDDVVNAEGPVLVDFWAEWCGPCKMIAPILQEVAAEYAGKVTIGKLN
CCCEEEECCCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
IDENSATPPKFGIRGIPTLLLFKDGKVAATKVGALSKTQLVEFLDANI
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]