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The map label for this gene is prpC [H]

Identifier: 119945563

GI number: 119945563

Start: 2271922

End: 2273052

Strand: Reverse

Name: prpC [H]

Synonym: Ping_1868

Alternate gene names: 119945563

Gene position: 2273052-2271922 (Counterclockwise)

Preceding gene: 119945564

Following gene: 119945562

Centisome position: 49.85

GC content: 42.18

Gene sequence:

>1131_bases
ATGAGCAATAAAAAAGCGGGCGGTGCAGGTCTTCGTGGACAAAGCGCAGGTGAAACAACATTATGTACTGTTGGGCAATC
CGGTAGTGGCTTAACCTATTGTGGTTACGATATTGCAGATCTTGCAGAGAATGTTACTTTTGAAGAAGTTGCTTATTTGT
TATTTAATGGCGAATTACCGACGCAGCAACAGCTTGATAGTTATAAAACAGAGCTCAATACGCTGCGTGATTTACCGCAA
GCTTTAAAGGAAGTGTTAAAGCTTATTCCTGCCAATTCACACCCGATGGATGTGATGAGAACAGGTTGTTCTTTTTTAGG
CAATCTTGAACCTGAGGCTGATTTTTCCGAGCAAAAGCGGGCTTCAAACAGATTGCTGGCAGCATTTCCTGCGATCATGT
GCTACTGGTACAGATATTCTCACGATGGTGTTGAAATCGATTGTCAGACCGATCAGCCGACACTTGGCGGACACTTTCTG
AAATTATTAAAGGGTGAAACAGCCTCGTTACAACATCAGCGCGTAATGGATGTATCATTAATTTTATATGCAGAGCATGA
GTTTAATGCCTCTACCTTTACGGCGCGTGTTTGTGCATCAACGTTATCAGATATGTTCTCCTGTACCACAGGTGCCATTG
GTACCCTGCGTGGTCCATTACATGGCGGTGCAAATGAAGCAGCCATGGATATGATTGAAAAATTCACTTCACCGGAAGAT
GCTAAAGAGAAAATGGGATTAATGCTGGAACGCAAAGAAAAAATCATGGGCTTTGGTCATGCTATCTACAAAACCTCTGA
TCCGCGTAACATTATTATTAAAAAATGGTCAGAAAAACTGGCAAAAGAAAATGGTGACACTTCTTTATATGATATCTCGG
TTGCCTGTGAAGAATTTATGTGGGATACCAAAAAATTATTTTGTAATGCCGATTTCTTCCATGCTTCAACCTATAACTAC
ATGGGTATTCCAACTAAACTGTTTACGCCAATTTTTGTCTGTTCACGCTTAACCGGTTGGGCTGCACATGTGATGGAACA
ACGTGCCAATAACCGTATTATTCGCCCAAGTGCAGATTATACCGGTAGCGCACCGCGTAAGGTCATCGCCATCGCTGAAC
GTGAAGCATAA

Upstream 100 bases:

>100_bases
CAAAAACTTGACGAATTATTTGCCGATCAAAAAAACAAGTAACGTTGAGTCATCTTGACAATAAATTCAATTAAAAATTT
AATAAATATAAGGAAAGTAT

Downstream 100 bases:

>100_bases
TCAGTAAAGCAGGAATAAATTATGAATGATAATTACCGTAAACCCTTACCGGGTACAAGCTTAGACTATTTTGATACGCG
TGAAGCCGTTAACAATATCA

Product: 2-methylcitrate synthase/citrate synthase II

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSNKKAGGAGLRGQSAGETTLCTVGQSGSGLTYCGYDIADLAENVTFEEVAYLLFNGELPTQQQLDSYKTELNTLRDLPQ
ALKEVLKLIPANSHPMDVMRTGCSFLGNLEPEADFSEQKRASNRLLAAFPAIMCYWYRYSHDGVEIDCQTDQPTLGGHFL
KLLKGETASLQHQRVMDVSLILYAEHEFNASTFTARVCASTLSDMFSCTTGAIGTLRGPLHGGANEAAMDMIEKFTSPED
AKEKMGLMLERKEKIMGFGHAIYKTSDPRNIIIKKWSEKLAKENGDTSLYDISVACEEFMWDTKKLFCNADFFHASTYNY
MGIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADYTGSAPRKVIAIAEREA

Sequences:

>Translated_376_residues
MSNKKAGGAGLRGQSAGETTLCTVGQSGSGLTYCGYDIADLAENVTFEEVAYLLFNGELPTQQQLDSYKTELNTLRDLPQ
ALKEVLKLIPANSHPMDVMRTGCSFLGNLEPEADFSEQKRASNRLLAAFPAIMCYWYRYSHDGVEIDCQTDQPTLGGHFL
KLLKGETASLQHQRVMDVSLILYAEHEFNASTFTARVCASTLSDMFSCTTGAIGTLRGPLHGGANEAAMDMIEKFTSPED
AKEKMGLMLERKEKIMGFGHAIYKTSDPRNIIIKKWSEKLAKENGDTSLYDISVACEEFMWDTKKLFCNADFFHASTYNY
MGIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADYTGSAPRKVIAIAEREA
>Mature_375_residues
SNKKAGGAGLRGQSAGETTLCTVGQSGSGLTYCGYDIADLAENVTFEEVAYLLFNGELPTQQQLDSYKTELNTLRDLPQA
LKEVLKLIPANSHPMDVMRTGCSFLGNLEPEADFSEQKRASNRLLAAFPAIMCYWYRYSHDGVEIDCQTDQPTLGGHFLK
LLKGETASLQHQRVMDVSLILYAEHEFNASTFTARVCASTLSDMFSCTTGAIGTLRGPLHGGANEAAMDMIEKFTSPEDA
KEKMGLMLERKEKIMGFGHAIYKTSDPRNIIIKKWSEKLAKENGDTSLYDISVACEEFMWDTKKLFCNADFFHASTYNYM
GIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADYTGSAPRKVIAIAEREA

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=378, Percent_Identity=23.2804232804233, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786527, Length=375, Percent_Identity=49.8666666666667, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786939, Length=378, Percent_Identity=31.4814814814815, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=374, Percent_Identity=24.5989304812834, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319850, Length=395, Percent_Identity=24.8101265822785, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325257, Length=356, Percent_Identity=26.4044943820225, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324328, Length=339, Percent_Identity=23.0088495575221, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640124, Length=378, Percent_Identity=25.3968253968254, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640126, Length=378, Percent_Identity=25.3968253968254, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356863, Length=336, Percent_Identity=24.1071428571429, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41708; Mature: 41577

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKKAGGAGLRGQSAGETTLCTVGQSGSGLTYCGYDIADLAENVTFEEVAYLLFNGELP
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHHCCCCCC
TQQQLDSYKTELNTLRDLPQALKEVLKLIPANSHPMDVMRTGCSFLGNLEPEADFSEQKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
ASNRLLAAFPAIMCYWYRYSHDGVEIDCQTDQPTLGGHFLKLLKGETASLQHQRVMDVSL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEE
ILYAEHEFNASTFTARVCASTLSDMFSCTTGAIGTLRGPLHGGANEAAMDMIEKFTSPED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCH
AKEKMGLMLERKEKIMGFGHAIYKTSDPRNIIIKKWSEKLAKENGDTSLYDISVACEEFM
HHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
WDTKKLFCNADFFHASTYNYMGIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADY
HHHHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
TGSAPRKVIAIAEREA
CCCCCCEEEEEECCCC
>Mature Secondary Structure 
SNKKAGGAGLRGQSAGETTLCTVGQSGSGLTYCGYDIADLAENVTFEEVAYLLFNGELP
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHHCCCCCC
TQQQLDSYKTELNTLRDLPQALKEVLKLIPANSHPMDVMRTGCSFLGNLEPEADFSEQKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
ASNRLLAAFPAIMCYWYRYSHDGVEIDCQTDQPTLGGHFLKLLKGETASLQHQRVMDVSL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEE
ILYAEHEFNASTFTARVCASTLSDMFSCTTGAIGTLRGPLHGGANEAAMDMIEKFTSPED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCH
AKEKMGLMLERKEKIMGFGHAIYKTSDPRNIIIKKWSEKLAKENGDTSLYDISVACEEFM
HHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
WDTKKLFCNADFFHASTYNYMGIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADY
HHHHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
TGSAPRKVIAIAEREA
CCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]