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The map label for this gene is hisB [H]

Identifier: 119945366

GI number: 119945366

Start: 2010821

End: 2011891

Strand: Reverse

Name: hisB [H]

Synonym: Ping_1654

Alternate gene names: 119945366

Gene position: 2011891-2010821 (Counterclockwise)

Preceding gene: 119945367

Following gene: 119945365

Centisome position: 44.12

GC content: 41.64

Gene sequence:

>1071_bases
ATGAGCAAACAAAAATTTCTATTCATCGATCGTGATGGTACTTTAATTGATGAGCCCATCAGCGACAAACAGGTTGATAG
TTTAGAAAAATTAATTTTTGAACCCTATGTCATCCCGAGCTTACTGACATTACAAGATGCAGGTTATATTCTGGTGATTG
TATCAAACCAGGATGGTCTGGGAACCGACAGTTATCCGCAGTCTGATTTTGATATTCCGCAGAATAAAATGATGGAAATT
TTTGCATCTCAAGGTGTAAAATTTGAAGCCACTCTGCTTTGTCCGCACTTCACTACGGATAACTGCAGCTGCCGTAAACC
CCATTTAGGGATAGTCAGTGAATACCTGAAATCAGGACGCATCGATTTTGCACATTCCTATGTTATTGGCGATCGTATTA
CCGATATCCAGCTTGCTGACAATATGGGCATCACCGGCATTATGTACAACAGAGAAACCGGTGGCTGGAATGCGATTGTT
AAACAGTTAACCAGCCAAGGGCGTATTGCCTCCGTTACCCGTACAACCAAAGAAACTGATATTAATGTCACCTTAGATTT
AGATCATACGGGTGAAAACCATATTGATACCGGCATGGGCTTCTTTGACCATATGTTAGATCAAATCGCCACCCATGGTG
GTTTCCAAATGGATGTACAGGTTAAAGGTGATTTACACATAGACGATCATCATACGGTTGAAGATACCGCGCTTGCACTT
GGTGAAGCCTTTAAAAAGGCACTCGGAGACAAACGTGGTATTGGCCGTTTTGGATTTGTTTTACCTATGGATGAAACAAA
AGCCAGTTGTACATTGGATTTATCCGGCCGCCCATACCTTAAATTTAAAGCGGATTTTCCGCGTGAATTAGTCGGTACTA
TGTCAACGGAAATGGTTCAACATTTTTTCCATTCCTTAACACAAGCGATGGGCGCAACCTTACACCTTGAAGTTGAAAAG
GGTAATACTCACCATATGGTTGAAGGTTTATTCAAAACGTTTGGCCGTACCCTTCGCCAATGTATACAAGTTGTGGGAAC
CGACTTACCTTCAAGCAAAGGTGTTTTATGA

Upstream 100 bases:

>100_bases
AATAAGCCACGTTTAAAAAACTGTATTCGCATTACTATCGGCACAGAAGCTGAAATGCAGGCAACATTAACCACCTTAAA
CTCGCTATAGGAAATAAATA

Downstream 100 bases:

>100_bases
ACATAGTCATTATTGATACGGGTTGCGCTAACCTCTCTTCGGTTAGGTTTGCCATCGAACGTTTAGGCTATAGTGTCACC
GTCAGTAAAGATCCGGCCAT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSKQKFLFIDRDGTLIDEPISDKQVDSLEKLIFEPYVIPSLLTLQDAGYILVIVSNQDGLGTDSYPQSDFDIPQNKMMEI
FASQGVKFEATLLCPHFTTDNCSCRKPHLGIVSEYLKSGRIDFAHSYVIGDRITDIQLADNMGITGIMYNRETGGWNAIV
KQLTSQGRIASVTRTTKETDINVTLDLDHTGENHIDTGMGFFDHMLDQIATHGGFQMDVQVKGDLHIDDHHTVEDTALAL
GEAFKKALGDKRGIGRFGFVLPMDETKASCTLDLSGRPYLKFKADFPRELVGTMSTEMVQHFFHSLTQAMGATLHLEVEK
GNTHHMVEGLFKTFGRTLRQCIQVVGTDLPSSKGVL

Sequences:

>Translated_356_residues
MSKQKFLFIDRDGTLIDEPISDKQVDSLEKLIFEPYVIPSLLTLQDAGYILVIVSNQDGLGTDSYPQSDFDIPQNKMMEI
FASQGVKFEATLLCPHFTTDNCSCRKPHLGIVSEYLKSGRIDFAHSYVIGDRITDIQLADNMGITGIMYNRETGGWNAIV
KQLTSQGRIASVTRTTKETDINVTLDLDHTGENHIDTGMGFFDHMLDQIATHGGFQMDVQVKGDLHIDDHHTVEDTALAL
GEAFKKALGDKRGIGRFGFVLPMDETKASCTLDLSGRPYLKFKADFPRELVGTMSTEMVQHFFHSLTQAMGATLHLEVEK
GNTHHMVEGLFKTFGRTLRQCIQVVGTDLPSSKGVL
>Mature_355_residues
SKQKFLFIDRDGTLIDEPISDKQVDSLEKLIFEPYVIPSLLTLQDAGYILVIVSNQDGLGTDSYPQSDFDIPQNKMMEIF
ASQGVKFEATLLCPHFTTDNCSCRKPHLGIVSEYLKSGRIDFAHSYVIGDRITDIQLADNMGITGIMYNRETGGWNAIVK
QLTSQGRIASVTRTTKETDINVTLDLDHTGENHIDTGMGFFDHMLDQIATHGGFQMDVQVKGDLHIDDHHTVEDTALALG
EAFKKALGDKRGIGRFGFVLPMDETKASCTLDLSGRPYLKFKADFPRELVGTMSTEMVQHFFHSLTQAMGATLHLEVEKG
NTHHMVEGLFKTFGRTLRQCIQVVGTDLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=353, Percent_Identity=65.4390934844193, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786399, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=166, Percent_Identity=46.3855421686747, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39582; Mature: 39450

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKFLFIDRDGTLIDEPISDKQVDSLEKLIFEPYVIPSLLTLQDAGYILVIVSNQDGL
CCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHEECCCCEEEEEEECCCCC
GTDSYPQSDFDIPQNKMMEIFASQGVKFEATLLCPHFTTDNCSCRKPHLGIVSEYLKSGR
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
IDFAHSYVIGDRITDIQLADNMGITGIMYNRETGGWNAIVKQLTSQGRIASVTRTTKETD
CEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCE
INVTLDLDHTGENHIDTGMGFFDHMLDQIATHGGFQMDVQVKGDLHIDDHHTVEDTALAL
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCHHHHHHHH
GEAFKKALGDKRGIGRFGFVLPMDETKASCTLDLSGRPYLKFKADFPRELVGTMSTEMVQ
HHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
HFFHSLTQAMGATLHLEVEKGNTHHMVEGLFKTFGRTLRQCIQVVGTDLPSSKGVL
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKQKFLFIDRDGTLIDEPISDKQVDSLEKLIFEPYVIPSLLTLQDAGYILVIVSNQDGL
CCCEEEEEECCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHEECCCCEEEEEEECCCCC
GTDSYPQSDFDIPQNKMMEIFASQGVKFEATLLCPHFTTDNCSCRKPHLGIVSEYLKSGR
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
IDFAHSYVIGDRITDIQLADNMGITGIMYNRETGGWNAIVKQLTSQGRIASVTRTTKETD
CEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCE
INVTLDLDHTGENHIDTGMGFFDHMLDQIATHGGFQMDVQVKGDLHIDDHHTVEDTALAL
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCHHHHHHHH
GEAFKKALGDKRGIGRFGFVLPMDETKASCTLDLSGRPYLKFKADFPRELVGTMSTEMVQ
HHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
HFFHSLTQAMGATLHLEVEKGNTHHMVEGLFKTFGRTLRQCIQVVGTDLPSSKGVL
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA