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The map label for this gene is lpxC [H]

Identifier: 119944909

GI number: 119944909

Start: 1443071

End: 1443997

Strand: Direct

Name: lpxC [H]

Synonym: Ping_1153

Alternate gene names: 119944909

Gene position: 1443071-1443997 (Clockwise)

Preceding gene: 119944908

Following gene: 119944911

Centisome position: 31.65

GC content: 38.08

Gene sequence:

>927_bases
ATGATTAAACAAAGAACACTTAAGAAGAGTGTCAAGTCAATAGGTATTGGCCTGCACTCAGGTAATAAGGTGAAAATTGA
ATTCCACCCTGCACCAGCCAATAGCGGTATTGTATACCGCCGTACCGATCTTGATCCTATTGTTAGTTTTAAAGCGCATG
CACAAGCGGTCCAAGAAACGCTTTTATGCACTTGCTTAGTTAACGATCAGGGCCAAAAAATATCAACGGTAGAACATCTT
TCTGCTGCACTTGCCGGGTTGGGTATTGATAATATAATTATTGATGTTGACGCCCCTGAAATTCCAATTATGGATGGCAG
TGCAAGTCCTTTTATTTTTCTCCTGCAATCGGCAGGTATTGAAGAGATAAACAGTCCGAAAAAATTCATTCGTATTAAAA
AAATGGTTCGGGTTGAAGATGAAAAAGAGGGTAAATGGGCTGAATTACACCCATCGAATAAAGGCTTTAGTTTAGATTTT
AAAATCGACTTCGATCACCCCGTTTTTGAAGGTCAAAATCAACATATAAAAATGGACTTTTCCGGTGATCTTTTTGTAAA
AGAGATCAGCCGCGCCAGAACCTTTGGTTTTATGAAAAGTGTAGAATATTTACAATCAAATAATTTAGCCTTAGGGGCTA
GTTTGGATAATGCGATTGGTTTAGATGAGTTTCGGGTATTAAATCCTGATGGTTTACGTTATGAAGACGAGTTCGTAAAA
CATAAAGTACTGGATGCCATTGGTGACCTTTATCTTTCTGGTTATACTATTTTAGGTCATCTTAAAGCCTTTAAAACAGG
ACATGCACTTAATAACCAACTTTTGTGTGCTTTATTAGCAGACCAAGAAGCTTGGGAAATGGTCACCTTTGAAGAGCCAG
TAAGTGAATCCCCCATTCAATACGTATCTCCTGTTTTTGCTCTCTAA

Upstream 100 bases:

>100_bases
TAAACAGGCTGATTAATCATTATTAGCAGTTTGCGATATTCATCACAAACTGCTAAAATTCCGCTTATTATATAACGCTA
GAGCGGCGGTAGGGGGAACA

Downstream 100 bases:

>100_bases
ATAAAAAATCCTTTAGTTTTCTAAAGGATTTTTTTTGTTATTTTTATCAACTTATTTTTTAGAATAGTCGGCTAACGAGC
GTAACGCTTTTTGCAATCCC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MIKQRTLKKSVKSIGIGLHSGNKVKIEFHPAPANSGIVYRRTDLDPIVSFKAHAQAVQETLLCTCLVNDQGQKISTVEHL
SAALAGLGIDNIIIDVDAPEIPIMDGSASPFIFLLQSAGIEEINSPKKFIRIKKMVRVEDEKEGKWAELHPSNKGFSLDF
KIDFDHPVFEGQNQHIKMDFSGDLFVKEISRARTFGFMKSVEYLQSNNLALGASLDNAIGLDEFRVLNPDGLRYEDEFVK
HKVLDAIGDLYLSGYTILGHLKAFKTGHALNNQLLCALLADQEAWEMVTFEEPVSESPIQYVSPVFAL

Sequences:

>Translated_308_residues
MIKQRTLKKSVKSIGIGLHSGNKVKIEFHPAPANSGIVYRRTDLDPIVSFKAHAQAVQETLLCTCLVNDQGQKISTVEHL
SAALAGLGIDNIIIDVDAPEIPIMDGSASPFIFLLQSAGIEEINSPKKFIRIKKMVRVEDEKEGKWAELHPSNKGFSLDF
KIDFDHPVFEGQNQHIKMDFSGDLFVKEISRARTFGFMKSVEYLQSNNLALGASLDNAIGLDEFRVLNPDGLRYEDEFVK
HKVLDAIGDLYLSGYTILGHLKAFKTGHALNNQLLCALLADQEAWEMVTFEEPVSESPIQYVSPVFAL
>Mature_308_residues
MIKQRTLKKSVKSIGIGLHSGNKVKIEFHPAPANSGIVYRRTDLDPIVSFKAHAQAVQETLLCTCLVNDQGQKISTVEHL
SAALAGLGIDNIIIDVDAPEIPIMDGSASPFIFLLQSAGIEEINSPKKFIRIKKMVRVEDEKEGKWAELHPSNKGFSLDF
KIDFDHPVFEGQNQHIKMDFSGDLFVKEISRARTFGFMKSVEYLQSNNLALGASLDNAIGLDEFRVLNPDGLRYEDEFVK
HKVLDAIGDLYLSGYTILGHLKAFKTGHALNNQLLCALLADQEAWEMVTFEEPVSESPIQYVSPVFAL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=62.171052631579, Blast_Score=406, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34229; Mature: 34229

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKKSVKSIGIGLHSGNKVKIEFHPAPANSGIVYRRTDLDPIVSFKAHAQAVQET
CCCHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
LLCTCLVNDQGQKISTVEHLSAALAGLGIDNIIIDVDAPEIPIMDGSASPFIFLLQSAGI
HEEEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEEECCCC
EEINSPKKFIRIKKMVRVEDEKEGKWAELHPSNKGFSLDFKIDFDHPVFEGQNQHIKMDF
HHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEC
SGDLFVKEISRARTFGFMKSVEYLQSNNLALGASLDNAIGLDEFRVLNPDGLRYEDEFVK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHH
HKVLDAIGDLYLSGYTILGHLKAFKTGHALNNQLLCALLADQEAWEMVTFEEPVSESPIQ
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHEEEEECCCCCCCCHH
YVSPVFAL
HHHHHHCC
>Mature Secondary Structure
MIKQRTLKKSVKSIGIGLHSGNKVKIEFHPAPANSGIVYRRTDLDPIVSFKAHAQAVQET
CCCHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
LLCTCLVNDQGQKISTVEHLSAALAGLGIDNIIIDVDAPEIPIMDGSASPFIFLLQSAGI
HEEEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEEECCCC
EEINSPKKFIRIKKMVRVEDEKEGKWAELHPSNKGFSLDFKIDFDHPVFEGQNQHIKMDF
HHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEC
SGDLFVKEISRARTFGFMKSVEYLQSNNLALGASLDNAIGLDEFRVLNPDGLRYEDEFVK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHH
HKVLDAIGDLYLSGYTILGHLKAFKTGHALNNQLLCALLADQEAWEMVTFEEPVSESPIQ
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHEEEEECCCCCCCCHH
YVSPVFAL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA