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The map label for this gene is fklB [H]

Identifier: 119944680

GI number: 119944680

Start: 1151467

End: 1152087

Strand: Direct

Name: fklB [H]

Synonym: Ping_0919

Alternate gene names: 119944680

Gene position: 1151467-1152087 (Clockwise)

Preceding gene: 119944679

Following gene: 119944682

Centisome position: 25.25

GC content: 44.12

Gene sequence:

>621_bases
ATGTCTGAACTACAGCTAAACACTCAAGAAAAACAAGCAAGTTACGGTATCGGTCTACAAATGGGAGAGCAACTTGCTGC
TAATCCTTTTGACGGTTTAGAAATCTCTGCTATTTCTGCAGGAATCTCAGACGCATTTGCCGGCGCTGAAAGCCAAGTAT
CTCGCGAAGATTTACAAACTGCTTTTGAAGTTATCTCTGGACGTATGCAAGCCGCTGCTGCTGAGCAAGCAGAAGTATTG
GGTGCAGCTGGTGCAGCTTACCTTGCTGAAAATGCAGCTAAAGAAGGTGTGACAGTGACTGAATCTGGACTTCATTATGA
AGTCATCACGCTAGGTGAAGGTGAAAAACCGACTGCTGAATCTACTGTTAGTGTTCATTACCACGGAACGTTGACTGACG
GTACTGTATTTGACAGTTCTGTTGAACGTGGCGAACCTGCTGAATTCCCTATTGGTGGTGTTATTGCTGGTTGGACTGAG
GCATTACAACTTATGCCTGTTGGTTCAAAATTCAAATTAGCTGTTCCTGCAGATCTTGCCTATGGCGAGCGTGGCGCTGG
CGCTGCAATTGGACCACATGCTACATTAGTATTTGAAGTTGAATTATTAGCTATTAAATAA

Upstream 100 bases:

>100_bases
GATATAACGAAAGCTGCGAGCAAATGGAACAGAGCCATTTATTAAGTCACCATATATGATAGAATTAAGCAAATACATTC
AATAAATTAAGAGAATAAAT

Downstream 100 bases:

>100_bases
TTTACTTGCCTACTGTCATAAGTAGGACATGAAAATATTAAAGCCCTTCTCTGGTAACAGATTAGGGCTTTTTTTATATG
TATAATAAAGCGAATAAAAA

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSELQLNTQEKQASYGIGLQMGEQLAANPFDGLEISAISAGISDAFAGAESQVSREDLQTAFEVISGRMQAAAAEQAEVL
GAAGAAYLAENAAKEGVTVTESGLHYEVITLGEGEKPTAESTVSVHYHGTLTDGTVFDSSVERGEPAEFPIGGVIAGWTE
ALQLMPVGSKFKLAVPADLAYGERGAGAAIGPHATLVFEVELLAIK

Sequences:

>Translated_206_residues
MSELQLNTQEKQASYGIGLQMGEQLAANPFDGLEISAISAGISDAFAGAESQVSREDLQTAFEVISGRMQAAAAEQAEVL
GAAGAAYLAENAAKEGVTVTESGLHYEVITLGEGEKPTAESTVSVHYHGTLTDGTVFDSSVERGEPAEFPIGGVIAGWTE
ALQLMPVGSKFKLAVPADLAYGERGAGAAIGPHATLVFEVELLAIK
>Mature_205_residues
SELQLNTQEKQASYGIGLQMGEQLAANPFDGLEISAISAGISDAFAGAESQVSREDLQTAFEVISGRMQAAAAEQAEVLG
AAGAAYLAENAAKEGVTVTESGLHYEVITLGEGEKPTAESTVSVHYHGTLTDGTVFDSSVERGEPAEFPIGGVIAGWTEA
LQLMPVGSKFKLAVPADLAYGERGAGAAIGPHATLVFEVELLAIK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=50.5747126436782, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=50.5747126436782, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=50.5747126436782, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=42.4528301886792, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503727, Length=134, Percent_Identity=38.0597014925373, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4503729, Length=94, Percent_Identity=43.6170212765958, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI224809329, Length=102, Percent_Identity=40.1960784313725, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI224809327, Length=102, Percent_Identity=40.1960784313725, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4758384, Length=102, Percent_Identity=40.1960784313725, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=42.3529411764706, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI224809331, Length=102, Percent_Identity=40.1960784313725, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=205, Percent_Identity=55.1219512195122, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI1789745, Length=215, Percent_Identity=35.3488372093023, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=45.2830188679245, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=44.0860215053763, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=90, Percent_Identity=44.4444444444444, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324194, Length=111, Percent_Identity=42.3423423423423, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320727, Length=87, Percent_Identity=52.8735632183908, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281363946, Length=112, Percent_Identity=44.6428571428571, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17352457, Length=112, Percent_Identity=44.6428571428571, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=42.9906542056075, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647110, Length=117, Percent_Identity=41.8803418803419, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356629, Length=86, Percent_Identity=44.1860465116279, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21284; Mature: 21153

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELQLNTQEKQASYGIGLQMGEQLAANPFDGLEISAISAGISDAFAGAESQVSREDLQT
CCCCCCCCHHHHHHCCCCHHHCHHHHCCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHH
AFEVISGRMQAAAAEQAEVLGAAGAAYLAENAAKEGVTVTESGLHYEVITLGEGEKPTAE
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCC
STVSVHYHGTLTDGTVFDSSVERGEPAEFPIGGVIAGWTEALQLMPVGSKFKLAVPADLA
CEEEEEEEEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCEEEEECCCCC
YGERGAGAAIGPHATLVFEVELLAIK
CCCCCCCCCCCCCEEEEEEEEEEEEC
>Mature Secondary Structure 
SELQLNTQEKQASYGIGLQMGEQLAANPFDGLEISAISAGISDAFAGAESQVSREDLQT
CCCCCCCHHHHHHCCCCHHHCHHHHCCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHH
AFEVISGRMQAAAAEQAEVLGAAGAAYLAENAAKEGVTVTESGLHYEVITLGEGEKPTAE
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCC
STVSVHYHGTLTDGTVFDSSVERGEPAEFPIGGVIAGWTEALQLMPVGSKFKLAVPADLA
CEEEEEEEEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCEEEEECCCCC
YGERGAGAAIGPHATLVFEVELLAIK
CCCCCCCCCCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]