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The map label for this gene is tyrS [H]

Identifier: 119944682

GI number: 119944682

Start: 1153039

End: 1154310

Strand: Direct

Name: tyrS [H]

Synonym: Ping_0921

Alternate gene names: 119944682

Gene position: 1153039-1154310 (Clockwise)

Preceding gene: 119944680

Following gene: 119944683

Centisome position: 25.29

GC content: 38.84

Gene sequence:

>1272_bases
ATGAATGCTCTACTTGAAGATTTACAAGCGCGAGGTTTAATCGCGCAAATGACTGCAGATGAAGAATTACATGAACATTT
ATCAAGTGGCTGCAAAACACTTTATTGTGGATTTGATCCGACGGCAGACAGCCTGCATATCGGAAGTTTAGTGCCACTCG
TCACATTGAAACGTTTCCAGGACGCGGGTCATAAGCCATTAGCTTTGGTCGGTGGCGCAACCGGATTGATTGGTGATCCA
AGCTTTAAAGCGGTGGAACGTAAATTAAATACTGATGATGTTGTTGCAGATTGGGCGGAAAAAATCAAAGGGCAAGTCAG
TGCTTTTATCGAATTTGGTGATCGGGAAAATTCAGCAGAGGTTGTTAATAACCTTGATTGGATTGGCAAAATGGATACTA
TTTCCTTTTTGCGTGATGTGGGTAAACATTTTAGTGTTAATGCCATGATTCAAAAAGAATCTGTTAAACAGCGTATTGAT
CGTGATGGTTCGGGTATGTCATTTACTGAATTTACCTATATGTTATTACAATCTTATGATTTTGCAGCTTTAAATAAAGC
TAATGGTTGTTCACTGCAGATTGGTGGCTCAGATCAATGGGGTAATATAACCGGCGGTATTGATTTAACACGGCGCATGA
ATCAAGAAAAAGTATTTGGTTTGACGCTACCTTTAGTCACTAAATCTGACGGCACAAAATTTGGTAAGACAGAAGCAGGC
ACTATCTGGCTTGATGCCGCAAAAACATCGCCTTATGCATTCTTCCAATTCTGGATAACAACATTAGATGCGGATGTTTA
CAAATTTCTTCATTATTTTACTTTCTTATCTGTTGAAGAAATTGCTGCGATTGAAGAAAATGATAAAACCATTCAAGGCC
GTCCTGAAGGGCAAAATATTTTGGCGCAGCAAGTTACAAAGATGGTTCATGGTGAACAAGGTTTAGGCTCAGCACAACGT
ATTACCGAAGCCCTGTTTTCTGGTGATTTAAGCGCATTAGATGAATCGGATCTGGCACAACTTGCGCAGGATGGTTTACC
TGCAACCTTTGTTGAAGGGACAGAAAAACCATTAGTTGAATTATTGACCAGTTGTGAGCTTGCTAAATCGAATAAAATGG
CGCGAGAATTTATTAAAAATGGTGCGGTCAGTATTAATGGCGAAAAACAAACCGATAGTGAAGTCATTTTACAAAAATTA
GATGCGTTATTTGGTAAATATACTGTGATTAAGCGTGGTAAACGCTTGTTCAATTTATTTATATGGAGATAA

Upstream 100 bases:

>100_bases
AAGTGCCTTATATCGGCACTCTATGGTTTTTTTGTGTCTCTTAAATGTGTAATATCTTGAGCATAAAATATTGGATTCTT
AATGATCAGGAAGTAAATAA

Downstream 100 bases:

>100_bases
GTGAGATGTTGAAGATTAAAAAAATAAAGCTATTAAGTAGCGCCTTCTTTTGTATTTTTGTAGGTCAAGCCGTGGCGCAA
CAGCCGGCGCAAACTAAATA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNALLEDLQARGLIAQMTADEELHEHLSSGCKTLYCGFDPTADSLHIGSLVPLVTLKRFQDAGHKPLALVGGATGLIGDP
SFKAVERKLNTDDVVADWAEKIKGQVSAFIEFGDRENSAEVVNNLDWIGKMDTISFLRDVGKHFSVNAMIQKESVKQRID
RDGSGMSFTEFTYMLLQSYDFAALNKANGCSLQIGGSDQWGNITGGIDLTRRMNQEKVFGLTLPLVTKSDGTKFGKTEAG
TIWLDAAKTSPYAFFQFWITTLDADVYKFLHYFTFLSVEEIAAIEENDKTIQGRPEGQNILAQQVTKMVHGEQGLGSAQR
ITEALFSGDLSALDESDLAQLAQDGLPATFVEGTEKPLVELLTSCELAKSNKMAREFIKNGAVSINGEKQTDSEVILQKL
DALFGKYTVIKRGKRLFNLFIWR

Sequences:

>Translated_423_residues
MNALLEDLQARGLIAQMTADEELHEHLSSGCKTLYCGFDPTADSLHIGSLVPLVTLKRFQDAGHKPLALVGGATGLIGDP
SFKAVERKLNTDDVVADWAEKIKGQVSAFIEFGDRENSAEVVNNLDWIGKMDTISFLRDVGKHFSVNAMIQKESVKQRID
RDGSGMSFTEFTYMLLQSYDFAALNKANGCSLQIGGSDQWGNITGGIDLTRRMNQEKVFGLTLPLVTKSDGTKFGKTEAG
TIWLDAAKTSPYAFFQFWITTLDADVYKFLHYFTFLSVEEIAAIEENDKTIQGRPEGQNILAQQVTKMVHGEQGLGSAQR
ITEALFSGDLSALDESDLAQLAQDGLPATFVEGTEKPLVELLTSCELAKSNKMAREFIKNGAVSINGEKQTDSEVILQKL
DALFGKYTVIKRGKRLFNLFIWR
>Mature_423_residues
MNALLEDLQARGLIAQMTADEELHEHLSSGCKTLYCGFDPTADSLHIGSLVPLVTLKRFQDAGHKPLALVGGATGLIGDP
SFKAVERKLNTDDVVADWAEKIKGQVSAFIEFGDRENSAEVVNNLDWIGKMDTISFLRDVGKHFSVNAMIQKESVKQRID
RDGSGMSFTEFTYMLLQSYDFAALNKANGCSLQIGGSDQWGNITGGIDLTRRMNQEKVFGLTLPLVTKSDGTKFGKTEAG
TIWLDAAKTSPYAFFQFWITTLDADVYKFLHYFTFLSVEEIAAIEENDKTIQGRPEGQNILAQQVTKMVHGEQGLGSAQR
ITEALFSGDLSALDESDLAQLAQDGLPATFVEGTEKPLVELLTSCELAKSNKMAREFIKNGAVSINGEKQTDSEVILQKL
DALFGKYTVIKRGKRLFNLFIWR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=440, Percent_Identity=36.8181818181818, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1787925, Length=420, Percent_Identity=61.1904761904762, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25145802, Length=402, Percent_Identity=36.0696517412935, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25145805, Length=312, Percent_Identity=33.6538461538462, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325160, Length=413, Percent_Identity=35.5932203389831, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI20130383, Length=425, Percent_Identity=37.1764705882353, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46662; Mature: 46662

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALLEDLQARGLIAQMTADEELHEHLSSGCKTLYCGFDPTADSLHIGSLVPLVTLKRFQ
CCHHHHHHHHCCCCEECCCHHHHHHHHHCCCCEEEECCCCCCCCEECCHHHHHHHHHHHH
DAGHKPLALVGGATGLIGDPSFKAVERKLNTDDVVADWAEKIKGQVSAFIEFGDRENSAE
CCCCCCEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VVNNLDWIGKMDTISFLRDVGKHFSVNAMIQKESVKQRIDRDGSGMSFTEFTYMLLQSYD
HHHHHHHCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
FAALNKANGCSLQIGGSDQWGNITGGIDLTRRMNQEKVFGLTLPLVTKSDGTKFGKTEAG
HHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCHHEEEEEEEEEECCCCCCCCCCCCC
TIWLDAAKTSPYAFFQFWITTLDADVYKFLHYFTFLSVEEIAAIEENDKTIQGRPEGQNI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHH
LAQQVTKMVHGEQGLGSAQRITEALFSGDLSALDESDLAQLAQDGLPATFVEGTEKPLVE
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCEEECCCCHHHHHH
LLTSCELAKSNKMAREFIKNGAVSINGEKQTDSEVILQKLDALFGKYTVIKRGKRLFNLF
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWR
CCC
>Mature Secondary Structure
MNALLEDLQARGLIAQMTADEELHEHLSSGCKTLYCGFDPTADSLHIGSLVPLVTLKRFQ
CCHHHHHHHHCCCCEECCCHHHHHHHHHCCCCEEEECCCCCCCCEECCHHHHHHHHHHHH
DAGHKPLALVGGATGLIGDPSFKAVERKLNTDDVVADWAEKIKGQVSAFIEFGDRENSAE
CCCCCCEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VVNNLDWIGKMDTISFLRDVGKHFSVNAMIQKESVKQRIDRDGSGMSFTEFTYMLLQSYD
HHHHHHHCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
FAALNKANGCSLQIGGSDQWGNITGGIDLTRRMNQEKVFGLTLPLVTKSDGTKFGKTEAG
HHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCHHEEEEEEEEEECCCCCCCCCCCCC
TIWLDAAKTSPYAFFQFWITTLDADVYKFLHYFTFLSVEEIAAIEENDKTIQGRPEGQNI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHH
LAQQVTKMVHGEQGLGSAQRITEALFSGDLSALDESDLAQLAQDGLPATFVEGTEKPLVE
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCEEECCCCHHHHHH
LLTSCELAKSNKMAREFIKNGAVSINGEKQTDSEVILQKLDALFGKYTVIKRGKRLFNLF
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA