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The map label for this gene is pepD [H]

Identifier: 119944655

GI number: 119944655

Start: 1120264

End: 1121721

Strand: Reverse

Name: pepD [H]

Synonym: Ping_0894

Alternate gene names: 119944655

Gene position: 1121721-1120264 (Counterclockwise)

Preceding gene: 119944659

Following gene: 119944649

Centisome position: 24.6

GC content: 40.67

Gene sequence:

>1458_bases
ATGCAGGCTTTACACTCAACAATCGCTTCCCCCGTTTGGTCTTATTTCTCGACTATTTGCTCTATCCCGCATCCTTCTAA
ACACGATCGGAAACTTGCAGATTGGATAATCCATTGGGCGAAAGAAAAAAATATAAGCTGTGTACAAGATGAAATTGGTA
ATCTAATTTTAAAAAAAGCCGCAAGTCATGGTTATGAAAATAACACGGCTATTATTCTTCAGGCGCACCTTGATATGGTG
CCGCAAAAAAACAACAATATTGACCACAATTTTTTAACCGATGCGATTAAGCCTATTATCGAGGGTGAATGGTTACGCGC
TGACAATACAACATTGGGTGCAGATAACGGGATCGGCATGGCAGCTTGTTTAGCTGTATTAGCTGATAACACACTACAGC
ATGGCCCCCTTGAAGTACTTTTAACAACCGACGAAGAAACCGGCATGACCGGTGCATTTGGCCTGAAAGCGAATGCACTC
CAGGGAAAAATCCTACTTAATACGGATTCTGAACAAGAAGGTGAACTTTTTGTGGGTTGTGCGGGAGGCGTTAATGTAAC
GGTGACCCTACCCTATGAAATAATGGAACGTGAACCGGACAACAGTGCGTTTGAAATTTGTCTGGATGGCCTTAAGGGAG
GGCATTCCGGTTGTGATATTAATTTGGGCCGTGCAAATGCAATAAAAACACTGGTATCAGTGTTGAACAACCTCGAGGGC
ATTCCATTTCACCTTGCGTATTTTGAAGGCGGCAGTTTACGTAATGCTATTCCACGAGAAGCGAGTTGTGTCATTATTTG
TGACCCTCAGTATCAAAATAGTATAGAAATCATCATCAATACCCTGCAAAAAAATCTCTGTAGTCAATTTAAAGCGTCTG
AGCCTAATTTAGCACTTTCGGTGAAATCCTGTGCCTTACCCGGTTTTATCTTAACCCATAAAAGCCAAGCTAATTTATTA
ACCAGCCTGACCCAATGTAATAATGGAGTATTCAGTATGGATAATAATTTTTCTGATGTAGTGCAAACCTCTTCAAATTT
AGGCGTTGTTTCACAAAACAGAAATAACCGTGGCGTTTTTGATATTCAGGTCTTAGTACGTTCTCAGGTTGAGCAGGAAA
AACAAGCTGAAGCACAAAAAATTGCACAACAATTTGAGCAGCATGATGCAACCGTTTCGTTGACGGGTAACTATCCCGGC
TGGACGCCAAACCCGCACTCAGAAATTTATAAAACAGTTGAAAAACAATATGTTAAACTTTTTGACAAACAGCCCAAAGC
AATGGTGATTCATGCAGGATTAGAATGCGGTTTGTTTAGTGCTGAATATCCACAATGGGATATGATTTCATTCGGCCCAA
CCATTAAATTTCCGCATAGCCCCGATGAAAAAGTGCAGATCAACAGTGTTGATAAATTTTGGCAATTATTAGTGGCAACA
TTAAAAGCGATTGATTAG

Upstream 100 bases:

>100_bases
TAAATATGTTAATGTTATTGATCTAGATCAATTTAAGTATACCCCGAACGGTTGTAGATTAGCAGCAACTCATTCCGTAT
TTTTCAAAACAGGATCTTTT

Downstream 100 bases:

>100_bases
GCTATCTTGGCGCTTTAATTAATTATTTTCTATTTATTTATACCAGTTAAAACGAATACTGGCTGGTGATCACGCACGGT
TTTGGCGTTGGTTATTGATT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQALHSTIASPVWSYFSTICSIPHPSKHDRKLADWIIHWAKEKNISCVQDEIGNLILKKAASHGYENNTAIILQAHLDMV
PQKNNNIDHNFLTDAIKPIIEGEWLRADNTTLGADNGIGMAACLAVLADNTLQHGPLEVLLTTDEETGMTGAFGLKANAL
QGKILLNTDSEQEGELFVGCAGGVNVTVTLPYEIMEREPDNSAFEICLDGLKGGHSGCDINLGRANAIKTLVSVLNNLEG
IPFHLAYFEGGSLRNAIPREASCVIICDPQYQNSIEIIINTLQKNLCSQFKASEPNLALSVKSCALPGFILTHKSQANLL
TSLTQCNNGVFSMDNNFSDVVQTSSNLGVVSQNRNNRGVFDIQVLVRSQVEQEKQAEAQKIAQQFEQHDATVSLTGNYPG
WTPNPHSEIYKTVEKQYVKLFDKQPKAMVIHAGLECGLFSAEYPQWDMISFGPTIKFPHSPDEKVQINSVDKFWQLLVAT
LKAID

Sequences:

>Translated_485_residues
MQALHSTIASPVWSYFSTICSIPHPSKHDRKLADWIIHWAKEKNISCVQDEIGNLILKKAASHGYENNTAIILQAHLDMV
PQKNNNIDHNFLTDAIKPIIEGEWLRADNTTLGADNGIGMAACLAVLADNTLQHGPLEVLLTTDEETGMTGAFGLKANAL
QGKILLNTDSEQEGELFVGCAGGVNVTVTLPYEIMEREPDNSAFEICLDGLKGGHSGCDINLGRANAIKTLVSVLNNLEG
IPFHLAYFEGGSLRNAIPREASCVIICDPQYQNSIEIIINTLQKNLCSQFKASEPNLALSVKSCALPGFILTHKSQANLL
TSLTQCNNGVFSMDNNFSDVVQTSSNLGVVSQNRNNRGVFDIQVLVRSQVEQEKQAEAQKIAQQFEQHDATVSLTGNYPG
WTPNPHSEIYKTVEKQYVKLFDKQPKAMVIHAGLECGLFSAEYPQWDMISFGPTIKFPHSPDEKVQINSVDKFWQLLVAT
LKAID
>Mature_485_residues
MQALHSTIASPVWSYFSTICSIPHPSKHDRKLADWIIHWAKEKNISCVQDEIGNLILKKAASHGYENNTAIILQAHLDMV
PQKNNNIDHNFLTDAIKPIIEGEWLRADNTTLGADNGIGMAACLAVLADNTLQHGPLEVLLTTDEETGMTGAFGLKANAL
QGKILLNTDSEQEGELFVGCAGGVNVTVTLPYEIMEREPDNSAFEICLDGLKGGHSGCDINLGRANAIKTLVSVLNNLEG
IPFHLAYFEGGSLRNAIPREASCVIICDPQYQNSIEIIINTLQKNLCSQFKASEPNLALSVKSCALPGFILTHKSQANLL
TSLTQCNNGVFSMDNNFSDVVQTSSNLGVVSQNRNNRGVFDIQVLVRSQVEQEKQAEAQKIAQQFEQHDATVSLTGNYPG
WTPNPHSEIYKTVEKQYVKLFDKQPKAMVIHAGLECGLFSAEYPQWDMISFGPTIKFPHSPDEKVQINSVDKFWQLLVAT
LKAID

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=488, Percent_Identity=46.5163934426229, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53301; Mature: 53301

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALHSTIASPVWSYFSTICSIPHPSKHDRKLADWIIHWAKEKNISCVQDEIGNLILKKA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASHGYENNTAIILQAHLDMVPQKNNNIDHNFLTDAIKPIIEGEWLRADNTTLGADNGIGM
HHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCEECCCCCCCH
AACLAVLADNTLQHGPLEVLLTTDEETGMTGAFGLKANALQGKILLNTDSEQEGELFVGC
HHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCEEEEECCCCCCCCEEEEE
AGGVNVTVTLPYEIMEREPDNSAFEICLDGLKGGHSGCDINLGRANAIKTLVSVLNNLEG
CCCCEEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
IPFHLAYFEGGSLRNAIPREASCVIICDPQYQNSIEIIINTLQKNLCSQFKASEPNLALS
CCEEEEEECCCCHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VKSCALPGFILTHKSQANLLTSLTQCNNGVFSMDNNFSDVVQTSSNLGVVSQNRNNRGVF
EHHHCCCCEEEECCCHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCEEECCCCCCCEE
DIQVLVRSQVEQEKQAEAQKIAQQFEQHDATVSLTGNYPGWTPNPHSEIYKTVEKQYVKL
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
FDKQPKAMVIHAGLECGLFSAEYPQWDMISFGPTIKFPHSPDEKVQINSVDKFWQLLVAT
HCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEECCHHHHHHHHHHH
LKAID
HHHCC
>Mature Secondary Structure
MQALHSTIASPVWSYFSTICSIPHPSKHDRKLADWIIHWAKEKNISCVQDEIGNLILKKA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASHGYENNTAIILQAHLDMVPQKNNNIDHNFLTDAIKPIIEGEWLRADNTTLGADNGIGM
HHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCEECCCCCCCH
AACLAVLADNTLQHGPLEVLLTTDEETGMTGAFGLKANALQGKILLNTDSEQEGELFVGC
HHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCEEEEECCCCCCCCEEEEE
AGGVNVTVTLPYEIMEREPDNSAFEICLDGLKGGHSGCDINLGRANAIKTLVSVLNNLEG
CCCCEEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
IPFHLAYFEGGSLRNAIPREASCVIICDPQYQNSIEIIINTLQKNLCSQFKASEPNLALS
CCEEEEEECCCCHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VKSCALPGFILTHKSQANLLTSLTQCNNGVFSMDNNFSDVVQTSSNLGVVSQNRNNRGVF
EHHHCCCCEEEECCCHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCEEECCCCCCCEE
DIQVLVRSQVEQEKQAEAQKIAQQFEQHDATVSLTGNYPGWTPNPHSEIYKTVEKQYVKL
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
FDKQPKAMVIHAGLECGLFSAEYPQWDMISFGPTIKFPHSPDEKVQINSVDKFWQLLVAT
HCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEECCHHHHHHHHHHH
LKAID
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]