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The map label for this gene is wecG [H]

Identifier: 119944214

GI number: 119944214

Start: 553083

End: 553886

Strand: Direct

Name: wecG [H]

Synonym: Ping_0436

Alternate gene names: 119944214

Gene position: 553083-553886 (Clockwise)

Preceding gene: 119944211

Following gene: 119944215

Centisome position: 12.13

GC content: 43.28

Gene sequence:

>804_bases
ATGTCAGCGTCGCAAAATATTGGGGATCTCTCCTCGCTTTCTACATTGGAAGTAACACAAAGGGATGTCTGTCTATTCGG
TATTACAGTTCATGCTCTTACCTCATCGCAAGCTCTTGATAATATTGACAGTGCGATAAAAAACAAACAATCCTTACATA
TCGGCATGTTAAATGCGGCTAAAATTGTCAATATGAAGCGCAACCCTACACTTGGCGAAGATGTCCGTAGTTCGAATATG
ATCCTTGCTGACGGCAGTTCTGTTGTCATGGCAAGTAAAATTTTAAGAAAAACCTTACCTGAACGTGTTACTGGAATTGA
TTTGATGCATGGCATCTTGAGCCGCGGTAATAAAGAAGGCTACCGTGTATTTTGTCTTGGTGCTACTCCTGAAATATTGG
CTAGAACCGAGGCGGAAATTCGTAAACAATATCCTGGTGTCGTTATTGCGGGCACCCAACACGGTTATTTTAGTGACAGT
GAAGAAGCTGCTGTGGCACAAAAAATCACTGATTCTGATGCTGATGTTTTATTTGTTGCTATTACTTCCCCCAAAAAAGA
GCAATTTATGGCCCGTTGGAATACAGCTATGCGCGTACCGGTTGTGCATGGTGTCGGCGGTTCATTCGATGTGCTGGCAG
GAAAAGTACAGCGTGCCCCACTAATCTGGCAAAAATATGGCATGGAATGGCTTTATCGCGTAGTACAAGAGCCTGGGCGC
TTATGGAAACGCTATCTGGTCACCAACACTTTGTTTTTAGGTATGTTAGCCAAAGAACTTTTTCTTCCTAGCAAACCCCT
CTAG

Upstream 100 bases:

>100_bases
ATAAAGCTCAGTGGCAGAAATTACAATTTGATATATTCTAATTATGTTCCTATTGTTTATTTTCTTATTTAACGACATTT
TCAATTATGTGGAGTGGTTT

Downstream 100 bases:

>100_bases
TCAATAAAATTAAGCCTTTAAATTATGAGTCGTAAAAAACAACAGTTAATTTATTTAGCCGCCGCCAGCCATTCGGGCTC
AACCATGACAGCTATGCTAC

Product: UDP-N-acetyl-D-mannosamine transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSASQNIGDLSSLSTLEVTQRDVCLFGITVHALTSSQALDNIDSAIKNKQSLHIGMLNAAKIVNMKRNPTLGEDVRSSNM
ILADGSSVVMASKILRKTLPERVTGIDLMHGILSRGNKEGYRVFCLGATPEILARTEAEIRKQYPGVVIAGTQHGYFSDS
EEAAVAQKITDSDADVLFVAITSPKKEQFMARWNTAMRVPVVHGVGGSFDVLAGKVQRAPLIWQKYGMEWLYRVVQEPGR
LWKRYLVTNTLFLGMLAKELFLPSKPL

Sequences:

>Translated_267_residues
MSASQNIGDLSSLSTLEVTQRDVCLFGITVHALTSSQALDNIDSAIKNKQSLHIGMLNAAKIVNMKRNPTLGEDVRSSNM
ILADGSSVVMASKILRKTLPERVTGIDLMHGILSRGNKEGYRVFCLGATPEILARTEAEIRKQYPGVVIAGTQHGYFSDS
EEAAVAQKITDSDADVLFVAITSPKKEQFMARWNTAMRVPVVHGVGGSFDVLAGKVQRAPLIWQKYGMEWLYRVVQEPGR
LWKRYLVTNTLFLGMLAKELFLPSKPL
>Mature_266_residues
SASQNIGDLSSLSTLEVTQRDVCLFGITVHALTSSQALDNIDSAIKNKQSLHIGMLNAAKIVNMKRNPTLGEDVRSSNMI
LADGSSVVMASKILRKTLPERVTGIDLMHGILSRGNKEGYRVFCLGATPEILARTEAEIRKQYPGVVIAGTQHGYFSDSE
EAAVAQKITDSDADVLFVAITSPKKEQFMARWNTAMRVPVVHGVGGSFDVLAGKVQRAPLIWQKYGMEWLYRVVQEPGRL
WKRYLVTNTLFLGMLAKELFLPSKPL

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=210, Percent_Identity=38.0952380952381, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 29408; Mature: 29276

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASQNIGDLSSLSTLEVTQRDVCLFGITVHALTSSQALDNIDSAIKNKQSLHIGMLNAA
CCCCCCCCCHHCCHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
KIVNMKRNPTLGEDVRSSNMILADGSSVVMASKILRKTLPERVTGIDLMHGILSRGNKEG
HHEECCCCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YRVFCLGATPEILARTEAEIRKQYPGVVIAGTQHGYFSDSEEAAVAQKITDSDADVLFVA
CEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
ITSPKKEQFMARWNTAMRVPVVHGVGGSFDVLAGKVQRAPLIWQKYGMEWLYRVVQEPGR
ECCCCHHHHHHHHCCEEECEEEECCCCCHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHH
LWKRYLVTNTLFLGMLAKELFLPSKPL
HHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SASQNIGDLSSLSTLEVTQRDVCLFGITVHALTSSQALDNIDSAIKNKQSLHIGMLNAA
CCCCCCCCHHCCHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
KIVNMKRNPTLGEDVRSSNMILADGSSVVMASKILRKTLPERVTGIDLMHGILSRGNKEG
HHEECCCCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YRVFCLGATPEILARTEAEIRKQYPGVVIAGTQHGYFSDSEEAAVAQKITDSDADVLFVA
CEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
ITSPKKEQFMARWNTAMRVPVVHGVGGSFDVLAGKVQRAPLIWQKYGMEWLYRVVQEPGR
ECCCCHHHHHHHHCCEEECEEEECCCCCHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHH
LWKRYLVTNTLFLGMLAKELFLPSKPL
HHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]