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The map label for this gene is fba [H]

Identifier: 119944152

GI number: 119944152

Start: 477695

End: 478771

Strand: Direct

Name: fba [H]

Synonym: Ping_0372

Alternate gene names: 119944152

Gene position: 477695-478771 (Clockwise)

Preceding gene: 119944151

Following gene: 119944153

Centisome position: 10.48

GC content: 42.43

Gene sequence:

>1077_bases
ATGACTAAGATTTTAGACGTAGTAAAACCTGGTGTTCTCACTGGTGATGATTTACAAAAAGTATTTAAAGTTGCAAAAGA
AAACAAATTTGCACTTCCAGCGGTAAACGTTGTTGGCAGTGATTCAATCAATGCTGTACTTGAAGCTGCAGCTAAAGTTA
AGGCACCCGTTGTAATCCAATTCTCTAATGGTGGTGCTGCATTTAACGCAGGTAAAGGTCTTAAACTTCCTGGTCACGAA
GCCGCTATTCTTGGTGCTGTTTCTGGTGCTAAACACGTTCACGCAATGGCTGAAGCTTATGGCGTTCCTGTTATTCTTCA
CACCGACCACGCTGCAAGGAAACTACTGCCTTGGATCGACGGACTACTAACTGCTTCTGAAGCGCATTTTGCAGAAACGG
GTAAGCCTCTTTTCTCTTCACACATGATAGATCTTTCTGAAGAGCCTCTAGAAGAAAATATTGCAACTTGTGCTGAGTAC
CTAACGCGTATGTCTAAAATGGGCATGACGTTAGAAATAGAACTAGGTTGTACTGGTGGTGAAGAAGACGGTGTTGATAA
CTCTGGTATGGATGACTCATTACTTTATACTCAACCCTCTGAAGTTGATTATGCCAATACTGAGCTTTCTAAAATCAGCC
CTAACTTCACTATTGCGGCTTCTTTTGGTAACGTACACGGCGTATACAAGCCAGGTAATGTTAAACTGACTCCAGCTATC
CTACGTGAATCACAAGCATTTGTGTCAGAGAAGCACGGTCTTCCAACAAACAGCTTAAACTTCGTATTCCACGGTGGTTC
TGGTTCATCTGAAGCTGAAATTCAAGAGTCTATCGGTTACGGTGTTATCAAAATGAATATCGATACAGATACGCAGTGGG
CATGTTGGGATGGCGTTCGTGGTTATGAAGCTAAAAACCATGATTTCCTACAAGGCCAAATCGGTAACCCAACGGGTGAA
GATGCTCCTAACAAGAAATACTATGATCCACGTGCATGGTTACGCGCTGCTCAAGAATCTATGGTTGCACGTCTTGAGAA
AGCATTCTCAGATCTTAACGCAGTTGATGTACTATAA

Upstream 100 bases:

>100_bases
TCCAATTTCCATTTTCGTGCTTTTCATCACAAAATTGTGTAATATCAGCCGTGAAATTGAGCAAAATGTAATTTAACTCT
AAATAAACAGGACTATCCTT

Downstream 100 bases:

>100_bases
TTTAACGGATTCAGTTACTAGTCAGTTGAATATTTAAATTATCAAGCCAGCTTAATTGCTGGCTTTTTTTTTACCCAAAA
TAACACCTCGATGCAACTAA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTKILDVVKPGVLTGDDLQKVFKVAKENKFALPAVNVVGSDSINAVLEAAAKVKAPVVIQFSNGGAAFNAGKGLKLPGHE
AAILGAVSGAKHVHAMAEAYGVPVILHTDHAARKLLPWIDGLLTASEAHFAETGKPLFSSHMIDLSEEPLEENIATCAEY
LTRMSKMGMTLEIELGCTGGEEDGVDNSGMDDSLLYTQPSEVDYANTELSKISPNFTIAASFGNVHGVYKPGNVKLTPAI
LRESQAFVSEKHGLPTNSLNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWACWDGVRGYEAKNHDFLQGQIGNPTGE
DAPNKKYYDPRAWLRAAQESMVARLEKAFSDLNAVDVL

Sequences:

>Translated_358_residues
MTKILDVVKPGVLTGDDLQKVFKVAKENKFALPAVNVVGSDSINAVLEAAAKVKAPVVIQFSNGGAAFNAGKGLKLPGHE
AAILGAVSGAKHVHAMAEAYGVPVILHTDHAARKLLPWIDGLLTASEAHFAETGKPLFSSHMIDLSEEPLEENIATCAEY
LTRMSKMGMTLEIELGCTGGEEDGVDNSGMDDSLLYTQPSEVDYANTELSKISPNFTIAASFGNVHGVYKPGNVKLTPAI
LRESQAFVSEKHGLPTNSLNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWACWDGVRGYEAKNHDFLQGQIGNPTGE
DAPNKKYYDPRAWLRAAQESMVARLEKAFSDLNAVDVL
>Mature_357_residues
TKILDVVKPGVLTGDDLQKVFKVAKENKFALPAVNVVGSDSINAVLEAAAKVKAPVVIQFSNGGAAFNAGKGLKLPGHEA
AILGAVSGAKHVHAMAEAYGVPVILHTDHAARKLLPWIDGLLTASEAHFAETGKPLFSSHMIDLSEEPLEENIATCAEYL
TRMSKMGMTLEIELGCTGGEEDGVDNSGMDDSLLYTQPSEVDYANTELSKISPNFTIAASFGNVHGVYKPGNVKLTPAIL
RESQAFVSEKHGLPTNSLNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWACWDGVRGYEAKNHDFLQGQIGNPTGED
APNKKYYDPRAWLRAAQESMVARLEKAFSDLNAVDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=360, Percent_Identity=77.2222222222222, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI87082041, Length=333, Percent_Identity=25.2252252252252, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788072, Length=310, Percent_Identity=25.4838709677419, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=49.002849002849, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38347; Mature: 38215

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00152 ATPASE_ALPHA_BETA ; PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILDVVKPGVLTGDDLQKVFKVAKENKFALPAVNVVGSDSINAVLEAAAKVKAPVVIQ
CCCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFNAGKGLKLPGHEAAILGAVSGAKHVHAMAEAYGVPVILHTDHAARKLLPWID
ECCCCCEEECCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLTASEAHFAETGKPLFSSHMIDLSEEPLEENIATCAEYLTRMSKMGMTLEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSGMDDSLLYTQPSEVDYANTELSKISPNFTIAASFGNVHGVYKPGNVKLTPAI
CCCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEECCCCCEEECCCCEEECHHH
LRESQAFVSEKHGLPTNSLNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWACWDGVR
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCEEEECCCC
GYEAKNHDFLQGQIGNPTGEDAPNKKYYDPRAWLRAAQESMVARLEKAFSDLNAVDVL
CCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TKILDVVKPGVLTGDDLQKVFKVAKENKFALPAVNVVGSDSINAVLEAAAKVKAPVVIQ
CCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFNAGKGLKLPGHEAAILGAVSGAKHVHAMAEAYGVPVILHTDHAARKLLPWID
ECCCCCEEECCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLTASEAHFAETGKPLFSSHMIDLSEEPLEENIATCAEYLTRMSKMGMTLEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSGMDDSLLYTQPSEVDYANTELSKISPNFTIAASFGNVHGVYKPGNVKLTPAI
CCCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEECCCCCEEECCCCEEECHHH
LRESQAFVSEKHGLPTNSLNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWACWDGVR
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCEEEECCCC
GYEAKNHDFLQGQIGNPTGEDAPNKKYYDPRAWLRAAQESMVARLEKAFSDLNAVDVL
CCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]