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The map label for this gene is rmlB [H]

Identifier: 119867134

GI number: 119867134

Start: 1166431

End: 1167438

Strand: Reverse

Name: rmlB [H]

Synonym: Mkms_1082

Alternate gene names: 119867134

Gene position: 1167438-1166431 (Counterclockwise)

Preceding gene: 119867135

Following gene: 119867133

Centisome position: 20.35

GC content: 69.15

Gene sequence:

>1008_bases
ATGCGGTTGCTGGTCACCGGCGGAGCGGGGTTCATCGGTGCGAACTTCGTCCACGCCACCGTGCGGGAGCATCCCGACTA
CGCGGTGACCGTGCTCGACGCGTTCACCTATGCGGGCAGCCGGGAGTCGCTGGCGCCGGTCGCCGACCGGATCCGACTGG
TCGAAGGCGACGTGGCCGACGCCGCGTTGGTCGGCGGGCTGGTCGACGACCTCGACCCGGCCACCGATGCCGTCGTGCAC
TTCGCCGCGGAAACCCACGTCGACAACGCGCTGGCCGATCCCGGCCCGTTCGTGCAGACCAACGTCGTCGGCACCTACAC
GGTGCTCGAGGCGGTCCGCCGGGCCGGCGTCCGGCTGCACCACGTGTCGACCGACGAGGTGTACGGCGACCTCGCCCTCG
ACGACCCACAGCGGTTCACCGAGTCGACGCCGTACAACCCGTCGAGTCCGTATTCGTCGACCAAGGCGGCCGCGGACCTG
CTGGTGCGCGCCTGGGTGCGGTCCTATGGCGTACGCGCGACGATCTCGAACTGCTCCAACAACTACGGGCCCTACCAGCA
CGTCGAGAAGTTCATCCCCCGGCAGATCACCAACATCCTCACCGGGCGGCGGCCCAAGCTCTACGGCACCGGCGCCAACG
TGCGCGACTGGATCCACGTCGACGACCACAACAGCGCGGTGTGGCGGATCCTGCGCGACGGCGTCGTGGGCCGCACGTAC
CTGATCGGCGCCGAGGGTGAACGCGACAACCTCTCGGTGCTGCGCACCCTGCTGCGCATCATGGACCGCGACCCCGACGA
CTTCGACCACGTCACCGACCGCGCCGGGCACGATCTGCGCTACGCCATCGACCCGTCGGTGCTCTACGACGAATTGGGTT
GGAAACCGGCACATCTCGACTTCGAGGAAGGGCTGCGCGCGACGGTGCAGTGGTACCGCGACAACGAGGCGTGGTGGCGG
CCGCTCAAGGACGCCGCCGAAGCGGCCTACGAGGAGCGCGGCCAGTGA

Upstream 100 bases:

>100_bases
GGTGCTGGGCGGTTGGGACAAACTCATCCCGACGCTCGAGGAGTTGGCGGGCCCGCTCGGGTTGACGAAGTAGGCGCGGG
CGGCCGCTAGGGTTTCCTCC

Downstream 100 bases:

>100_bases
GCGCGCGGGAGCTGGCGGTACCCGGCGCATGGGAGATCACCCCGACCGTGCACGCGGATTCGCGTGGGTCATTCATGGAG
TGGTTCACCGACCGCGAGTT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRLLVTGGAGFIGANFVHATVREHPDYAVTVLDAFTYAGSRESLAPVADRIRLVEGDVADAALVGGLVDDLDPATDAVVH
FAAETHVDNALADPGPFVQTNVVGTYTVLEAVRRAGVRLHHVSTDEVYGDLALDDPQRFTESTPYNPSSPYSSTKAAADL
LVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVDDHNSAVWRILRDGVVGRTY
LIGAEGERDNLSVLRTLLRIMDRDPDDFDHVTDRAGHDLRYAIDPSVLYDELGWKPAHLDFEEGLRATVQWYRDNEAWWR
PLKDAAEAAYEERGQ

Sequences:

>Translated_335_residues
MRLLVTGGAGFIGANFVHATVREHPDYAVTVLDAFTYAGSRESLAPVADRIRLVEGDVADAALVGGLVDDLDPATDAVVH
FAAETHVDNALADPGPFVQTNVVGTYTVLEAVRRAGVRLHHVSTDEVYGDLALDDPQRFTESTPYNPSSPYSSTKAAADL
LVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVDDHNSAVWRILRDGVVGRTY
LIGAEGERDNLSVLRTLLRIMDRDPDDFDHVTDRAGHDLRYAIDPSVLYDELGWKPAHLDFEEGLRATVQWYRDNEAWWR
PLKDAAEAAYEERGQ
>Mature_335_residues
MRLLVTGGAGFIGANFVHATVREHPDYAVTVLDAFTYAGSRESLAPVADRIRLVEGDVADAALVGGLVDDLDPATDAVVH
FAAETHVDNALADPGPFVQTNVVGTYTVLEAVRRAGVRLHHVSTDEVYGDLALDDPQRFTESTPYNPSSPYSSTKAAADL
LVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVDDHNSAVWRILRDGVVGRTY
LIGAEGERDNLSVLRTLLRIMDRDPDDFDHVTDRAGHDLRYAIDPSVLYDELGWKPAHLDFEEGLRATVQWYRDNEAWWR
PLKDAAEAAYEERGQ

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=335, Percent_Identity=33.4328358208955, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI42516563, Length=319, Percent_Identity=24.4514106583072, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4504031, Length=244, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI48994969, Length=348, Percent_Identity=46.8390804597701, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=43.7325905292479, Blast_Score=287, Evalue=8e-79,
Organism=Escherichia coli, GI1788366, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786974, Length=326, Percent_Identity=27.9141104294479, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=325, Percent_Identity=33.5384615384615, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI115532424, Length=319, Percent_Identity=29.7805642633229, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17539422, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=186, Percent_Identity=30.1075268817204, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=186, Percent_Identity=30.1075268817204, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=187, Percent_Identity=28.8770053475936, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=22.0543806646526, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24158427, Length=248, Percent_Identity=27.0161290322581, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356223, Length=330, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 37256; Mature: 37256

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVTGGAGFIGANFVHATVREHPDYAVTVLDAFTYAGSRESLAPVADRIRLVEGDVAD
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
AALVGGLVDDLDPATDAVVHFAAETHVDNALADPGPFVQTNVVGTYTVLEAVRRAGVRLH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCEEE
HVSTDEVYGDLALDDPQRFTESTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSN
ECCHHHHHCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHCCC
NYGPYQHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVDDHNSAVWRILRDGVVGRTY
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCEE
LIGAEGERDNLSVLRTLLRIMDRDPDDFDHVTDRAGHDLRYAIDPSVLYDELGWKPAHLD
EEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCC
FEEGLRATVQWYRDNEAWWRPLKDAAEAAYEERGQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLLVTGGAGFIGANFVHATVREHPDYAVTVLDAFTYAGSRESLAPVADRIRLVEGDVAD
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
AALVGGLVDDLDPATDAVVHFAAETHVDNALADPGPFVQTNVVGTYTVLEAVRRAGVRLH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCEEE
HVSTDEVYGDLALDDPQRFTESTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSN
ECCHHHHHCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHCCC
NYGPYQHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVDDHNSAVWRILRDGVVGRTY
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCEE
LIGAEGERDNLSVLRTLLRIMDRDPDDFDHVTDRAGHDLRYAIDPSVLYDELGWKPAHLD
EEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCC
FEEGLRATVQWYRDNEAWWRPLKDAAEAAYEERGQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA