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The map label for this gene is rmlC [H]

Identifier: 119867133

GI number: 119867133

Start: 1165847

End: 1166434

Strand: Reverse

Name: rmlC [H]

Synonym: Mkms_1081

Alternate gene names: 119867133

Gene position: 1166434-1165847 (Counterclockwise)

Preceding gene: 119867134

Following gene: 119867132

Centisome position: 20.33

GC content: 69.56

Gene sequence:

>588_bases
GTGAGCGCGCGGGAGCTGGCGGTACCCGGCGCATGGGAGATCACCCCGACCGTGCACGCGGATTCGCGTGGGTCATTCAT
GGAGTGGTTCACCGACCGCGAGTTCACCGCGTTCGCCGGCCACCGCCTCGATGTCCGGCAGGCCAACTGTTCGGTGTCGA
GGGCAGGCGTGCTGCGCGGTCTGCACTTCGCGGCGGTGCCGCCGGGTCAGGCGAAGTACGTCACCTGTGTGCGCGGGGCG
GTGTTCGACGTGGCCGTCGACATCCGGGTCGGCTCCCCCACCTTCGGGCGCTGGGATGCGGTGCTGCTCGACGACCGCGA
CCGCCGATCGATCTACCTGTCGGAGGGCTTGGGGCACGCTTTCCTTGCGCTGCAGGATGATTCGACCGTGATGTACCTGT
GCTCGACGGGTTACGACCCGGCCCGCGAGCACACGGTGTCGCCCACCGATCCGGCGCTGGGCATCGAGTGGCCCTTCGAC
GGTGAGCTGGTGCTGTCCGATCGTGACGCCGCGGCCCCGACGCTGGATCAGGCGCGCGACGCCGGCCTGCTCCCGACGTG
GGATGCCTACCTGGCGCTGCCGAGATAA

Upstream 100 bases:

>100_bases
AGGAAGGGCTGCGCGCGACGGTGCAGTGGTACCGCGACAACGAGGCGTGGTGGCGGCCGCTCAAGGACGCCGCCGAAGCG
GCCTACGAGGAGCGCGGCCA

Downstream 100 bases:

>100_bases
GGGTTCTGCCCCGCGTTCGCGCCTTTCGCGTGTCATGACCCTGATCTCGACGATCGAGGGAAGCCCCCTTGTCAACCACC
CCGACCAGTTACTAGGATGT

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSARELAVPGAWEITPTVHADSRGSFMEWFTDREFTAFAGHRLDVRQANCSVSRAGVLRGLHFAAVPPGQAKYVTCVRGA
VFDVAVDIRVGSPTFGRWDAVLLDDRDRRSIYLSEGLGHAFLALQDDSTVMYLCSTGYDPAREHTVSPTDPALGIEWPFD
GELVLSDRDAAAPTLDQARDAGLLPTWDAYLALPR

Sequences:

>Translated_195_residues
MSARELAVPGAWEITPTVHADSRGSFMEWFTDREFTAFAGHRLDVRQANCSVSRAGVLRGLHFAAVPPGQAKYVTCVRGA
VFDVAVDIRVGSPTFGRWDAVLLDDRDRRSIYLSEGLGHAFLALQDDSTVMYLCSTGYDPAREHTVSPTDPALGIEWPFD
GELVLSDRDAAAPTLDQARDAGLLPTWDAYLALPR
>Mature_194_residues
SARELAVPGAWEITPTVHADSRGSFMEWFTDREFTAFAGHRLDVRQANCSVSRAGVLRGLHFAAVPPGQAKYVTCVRGAV
FDVAVDIRVGSPTFGRWDAVLLDDRDRRSIYLSEGLGHAFLALQDDSTVMYLCSTGYDPAREHTVSPTDPALGIEWPFDG
ELVLSDRDAAAPTLDQARDAGLLPTWDAYLALPR

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N- acetylglucosamine-L-r

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=164, Percent_Identity=38.4146341463415, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17550412, Length=167, Percent_Identity=38.3233532934132, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21353; Mature: 21222

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARELAVPGAWEITPTVHADSRGSFMEWFTDREFTAFAGHRLDVRQANCSVSRAGVLRG
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHC
LHFAAVPPGQAKYVTCVRGAVFDVAVDIRVGSPTFGRWDAVLLDDRDRRSIYLSEGLGHA
CEEEECCCCCCEEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCEE
FLALQDDSTVMYLCSTGYDPAREHTVSPTDPALGIEWPFDGELVLSDRDAAAPTLDQARD
EEEEECCCEEEEEEECCCCHHHHCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHC
AGLLPTWDAYLALPR
CCCCCCCHHEEECCC
>Mature Secondary Structure 
SARELAVPGAWEITPTVHADSRGSFMEWFTDREFTAFAGHRLDVRQANCSVSRAGVLRG
CCCCCCCCCCEEEEEEEECCCCCCHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHC
LHFAAVPPGQAKYVTCVRGAVFDVAVDIRVGSPTFGRWDAVLLDDRDRRSIYLSEGLGHA
CEEEECCCCCCEEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCEE
FLALQDDSTVMYLCSTGYDPAREHTVSPTDPALGIEWPFDGELVLSDRDAAAPTLDQARD
EEEEECCCEEEEEEECCCCHHHHCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHC
AGLLPTWDAYLALPR
CCCCCCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA