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The map label for this gene is frdA [H]

Identifier: 119855014

GI number: 119855014

Start: 133294

End: 135069

Strand: Direct

Name: frdA [H]

Synonym: Mkms_5622

Alternate gene names: 119855014

Gene position: 133294-135069 (Clockwise)

Preceding gene: 119855013

Following gene: 119855015

Centisome position: 44.12

GC content: 62.73

Gene sequence:

>1776_bases
ATGGGCAGTGACCTGGATGTGTCGGTCCAAGAATGCGACGTCCTGGTAGTGGGTGGGGGAATTGGCGGAGCGCGGGCAGC
ACTACGGGCCGCGGAGTTGGGGTCGTCGGTGATTCTGGTGGAGAAAGCGGTGGTGTCTCGGGCAGGGCCGATGACGTATG
TCCACAGCCAATACGCCCCTGATCACCGGGTGCAGGGTGAGGAGATGACGGAGTGGGCGCGCGAGTTCGTGGTAGGCAGC
AATTATTTGGCCGATCAGGATTGGGTGCAGCAGTACATAGCCGAGGCCTATGACAGGGTTAACGAGCAGATCGAGTGGGG
TGTGCCCTATTCCACTCATGAGGATGGGTCGCTGAAGTATGTGACGGTCCGCGGCCACAACCTTGGCACGACGCTGGGTG
TGGATGGTCGCGTGTGTATGGAGATCCTCAAGGAGAGGATGAAAGCGGCGGGGGTGCGACTGTTCGAGCGGGTCGATGTG
ATCGATCTGCTGACCACCGACGGGTGTCGGCCCACCGCTGGTGCGGTGTGTGGTGCGGTGGGGGTAAATGTTGTCACTGG
CCAGTGTCATGTCTTCACGGCGGGCAGCGTCATCCTCAACACCGGCCCTTGGTACCCCAAGCTGCATTACGCGTTCGCCG
ACCATTGCAGCGGGGAAGGTCATGTGGCGGCCTGGCGAGTGGGTGCCGAGTTCGCCGGCATGGAATTCGGCCAGTTCGCT
GCCTGGAGTTACTTCAATCGGTCATTCTTCACACCGGGTCAAGCCAAGATTCAGGGGATCGGTGGCAAGTTCTGCAACGC
GGCGGGCGAGTACTTCATGGACCGCTATGACCCGATCTGGGGCGATAAGGGCGGGTTGTTCACCATCGCGCGCGCGATCA
TGACCGAGATGGTCGAGGGCCGAGGGCCGTGCTATCTCGACTTGCGTCACGTACCACAGGCGGATCTAGAGGTGCTGTAT
GAAGTGTCTCCGACGGTGCGGCGCGCCTTTACCGAGTTTGAGGTCGATCCCTCCACTGACCTGCTGGAGGTGACCCCGTT
CATCGTGCTCGGCACGAGCAGCACCAGCGGTCCCACGATCGACCTGGACGGAGCCACCACAGTGCCCGGCCTGTACGCGG
CCGGGTATGGCACGGCGTGTCCGCATTTGATGTCGGGAATTTCTGGCAGCGGGATCTCGAGCTTCTCGGCTGTTGCGGGG
TACCGGGCGGGCACTGCGGCGGCGGCGCGCGGCGGTCACGCGGTAGCGCGCAGTGTGTGGGAGAACCAGGCACAGGAGAG
CTTCGCGGAGTATTTCGCGCCGATGCGTCGGCTGCGGCAGGTCCGGCCGGTGGATGTGTGGAAAGCCATCGGCGAGGCGA
CGGCCAATCCGGCATTCGCATTGTTTAAGTCGGAGGCACGGATCGATTCAGCGCTCGCTGAGCTGTACCGGATCCGGGAT
CGGGTACTGCGTTACGTTTTCGCGCCGGACTATCAAGAACTTAAGAAGGCGCATGAGGTGCGCGCATACCTGACGTTGGC
GATCATCACCTGTGAGGCGATGAAGCGGCGCACCGAAAGTCGCGGGGAGCTGTTTCGTATCGACTACCCCTACGCCGACA
ACGATGAGTGGCTGAAGTGGCTGCTCGTGCGCCGGGGCAGCGGCGGTGAATTCGATCTGCAGTTCAGCGAACGCGACCTG
CCGATCCAGTCGTGGCCGGTGCAGGCCCCGCCCGGCCGCCATCCAAGTCCATATACCGTGCCGCAAGGCTACCGTGAGGA
GGCGGCGGTTCAGTGA

Upstream 100 bases:

>100_bases
CGCGTGGATATCGCCGATTCCAGAAAGGGTCCAACCATATGACCACCGAAACAACCGAGACGGACTTGATCGAGATGTTG
GTGAAGGCGTGACCGGCGTT

Downstream 100 bases:

>100_bases
TCGAAAGCATCGACGAAACAACGTGCGACGGGTGCAACGTCTGCATCGACAGCTGCCCAACCGGGGTGATCCGGCTGGTG
GAGGGCGACGAACCGTGGTC

Product: fumarate reductase/succinate dehydrogenase flavoprotein domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MGSDLDVSVQECDVLVVGGGIGGARAALRAAELGSSVILVEKAVVSRAGPMTYVHSQYAPDHRVQGEEMTEWAREFVVGS
NYLADQDWVQQYIAEAYDRVNEQIEWGVPYSTHEDGSLKYVTVRGHNLGTTLGVDGRVCMEILKERMKAAGVRLFERVDV
IDLLTTDGCRPTAGAVCGAVGVNVVTGQCHVFTAGSVILNTGPWYPKLHYAFADHCSGEGHVAAWRVGAEFAGMEFGQFA
AWSYFNRSFFTPGQAKIQGIGGKFCNAAGEYFMDRYDPIWGDKGGLFTIARAIMTEMVEGRGPCYLDLRHVPQADLEVLY
EVSPTVRRAFTEFEVDPSTDLLEVTPFIVLGTSSTSGPTIDLDGATTVPGLYAAGYGTACPHLMSGISGSGISSFSAVAG
YRAGTAAAARGGHAVARSVWENQAQESFAEYFAPMRRLRQVRPVDVWKAIGEATANPAFALFKSEARIDSALAELYRIRD
RVLRYVFAPDYQELKKAHEVRAYLTLAIITCEAMKRRTESRGELFRIDYPYADNDEWLKWLLVRRGSGGEFDLQFSERDL
PIQSWPVQAPPGRHPSPYTVPQGYREEAAVQ

Sequences:

>Translated_591_residues
MGSDLDVSVQECDVLVVGGGIGGARAALRAAELGSSVILVEKAVVSRAGPMTYVHSQYAPDHRVQGEEMTEWAREFVVGS
NYLADQDWVQQYIAEAYDRVNEQIEWGVPYSTHEDGSLKYVTVRGHNLGTTLGVDGRVCMEILKERMKAAGVRLFERVDV
IDLLTTDGCRPTAGAVCGAVGVNVVTGQCHVFTAGSVILNTGPWYPKLHYAFADHCSGEGHVAAWRVGAEFAGMEFGQFA
AWSYFNRSFFTPGQAKIQGIGGKFCNAAGEYFMDRYDPIWGDKGGLFTIARAIMTEMVEGRGPCYLDLRHVPQADLEVLY
EVSPTVRRAFTEFEVDPSTDLLEVTPFIVLGTSSTSGPTIDLDGATTVPGLYAAGYGTACPHLMSGISGSGISSFSAVAG
YRAGTAAAARGGHAVARSVWENQAQESFAEYFAPMRRLRQVRPVDVWKAIGEATANPAFALFKSEARIDSALAELYRIRD
RVLRYVFAPDYQELKKAHEVRAYLTLAIITCEAMKRRTESRGELFRIDYPYADNDEWLKWLLVRRGSGGEFDLQFSERDL
PIQSWPVQAPPGRHPSPYTVPQGYREEAAVQ
>Mature_590_residues
GSDLDVSVQECDVLVVGGGIGGARAALRAAELGSSVILVEKAVVSRAGPMTYVHSQYAPDHRVQGEEMTEWAREFVVGSN
YLADQDWVQQYIAEAYDRVNEQIEWGVPYSTHEDGSLKYVTVRGHNLGTTLGVDGRVCMEILKERMKAAGVRLFERVDVI
DLLTTDGCRPTAGAVCGAVGVNVVTGQCHVFTAGSVILNTGPWYPKLHYAFADHCSGEGHVAAWRVGAEFAGMEFGQFAA
WSYFNRSFFTPGQAKIQGIGGKFCNAAGEYFMDRYDPIWGDKGGLFTIARAIMTEMVEGRGPCYLDLRHVPQADLEVLYE
VSPTVRRAFTEFEVDPSTDLLEVTPFIVLGTSSTSGPTIDLDGATTVPGLYAAGYGTACPHLMSGISGSGISSFSAVAGY
RAGTAAAARGGHAVARSVWENQAQESFAEYFAPMRRLRQVRPVDVWKAIGEATANPAFALFKSEARIDSALAELYRIRDR
VLRYVFAPDYQELKKAHEVRAYLTLAIITCEAMKRRTESRGELFRIDYPYADNDEWLKWLLVRRGSGGEFDLQFSERDLP
IQSWPVQAPPGRHPSPYTVPQGYREEAAVQ

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=492, Percent_Identity=24.5934959349593, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1786942, Length=572, Percent_Identity=25, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=23.731884057971, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17505833, Length=491, Percent_Identity=25.050916496945, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550100, Length=495, Percent_Identity=24.8484848484848, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322701, Length=510, Percent_Identity=26.4705882352941, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322416, Length=504, Percent_Identity=25.9920634920635, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137288, Length=499, Percent_Identity=25.8517034068136, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24655642, Length=499, Percent_Identity=25.8517034068136, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24655647, Length=499, Percent_Identity=25.8517034068136, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24663005, Length=560, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64878; Mature: 64747

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDLDVSVQECDVLVVGGGIGGARAALRAAELGSSVILVEKAVVSRAGPMTYVHSQYAP
CCCCCCCCHHHCCEEEEECCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCEEECCCCCC
DHRVQGEEMTEWAREFVVGSNYLADQDWVQQYIAEAYDRVNEQIEWGVPYSTHEDGSLKY
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEE
VTVRGHNLGTTLGVDGRVCMEILKERMKAAGVRLFERVDVIDLLTTDGCRPTAGAVCGAV
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
GVNVVTGQCHVFTAGSVILNTGPWYPKLHYAFADHCSGEGHVAAWRVGAEFAGMEFGQFA
CCEEEECEEEEEEECEEEECCCCCCCEEEHHHHHCCCCCCCEEEEEECCHHCCCCCCHHH
AWSYFNRSFFTPGQAKIQGIGGKFCNAAGEYFMDRYDPIWGDKGGLFTIARAIMTEMVEG
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
RGPCYLDLRHVPQADLEVLYEVSPTVRRAFTEFEVDPSTDLLEVTPFIVLGTSSTSGPTI
CCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCEE
DLDGATTVPGLYAAGYGTACPHLMSGISGSGISSFSAVAGYRAGTAAAARGGHAVARSVW
ECCCCCCCCCHHCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHH
ENQAQESFAEYFAPMRRLRQVRPVDVWKAIGEATANPAFALFKSEARIDSALAELYRIRD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHH
RVLRYVFAPDYQELKKAHEVRAYLTLAIITCEAMKRRTESRGELFRIDYPYADNDEWLKW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LLVRRGSGGEFDLQFSERDLPIQSWPVQAPPGRHPSPYTVPQGYREEAAVQ
HHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
GSDLDVSVQECDVLVVGGGIGGARAALRAAELGSSVILVEKAVVSRAGPMTYVHSQYAP
CCCCCCCHHHCCEEEEECCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCEEECCCCCC
DHRVQGEEMTEWAREFVVGSNYLADQDWVQQYIAEAYDRVNEQIEWGVPYSTHEDGSLKY
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEE
VTVRGHNLGTTLGVDGRVCMEILKERMKAAGVRLFERVDVIDLLTTDGCRPTAGAVCGAV
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
GVNVVTGQCHVFTAGSVILNTGPWYPKLHYAFADHCSGEGHVAAWRVGAEFAGMEFGQFA
CCEEEECEEEEEEECEEEECCCCCCCEEEHHHHHCCCCCCCEEEEEECCHHCCCCCCHHH
AWSYFNRSFFTPGQAKIQGIGGKFCNAAGEYFMDRYDPIWGDKGGLFTIARAIMTEMVEG
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
RGPCYLDLRHVPQADLEVLYEVSPTVRRAFTEFEVDPSTDLLEVTPFIVLGTSSTSGPTI
CCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCEE
DLDGATTVPGLYAAGYGTACPHLMSGISGSGISSFSAVAGYRAGTAAAARGGHAVARSVW
ECCCCCCCCCHHCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHH
ENQAQESFAEYFAPMRRLRQVRPVDVWKAIGEATANPAFALFKSEARIDSALAELYRIRD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHH
RVLRYVFAPDYQELKKAHEVRAYLTLAIITCEAMKRRTESRGELFRIDYPYADNDEWLKW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LLVRRGSGGEFDLQFSERDLPIQSWPVQAPPGRHPSPYTVPQGYREEAAVQ
HHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]