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The map label for this gene is upp [H]

Identifier: 119900056

GI number: 119900056

Start: 4126875

End: 4127507

Strand: Direct

Name: upp [H]

Synonym: azo3767

Alternate gene names: 119900056

Gene position: 4126875-4127507 (Clockwise)

Preceding gene: 119900055

Following gene: 119900058

Centisome position: 94.31

GC content: 69.98

Gene sequence:

>633_bases
ATGCACCCTGCCCTGCGCGTGATCGACCACCCGCTGCTGCAGCACAAGCTCTCTGTGGCACGCAGCGCCGACACCACCAC
CGACAACTTCCGCCGCCTGGTGCGCGAGATCGCGGCGATGCTGGCCTACGAGGTCACCCGCGACCTGCCCACCGAACGGG
TCAGCGTCACCACGCCGATCGCGGAATGCAAGGTGCCGATGATTGCCGGCAAGAAGCTCTGCCTGGTGTCCATCCTGCGC
GCCGGCAACGGCATGCTGGACGGCATGATCGAGCTGCTGCCGGGCGCGCGTGTCGGCCACATCGGCCTTTACCGCGACCC
GCACACGCTGCAGCCGGTGGAGTACTACTTCAAGCTGCCGGAGGACATCGAGGAGCGCGAGGTGATCGTCGTCGACCCGA
TGCTCGCCACCGGCAACTCCGCCACCGCGGCGCTGTCGCGGCTGAAGGAGGAAGGCGTCGCCAGCCTGCGCCTGGTGTGC
CTGCTGGCGGCGCCGGAAGGGCTGGCGGCGCTCGCCGCCCACCATCCCGATGTGCCGGTGACGGCGGCGGCGGTCGACAG
CCACCTGGACGAGCACGGCTACATCGTGCCCGGCCTCGGCGATGCCGGCGACCGCCTGTTCGGCACCCGTTGA

Upstream 100 bases:

>100_bases
CGGCCGGCCGCCGCATCGCCGCCGACCGCCGGCCCGGTGGCGCGCCGCCGCTGGCCATCCTCAGCGATGGAACCGTGTTC
TGACCCCCGGGAGACCTGCC

Downstream 100 bases:

>100_bases
GCCGCGCTCAGGCGCCCGGCCGGGCCCAGAAGCGCAGCGGCGCCGCCGCGGCCAGGAAGGCGCTGGGCGGCGAGCCGGTG
TCCAGCGCAACGAAGCCGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MHPALRVIDHPLLQHKLSVARSADTTTDNFRRLVREIAAMLAYEVTRDLPTERVSVTTPIAECKVPMIAGKKLCLVSILR
AGNGMLDGMIELLPGARVGHIGLYRDPHTLQPVEYYFKLPEDIEEREVIVVDPMLATGNSATAALSRLKEEGVASLRLVC
LLAAPEGLAALAAHHPDVPVTAAAVDSHLDEHGYIVPGLGDAGDRLFGTR

Sequences:

>Translated_210_residues
MHPALRVIDHPLLQHKLSVARSADTTTDNFRRLVREIAAMLAYEVTRDLPTERVSVTTPIAECKVPMIAGKKLCLVSILR
AGNGMLDGMIELLPGARVGHIGLYRDPHTLQPVEYYFKLPEDIEEREVIVVDPMLATGNSATAALSRLKEEGVASLRLVC
LLAAPEGLAALAAHHPDVPVTAAAVDSHLDEHGYIVPGLGDAGDRLFGTR
>Mature_210_residues
MHPALRVIDHPLLQHKLSVARSADTTTDNFRRLVREIAAMLAYEVTRDLPTERVSVTTPIAECKVPMIAGKKLCLVSILR
AGNGMLDGMIELLPGARVGHIGLYRDPHTLQPVEYYFKLPEDIEEREVIVVDPMLATGNSATAALSRLKEEGVASLRLVC
LLAAPEGLAALAAHHPDVPVTAAAVDSHLDEHGYIVPGLGDAGDRLFGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=195, Percent_Identity=31.2820512820513, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI57863312, Length=195, Percent_Identity=31.2820512820513, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI21450816, Length=180, Percent_Identity=29.4444444444444, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=48.7684729064039, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45550449, Length=211, Percent_Identity=32.7014218009479, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573516, Length=211, Percent_Identity=32.7014218009479, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573514, Length=211, Percent_Identity=32.7014218009479, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573512, Length=211, Percent_Identity=32.7014218009479, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21358379, Length=137, Percent_Identity=28.4671532846715, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22707; Mature: 22707

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPALRVIDHPLLQHKLSVARSADTTTDNFRRLVREIAAMLAYEVTRDLPTERVSVTTPI
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCH
AECKVPMIAGKKLCLVSILRAGNGMLDGMIELLPGARVGHIGLYRDPHTLQPVEYYFKLP
HHCCCCHHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCC
EDIEEREVIVVDPMLATGNSATAALSRLKEEGVASLRLVCLLAAPEGLAALAAHHPDVPV
CCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCCCCC
TAAAVDSHLDEHGYIVPGLGDAGDRLFGTR
HHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHPALRVIDHPLLQHKLSVARSADTTTDNFRRLVREIAAMLAYEVTRDLPTERVSVTTPI
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCH
AECKVPMIAGKKLCLVSILRAGNGMLDGMIELLPGARVGHIGLYRDPHTLQPVEYYFKLP
HHCCCCHHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCC
EDIEEREVIVVDPMLATGNSATAALSRLKEEGVASLRLVCLLAAPEGLAALAAHHPDVPV
CCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCCCCC
TAAAVDSHLDEHGYIVPGLGDAGDRLFGTR
HHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA