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The map label for this gene is zraS [H]

Identifier: 119899787

GI number: 119899787

Start: 3839343

End: 3841346

Strand: Direct

Name: zraS [H]

Synonym: azo3498

Alternate gene names: 119899787

Gene position: 3839343-3841346 (Clockwise)

Preceding gene: 119899786

Following gene: 119899788

Centisome position: 87.74

GC content: 73.15

Gene sequence:

>2004_bases
ATGACCTCCAACCCTCCCCGCGTTCTCAGCCCGCGTCCGCGCGCCGCCAACGCCAGCGCCATCCTGGCCCTGCTGGGGCA
TGGGCTGCCCGCGTGGGGCGAGGTCGCGCTGGTCGCCGCGCGCGACCCGGCGCTGTGCCTTGCGCTGCTGTCCGCCTCCC
CGCTGGCTGGCGGCAAGGGCCTGGAGGATGGTCTCAACTCGGCGCTGCAAACCCGCCTGGAAACGCTCGGCGCCGATCTC
CTGCGCGCGTGGCTGTGCCACACCGAAAGCGCCAGCGGCCGCGCCGACGCCGCCGTGCTGCTGACGGCCGAATGCGCGCT
CCATCTCGCGCTCGAAACGCGTTACCCCCGCCCCGACGAAGCCTACCTCGCCGGCCTGTGGCTGACGCCCTCGACGTTCT
GCCTGCCCGCCCAGGCCGCCGACGCCGACGTCCCCCTGCTGCCGGCCGATCAAGCGGCGGCGCGGCACGTGCTCCACGCC
GCAATCGCCGAGGCCGCCGGGCGCTGCGGGCTTTCGGCCGCGGTCCGCGATGTGCTGGAGGCGGGCCAACTGCTGGACGA
GCAAGCTGCCCTGGCGCATCCGCTGCTGCGCATCGTGCACGCCGCGCGCCTGCTGGCGAGCGAATCGTGGCCGCGGCACC
TGCCGGCCATCGAGGCGCTGACCCGGCTGGACTCCGCGGCGCTGCGCAGCCTGCGTACCGACGTTGGCTACATCGTCGCC
GGCCACGCGGCCTATCCGCCCGCCGCCGTCCGCCCCGAGGGCCAGGCCCTGCCCGTCATCGTGGCGGCCGACCCTGCCGA
TGCCTTTCACGCGGCGGCGCTGCGCGGCCTGATCCTCGCGGCCTTTGCCGAACTGGACGAAAGCGCGGTAGCGCCGCGCG
CGGCGCTGGCCACCCGCCTGCTTGCCGGACGCGACCTGCCCTTGGTCGCACTCGCGGGCGAGGACGGCTGCTTTCAGGCG
GTGCTTGGCCCCGACCTCACCCGGACCGCGTTCAACGAACTGGCGCTCGCCGAAGACGACCCCGCCAGTTGCATTGCGCT
CGCCGCCCGCAGCGGGCGCGCCGCCGCCTTTGCCGACAACGCCCAGGGGCCGGCGCGCAGCGTGGCGGACTGGCAGGTCG
CGCGCTGGCTGGGCGGGCGCGGTTTCGACTGCCTGCCGTTGGCGGTGGGCGGCCGCTTCGGCGTGGCGATGGTCGCCGTG
GAGCCGGACGCCGACGGTGCCGCCAGCACGCGCTGGCTGCTCACCGAGCTGCTCGGTGCAGCGAGCAGGCGACTGCGCGA
ACACCACGCGGCGCGCGAGGCCAGCGCGGCGCGCGAAGCCGCCCTGCGCGGCCGCTTCCACGCCCATGCCCGGCGCATTG
CGCATGAAGCAGCCAATCCGCTGACGGTCATCCGCACGCGGCTGGACATGCTGGGCCAGCAGCAGGCGGCCGGCAGCGCG
CTGCACGGCGAGGTGGCGCTGCTGAATACGGAACTCGATCGCGTCGCCCGGCTGTTGCGCGGCGCCGGCGAACTGCCCGC
CGACGAAACCGAGCTGGCGCGCTGCAACCTGACCGAACTGCTGCTGGAAATGCGCACGATGTATGCCGACACGCTGTTCA
CCGCGAAGGGCATTACGTTCGAACTACGCGCGGCCAGCGGCGTACCACCCGTGGCGATCCCGCCCTCGGCGCTGCGCCAG
GTGCTGCTGAACCTGTTCCGCAATGCCGCGGAGGCCTTGCAGCCGGGTGGCCGGCTGGCGGTCGCGCTAGCGGGCCAGGC
CAATGCAAACGGGCGCAGCTGTGCGGAAATCCGCCTGGTGGACAATGGCCCCGGGCTGCCCGAGGACCGGCTCGCCGACC
TCTTCGCGCCGCGCCCCAGCACCAAGGGCGGCAGTCATCAAGGCGTGGGGCTCAGCGTCGTCCGCGACATTCTCGCGCAA
TGGAACGCCTCTATCCTTTGTCGGAGCCAGAGCGGCGGCGGAACGAGCTTCCAGATCTTTGTTCCGCTGGAACAAAGGCC
CTGA

Upstream 100 bases:

>100_bases
TCCGCCACGCGGAGACCGCACGCGACTTCGGTCACATCCCTGTCGCCCGGCGCCGGCTAGAATCGGCTGCAAAACAACGA
CTTCGGCGCCGGCCGCCAGG

Downstream 100 bases:

>100_bases
TTTGTAGCAATATTCATCTCACAAGACCCATAACGCGACCCGACCTCCAGGGGGCTCATGGTTATTCCAGCAGACCAGCC
GTTCCAGGTGCGCTCCGAGC

Product: putative sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MTSNPPRVLSPRPRAANASAILALLGHGLPAWGEVALVAARDPALCLALLSASPLAGGKGLEDGLNSALQTRLETLGADL
LRAWLCHTESASGRADAAVLLTAECALHLALETRYPRPDEAYLAGLWLTPSTFCLPAQAADADVPLLPADQAAARHVLHA
AIAEAAGRCGLSAAVRDVLEAGQLLDEQAALAHPLLRIVHAARLLASESWPRHLPAIEALTRLDSAALRSLRTDVGYIVA
GHAAYPPAAVRPEGQALPVIVAADPADAFHAAALRGLILAAFAELDESAVAPRAALATRLLAGRDLPLVALAGEDGCFQA
VLGPDLTRTAFNELALAEDDPASCIALAARSGRAAAFADNAQGPARSVADWQVARWLGGRGFDCLPLAVGGRFGVAMVAV
EPDADGAASTRWLLTELLGAASRRLREHHAAREASAAREAALRGRFHAHARRIAHEAANPLTVIRTRLDMLGQQQAAGSA
LHGEVALLNTELDRVARLLRGAGELPADETELARCNLTELLLEMRTMYADTLFTAKGITFELRAASGVPPVAIPPSALRQ
VLLNLFRNAAEALQPGGRLAVALAGQANANGRSCAEIRLVDNGPGLPEDRLADLFAPRPSTKGGSHQGVGLSVVRDILAQ
WNASILCRSQSGGGTSFQIFVPLEQRP

Sequences:

>Translated_667_residues
MTSNPPRVLSPRPRAANASAILALLGHGLPAWGEVALVAARDPALCLALLSASPLAGGKGLEDGLNSALQTRLETLGADL
LRAWLCHTESASGRADAAVLLTAECALHLALETRYPRPDEAYLAGLWLTPSTFCLPAQAADADVPLLPADQAAARHVLHA
AIAEAAGRCGLSAAVRDVLEAGQLLDEQAALAHPLLRIVHAARLLASESWPRHLPAIEALTRLDSAALRSLRTDVGYIVA
GHAAYPPAAVRPEGQALPVIVAADPADAFHAAALRGLILAAFAELDESAVAPRAALATRLLAGRDLPLVALAGEDGCFQA
VLGPDLTRTAFNELALAEDDPASCIALAARSGRAAAFADNAQGPARSVADWQVARWLGGRGFDCLPLAVGGRFGVAMVAV
EPDADGAASTRWLLTELLGAASRRLREHHAAREASAAREAALRGRFHAHARRIAHEAANPLTVIRTRLDMLGQQQAAGSA
LHGEVALLNTELDRVARLLRGAGELPADETELARCNLTELLLEMRTMYADTLFTAKGITFELRAASGVPPVAIPPSALRQ
VLLNLFRNAAEALQPGGRLAVALAGQANANGRSCAEIRLVDNGPGLPEDRLADLFAPRPSTKGGSHQGVGLSVVRDILAQ
WNASILCRSQSGGGTSFQIFVPLEQRP
>Mature_666_residues
TSNPPRVLSPRPRAANASAILALLGHGLPAWGEVALVAARDPALCLALLSASPLAGGKGLEDGLNSALQTRLETLGADLL
RAWLCHTESASGRADAAVLLTAECALHLALETRYPRPDEAYLAGLWLTPSTFCLPAQAADADVPLLPADQAAARHVLHAA
IAEAAGRCGLSAAVRDVLEAGQLLDEQAALAHPLLRIVHAARLLASESWPRHLPAIEALTRLDSAALRSLRTDVGYIVAG
HAAYPPAAVRPEGQALPVIVAADPADAFHAAALRGLILAAFAELDESAVAPRAALATRLLAGRDLPLVALAGEDGCFQAV
LGPDLTRTAFNELALAEDDPASCIALAARSGRAAAFADNAQGPARSVADWQVARWLGGRGFDCLPLAVGGRFGVAMVAVE
PDADGAASTRWLLTELLGAASRRLREHHAAREASAAREAALRGRFHAHARRIAHEAANPLTVIRTRLDMLGQQQAAGSAL
HGEVALLNTELDRVARLLRGAGELPADETELARCNLTELLLEMRTMYADTLFTAKGITFELRAASGVPPVAIPPSALRQV
LLNLFRNAAEALQPGGRLAVALAGQANANGRSCAEIRLVDNGPGLPEDRLADLFAPRPSTKGGSHQGVGLSVVRDILAQW
NASILCRSQSGGGTSFQIFVPLEQRP

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=29.9539170506912, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1790300, Length=298, Percent_Identity=27.1812080536913, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69698; Mature: 69567

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNPPRVLSPRPRAANASAILALLGHGLPAWGEVALVAARDPALCLALLSASPLAGGKG
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCC
LEDGLNSALQTRLETLGADLLRAWLCHTESASGRADAAVLLTAECALHLALETRYPRPDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
AYLAGLWLTPSTFCLPAQAADADVPLLPADQAAARHVLHAAIAEAAGRCGLSAAVRDVLE
CEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AGQLLDEQAALAHPLLRIVHAARLLASESWPRHLPAIEALTRLDSAALRSLRTDVGYIVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
GHAAYPPAAVRPEGQALPVIVAADPADAFHAAALRGLILAAFAELDESAVAPRAALATRL
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAGRDLPLVALAGEDGCFQAVLGPDLTRTAFNELALAEDDPASCIALAARSGRAAAFADN
HCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCC
AQGPARSVADWQVARWLGGRGFDCLPLAVGGRFGVAMVAVEPDADGAASTRWLLTELLGA
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
ASRRLREHHAAREASAAREAALRGRFHAHARRIAHEAANPLTVIRTRLDMLGQQQAAGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCC
LHGEVALLNTELDRVARLLRGAGELPADETELARCNLTELLLEMRTMYADTLFTAKGITF
CCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHEECCCEE
ELRAASGVPPVAIPPSALRQVLLNLFRNAAEALQPGGRLAVALAGQANANGRSCAEIRLV
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEE
DNGPGLPEDRLADLFAPRPSTKGGSHQGVGLSVVRDILAQWNASILCRSQSGGGTSFQIF
ECCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
VPLEQRP
EECCCCC
>Mature Secondary Structure 
TSNPPRVLSPRPRAANASAILALLGHGLPAWGEVALVAARDPALCLALLSASPLAGGKG
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCC
LEDGLNSALQTRLETLGADLLRAWLCHTESASGRADAAVLLTAECALHLALETRYPRPDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
AYLAGLWLTPSTFCLPAQAADADVPLLPADQAAARHVLHAAIAEAAGRCGLSAAVRDVLE
CEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AGQLLDEQAALAHPLLRIVHAARLLASESWPRHLPAIEALTRLDSAALRSLRTDVGYIVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
GHAAYPPAAVRPEGQALPVIVAADPADAFHAAALRGLILAAFAELDESAVAPRAALATRL
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAGRDLPLVALAGEDGCFQAVLGPDLTRTAFNELALAEDDPASCIALAARSGRAAAFADN
HCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCC
AQGPARSVADWQVARWLGGRGFDCLPLAVGGRFGVAMVAVEPDADGAASTRWLLTELLGA
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
ASRRLREHHAAREASAAREAALRGRFHAHARRIAHEAANPLTVIRTRLDMLGQQQAAGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCC
LHGEVALLNTELDRVARLLRGAGELPADETELARCNLTELLLEMRTMYADTLFTAKGITF
CCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHEECCCEE
ELRAASGVPPVAIPPSALRQVLLNLFRNAAEALQPGGRLAVALAGQANANGRSCAEIRLV
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEE
DNGPGLPEDRLADLFAPRPSTKGGSHQGVGLSVVRDILAQWNASILCRSQSGGGTSFQIF
ECCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
VPLEQRP
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]