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The map label for this gene is gmhA

Identifier: 119776488

GI number: 119776488

Start: 3984459

End: 3985052

Strand: Direct

Name: gmhA

Synonym: Sama_3356

Alternate gene names: 119776488

Gene position: 3984459-3985052 (Clockwise)

Preceding gene: 119776487

Following gene: 119776489

Centisome position: 92.53

GC content: 57.91

Gene sequence:

>594_bases
ATGTTAGAACGTATCAAAGACAGCTTTACCGAGTCGATTCAGACCAAGATCGATGCCGCAGAAGCTCTGCCGGATTCTAT
CGCCAAGGCGGCTGAGATGATGGTGGCCTGCCTGTTGGGTGGTAATAAGATCCTCGCCTGCGGTAACGGCGGCAGCGCCG
GTGATGCCCAGCACTTTTCCGCCGAGCTGCTGAACCGTTACGAAGTAGAGCGCCCACCACTGCCTGCCATCGCGCTGACC
ACAGATTCATCGACGCTCACTGCCATCGCCAACGACTACAGCTACGATGAGGTGTTTTCCAAGCAGATCCTTGCTCTGGG
CCAACCCGGCGACATACTGCTGGCCATCTCCACCAGCGGCAACTCATCCAACGTGATTAAAGCCATGGAAGCCGCCCTGA
GCCGCGACATGACCATCGTGGCCCTGACCGGGAAAGACGGTGGCGCCATGGCTGGACTCCTGGGTGCCAGCGACGTGGAA
ATTAGGGTACCGTCCAATGTGACAGCCCGCATCCAGGAAGTGCATCTTTTGGTGATCCACTGCCTGTGCGACAACATCGA
CCGCACCCTGTTCCCTCAGGACGAAAACGCATGA

Upstream 100 bases:

>100_bases
GCCACCCGCCACATCCGTGCACAACAATTTCACCCCCTGCCCTCTACTCGCGCGCCGCTTTGTGGCATGATAGCGGCAGT
TTATTTTGTAAGGATCCACC

Downstream 100 bases:

>100_bases
TACGACTGCTGCTGACCGCACTTGCCTGTATCACACTGACCGGCTGCGCCGGTGCCGTGATGGTAGGCGCCGTCGGTGGC
GCCGTGATGGCCAATGACGA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFSAELLNRYEVERPPLPAIALT
TDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSGNSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVE
IRVPSNVTARIQEVHLLVIHCLCDNIDRTLFPQDENA

Sequences:

>Translated_197_residues
MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFSAELLNRYEVERPPLPAIALT
TDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSGNSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVE
IRVPSNVTARIQEVHLLVIHCLCDNIDRTLFPQDENA
>Mature_197_residues
MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFSAELLNRYEVERPPLPAIALT
TDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSGNSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVE
IRVPSNVTARIQEVHLLVIHCLCDNIDRTLFPQDENA

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789539, Length=196, Percent_Identity=65.8163265306122, Blast_Score=272, Evalue=1e-74,
Organism=Escherichia coli, GI1786416, Length=166, Percent_Identity=48.1927710843374, Blast_Score=160, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_SHEAM (A1SB02)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929228.1
- ProteinModelPortal:   A1SB02
- SMR:   A1SB02
- STRING:   A1SB02
- GeneID:   4605603
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3356
- NMPDR:   fig|326297.7.peg.3159
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   HDREMIV
- PhylomeDB:   A1SB02
- ProtClustDB:   CLSK905682
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20778; Mature: 20778

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
AELLNRYEVERPPLPAIALTTDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCC
NSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVEIRVPSNVTARIQEVHLLVIH
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHH
CLCDNIDRTLFPQDENA
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
AELLNRYEVERPPLPAIALTTDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCC
NSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVEIRVPSNVTARIQEVHLLVIH
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHH
CLCDNIDRTLFPQDENA
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA