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The map label for this gene is hemC [H]

Identifier: 119776386

GI number: 119776386

Start: 3848789

End: 3849769

Strand: Direct

Name: hemC [H]

Synonym: Sama_3254

Alternate gene names: 119776386

Gene position: 3848789-3849769 (Clockwise)

Preceding gene: 119776384

Following gene: 119776387

Centisome position: 89.38

GC content: 55.56

Gene sequence:

>981_bases
ATGTTAGCATTGGCGCAACTAACGCAGACCATAAGATGGAAAATCGGCATGTCTCAAAACCTTATTCGTATCGCGACCCG
CAAAAGCCCCCTTGCCATGTGGCAGGCTGAGTTTGTTAAAGCAGAGCTCGAGCGCATTCATCCGGATTTGACCGTGGAAC
TGCTGCCCATGAGCACCAAGGGCGACGTTATTCTGGATACGCCTCTGGCCAAAGTGGGTGGTAAAGGCCTGTTCGTGAAA
GAACTGGAAGTTGCCATGCTGGAAGGCCGTGCCGACATTGCCGTGCACTCCATGAAAGACGTGCCAGTGGATTTTCCGGA
AGGCCTGGGTCTGGAAGTGATTTGTGAACGCGAAGACCCACGTGATGCTTTTGTGTCCAACACTTACAAGAGTATTGATG
AGCTGCCACAGGGCGCCGTAGTCGGCACCTCCAGCCTGCGTCGACAGTGTCAACTGCGCGCCCGTCGTCCCGACCTGATA
ATCAAAGACCTGCGCGGTAACGTTGGCACCCGTTTGGCCAAACTCGACTCAGGCGAATACGATGCCATCATCCTCGCCGC
GGCGGGTCTTATCCGCCTTAAACTTGCCGAGCGTATCGCAGGTTTTATCAGCACCGAAGAATCACTGCCCGCCAATGGAC
AGGGCGCTGTAGGCATTGAATGCCGTACCAATGATGAGCGTGTCAAAGCCTTACTGGCACCACTGGAGCACAAAGAAACC
CGCCTGCGGGTGCTTGCCGAACGAGCCATGAATACCCGTCTGGAAGGGGGCTGTCAGGTGCCTATTGGTGCCTTTGCCGA
AATCGAAGCCGACACCCTGACACTGCGTGGTTTGGTGGGTAACCCCGATGGCAGCGAAGTGATCACCGGCTCTGTGACAG
GTTCAACTGCTGATGCCATTGCATTGGGTCATCAACTGGCGGACGACCTGCTCAGTCGTGGTGCAAAAACCATTCTGGAT
GCGGTCTACGCCCGGAACTGA

Upstream 100 bases:

>100_bases
CGAACGCAAACATTTGCGATAGAGATCACATTTTTACCGACAGTTTCTCCTTTCACACCACAAAGATGCGACAGCGGTTC
CTTACATAGTCGCCGAGGCA

Downstream 100 bases:

>100_bases
CCATGAAGCTGCTGCTCACCCGTCCTGAGGGCAAAAACGCCGCCATGGCCAGTGCACTGGATGCGCTGGCCATTCCTTAT
TTGGTGGAACCCTTGTTATC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLALAQLTQTIRWKIGMSQNLIRIATRKSPLAMWQAEFVKAELERIHPDLTVELLPMSTKGDVILDTPLAKVGGKGLFVK
ELEVAMLEGRADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKSIDELPQGAVVGTSSLRRQCQLRARRPDLI
IKDLRGNVGTRLAKLDSGEYDAIILAAAGLIRLKLAERIAGFISTEESLPANGQGAVGIECRTNDERVKALLAPLEHKET
RLRVLAERAMNTRLEGGCQVPIGAFAEIEADTLTLRGLVGNPDGSEVITGSVTGSTADAIALGHQLADDLLSRGAKTILD
AVYARN

Sequences:

>Translated_326_residues
MLALAQLTQTIRWKIGMSQNLIRIATRKSPLAMWQAEFVKAELERIHPDLTVELLPMSTKGDVILDTPLAKVGGKGLFVK
ELEVAMLEGRADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKSIDELPQGAVVGTSSLRRQCQLRARRPDLI
IKDLRGNVGTRLAKLDSGEYDAIILAAAGLIRLKLAERIAGFISTEESLPANGQGAVGIECRTNDERVKALLAPLEHKET
RLRVLAERAMNTRLEGGCQVPIGAFAEIEADTLTLRGLVGNPDGSEVITGSVTGSTADAIALGHQLADDLLSRGAKTILD
AVYARN
>Mature_326_residues
MLALAQLTQTIRWKIGMSQNLIRIATRKSPLAMWQAEFVKAELERIHPDLTVELLPMSTKGDVILDTPLAKVGGKGLFVK
ELEVAMLEGRADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKSIDELPQGAVVGTSSLRRQCQLRARRPDLI
IKDLRGNVGTRLAKLDSGEYDAIILAAAGLIRLKLAERIAGFISTEESLPANGQGAVGIECRTNDERVKALLAPLEHKET
RLRVLAERAMNTRLEGGCQVPIGAFAEIEADTLTLRGLVGNPDGSEVITGSVTGSTADAIALGHQLADDLLSRGAKTILD
AVYARN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=339, Percent_Identity=41.8879056047198, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI20149500, Length=339, Percent_Identity=41.8879056047198, Blast_Score=228, Evalue=6e-60,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=69.3811074918567, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.3177570093458, Blast_Score=201, Evalue=9e-53,
Organism=Drosophila melanogaster, GI20130425, Length=313, Percent_Identity=39.9361022364217, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35263; Mature: 35263

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALAQLTQTIRWKIGMSQNLIRIATRKSPLAMWQAEFVKAELERIHPDLTVELLPMSTK
CCCHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GDVILDTPLAKVGGKGLFVKELEVAMLEGRADIAVHSMKDVPVDFPEGLGLEVICEREDP
CCEEEECCHHHHCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCC
RDAFVSNTYKSIDELPQGAVVGTSSLRRQCQLRARRPDLIIKDLRGNVGTRLAKLDSGEY
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCEEEHHHCCCHHHEEEECCCCCC
DAIILAAAGLIRLKLAERIAGFISTEESLPANGQGAVGIECRTNDERVKALLAPLEHKET
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
RLRVLAERAMNTRLEGGCQVPIGAFAEIEADTLTLRGLVGNPDGSEVITGSVTGSTADAI
HHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCEEEEECCCCCHHHH
ALGHQLADDLLSRGAKTILDAVYARN
HHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MLALAQLTQTIRWKIGMSQNLIRIATRKSPLAMWQAEFVKAELERIHPDLTVELLPMSTK
CCCHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GDVILDTPLAKVGGKGLFVKELEVAMLEGRADIAVHSMKDVPVDFPEGLGLEVICEREDP
CCEEEECCHHHHCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCC
RDAFVSNTYKSIDELPQGAVVGTSSLRRQCQLRARRPDLIIKDLRGNVGTRLAKLDSGEY
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCEEEHHHCCCHHHEEEECCCCCC
DAIILAAAGLIRLKLAERIAGFISTEESLPANGQGAVGIECRTNDERVKALLAPLEHKET
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
RLRVLAERAMNTRLEGGCQVPIGAFAEIEADTLTLRGLVGNPDGSEVITGSVTGSTADAI
HHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCEEEEECCCCCHHHH
ALGHQLADDLLSRGAKTILDAVYARN
HHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA