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The map label for this gene is hemD [H]

Identifier: 119776387

GI number: 119776387

Start: 3849772

End: 3850491

Strand: Direct

Name: hemD [H]

Synonym: Sama_3255

Alternate gene names: 119776387

Gene position: 3849772-3850491 (Clockwise)

Preceding gene: 119776386

Following gene: 119776388

Centisome position: 89.4

GC content: 55.56

Gene sequence:

>720_bases
ATGAAGCTGCTGCTCACCCGTCCTGAGGGCAAAAACGCCGCCATGGCCAGTGCACTGGATGCGCTGGCCATTCCTTATTT
GGTGGAACCCTTGTTATCGGTGGAGGCAGCAGCCGTCACTCAAGCGCAGTTGGATGAACTTTCACGCGCCGACATACTCA
TCTTTATCAGTACCAGTGCGGTCAGTTTTGCCACCCCCTGGCTGAAGGACCAATGGCCAAAAGCCACCTATTACGCGGTG
GGAGATGCCACTGCCGATGCCCTGGCTTTGCAAGGTATCACAGCCGAACGCTCACCCGCCGACAGCCAGGCCACAGAAGG
TTTACTCACACTCCCCTCTCTGGAACAGGTGTCCGGTAAACAGATAGTCATAGTCCGGGGTAAAGGTGGCCGCGAAGCCA
TGGCCGATGGTTTGCGGCTTCGAGGGGCAAATGTGAGCTATCTTGAGGTCTATCAGCGGGCCTGTCCGCCGCTGGATGCC
CCTGCAAGTGTCAGTCGCTGGCAATCCTTCGGTATAGACACCATAGTAGTGACCAGTGGTGAAGTACTGGAAAACTTAAT
AAATCTGGTTCCCAAAGACAGTTTTGCATGGCTCAGAGACTGTCATATCATAGTCCCCAGTGCCCGGGTCGAAACCCAGG
CAAGGAAAAAGGGACTTCGTCGAGTCACCAACGCCGGAGCAGCAAACCAAGCCGCCGTACTGGACGCATTGGGCATGTAA

Upstream 100 bases:

>100_bases
CAACTGCTGATGCCATTGCATTGGGTCATCAACTGGCGGACGACCTGCTCAGTCGTGGTGCAAAAACCATTCTGGATGCG
GTCTACGCCCGGAACTGACC

Downstream 100 bases:

>100_bases
ACTTTTGCTGCTTTAGTTTCCCTGAATTGCACGCTTTCTAGCATCAAGGATTGTTTCATGGAAAACCAACAGCAAGAGGC
CGCCGCAGCAGAGTCCACTA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQAQLDELSRADILIFISTSAVSFATPWLKDQWPKATYYAV
GDATADALALQGITAERSPADSQATEGLLTLPSLEQVSGKQIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDA
PASVSRWQSFGIDTIVVTSGEVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAVLDALGM

Sequences:

>Translated_239_residues
MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQAQLDELSRADILIFISTSAVSFATPWLKDQWPKATYYAV
GDATADALALQGITAERSPADSQATEGLLTLPSLEQVSGKQIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDA
PASVSRWQSFGIDTIVVTSGEVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAVLDALGM
>Mature_239_residues
MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQAQLDELSRADILIFISTSAVSFATPWLKDQWPKATYYAV
GDATADALALQGITAERSPADSQATEGLLTLPSLEQVSGKQIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDA
PASVSRWQSFGIDTIVVTSGEVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAVLDALGM

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=247, Percent_Identity=35.6275303643725, Blast_Score=133, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 25484; Mature: 25484

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQAQLDELSRADILIFISTSA
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VSFATPWLKDQWPKATYYAVGDATADALALQGITAERSPADSQATEGLLTLPSLEQVSGK
HHHCCCCHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCHHHHCCEEECCCHHHCCCC
QIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDAPASVSRWQSFGIDTIVVTSG
EEEEEECCCCHHHHHCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECH
EVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAVLDALGM
HHHHHHHHHCCCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQAQLDELSRADILIFISTSA
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VSFATPWLKDQWPKATYYAVGDATADALALQGITAERSPADSQATEGLLTLPSLEQVSGK
HHHCCCCHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCHHHHCCEEECCCHHHCCCC
QIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDAPASVSRWQSFGIDTIVVTSG
EEEEEECCCCHHHHHCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECH
EVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAVLDALGM
HHHHHHHHHCCCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]